{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T17:23:36Z","timestamp":1788283416535,"version":"build-2803163510"},"reference-count":37,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T00:00:00Z","timestamp":1674777600000},"content-version":"vor","delay-in-days":2248,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.3945\/jn.116.232678","type":"journal-article","created":{"date-parts":[[2016,10,27]],"date-time":"2016-10-27T02:59:21Z","timestamp":1477537161000},"page":"2429-2435","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"title":["The Noncaloric Sweetener Rebaudioside A Stimulates Glucagon-Like Peptide 1 Release and Increases Enteroendocrine Cell Numbers in 2-Dimensional Mouse Organoids Derived from Different Locations of the Intestine"],"prefix":"10.1016","volume":"146","author":[{"given":"Nikkie","family":"van der Wielen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Paul","family":"ten Klooster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Muckenschnabl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond","family":"Pieters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henk FJ","family":"Hendriks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renger F","family":"Witkamp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jocelijn","family":"Meijerink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.3945\/jn.116.232678_bib1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1177\/2040622313506730","article-title":"The future role of gut hormones in the treatment of obesity","volume":"5","author":"Troke","year":"2014","journal-title":"Ther Adv Chronic Dis"},{"key":"10.3945\/jn.116.232678_bib2","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.mce.2015.07.003","article-title":"Emerging opportunities for the treatment of metabolic diseases: glucagon-like peptide-1 based multi-agonists","volume":"418","author":"Finan","year":"2015","journal-title":"Mol Cell Endocrinol"},{"key":"10.3945\/jn.116.232678_bib3","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.physbeh.2008.07.018","article-title":"Ileal brake: a sensible food target for appetite control. A review","volume":"95","author":"Maljaars","year":"2008","journal-title":"Physiol Behav"},{"key":"10.3945\/jn.116.232678_bib4","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.cmet.2013.04.008","article-title":"Pharmacology, physiology, and mechanisms of incretin hormone action","volume":"17","author":"Campbell","year":"2013","journal-title":"Cell Metab"},{"issue":"Suppl 1","key":"10.3945\/jn.116.232678_bib5","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/j.1365-2982.2008.01104.x","article-title":"Vagal and hormonal gut-brain communication: from satiation to satisfaction","volume":"20","author":"Berthoud","year":"2008","journal-title":"Neurogastroenterol Motil"},{"key":"10.3945\/jn.116.232678_bib6","first-page":"121","article-title":"Glucagon and glucagon-like peptides 1 and 2","volume":"50","author":"Holst","year":"2010","journal-title":"Results Probl Cell Differ"},{"key":"10.3945\/jn.116.232678_bib7","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.peptides.2015.05.008","article-title":"Important species differences regarding lymph contribution to gut hormone responses","volume":"71","author":"Hansen","year":"2015","journal-title":"Peptides"},{"key":"10.3945\/jn.116.232678_bib8","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/nature07935","article-title":"Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche","volume":"459","author":"Sato","year":"2009","journal-title":"Nature"},{"key":"10.3945\/jn.116.232678_bib9","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1126\/science.1234852","article-title":"Growing self-organizing mini-guts from a single intestinal stem cell: mechanism and applications","volume":"340","author":"Sato","year":"2013","journal-title":"Science"},{"key":"10.3945\/jn.116.232678_bib10","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/S0016-5085(83)80080-8","article-title":"Endocrine cells in human intestine: an immunocytochemical study","volume":"85","author":"Sj\u00f6lund","year":"1983","journal-title":"Gastroenterology"},{"key":"10.3945\/jn.116.232678_bib11","doi-asserted-by":"crossref","first-page":"410","DOI":"10.2337\/db13-0991","article-title":"Generation of L cells in mouse and human small intestine organoids","volume":"63","author":"Petersen","year":"2014","journal-title":"Diabetes"},{"key":"10.3945\/jn.116.232678_bib12","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1172\/JCI75838","article-title":"Targeting development of incretin-producing cells increases insulin secretion","volume":"125","author":"Petersen","year":"2015","journal-title":"J Clin Invest"},{"key":"10.3945\/jn.116.232678_bib13","doi-asserted-by":"crossref","first-page":"15069","DOI":"10.1073\/pnas.0706890104","article-title":"Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1","volume":"104","author":"Jang","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.3945\/jn.116.232678_bib14","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.mce.2014.07.004","article-title":"Diverse signaling systems activated by the sweet taste receptor in human GLP-1-secreting cells","volume":"394","author":"Ohtsu","year":"2014","journal-title":"Mol Cell Endocrinol"},{"key":"10.3945\/jn.116.232678_bib15","doi-asserted-by":"crossref","first-page":"E473","DOI":"10.1152\/ajpendo.90636.2008","article-title":"Incretin release from gut is acutely enhanced by sugar but not by sweeteners in vivo","volume":"296","author":"Fujita","year":"2009","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.3945\/jn.116.232678_bib16","doi-asserted-by":"crossref","first-page":"G735","DOI":"10.1152\/ajpgi.90708.2008","article-title":"Effect of the artificial sweetener, sucralose, on gastric emptying and incretin hormone release in healthy subjects","volume":"296","author":"Ma","year":"2009","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.3945\/jn.116.232678_bib17","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.appet.2010.03.009","article-title":"Effects of stevia, aspartame, and sucrose on food intake, satiety, and postprandial glucose and insulin levels","volume":"55","author":"Anton","year":"2010","journal-title":"Appetite"},{"key":"10.3945\/jn.116.232678_bib18","doi-asserted-by":"crossref","first-page":"6782","DOI":"10.1021\/jf301297n","article-title":"Human psychometric and taste receptor responses to steviol glycosides","volume":"60","author":"Hellfritsch","year":"2012","journal-title":"J Agric Food Chem"},{"issue":"Suppl 7","key":"10.3945\/jn.116.232678_bib19","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.fct.2008.05.003","article-title":"Overview: the history, technical function and safety of rebaudioside A, a naturally occurring steviol glycoside, for use in food and beverages","volume":"46","author":"Carakostas","year":"2008","journal-title":"Food Chem Toxicol"},{"key":"10.3945\/jn.116.232678_bib20","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.1073\/pnas.042617699","article-title":"Expression of bitter taste receptors of the T2R family in the gastrointestinal tract and enteroendocrine STC-1 cells","volume":"99","author":"Wu","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.3945\/jn.116.232678_bib21","doi-asserted-by":"crossref","first-page":"8365","DOI":"10.1021\/jf501105w","article-title":"Steviol glycoside rebaudioside A induces glucagon-like peptide-1 and peptide YY release in a porcine ex vivo intestinal model","volume":"62","author":"Ripken","year":"2014","journal-title":"J Agric Food Chem"},{"key":"10.3945\/jn.116.232678_bib22","doi-asserted-by":"crossref","first-page":"e107531","DOI":"10.1371\/journal.pone.0107531","article-title":"Cross-species comparison of genes related to nutrient sensing mechanisms expressed along the intestine","volume":"9","author":"van der Wielen","year":"2014","journal-title":"PLoS One"},{"key":"10.3945\/jn.116.232678_bib23","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.lfs.2015.10.025","article-title":"Men and mice: relating their ages","volume":"152","author":"Dutta","year":"2016","journal-title":"Life Sci"},{"key":"10.3945\/jn.116.232678_bib24","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1002\/stem.1655","article-title":"Adult stem cells in the small intestine are intrinsically programmed with their location-specific function","volume":"32","author":"Middendorp","year":"2014","journal-title":"Stem Cells"},{"key":"10.3945\/jn.116.232678_bib25","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.2337\/diabetes.52.5.1147","article-title":"A novel glucose-sensing mechanism contributing to glucagon-like peptide-1 secretion from the GLUTag cell line","volume":"52","author":"Gribble","year":"2003","journal-title":"Diabetes"},{"key":"10.3945\/jn.116.232678_bib26","doi-asserted-by":"crossref","first-page":"16831","DOI":"10.1038\/srep16831","article-title":"Intestinal organoids for assessing nutrient transport, sensing and incretin secretion","volume":"5","author":"Zietek","year":"2015","journal-title":"Sci Rep"},{"key":"10.3945\/jn.116.232678_bib27","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1007\/s00125-014-3326-5","article-title":"Denatonium induces secretion of glucagon-like peptide-1 through activation of bitter taste receptor pathways","volume":"57","author":"Kim","year":"2014","journal-title":"Diabetologia"},{"key":"10.3945\/jn.116.232678_bib28","doi-asserted-by":"crossref","first-page":"G1368","DOI":"10.1152\/ajpgi.00135.2010","article-title":"The steroid glycoside H.g.-12 from Hoodia gordonii activates the human bitter receptor TAS2R14 and induces CCK release from HuTu-80 cells","volume":"299","author":"Le Nev\u00e9","year":"2010","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.3945\/jn.116.232678_bib29","doi-asserted-by":"crossref","first-page":"729","DOI":"10.3945\/ajcn.115.113266","article-title":"Intraduodenal infusion of a combination of tastants decreases food intake in humans","volume":"102","author":"van Avesaat","year":"2015","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/jn.116.232678_bib30","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1007\/s00394-012-0439-9","article-title":"Examining acute and chronic effects of short- and long-chain fatty acids on peptide YY (PYY) gene expression, cellular storage and secretion in STC-1 cells","volume":"52","author":"Hand","year":"2013","journal-title":"Eur J Nutr"},{"key":"10.3945\/jn.116.232678_bib31","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1053\/j.gastro.2009.08.059","article-title":"Foxa1 and Foxa2 control the differentiation of goblet and enteroendocrine L- and D-cells in mice","volume":"137","author":"Ye","year":"2009","journal-title":"Gastroenterology"},{"key":"10.3945\/jn.116.232678_bib32","doi-asserted-by":"crossref","first-page":"274","DOI":"10.3945\/jn.112.169672","article-title":"A diet high in resistant starch modulates microbiota composition, SCFA concentrations, and gene expression in pig intestine","volume":"143","author":"Haenen","year":"2013","journal-title":"J Nutr"},{"key":"10.3945\/jn.116.232678_bib33","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s10735-010-9304-4","article-title":"Density distribution of free fatty acid receptor 2 (FFA2)-expressing and GLP-1-producing enteroendocrine L cells in human and rat lower intestine, and increased cell numbers after ingestion of fructo-oligosaccharide","volume":"42","author":"Kaji","year":"2011","journal-title":"J Mol Histol"},{"key":"10.3945\/jn.116.232678_bib34","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1038\/ijo.2014.20","article-title":"Impact of high-fat feeding on basic helix-loop-helix transcription factors controlling enteroendocrine cell differentiation","volume":"38","author":"Sakar","year":"2014","journal-title":"Int J Obes (Lond)"},{"key":"10.3945\/jn.116.232678_bib35","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1038\/mi.2013.98","article-title":"Development of a primary mouse intestinal epithelial cell monolayer culture system to evaluate factors that modulate IgA transcytosis","volume":"7","author":"Moon","year":"2014","journal-title":"Mucosal Immunol"},{"key":"10.3945\/jn.116.232678_bib36","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1136\/gutjnl-2013-306651","article-title":"Development of an enhanced human gastrointestinal epithelial culture system to facilitate patient-based assays","volume":"64","author":"VanDussen","year":"2015","journal-title":"Gut"},{"key":"10.3945\/jn.116.232678_bib37","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/nature14484","article-title":"Cloning and variation of ground state intestinal stem cells","volume":"522","author":"Wang","year":"2015","journal-title":"Nature"}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316623007915?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316623007915?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/jn\/article-pdf\/146\/12\/2429\/23969218\/jn232678.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T16:23:56Z","timestamp":1735662236000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316623007915"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":37,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["S0022316623007915"],"URL":"https:\/\/doi.org\/10.3945\/jn.116.232678","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Noncaloric Sweetener Rebaudioside A Stimulates Glucagon-Like Peptide 1 Release and Increases Enteroendocrine Cell Numbers in 2-Dimensional Mouse Organoids Derived from Different Locations of the Intestine","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.3945\/jn.116.232678","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 American Society of Nutrition. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}