{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:03:37Z","timestamp":1790730217410,"version":"4.1.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,28]],"date-time":"2023-01-28T00:00:00Z","timestamp":1674864000000},"content-version":"vor","delay-in-days":2218,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.3945\/jn.116.231662","type":"journal-article","created":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T03:10:36Z","timestamp":1480561836000},"page":"52-60","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"title":["Dietary Mung Bean Protein Reduces Hepatic Steatosis, Fibrosis, and Inflammation in Male Mice with Diet-Induced, Nonalcoholic Fatty Liver Disease"],"prefix":"10.1016","volume":"147","author":[{"given":"Hitoshi","family":"Watanabe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuka","family":"Inaba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumi","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun-ichiro","family":"Asahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiaki","family":"Kido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michihiro","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayasu","family":"Motoyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhiko","family":"Tachibana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuichi","family":"Kaneko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsutaka","family":"Kohno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.3945\/jn.116.231662_bib1","doi-asserted-by":"crossref","DOI":"10.1038\/nrendo.2011.72","article-title":"Nonalcoholic fatty liver disease and diabetes mellitus: pathogenesis and treatment","volume":"7","author":"Smith","year":"2011","journal-title":"Nat Rev Endocrinol"},{"key":"10.3945\/jn.116.231662_bib2","doi-asserted-by":"crossref","DOI":"10.1038\/nrgastro.2013.41","article-title":"Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosis","volume":"10","author":"Anstee","year":"2013","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.3945\/jn.116.231662_bib3","doi-asserted-by":"crossref","DOI":"10.1038\/ncpendmet0505","article-title":"Nonalcoholic fatty liver disease: from pathogenesis to patient care","volume":"3","author":"Perlemuter","year":"2007","journal-title":"Nat Clin Pract Endocrinol Metab"},{"key":"10.3945\/jn.116.231662_bib4","doi-asserted-by":"crossref","DOI":"10.3748\/wjg.v20.i45.16831","article-title":"Alimentary regimen in non-alcoholic fatty liver disease: Mediterranean diet","volume":"20","author":"Abenavoli","year":"2014","journal-title":"World J Gastroenterol"},{"key":"10.3945\/jn.116.231662_bib5","doi-asserted-by":"crossref","DOI":"10.2337\/dc05-2565","article-title":"Effect of calorie restriction with or without exercise on insulin sensitivity, beta-cell function, fat cell size, and ectopic lipid in overweight subjects","volume":"29","author":"Larson-Meyer","year":"2006","journal-title":"Diabetes Care"},{"key":"10.3945\/jn.116.231662_bib6","doi-asserted-by":"crossref","DOI":"10.2337\/dc10-0856","article-title":"Effect of a 12-month intensive lifestyle intervention on hepatic steatosis in adults with type 2 diabetes","volume":"33","author":"Lazo","year":"2010","journal-title":"Diabetes Care"},{"key":"10.3945\/jn.116.231662_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhep.2012.07.003","article-title":"Phenotyping the effect of diet on non-alcoholic fatty liver disease","volume":"57","author":"de Wit","year":"2012","journal-title":"J Hepatol"},{"key":"10.3945\/jn.116.231662_bib8","doi-asserted-by":"crossref","DOI":"10.3748\/wjg.v17.i29.3377","article-title":"Nutrition and physical activity in NAFLD: an overview of the epidemiological evidence","volume":"17","author":"Zelber-Sagi","year":"2011","journal-title":"World J Gastroenterol"},{"key":"10.3945\/jn.116.231662_bib9","doi-asserted-by":"crossref","DOI":"10.4254\/wjh.v7.i3.575","article-title":"Role of diet on non-alcoholic fatty liver disease: an updated narrative review","volume":"7","author":"Papandreou","year":"2015","journal-title":"World J Hepatol"},{"key":"10.3945\/jn.116.231662_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.clnu.2013.11.003","article-title":"Diets and nonalcoholic fatty liver disease: the good and the bad","volume":"33","author":"Asrih","year":"2014","journal-title":"Clin Nutr"},{"key":"10.3945\/jn.116.231662_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.nut.2010.09.004","article-title":"Soy protein retards the progression of non-alcoholic steatohepatitis via improvement of insulin resistance and steatosis","volume":"27","author":"Yang","year":"2011","journal-title":"Nutrition"},{"key":"10.3945\/jn.116.231662_bib12","doi-asserted-by":"crossref","DOI":"10.1093\/jn\/138.3.462","article-title":"Soy protein ameliorates metabolic abnormalities in liver and adipose tissue of rats fed a high fat diet","volume":"138","author":"Torre-Villalvazo","year":"2008","journal-title":"J Nutr"},{"key":"10.3945\/jn.116.231662_bib13","doi-asserted-by":"crossref","DOI":"10.1093\/jn\/134.3.522","article-title":"Soy protein affects serum insulin and hepatic SREBP-1 mRNA and reduces fatty liver in rats","volume":"134","author":"Ascencio","year":"2004","journal-title":"J Nutr"},{"key":"10.3945\/jn.116.231662_bib14","doi-asserted-by":"crossref","DOI":"10.1046\/j.1432-1327.2001.02268.x","article-title":"Crystal structures of recombinant and native soybean beta-conglycinin beta homotrimers","volume":"268","author":"Maruyama","year":"2001","journal-title":"Eur J Biochem"},{"key":"10.3945\/jn.116.231662_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.orcp.2014.03.005","article-title":"Soy beta-conglycinin improves obesity-induced metabolic abnormalities in a rat model of nonalcoholic fatty liver disease","volume":"9","author":"Wanezaki","year":"2015","journal-title":"Obes Res Clin Pract"},{"key":"10.3945\/jn.116.231662_bib16","doi-asserted-by":"crossref","DOI":"10.1271\/bbb.65.1071","article-title":"Reduction by phytate-reduced soybean beta-conglycinin of plasma triglyceride level of young and adult rats","volume":"65","author":"Aoyama","year":"2001","journal-title":"Biosci Biotechnol Biochem"},{"key":"10.3945\/jn.116.231662_bib17","doi-asserted-by":"crossref","DOI":"10.1107\/S090744490601804X","article-title":"Structure of 8Salpha globulin, the major seed storage protein of mung bean","volume":"62","author":"Itoh","year":"2006","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"key":"10.3945\/jn.116.231662_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2006.05.054","article-title":"Abundant proteins associated with lecithin in soy protein isolate","volume":"102","author":"Samoto","year":"2007","journal-title":"Food Chem"},{"key":"10.3945\/jn.116.231662_bib19","doi-asserted-by":"crossref","DOI":"10.1038\/2417","article-title":"A new logic for DNA engineering using recombination in Escherichia coli","volume":"20","author":"Zhang","year":"1998","journal-title":"Nat Genet"},{"key":"10.3945\/jn.116.231662_bib20","doi-asserted-by":"crossref","DOI":"10.1038\/nm980","article-title":"Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo","volume":"10","author":"Inoue","year":"2004","journal-title":"Nat Med"},{"key":"10.3945\/jn.116.231662_bib21","doi-asserted-by":"crossref","DOI":"10.1002\/hep.21874","article-title":"Lipid-induced oxidative stress causes steatohepatitis in mice fed an atherogenic diet","volume":"46","author":"Matsuzawa","year":"2007","journal-title":"Hepatology"},{"key":"10.3945\/jn.116.231662_bib22","doi-asserted-by":"crossref","DOI":"10.1002\/hep.27619","article-title":"Growth arrest and DNA damage-inducible 34 regulates liver regeneration in hepatic steatosis in mice","volume":"61","author":"Inaba","year":"2015","journal-title":"Hepatology"},{"key":"10.3945\/jn.116.231662_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/S0021-9258(18)64849-5","article-title":"A simple method for the isolation and purification of total lipides from animal tissues","volume":"226","author":"Folch","year":"1957","journal-title":"J Biol Chem"},{"key":"10.3945\/jn.116.231662_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/0009-8981(68)90041-7","article-title":"A colorimetric method for estimating serum triglycerides","volume":"22","author":"Fletcher","year":"1968","journal-title":"Clin Chim Acta"},{"key":"10.3945\/jn.116.231662_bib25","doi-asserted-by":"crossref","DOI":"10.2337\/db12-1701","article-title":"Histidine augments the suppression of hepatic glucose production by central insulin action","volume":"62","author":"Kimura","year":"2013","journal-title":"Diabetes"},{"key":"10.3945\/jn.116.231662_bib26","doi-asserted-by":"crossref","first-page":"61","DOI":"10.2337\/db10-1684","article-title":"Endoplasmic reticulum stress inhibits STAT3-dependent suppression of hepatic gluconeogenesis via dephosphorylation and deacetylation","volume":"61","author":"Kimura","year":"2012","journal-title":"Diabetes"},{"key":"10.3945\/jn.116.231662_bib27","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3136\/fstr.13.45","article-title":"Improvement in the intestinal absorption of soy protein by enzymatic digestion to oligopeptide in healthy adult men","volume":"13","author":"Maebuchi","year":"2007","journal-title":"Food Sci Technol Res"},{"key":"10.3945\/jn.116.231662_bib28","doi-asserted-by":"crossref","DOI":"10.1038\/ncpendmet0190","article-title":"Mechanisms of disease: hepatic steatosis in type 2 diabetes\u2013pathogenesis and clinical relevance","volume":"2","author":"Roden","year":"2006","journal-title":"Nat Clin Pract Endocrinol Metab"},{"key":"10.3945\/jn.116.231662_bib29","doi-asserted-by":"crossref","DOI":"10.1172\/JCI34275","article-title":"Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice","volume":"118","author":"Postic","year":"2008","journal-title":"J Clin Invest"},{"key":"10.3945\/jn.116.231662_bib30","doi-asserted-by":"crossref","DOI":"10.1017\/S0954422414000225","article-title":"Are intact peptides absorbed from the healthy gut in the adult human?","volume":"27","author":"Miner-Williams","year":"2014","journal-title":"Nutr Res Rev"},{"key":"10.3945\/jn.116.231662_bib31","doi-asserted-by":"crossref","DOI":"10.3748\/wjg.v20.i44.16452","article-title":"Obesity, fatty liver disease and intestinal microbiota","volume":"20","author":"Arslan","year":"2014","journal-title":"World J Gastroenterol"},{"key":"10.3945\/jn.116.231662_bib32","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.270.51.30339","article-title":"Hormonal and nutritional control of the fatty acid synthase promoter in transgenic mice","volume":"270","author":"Soncini","year":"1995","journal-title":"J Biol Chem"},{"key":"10.3945\/jn.116.231662_bib33","doi-asserted-by":"crossref","DOI":"10.1038\/nprot.2009.28","article-title":"Gaussia luciferase reporter assay for monitoring biological processes in culture and in vivo","volume":"4","author":"Tannous","year":"2009","journal-title":"Nat Protoc"},{"key":"10.3945\/jn.116.231662_bib34","article-title":"Characteristics of hepatic fatty acid compositions in patients with nonalcoholic steatohepatitis","volume":"35","author":"Yamada","year":"2015","journal-title":"Liver Int"},{"key":"10.3945\/jn.116.231662_bib35","doi-asserted-by":"crossref","DOI":"10.1271\/bbb.110224","article-title":"Consumption of soy protein isolate reduces hepatic SREBP-1c and lipogenic expression in wild-type mice, but not in FXR-deficient mice","volume":"75","author":"Hashidume","year":"2011","journal-title":"Biosci Biotechnol Biochem"},{"key":"10.3945\/jn.116.231662_bib36","doi-asserted-by":"crossref","DOI":"10.1002\/iub.1017","article-title":"Glucose-6-phosphate dehydrogenase, NADPH, and cell survival","volume":"64","author":"Stanton","year":"2012","journal-title":"IUBMB Life"},{"key":"10.3945\/jn.116.231662_bib37","doi-asserted-by":"crossref","DOI":"10.3945\/jn.109.116228","article-title":"Current in vitro testing of bioactive peptides is not valuable","volume":"140","author":"Foltz","year":"2010","journal-title":"J Nutr"},{"key":"10.3945\/jn.116.231662_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.bpg.2016.02.007","article-title":"Physiology of intestinal absorption and secretion","volume":"30","author":"Kiela","year":"2016","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"10.3945\/jn.116.231662_bib39","doi-asserted-by":"crossref","DOI":"10.1093\/jn\/138.6.1244S","article-title":"Health effects of soy protein and isoflavones in humans","volume":"138","author":"Xiao","year":"2008","journal-title":"J Nutr"},{"key":"10.3945\/jn.116.231662_bib40","doi-asserted-by":"crossref","DOI":"10.1207\/s15327914nc5402_5","article-title":"Phytoestrogen content of foods consumed in Canada, including isoflavones, lignans, and coumestan","volume":"54","author":"Thompson","year":"2006","journal-title":"Nutr Cancer"},{"key":"10.3945\/jn.116.231662_bib41","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/nrgastro.2010.191","article-title":"Animal models of nonalcoholic fatty liver disease","volume":"8","author":"Hebbard","year":"2011","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.3945\/jn.116.231662_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmet.2013.05.011","article-title":"Innate immune receptors: key regulators of metabolic disease progression","volume":"17","author":"Jin","year":"2013","journal-title":"Cell Metab"}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622105572?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622105572?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.3945\/jn.116.231662","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T23:36:23Z","timestamp":1686699383000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316622105572"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["S0022316622105572"],"URL":"https:\/\/doi.org\/10.3945\/jn.116.231662","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dietary Mung Bean Protein Reduces Hepatic Steatosis, Fibrosis, and Inflammation in Male Mice with Diet-Induced, Nonalcoholic Fatty Liver Disease","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.3945\/jn.116.231662","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2017 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}