{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:48:09Z","timestamp":1790365689005,"version":"4.1.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T00:00:00Z","timestamp":1675296000000},"content-version":"vor","delay-in-days":2681,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"NIH","award":["NR012642"],"award-info":[{"award-number":["NR012642"]}]},{"name":"NIH","award":["K23HL116209"],"award-info":[{"award-number":["K23HL116209"]}]},{"DOI":"10.13039\/100007917","name":"USDA Agricultural Research Service","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007917","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007813","name":"Center for AIDS Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007813","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100008136","name":"Case Western Reserve University","doi-asserted-by":"publisher","award":["P30 AI36219"],"award-info":[{"award-number":["P30 AI36219"]}],"id":[{"id":"10.13039\/100008136","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.3945\/jn.115.214577","type":"journal-article","created":{"date-parts":[[2015,8,13]],"date-time":"2015-08-13T02:29:36Z","timestamp":1439432976000},"page":"2293-2299","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Plasma Selenium Concentrations Are Sufficient and Associated with Protease Inhibitor Use in Treated HIV-Infected Adults"],"prefix":"10.1016","volume":"145","author":[{"given":"Corrilynn O","family":"Hileman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahera","family":"Dirajlal-Fargo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suet Kam","family":"Lam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig","family":"Lacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Gerald F","family":"Combs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace A","family":"McComsey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.3945\/jn.115.214577_bib1","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1074\/jbc.R800045200","article-title":"Selenoproteins","volume":"284","author":"Lu","year":"2009","journal-title":"J Biol Chem"},{"key":"10.3945\/jn.115.214577_bib2","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1093\/ajcn\/84.4.762","article-title":"Selenium and coronary heart disease: a meta-analysis","volume":"84","author":"Flores-Mateo","year":"2006","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/jn.115.214577_bib3","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0009-2797(94)90038-8","article-title":"Selenium deficiency in HIV infection and the acquired immunodeficiency syndrome (AIDS)","volume":"91","author":"Dworkin","year":"1994","journal-title":"Chem Biol Interact"},{"key":"10.3945\/jn.115.214577_bib4","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1111\/j.1753-4887.2010.00337.x","article-title":"Role of selenium in HIV infection","volume":"68","author":"Stone","year":"2010","journal-title":"Nutr Rev"},{"issue":"5","key":"10.3945\/jn.115.214577_bib5","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1097\/00042560-199708150-00007","article-title":"High risk of HIV-related mortality is associated with selenium deficiency","volume":"15","author":"Baum","year":"1997","journal-title":"J Acquir Immune Defic Syndr Hum Retrovirol"},{"issue":"5","key":"10.3945\/jn.115.214577_bib6","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1097\/00042560-199904150-00015","article-title":"Mortality risk in selenium-deficient HIV-positive children","volume":"20","author":"Campa","year":"1999","journal-title":"J Acquir Immune Defic Syndr Hum Retrovirol"},{"key":"10.3945\/jn.115.214577_bib7","doi-asserted-by":"crossref","first-page":"2556","DOI":"10.1093\/jn\/134.10.2556","article-title":"Selenium status is associated with accelerated HIV disease progression among HIV-1-infected pregnant women in Tanzania","volume":"134","author":"Kupka","year":"2004","journal-title":"J Nutr"},{"key":"10.3945\/jn.115.214577_bib8","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1097\/QAD.0b013e32834273ad","article-title":"Effect of highly active antiretroviral therapy on biomarkers of B-lymphocyte activation and inflammation","volume":"25","author":"Regidor","year":"2011","journal-title":"AIDS"},{"key":"10.3945\/jn.115.214577_bib9","first-page":"1119","article-title":"Relationship between inflammatory markers, endothelial activation markers, and carotid intima-media thickness in HIV-infected patients receiving antiretroviral therapy","volume":"49","author":"Ross","year":"2009","journal-title":"Nephrol Dial Transplant"},{"issue":"7","key":"10.3945\/jn.115.214577_bib10","doi-asserted-by":"crossref","first-page":"2506","DOI":"10.1210\/jc.2006-2190","article-title":"Increased acute myocardial infarction rates and cardiovascular risk factors among patients with human immunodeficiency virus disease","volume":"92","author":"Triant","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"10.3945\/jn.115.214577_bib11","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1001\/jamainternmed.2013.3728","article-title":"HIV infection and the risk of acute myocardial infarction","volume":"173","author":"Freiberg","year":"2013","journal-title":"JAMA Intern Med"},{"key":"10.3945\/jn.115.214577_bib12","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1001\/jama.2012.6698","article-title":"Arterial inflammation in patients with HIV","volume":"308","author":"Subramanian","year":"2012","journal-title":"JAMA"},{"key":"10.3945\/jn.115.214577_bib13","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1097\/QAD.0000000000000145","article-title":"Immunologic predictors of coronary artery calcium progression in a contemporary HIV cohort","volume":"28","author":"Baker","year":"2014","journal-title":"AIDS"},{"key":"10.3945\/jn.115.214577_bib14","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1097\/QAI.0000000000000063","article-title":"C-reactive protein predicts 96-week carotid intima media thickness progression in HIV-infected adults naive to antiretroviral therapy","volume":"65","author":"Hileman","year":"2014","journal-title":"J Acquir Immune Defic Syndr"},{"key":"10.3945\/jn.115.214577_bib15","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.3945\/ajcn.2009.28816","article-title":"Micronutrient concentrations and subclinical atherosclerosis in adults with HIV","volume":"91","author":"Falcone","year":"2010","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/jn.115.214577_bib16","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jtemb.2009.06.005","article-title":"Chronic treatment with statins increases the availability of selenium in the antioxidant defence systems of hemodialysis patients","volume":"24","author":"Taccone-Gallucci","year":"2010","journal-title":"J Trace Elem Med Biol"},{"key":"10.3945\/jn.115.214577_bib17","first-page":"588","article-title":"Rosuvastatin treatment reduces markers of monocyte activation in HIV-infected subjects on antiretroviral therapy","volume":"58","author":"Funderburg","year":"2014","journal-title":"Nephrol Dial Transplant"},{"key":"10.3945\/jn.115.214577_bib18","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/1475-2891-10-75","article-title":"Determinants of selenium status in healthy adults","volume":"10","author":"Combs","year":"2011","journal-title":"Nutr J"},{"key":"10.3945\/jn.115.214577_bib19","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1001\/jama.1996.03540240035027","article-title":"Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. Nutritional Prevention of Cancer Study Group","volume":"276","author":"Clark","year":"1996","journal-title":"JAMA"},{"key":"10.3945\/jn.115.214577_bib20","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1097\/QAD.0000000000000158","article-title":"Soluble CD14 is independently associated with coronary calcification and extent of subclinical vascular disease in treated HIV infection","volume":"28","author":"Longenecker","year":"2014","journal-title":"AIDS"},{"key":"10.3945\/jn.115.214577_bib21","first-page":"1148","article-title":"Rosuvastatin preserves renal function and lowers cystatin C in HIV-infected subjects on antiretroviral therapy: the SATURN-HIV trial","volume":"59","author":"Longenecker","year":"2014","journal-title":"Nephrol Dial Transplant"},{"key":"10.3945\/jn.115.214577_bib22","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia"},{"key":"10.3945\/jn.115.214577_bib23","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1097\/QAI.0000000000000478","article-title":"Rosuvastatin reduces vascular inflammation and T-cell and monocyte activation in HIV-infected subjects on antiretroviral therapy","volume":"68","author":"Funderburg","year":"2015","journal-title":"J Acquir Immune Defic Syndr"},{"key":"10.3945\/jn.115.214577_bib24","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/BF02990269","article-title":"Serum trace element levels in HIV-infected subjects","volume":"25","author":"Beck","year":"1990","journal-title":"Biol Trace Elem Res"},{"key":"10.3945\/jn.115.214577_bib25","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1093\/ajcn\/64.1.101","article-title":"The enzymatic antioxidant system in blood and glutathione status in human immunodeficiency virus (HIV)-infected patients: effects of supplementation with selenium or beta-carotene","volume":"64","author":"Delmas-Beauvieux","year":"1996","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/jn.115.214577_bib26","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1093\/ajcn\/85.5.1327","article-title":"Nutritional biomarkers associated with gynecological conditions among US women with or at risk of HIV infection","volume":"85","author":"Tohill","year":"2007","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/jn.115.214577_bib27","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1093\/ajcn\/67.1.143","article-title":"Oxidative stress and plasma antioxidant micronutrients in humans with HIV infection","volume":"67","author":"Allard","year":"1998","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/jn.115.214577_bib28","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1057\/jphp.2009.20","article-title":"Factors associated with serum retinol, alpha-tocopherol, carotenoids, and selenium in Hispanics with problems of HIV, chronic hepatitis C, and drug use","volume":"30","author":"Forrester","year":"2009","journal-title":"J Public Health Policy"},{"key":"10.3945\/jn.115.214577_bib29","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/sj.ejcn.1600401","article-title":"Serum selenium, plasma glutathione (GSH) and erythrocyte glutathione peroxidase (GSH-Px)-levels in asymptomatic versus symptomatic human immunodeficiency virus-1 (HIV-1)-infection","volume":"51","author":"Look","year":"1997","journal-title":"Eur J Clin Nutr"},{"key":"10.3945\/jn.115.214577_bib30","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1097\/01.qai.0000243096.27029.fe","article-title":"Micronutrient levels and HIV disease status in HIV-infected patients on highly active antiretroviral therapy in the Nutrition for Healthy Living cohort","volume":"43","author":"Jones","year":"2006","journal-title":"J Acquir Immune Defic Syndr"},{"key":"10.3945\/jn.115.214577_bib31","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.clnu.2014.03.012","article-title":"A longer time of exposure to antiretroviral therapy improves selenium levels","volume":"34","author":"de Menezes Barbosa","year":"2015","journal-title":"Clin Nutr"},{"key":"10.3945\/jn.115.214577_bib32","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1111\/hiv.12049","article-title":"Higher vitamin D levels in HIV-infected out-patients on treatment with boosted protease inhibitor monotherapy","volume":"14","author":"Cervero","year":"2013","journal-title":"HIV Med"},{"key":"10.3945\/jn.115.214577_bib33","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.jtemb.2014.07.016","article-title":"Serum and urinary selenium levels in obese children: a cross-sectional study","volume":"29","author":"Blazewicz","year":"2015","journal-title":"J Trace Elem Med Biol"},{"key":"10.3945\/jn.115.214577_bib34","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1824-7288-40-20","article-title":"Serum trace elements in obese Egyptian children: a case-control study","volume":"40","author":"Azab","year":"2014","journal-title":"Ital J Pediatr"},{"issue":"2","key":"10.3945\/jn.115.214577_bib35","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S1096-2190(00)00009-3","article-title":"beta-Carotene and selenium supplementation enhances immune response in aged humans","volume":"2","author":"Wood","year":"2000","journal-title":"Integr Med"},{"key":"10.3945\/jn.115.214577_bib36","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1385\/BTER:97:1:31","article-title":"Alterations in plasma essential trace elements selenium, manganese, zinc, copper, and iron concentrations and the possible role of these elements on oxidative status in patients with childhood asthma","volume":"97","author":"Kocyigit","year":"2004","journal-title":"Biol Trace Elem Res"},{"key":"10.3945\/jn.115.214577_bib37","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1164\/rccm.200301-055OC","article-title":"Relationship of serum antioxidants to asthma prevalence in youth","volume":"169","author":"Rubin","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"key":"10.3945\/jn.115.214577_bib38","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1164\/ajrccm.164.10.2104061","article-title":"Dietary antioxidants and asthma in adults: population-based case-control study","volume":"164","author":"Shaheen","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"issue":"2","key":"10.3945\/jn.115.214577_bib39","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/j.1365-2222.2007.02657.x","article-title":"Supplementation with vitamins C, E, beta-carotene and selenium has no effect on anti-oxidant status and immune responses in allergic adults: a randomized controlled trial","volume":"37","author":"Dunstan","year":"2007","journal-title":"Clin Exp Allergy"},{"issue":"1","key":"10.3945\/jn.115.214577_bib40","first-page":"17","article-title":"The influence of selenium supplementation on the immunity of corticoid-dependent asthmatics","volume":"103","author":"Gazdik","year":"2002","journal-title":"Bratisl Lek Listy"},{"key":"10.3945\/jn.115.214577_bib41","doi-asserted-by":"crossref","first-page":"129","DOI":"10.2174\/157016207779316288","article-title":"Prevalence of dilated cardiomyopathy in HIV-infected African patients not receiving HAART: a multicenter, observational, prospective, cohort study in Rwanda","volume":"5","author":"Twagirumukiza","year":"2007","journal-title":"Curr HIV Res"},{"key":"10.3945\/jn.115.214577_bib42","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1177\/0148607188012005537","article-title":"Is nonobstructive cardiomyopathy in AIDS a selenium deficiency-related disease?","volume":"12","author":"Zazzo","year":"1988","journal-title":"JPEN J Parenter Enteral Nutr"},{"key":"10.3945\/jn.115.214577_bib43","first-page":"CD009671","article-title":"Selenium supplementation for the primary prevention of cardiovascular disease","volume":"1","author":"Rees","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"10.3945\/jn.115.214577_bib44","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1111\/hiv.12013","article-title":"Markers of inflammation and CD8 T-cell activation, but not monocyte activation, are associated with subclinical carotid artery disease in HIV-infected individuals","volume":"14","author":"Longenecker","year":"2013","journal-title":"HIV Med"},{"key":"10.3945\/jn.115.214577_bib45","first-page":"1005","article-title":"Effects of statin therapy on serum trace element status in dyslipidemic patients: results of a randomized placebo-controlled cross-over trial","volume":"58","author":"Farrokhi","year":"2012","journal-title":"Clin Lab"}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622088927?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622088927?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/jn\/article-pdf\/145\/10\/2293\/23969509\/jn214577.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T23:29:04Z","timestamp":1686698944000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316622088927"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":45,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["S0022316622088927"],"URL":"https:\/\/doi.org\/10.3945\/jn.115.214577","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[2015,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Plasma Selenium Concentrations Are Sufficient and Associated with Protease Inhibitor Use in Treated HIV-Infected Adults","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.3945\/jn.115.214577","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 American Society of Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}