{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T13:54:35Z","timestamp":1772805275842,"version":"3.50.1"},"reference-count":92,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T00:00:00Z","timestamp":1675641600000},"content-version":"vor","delay-in-days":2502,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"Spanish government, Institute of Health Carlos III","award":["RTIC G03\/140"],"award-info":[{"award-number":["RTIC G03\/140"]}]},{"name":"Spanish government, Institute of Health Carlos III","award":["RTIC RD 06\/0045"],"award-info":[{"award-number":["RTIC RD 06\/0045"]}]},{"name":"Biomedical Research Networking Center Consortium Physiopathology of Obesity and Nutrition (CIBERobn)"},{"name":"NIH; Department of Health and Human Services"},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["1R01HL118264-01"],"award-info":[{"award-number":["1R01HL118264-01"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.3945\/jn.115.219147","type":"journal-article","created":{"date-parts":[[2016,3,10]],"date-time":"2016-03-10T04:09:41Z","timestamp":1457582981000},"page":"913S-919S","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"title":["Intervention Trials with the Mediterranean Diet in Cardiovascular Prevention: Understanding Potential Mechanisms through Metabolomic Profiling"],"prefix":"10.1016","volume":"146","author":[{"given":"Miguel \u00c1","family":"Mart\u00ednez-Gonz\u00e1lez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Ruiz-Canela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adela","family":"Hruby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liming","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonia","family":"Trichopoulou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank B","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.3945\/jn.115.219147_bib1","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1016\/S0140-6736(12)61766-8","article-title":"A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990\u20132010: A systematic analysis for the Global Burden of Disease Study 2010","volume":"380","author":"Lim","year":"2012","journal-title":"Lancet"},{"key":"10.3945\/jn.115.219147_bib2","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/1741-7015-12-112","article-title":"Definitions and potential health benefits of the Mediterranean diet: views from experts around the world","volume":"12","author":"Trichopoulou","year":"2014","journal-title":"BMC Med"},{"key":"10.3945\/jn.115.219147_bib3","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1097\/MOL.0000000000000044","article-title":"Dietary patterns, Mediterranean diet, and cardiovascular disease","volume":"25","author":"Martinez-Gonzalez","year":"2014","journal-title":"Curr Opin Lipidol"},{"key":"10.3945\/jn.115.219147_bib4","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.pcad.2015.04.003","article-title":"PREDIMED INVESTIGATORS. Benefits of the Mediterranean diet: Insights from the PREDIMED Study","volume":"58","author":"Mart\u00ednez-Gonz\u00e1lez","year":"2015","journal-title":"Prog Cardiovasc Dis"},{"key":"10.3945\/jn.115.219147_bib5","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.3945\/ajcn.2010.29673","article-title":"Accruing evidence on benefits of adherence to the Mediterranean diet on health: An updated systematic review and meta-analysis","volume":"92","author":"Sofi","year":"2010","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/jn.115.219147_bib6","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1017\/S1368980013003169","article-title":"Mediterranean diet and health status: An updated meta-analysis and a proposal for a literature-based adherence score","volume":"17","author":"Sofi","year":"2014","journal-title":"Public Health Nutr"},{"key":"10.3945\/jn.115.219147_bib7","series-title":"A series of systematic reviews on the relationship between dietary patterns and health outcomes.","article-title":"For the Evidence Analysis Library Division Center for Nutrition Policy and Promotion, US Department of Agriculture","author":"Stoody","year":"2014"},{"key":"10.3945\/jn.115.219147_bib8","doi-asserted-by":"crossref","first-page":"2599","DOI":"10.1056\/NEJMoa025039","article-title":"Adherence to a Mediterranean diet and survival in a Greek population","volume":"348","author":"Trichopoulou","year":"2003","journal-title":"N Engl J Med"},{"key":"10.3945\/jn.115.219147_bib9","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1161\/CIRCULATIONAHA.108.816736","article-title":"Mediterranean diet and incidence of and mortality from coronary heart disease and stroke in women","volume":"119","author":"Fung","year":"2009","journal-title":"Circulation"},{"key":"10.3945\/jn.115.219147_bib10","doi-asserted-by":"crossref","first-page":"587","DOI":"10.3945\/ajcn.114.090688","article-title":"Associations of key diet-quality indexes with mortality in the Multiethnic Cohort: The Dietary Patterns Methods Project","volume":"101","author":"Harmon","year":"2015","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/jn.115.219147_bib11","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1161\/01.CIR.99.6.779","article-title":"Mediterranean diet, traditional risk factors, and the rate of cardiovascular complications after myocardial infarction: Final report of the Lyon Diet Heart Study","volume":"99","author":"de Lorgeril","year":"1999","journal-title":"Circulation"},{"key":"10.3945\/jn.115.219147_bib12","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1093\/ije\/dyq250","article-title":"Cohort profile: Design and methods of the PREDIMED study","volume":"41","author":"Mart\u00ednez-Gonz\u00e1lez","year":"2012","journal-title":"Int J Epidemiol"},{"key":"10.3945\/jn.115.219147_bib13","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1056\/NEJMoa1200303","article-title":"Primary prevention of cardiovascular disease with a Mediterranean diet","volume":"368","author":"Estruch","year":"2013","journal-title":"N Engl J Med"},{"key":"10.3945\/jn.115.219147_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7326\/0003-4819-145-1-200607040-00004","article-title":"Effects of a Mediterranean-style diet on cardiovascular risk factors","volume":"145","author":"Estruch","year":"2006","journal-title":"Ann Intern Med"},{"key":"10.3945\/jn.115.219147_bib15","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.atherosclerosis.2011.04.026","article-title":"Effect of a traditional Mediterranean diet on apolipoproteins B, A-I, and their ratio: A randomized, controlled trial","volume":"218","author":"Sol\u00e1","year":"2011","journal-title":"Atherosclerosis"},{"key":"10.3945\/jn.115.219147_bib16","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.atherosclerosis.2013.08.014","article-title":"Mediterranean diet supplemented with nuts reduces waist circumference and shifts lipoprotein subfractions to a less atherogenic pattern in subjects at high cardiovascular risk","volume":"230","author":"Damasceno","year":"2013","journal-title":"Atherosclerosis"},{"key":"10.3945\/jn.115.219147_bib17","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1186\/1741-7015-11-207","article-title":"Effect of the Mediterranean diet on blood pressure in the PREDIMED trial: Results from a randomized controlled trial","volume":"11","author":"Toledo","year":"2013","journal-title":"BMC Med"},{"key":"10.3945\/jn.115.219147_bib18","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1161\/HYPERTENSIONAHA.113.03353","article-title":"Mediterranean diet reduces 24-hour ambulatory blood pressure, blood glucose, and lipids: One-year randomized, clinical trial","volume":"64","author":"Dom\u00e9nech","year":"2014","journal-title":"Hypertension"},{"key":"10.3945\/jn.115.219147_bib19","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1056\/NEJMra043430","article-title":"Inflammation, atherosclerosis, and coronary artery disease","volume":"352","author":"Hansson","year":"2005","journal-title":"N Engl J Med"},{"key":"10.3945\/jn.115.219147_bib20","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/S0140-6736(09)61717-7","article-title":"C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: An individual participant meta-analysis","volume":"375","author":"Kaptoge","year":"2010","journal-title":"Lancet"},{"key":"10.3945\/jn.115.219147_bib21","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.numecd.2014.03.003","article-title":"Mediterranean dietary pattern, inflammation and endothelial function: A systematic review and meta-analysis of intervention trials","volume":"24","author":"Schwingshackl","year":"2014","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"10.3945\/jn.115.219147_bib22","doi-asserted-by":"crossref","first-page":"248","DOI":"10.3945\/ajcn.2008.26094","article-title":"Inhibition of circulating immune cell activation: a molecular antiinflammatory effect of the Mediterranean diet","volume":"89","author":"Mena","year":"2009","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/jn.115.219147_bib23","doi-asserted-by":"crossref","first-page":"128","DOI":"10.3945\/jn.108.093054","article-title":"Polymorphisms cyclooxygenase-2\u2013765G>C and interleukin-6\u2013174G>C are associated with serum inflammation markers in a high cardiovascular risk population and do not modify the response to a Mediterranean diet supplemented with virgin olive oil or nuts","volume":"139","author":"Corella","year":"2009","journal-title":"J Nutr"},{"key":"10.3945\/jn.115.219147_bib24","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1017\/S0029665110001539","article-title":"Anti-inflammatory effects of the Mediterranean diet: the experience of the PREDIMED study","volume":"69","author":"Estruch","year":"2010","journal-title":"Proc Nutr Soc"},{"key":"10.3945\/jn.115.219147_bib25","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.phrs.2012.03.006","article-title":"Virgin olive oil and nuts as key foods of the Mediterranean diet effects on inflammatory biomakers related to atherosclerosis","volume":"65","author":"Urpi-Sarda","year":"2012","journal-title":"Pharmacol Res"},{"key":"10.3945\/jn.115.219147_bib26","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.3945\/jn.111.148726","article-title":"The Mediterranean diet pattern and its main components are associated with lower plasma concentrations of tumor necrosis factor receptor 60 in patients at high risk for cardiovascular disease","volume":"142","author":"Urpi-Sarda","year":"2012","journal-title":"J Nutr"},{"key":"10.3945\/jn.115.219147_bib27","doi-asserted-by":"crossref","first-page":"e100084","DOI":"10.1371\/journal.pone.0100084","article-title":"The effects of the Mediterranean diet on biomarkers of vascular wall inflammation and plaque vulnerability in subjects with high risk for cardiovascular disease. A randomized trial","volume":"9","author":"Casas","year":"2014","journal-title":"PLoS One"},{"key":"10.3945\/jn.115.219147_bib28","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1001\/jama.2013.280618","article-title":"Mediterranean diet inversely associated with peripheral artery disease: the PREDIMED randomized trial","volume":"311","author":"Ruiz-Canela","year":"2014","journal-title":"JAMA"},{"key":"10.3945\/jn.115.219147_bib29","doi-asserted-by":"crossref","first-page":"2488","DOI":"10.1161\/01.CIR.91.9.2488","article-title":"Atherosclerosis: Basic mechanisms. Oxidation, inflammation, and genetics","volume":"91","author":"Berliner","year":"1995","journal-title":"Circulation"},{"key":"10.3945\/jn.115.219147_bib30","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1001\/archinte.167.11.1195","article-title":"Effect of a traditional Mediterranean diet on lipoprotein oxidation. A randomized controlled trial","volume":"167","author":"Fit\u00f3","year":"2007","journal-title":"Arch Intern Med"},{"key":"10.3945\/jn.115.219147_bib31","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1038\/ejcn.2009.106","article-title":"3 years follow-up of a Mediterranean diet rich in virgin olive oil is associated with high plasma antioxidant capacity and reduced body weight gain","volume":"63","author":"Razquin","year":"2009","journal-title":"Eur J Clin Nutr"},{"key":"10.3945\/jn.115.219147_bib32","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.clnu.2012.08.002","article-title":"The Mediterranean diet improves the systemic lipid and DNA oxidative damage in metabolic syndrome individuals. A randomized, controlled, trial","volume":"32","author":"Mitjavila","year":"2013","journal-title":"Clin Nutr"},{"key":"10.3945\/jn.115.219147_bib33","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/j.numecd.2012.12.008","article-title":"Mediterranean diet and non enzymatic antioxidant capacity in the PREDIMED study: Evidence for a mechanism of antioxidant tuning","volume":"23","author":"Zamora-Ros","year":"2013","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"10.3945\/jn.115.219147_bib34","doi-asserted-by":"crossref","first-page":"845","DOI":"10.3945\/ajcn.113.060582","article-title":"In vivo transcriptomic profile after a Mediterranean diet in high-cardiovascular risk patients: A randomized controlled trial","volume":"98","author":"Casta\u00f1er","year":"2013","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/jn.115.219147_bib35","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.atherosclerosis.2009.08.004","article-title":"Effect of Mediterranean diet on the expression of pro-atherogenic genes in a population at high cardiovascular risk","volume":"208","author":"Llorente-Cort\u00e9s","year":"2010","journal-title":"Atherosclerosis"},{"key":"10.3945\/jn.115.219147_bib36","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.numecd.2014.09.001","article-title":"Effects of total dietary polyphenols on plasma nitric oxide and blood pressure in a high cardiovascular risk cohort. The PREDIMED randomized trial","volume":"25","author":"Medina-Rem\u00f3n","year":"2015","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"10.3945\/jn.115.219147_bib37","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1097\/FJC.0b013e3181c5e7fd","article-title":"Olive oil and cardiovascular health","volume":"54","author":"Covas","year":"2009","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.3945\/jn.115.219147_bib38","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1038\/sj.ejcn.1602724","article-title":"Anti-inflammatory effect of virgin olive oil in stable coronary disease patients: A randomized, crossover, controlled trial","volume":"62","author":"Fit\u00f3","year":"2008","journal-title":"Eur J Clin Nutr"},{"key":"10.3945\/jn.115.219147_bib39","doi-asserted-by":"crossref","first-page":"333","DOI":"10.7326\/0003-4819-145-5-200609050-00006","article-title":"The effect of polyphenols in olive oil on heart disease risk factors: A randomized trial","volume":"145","author":"Covas","year":"2006","journal-title":"Ann Intern Med"},{"key":"10.3945\/jn.115.219147_bib40","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/s00394-010-0162-3","article-title":"Anti-platelet effects of olive oil extract: In vitro functional and proteomic studies","volume":"50","author":"de Roos","year":"2011","journal-title":"Eur J Nutr"},{"key":"10.3945\/jn.115.219147_bib41","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.jnutbio.2009.03.012","article-title":"Hydroxytyrosol promotes mitochondrial biogenesis and mitochondrial function in 3T3\u2013L1 adipocytes","volume":"21","author":"Hao","year":"2010","journal-title":"J Nutr Biochem"},{"key":"10.3945\/jn.115.219147_bib42","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.3945\/jn.108.103622","article-title":"Regular consumption of nuts is associated with a lower risk of cardiovascular disease in women with type 2 diabetes","volume":"139","author":"Li","year":"2009","journal-title":"J Nutr"},{"key":"10.3945\/jn.115.219147_bib43","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1093\/aje\/kwj033","article-title":"Nut and seed consumption and inflammatory markers in the multi-ethnic study of atherosclerosis","volume":"163","author":"Jiang","year":"2006","journal-title":"Am J Epidemiol"},{"key":"10.3945\/jn.115.219147_bib44","doi-asserted-by":"crossref","first-page":"1649S","DOI":"10.3945\/ajcn.2009.26736R","article-title":"Nuts and novel biomarkers of cardiovascular disease","volume":"89","author":"Ros","year":"2009","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/jn.115.219147_bib45","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s13668-013-0052-4","article-title":"Systems epidemiology: A new direction in nutrition and metabolic disease research","volume":"2","author":"Cornelis","year":"2013","journal-title":"Curr Nutr Rep"},{"key":"10.3945\/jn.115.219147_bib46","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s11883-010-0112-9","article-title":"Metabolomics and atherosclerosis","volume":"12","author":"Goonewardena","year":"2010","journal-title":"Curr Atheroscler Rep"},{"key":"10.3945\/jn.115.219147_bib47","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3389\/fmolb.2014.00022","article-title":"Linking metabolomics data to underlying metabolic regulation","volume":"1","author":"N\u00e4gele","year":"2014","journal-title":"Front Mol Biosci"},{"key":"10.3945\/jn.115.219147_bib48","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1214\/aos\/1013699998","article-title":"The control of the false discovery rate in multiple testing under dependency","volume":"29","author":"Benjamini","year":"2001","journal-title":"Ann Statist"},{"key":"10.3945\/jn.115.219147_bib49","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s11306-011-0320-5","article-title":"Plasma metabolomics and proteomics profiling after a postprandial challenge reveal subtle diet effects on human metabolic status","volume":"8","author":"Pellis","year":"2012","journal-title":"Metabolomics"},{"key":"10.3945\/jn.115.219147_bib50","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.numecd.2009.04.009","article-title":"Dietary carbohydrate modification alters serum metabolic profiles in individuals with the metabolic syndrome","volume":"20","author":"Lankinen","year":"2010","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"10.3945\/jn.115.219147_bib51","doi-asserted-by":"crossref","first-page":"e90352","DOI":"10.1371\/journal.pone.0090352","article-title":"Effects of whole grain, fish and bilberries on serum metabolic profile and lipid transfer protein activities: A randomized trial (Sysdimet)","volume":"9","author":"Lankinen","year":"2014","journal-title":"PLoS One"},{"key":"10.3945\/jn.115.219147_bib52","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s10654-010-9524-7","article-title":"Questionnaire-based self-reported nutrition habits associate with serum metabolism as revealed by quantitative targeted metabolomics","volume":"26","author":"Altmaier","year":"2011","journal-title":"Eur J Epidemiol"},{"key":"10.3945\/jn.115.219147_bib53","doi-asserted-by":"crossref","first-page":"4368","DOI":"10.1021\/pr100101p","article-title":"Metabolic profiling of plasma in overweight\/obese and lean men using ultra performance liquid chromatography and Q-TOF mass spectrometry (UPLC-Q-TOF MS)","volume":"9","author":"Kim","year":"2010","journal-title":"J Proteome Res"},{"key":"10.3945\/jn.115.219147_bib54","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1002\/mnfr.200900116","article-title":"Variation in the human lipidome associated with coffee consumption as revealed by quantitative targeted metabolomics","volume":"53","author":"Altmaier","year":"2009","journal-title":"Mol Nutr Food Res"},{"key":"10.3945\/jn.115.219147_bib55","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1007\/s11306-012-0469-6","article-title":"Targeted metabolomics profiles are strongly correlated with nutritional patterns in women","volume":"9","author":"Menni","year":"2013","journal-title":"Metabolomics"},{"key":"10.3945\/jn.115.219147_bib56","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.2337\/dc08-2075","article-title":"Relationships between circulating metabolic intermediates and insulin action in overweight to obese, inactive men and women","volume":"32","author":"Huffman","year":"2009","journal-title":"Diabetes Care"},{"key":"10.3945\/jn.115.219147_bib57","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1093\/aje\/kwu073","article-title":"Human metabolome associates with dietary intake habits among African Americans in the atherosclerosis risk in communities study","volume":"179","author":"Zheng","year":"2014","journal-title":"Am J Epidemiol"},{"key":"10.3945\/jn.115.219147_bib58","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1056\/NEJM196910092811503","article-title":"Plasma amino acid levels and insulin secretion in obesity","volume":"281","author":"Felig","year":"1969","journal-title":"N Engl J Med"},{"key":"10.3945\/jn.115.219147_bib59","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.regpep.2009.08.001","article-title":"Selective amino acid deficiency in patients with impaired glucose tolerance and type 2 diabetes","volume":"160","author":"Menge","year":"2010","journal-title":"Regul Pept"},{"key":"10.3945\/jn.115.219147_bib60","doi-asserted-by":"crossref","first-page":"e10883","DOI":"10.1371\/journal.pone.0010883","article-title":"Alpha-hydroxybutyrate is an early biomarker of insulin resistance and glucose intolerance in a nondiabetic population","volume":"5","author":"Gall","year":"2010","journal-title":"PLoS One"},{"key":"10.3945\/jn.115.219147_bib61","doi-asserted-by":"crossref","first-page":"e15234","DOI":"10.1371\/journal.pone.0015234","article-title":"Plasma metabolomic profiles reflective of glucose homeostasis in non-diabetic and type 2 diabetic obese African-American women","volume":"5","author":"Fiehn","year":"2010","journal-title":"PLoS One"},{"key":"10.3945\/jn.115.219147_bib62","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1007\/s00125-009-1637-8","article-title":"Insulin resistance is associated with a metabolic profile of altered protein metabolism in Chinese and Asian-Indian men","volume":"53","author":"Tai","year":"2010","journal-title":"Diabetologia"},{"key":"10.3945\/jn.115.219147_bib63","doi-asserted-by":"crossref","first-page":"E736","DOI":"10.1152\/ajpendo.00231.2015","article-title":"Alterations of plasma metabolite profiles related to adipose tissue distribution and cardiometabolic risk.","volume":"309","author":"Boulet","year":"2015","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.3945\/jn.115.219147_bib64","doi-asserted-by":"crossref","first-page":"e51","DOI":"10.1371\/journal.pmed.0050051","article-title":"Global transcript profiles of fat in monozygotic twins discordant for BMI: Pathways behind acquired obesity","volume":"5","author":"Pietil\u00e4inen","year":"2008","journal-title":"PLoS Med"},{"key":"10.3945\/jn.115.219147_bib65","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1038\/ijo.2015.65","article-title":"The metabolome profiling and pathway analysis in metabolic healthy and abnormal obesity","volume":"39","author":"Chen","year":"2015","journal-title":"Int J Obes (Lond)"},{"key":"10.3945\/jn.115.219147_bib66","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.cmet.2009.02.002","article-title":"A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance","volume":"9","author":"Newgard","year":"2009","journal-title":"Cell Metab"},{"key":"10.3945\/jn.115.219147_bib67","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.1161\/CIRCULATIONAHA.111.067827","article-title":"Metabolite profiling identifies pathways associated with metabolic risk in humans","volume":"125","author":"Cheng","year":"2012","journal-title":"Circulation"},{"key":"10.3945\/jn.115.219147_bib68","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.2337\/db11-1355","article-title":"Metabolic signatures of insulin resistance in 7,098 young adults","volume":"61","author":"W\u00fcrtz","year":"2012","journal-title":"Diabetes"},{"key":"10.3945\/jn.115.219147_bib69","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/nrendo.2014.171","article-title":"Branched-chain amino acids in metabolic signalling and insulin resistance","volume":"10","author":"Lynch","year":"2014","journal-title":"Nat Rev Endocrinol"},{"key":"10.3945\/jn.115.219147_bib70","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/nm.2307","article-title":"Metabolite profiles and the risk of developing diabetes","volume":"17","author":"Wang","year":"2011","journal-title":"Nat Med"},{"key":"10.3945\/jn.115.219147_bib71","doi-asserted-by":"crossref","first-page":"e99598","DOI":"10.1371\/journal.pone.0099598","article-title":"Association of branched-chain amino acids with carotid intima-media thickness and coronary artery disease risk factors","volume":"9","author":"Yang","year":"2014","journal-title":"PLoS One"},{"key":"10.3945\/jn.115.219147_bib72","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1161\/CIRCULATIONAHA.114.013116","article-title":"Metaboliteprofiling and cardiovascular event risk: A prospective study of 3 population-based cohorts","volume":"131","author":"W\u00fcrtz","year":"2015","journal-title":"Circulation"},{"key":"10.3945\/jn.115.219147_bib73","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1161\/CIRCGENETICS.109.852814","article-title":"Association of a peripheral blood metabolic profile with coronary artery disease and risk of subsequent cardiovascular events","volume":"3","author":"Shah","year":"2010","journal-title":"Circ Cardiovasc Genet"},{"key":"10.3945\/jn.115.219147_bib74","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.ahj.2012.02.005","article-title":"Baseline metabolomic profiles predict cardiovascular events in patients at risk for coronary artery disease","volume":"163","author":"Shah","year":"2012","journal-title":"Am Heart J"},{"key":"10.3945\/jn.115.219147_bib75","doi-asserted-by":"crossref","first-page":"106","DOI":"10.3945\/ajcn.2008.26362","article-title":"Oral glutamine increases circulating glucagon-like peptide 1, glucagon, and insulin concentrations in lean, obese, and type 2 diabetic subjects","volume":"89","author":"Greenfield","year":"2009","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/jn.115.219147_bib76","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1093\/jn\/126.1.273","article-title":"L-glutamine supplementation of a high fat diet reduces body weight and attenuates hyperglycemia and hyperinsulinemia in C57BL\/6J mice","volume":"126","author":"Opara","year":"1996","journal-title":"J Nutr"},{"key":"10.3945\/jn.115.219147_bib77","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.3945\/jn.108.103754","article-title":"Plasma acylcarnitine profiles suggest incomplete long-chain fatty acid beta-oxidation and altered tricarboxylic acid cycle activity in type 2 diabetic African-American women","volume":"139","author":"Adams","year":"2009","journal-title":"J Nutr"},{"key":"10.3945\/jn.115.219147_bib78","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1038\/oby.2009.510","article-title":"Increased levels of plasma acylcarnitines in obesity and type 2 diabetes and identification of a marker of glucolipotoxicity","volume":"18","author":"Mihalik","year":"2010","journal-title":"Obesity (Silver Spring)"},{"key":"10.3945\/jn.115.219147_bib79","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1196\/annals.1320.009","article-title":"Carnitine in type 2 diabetes","volume":"1033","author":"Mingrone","year":"2004","journal-title":"Ann N Y Acad Sci"},{"key":"10.3945\/jn.115.219147_bib80","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1097\/MCO.0b013e328348c06d","article-title":"Gut microbiota interactions with obesity, insulin resistance and type 2 diabetes: Did gut microbiote co-evolve with insulin resistance?","volume":"14","author":"Esteve","year":"2011","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"10.3945\/jn.115.219147_bib81","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1210\/er.2009-0030","article-title":"Gut microbiota, lipopolysaccharides, and innate immunity in the pathogenesis of obesity and cardiovascular risk","volume":"31","author":"Manco","year":"2010","journal-title":"Endocr Rev"},{"key":"10.3945\/jn.115.219147_bib82","doi-asserted-by":"crossref","first-page":"4204","DOI":"10.1172\/JCI72331","article-title":"The contributory role of gut microbiota in cardiovascular disease","volume":"124","author":"Tang","year":"2014","journal-title":"J Clin Invest"},{"key":"10.3945\/jn.115.219147_bib83","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1093\/eurheartj\/ehu002","article-title":"Prognostic value of choline and betaine depends on intestinal microbiota-generated metabolite trimethylamine-N-oxide","volume":"35","author":"Wang","year":"2014","journal-title":"Eur Heart J"},{"key":"10.3945\/jn.115.219147_bib84","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature09922","article-title":"Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease","volume":"472","author":"Wang","year":"2011","journal-title":"Nature"},{"key":"10.3945\/jn.115.219147_bib85","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1056\/NEJMoa1109400","article-title":"Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk","volume":"368","author":"Tang","year":"2013","journal-title":"N Engl J Med"},{"key":"10.3945\/jn.115.219147_bib86","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s11883-015-0505-x","article-title":"Nutri(meta)genetics and cardiovascular disease: novel concepts in the interaction of diet and genomic variation","volume":"17","author":"Joseph","year":"2015","journal-title":"Curr Atheroscler Rep"},{"key":"10.3945\/jn.115.219147_bib87","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/msb.2008.50","article-title":"Metabolic profiling of the human response to a glucose challenge reveals distinct axes of insulin sensitivity","volume":"4","author":"Shaham","year":"2008","journal-title":"Mol Syst Biol"},{"key":"10.3945\/jn.115.219147_bib88","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1007\/s11306-010-0203-1","article-title":"Metabonomic fingerprints of fasting plasma and spot urine reveal human pre-diabetic metabolic traits","volume":"6","author":"Zhao","year":"2010","journal-title":"Metabolomics"},{"key":"10.3945\/jn.115.219147_bib89","doi-asserted-by":"crossref","first-page":"684","DOI":"10.3945\/ajcn.110.004622","article-title":"The role of reducing intakes of saturated fat in the prevention of cardiovascular disease: Where does the evidence stand in 2010?","volume":"93","author":"Astrup","year":"2011","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/jn.115.219147_bib90","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1093\/aje\/kwi085","article-title":"Dietary fat intake and risk of coronary heart disease in women: 20 years of follow-up of the Nurses\u2019 Health Study","volume":"161","author":"Oh","year":"2005","journal-title":"Am J Epidemiol"},{"key":"10.3945\/jn.115.219147_bib91","doi-asserted-by":"crossref","first-page":"b2337","DOI":"10.1136\/bmj.b2337","article-title":"Anatomy of health effects of Mediterranean diet: Greek EPIC prospective cohort study","volume":"338","author":"Trichopoulou","year":"2009","journal-title":"BMJ"},{"key":"10.3945\/jn.115.219147_bib92","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1172\/JCI44442","article-title":"Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans","volume":"121","author":"Rhee","year":"2011","journal-title":"J Clin Invest"}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316623005886?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316623005886?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/jn\/article-pdf\/146\/4\/913S\/23969133\/jn219147.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T00:13:24Z","timestamp":1686701604000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316623005886"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":92,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["S0022316623005886"],"URL":"https:\/\/doi.org\/10.3945\/jn.115.219147","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[2016,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intervention Trials with the Mediterranean Diet in Cardiovascular Prevention: Understanding Potential Mechanisms through Metabolomic Profiling","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.3945\/jn.115.219147","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 American Society of Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}