{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T16:50:39Z","timestamp":1789750239653,"version":"4.0.1"},"reference-count":54,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T00:00:00Z","timestamp":1675296000000},"content-version":"vor","delay-in-days":2011,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100007917","name":"USDA\u2013Agricultural Research Service Project","doi-asserted-by":"publisher","award":["6026-51000-010-05S"],"award-info":[{"award-number":["6026-51000-010-05S"]}],"id":[{"id":"10.13039\/100007917","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.3945\/jn.117.252767","type":"journal-article","created":{"date-parts":[[2017,6,29]],"date-time":"2017-06-29T00:25:31Z","timestamp":1498695931000},"page":"1499-1509","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"title":["Early Postnatal Diets Affect the Bioregional Small Intestine Microbiome and Ileal Metabolome in Neonatal Pigs"],"prefix":"10.1016","volume":"147","author":[{"given":"Brian D","family":"Piccolo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly E","family":"Mercer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudeepa","family":"Bhattacharyya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne K","family":"Bowlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish K","family":"Saraf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay","family":"Pack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sree V","family":"Chintapalli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kartik","family":"Shankar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean H","family":"Adams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M","family":"Badger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laxmi","family":"Yeruva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.3945\/jn.117.252767_bib1","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2011-3121","article-title":"Developmental status of 1-year-old infants fed breast milk, cow's milk formula, or soy formula","volume":"129","author":"Andres","year":"2012","journal-title":"Pediatrics"},{"key":"10.3945\/jn.117.252767_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/S0022-3476(95)70544-9","article-title":"Relation between infant feeding and infections during the first six months of life","volume":"126","author":"Beaudry","year":"1995","journal-title":"J Pediatr"},{"key":"10.3945\/jn.117.252767_bib3","article-title":"Breast feeding and protection against infection in industrialized countries","volume":"3","author":"Beaudry","year":"1996","journal-title":"Arch Pediatr"},{"key":"10.3945\/jn.117.252767_bib4","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/S0022-3476(95)70395-0","article-title":"Differences in morbidity between breast-fed and formula-fed infants","volume":"126","author":"Dewey","year":"1995","journal-title":"J Pediatr"},{"key":"10.3945\/jn.117.252767_bib5","doi-asserted-by":"crossref","DOI":"10.1159\/000334148","article-title":"Breastfeeding and allergy: the evidence","volume":"59","author":"Kramer","year":"2011","journal-title":"Ann Nutr Metab"},{"key":"10.3945\/jn.117.252767_bib6","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1017\/S0954422410000065","article-title":"Breast- v. formula-feeding: impacts on the digestive tract and immediate and long-term health effects","volume":"23","author":"Le Hu\u00ebrou-Luron","year":"2010","journal-title":"Nutr Res Rev"},{"key":"10.3945\/jn.117.252767_bib7","doi-asserted-by":"crossref","DOI":"10.1021\/jf9044205","article-title":"Consumption of human milk oligosaccharides by gut-related microbes","volume":"58","author":"Marcobal","year":"2010","journal-title":"J Agric Food Chem"},{"key":"10.3945\/jn.117.252767_bib8","doi-asserted-by":"crossref","DOI":"10.1093\/ajcn\/69.5.1035s","article-title":"Developmental microbial ecology of the neonatal gastrointestinal tract","volume":"69","author":"Mackie","year":"1999","journal-title":"Am J Clin Nutr"},{"key":"10.3945\/jn.117.252767_bib9","doi-asserted-by":"crossref","DOI":"10.1079\/BJN20061743","article-title":"Formula-feeding reduces lactose digestive capacity in neonatal pigs","volume":"95","author":"Thymann","year":"2006","journal-title":"Br J Nutr"},{"key":"10.3945\/jn.117.252767_bib10","doi-asserted-by":"crossref","DOI":"10.1017\/S0007114514003201","article-title":"Effect of bovine colostrum feeding in comparison with milk replacer and natural feeding on the immune responses and colonisation of enterotoxigenic Escherichia coli in the intestinal tissue of piglets","volume":"113","author":"Sugiharto","year":"2015","journal-title":"Br J Nutr"},{"key":"10.3945\/jn.117.252767_bib11","doi-asserted-by":"crossref","DOI":"10.1146\/annurev-food-022510-133743","article-title":"The influence of milk oligosaccharides on microbiota of infants: opportunities for formulas","volume":"2","author":"Chichlowski","year":"2011","journal-title":"Annu Rev Food Sci Technol"},{"key":"10.3945\/jn.117.252767_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.chom.2011.10.007","article-title":"Bacteroides in the infant gut consume milk oligosaccharides via mucus-utilization pathways","volume":"10","author":"Marcobal","year":"2011","journal-title":"Cell Host Microbe"},{"key":"10.3945\/jn.117.252767_bib13","doi-asserted-by":"crossref","DOI":"10.1099\/mic.0.064113-0","article-title":"Consumption of human milk glycoconjugates by infant-associated bifidobacteria: mechanisms and implications","volume":"159","author":"Garrido","year":"2013","journal-title":"Microbiology"},{"key":"10.3945\/jn.117.252767_bib14","doi-asserted-by":"crossref","DOI":"10.1097\/00005176-200001000-00019","article-title":"Analysis of intestinal flora development in breast-fed and formula-fed infants by using molecular identification and detection methods","volume":"30","author":"Harmsen","year":"2000","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.3945\/jn.117.252767_bib15","doi-asserted-by":"crossref","DOI":"10.3109\/00365521.2014.898326","article-title":"Surface area of the digestive tract \u2013 revisited","volume":"49","author":"Helander","year":"2014","journal-title":"Scand J Gastroenterol"},{"key":"10.3945\/jn.117.252767_bib16","doi-asserted-by":"crossref","DOI":"10.1111\/pai.12079","article-title":"The gut mucosal immune system in the neonatal period","volume":"24","author":"Battersby","year":"2013","journal-title":"Pediatr Allergy Immunol"},{"key":"10.3945\/jn.117.252767_bib17","doi-asserted-by":"crossref","DOI":"10.1111\/j.1399-3038.2005.00370.x","article-title":"Faecal SIgA secretion in infants fed on pre- or probiotic infant formula","volume":"17","author":"Bakker-Zierikzee","year":"2006","journal-title":"Pediatr Allergy Immunol"},{"key":"10.3945\/jn.117.252767_bib18","doi-asserted-by":"crossref","DOI":"10.1038\/ni.2640","article-title":"Commensal bacteria at the interface of host metabolism and the immune system","volume":"14","author":"Brestoff","year":"2013","journal-title":"Nat Immunol"},{"key":"10.3945\/jn.117.252767_bib19","doi-asserted-by":"crossref","first-page":"e86297","DOI":"10.1371\/journal.pone.0086297","article-title":"A coculture model of the developing small intestine offers new insight in the early immunomodulation of enterocytes and macrophages by lactobacillus spp. through STAT1 and NF-kB p65 translocation","volume":"9","author":"Trapecar","year":"2014","journal-title":"PLoS One"},{"key":"10.3945\/jn.117.252767_bib20","doi-asserted-by":"crossref","DOI":"10.1038\/nri1373","article-title":"Interactions between commensal intestinal bacteria and the immune system","volume":"4","author":"Macpherson","year":"2004","journal-title":"Nat Rev Immunol"},{"key":"10.3945\/jn.117.252767_bib21","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s12876-016-0456-x","article-title":"Formula diet alters small intestine morphology, microbial abundance and reduces VE-cadherin and IL-10 expression in neonatal porcine model","volume":"16","author":"Yeruva","year":"2016","journal-title":"BMC Gastroenterol"},{"key":"10.3945\/jn.117.252767_bib22","doi-asserted-by":"crossref","DOI":"10.1097\/00005176-199511000-00004","article-title":"The three-week-old piglet as a model animal for studying protein digestion in human infants","volume":"21","author":"Darragh","year":"1995","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.3945\/jn.117.252767_bib23","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1159\/000419461","article-title":"The piglet as a model animal for studying aspects of digestion and absorption in milk-fed human infants","volume":"67","author":"Moughan","year":"1992","journal-title":"World Rev Nutr Diet"},{"key":"10.3945\/jn.117.252767_bib24","doi-asserted-by":"crossref","DOI":"10.1097\/00005176-199004000-00020","article-title":"An evaluation with piglets of bovine milk, hydrolyzed bovine milk, and isolated soybean proteins included in infant milk formulas. I. Effect on organ development, digestive enzyme activities, and amino acid digestibility","volume":"10","author":"Moughan","year":"1990","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.3945\/jn.117.252767_bib25","doi-asserted-by":"crossref","DOI":"10.1146\/annurev-animal-022513-114158","article-title":"The suckling piglet as an agrimedical model for the study of pediatric nutrition and metabolism","volume":"2","author":"Odle","year":"2014","journal-title":"Annu Rev Anim Biosci"},{"key":"10.3945\/jn.117.252767_bib26","doi-asserted-by":"crossref","first-page":"e21205","DOI":"10.1371\/journal.pone.0021205","article-title":"SCFAs induce mouse neutrophil chemotaxis through the GPR43 receptor","volume":"6","author":"Vinolo","year":"2011","journal-title":"PLoS One"},{"key":"10.3945\/jn.117.252767_bib27","doi-asserted-by":"crossref","DOI":"10.1201\/9781439831953.ch7","article-title":"A simplified method to study the effect of intravenous fat infusion in Neonatal piglets","author":"Morris","year":"1998","journal-title":"Lipids in infant nutrition."},{"key":"10.3945\/jn.117.252767_bib28","doi-asserted-by":"crossref","DOI":"10.2527\/jas1954.132375x","article-title":"The effect of rations on selected vitamin content of sows' milk","volume":"13","author":"Barnhart","year":"1954","journal-title":"J Anim Sci"},{"key":"10.3945\/jn.117.252767_bib29","doi-asserted-by":"crossref","DOI":"10.1128\/AEM.01043-13","article-title":"Development of a dual-index sequencing strategy and curation pipeline for analyzing amplicon sequence data on the MiSeq Illumina sequencing platform","volume":"79","author":"Kozich","year":"2013","journal-title":"Appl Environ Microbiol"},{"key":"10.3945\/jn.117.252767_bib30","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"key":"10.3945\/jn.117.252767_bib31","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J R Stat Soc Ser B"},{"key":"10.3945\/jn.117.252767_bib32","article-title":"Metabolome-wide association study of primary open angle Glaucoma","volume":"56","author":"Burgess","year":"2015","journal-title":"Invest Opthalmol Vis Sci"},{"key":"10.3945\/jn.117.252767_bib33","first-page":"43","article-title":"Mitochondrial metabolomics using high-resolution Fourier-transform mass spectrometry","author":"Go","year":"2014","journal-title":"BT - mass spectrometry in metabolomics: methods and protocols."},{"key":"10.3945\/jn.117.252767_bib34","doi-asserted-by":"crossref","DOI":"10.1093\/bioinformatics\/17.6.520","article-title":"Missing value estimation methods for DNA microarrays","volume":"17","author":"Troyanskaya","year":"2001","journal-title":"Bioinformatics"},{"key":"10.3945\/jn.117.252767_bib35","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1186\/1471-2105-9-559","article-title":"WGCNA: an R package for weighted correlation network analysis","volume":"9","author":"Langfelder","year":"2008","journal-title":"BMC Bioinformatics"},{"key":"10.3945\/jn.117.252767_bib36","doi-asserted-by":"crossref","DOI":"10.1038\/nri3738","article-title":"Regional specialization within the intestinal immune system","volume":"14","author":"Mowat","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"10.3945\/jn.117.252767_bib37","doi-asserted-by":"crossref","first-page":"e19594","DOI":"10.1371\/journal.pone.0019594","article-title":"The level of protein in milk formula modifies ileal sensitivity to LPS later in life in a piglet model","volume":"6","author":"Chatelais","year":"2011","journal-title":"PLoS One"},{"key":"10.3945\/jn.117.252767_bib38","article-title":"Diet and faecal flora in the newborn: breast milk and infant formula","volume":"64","author":"Balmer","year":"1989","journal-title":"Arch Dis Child"},{"key":"10.3945\/jn.117.252767_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.anaerobe.2011.03.009","article-title":"Microbiota profile in feces of breast- and formula-fed newborns by using fluorescence in situ hybridization (FISH)","volume":"17","author":"Bezirtzoglou","year":"2011","journal-title":"Anaerobe"},{"key":"10.3945\/jn.117.252767_bib40","doi-asserted-by":"crossref","DOI":"10.1099\/mic.0.042143-0","article-title":"Determinants of the human infant intestinal microbiota after the introduction of first complementary foods in infant samples from five European centres","volume":"157","author":"Fallani","year":"2011","journal-title":"Microbiology"},{"key":"10.3945\/jn.117.252767_bib41","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/j.1651-2227.2003.tb00646.x","article-title":"Intestinal microflora in early infancy: composition and development","volume":"91","author":"Fanaro","year":"2003","journal-title":"Acta Paediatr Suppl"},{"key":"10.3945\/jn.117.252767_bib42","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1146\/annurev.arplant.59.032607.092915","article-title":"Plastid evolution","volume":"59","author":"Gould","year":"2008","journal-title":"Annu Rev Plant Biol"},{"key":"10.3945\/jn.117.252767_bib43","doi-asserted-by":"crossref","first-page":"e177","DOI":"10.1371\/journal.pbio.0050177","article-title":"Development of the human infant intestinal microbiota","volume":"5","author":"Palmer","year":"2007","journal-title":"PLoS Biol"},{"key":"10.3945\/jn.117.252767_bib44","doi-asserted-by":"crossref","DOI":"10.1289\/ehp.1306534","article-title":"Exercise attenuates PCB-induced changes in the mouse gut microbiome","volume":"121","author":"Choi","year":"2013","journal-title":"Environ Health Perspect"},{"key":"10.3945\/jn.117.252767_bib45","doi-asserted-by":"crossref","first-page":"e0136150","DOI":"10.1371\/journal.pone.0136150","article-title":"Physical activity differentially affects the Cecal Microbiota of ovariectomized female rats selectively bred for high and low aerobic capacity","volume":"10","author":"Liu","year":"2015","journal-title":"PLoS One"},{"key":"10.3945\/jn.117.252767_bib46","doi-asserted-by":"crossref","first-page":"e01102","DOI":"10.7554\/eLife.01102","article-title":"The human gut and groundwater harbor non-photosynthetic bacteria belonging to a new candidate phylum sibling to cyanobacteria","volume":"2","author":"Di Rienzi","year":"2013","journal-title":"eLife"},{"key":"10.3945\/jn.117.252767_bib47","doi-asserted-by":"crossref","DOI":"10.1038\/ismej.2014.12","article-title":"Bacteria, phages and pigs: the effects of in-feed antibiotics on the microbiome at different gut locations","volume":"8","author":"Looft","year":"2014","journal-title":"ISME J"},{"key":"10.3945\/jn.117.252767_bib48","doi-asserted-by":"crossref","DOI":"10.1007\/s00248-008-9366-y","article-title":"Ecophysiology of the developing total bacterial and lactobacillus communities in the terminal small intestine of weaning piglets","volume":"56","author":"Pieper","year":"2008","journal-title":"Microb Ecol"},{"key":"10.3945\/jn.117.252767_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.livsci.2010.06.037","article-title":"Microbial succession in the gastrointestinal tract (GIT) of the preweaned pig","volume":"133","author":"Petri","year":"2010","journal-title":"Livest Sci"},{"key":"10.3945\/jn.117.252767_bib50","doi-asserted-by":"crossref","DOI":"10.1128\/IAI.71.1.428-436.2003","article-title":"Divergent patterns of colonization and immune response elicited from two intestinal Lactobacillus strains that display similar properties in vitro","volume":"71","author":"Ibnou-Zekri","year":"2003","journal-title":"Infect Immun"},{"key":"10.3945\/jn.117.252767_bib51","doi-asserted-by":"crossref","DOI":"10.4049\/jimmunol.1300678","article-title":"Divergent immunomodulating effects of probiotics on T cell responses to oral attenuated human rotavirus vaccine and virulent human rotavirus infection in a neonatal gnotobiotic piglet disease model","volume":"191","author":"Chattha","year":"2013","journal-title":"J Immunol"},{"key":"10.3945\/jn.117.252767_bib52","doi-asserted-by":"crossref","DOI":"10.1038\/nrendo.2015.129","article-title":"Acylcarnitines\u2014old actors auditioning for new roles in metabolic physiology","volume":"11","author":"McCoin","year":"2015","journal-title":"Nat Rev Endocrinol"},{"key":"10.3945\/jn.117.252767_bib53","doi-asserted-by":"crossref","DOI":"10.1194\/jlr.M300123-JLR200","article-title":"Inhibition of carnitine palmitoyltransferase in the rat small intestine reduces export of triacylglycerol into the lymph","volume":"44","author":"Washington","year":"2003","journal-title":"J Lipid Res"},{"key":"10.3945\/jn.117.252767_bib54","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1751-0147-51-26","article-title":"Bacteria in milk from anterior and posterior mammary glands in sows affected and unaffected by postpartum dysgalactia syndrome (PPDS)","volume":"51","author":"Kemper","year":"2009","journal-title":"Acta Vet Scand"}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622108345?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316622108345?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/jn\/article-pdf\/147\/8\/1499\/30128297\/jn252767.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jn\/article-pdf\/147\/8\/1499\/30128297\/jn252767.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T02:09:37Z","timestamp":1719281377000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316622108345"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8]]},"references-count":54,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["S0022316622108345"],"URL":"https:\/\/doi.org\/10.3945\/jn.117.252767","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[2017,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Early Postnatal Diets Affect the Bioregional Small Intestine Microbiome and Ileal Metabolome in Neonatal Pigs","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.3945\/jn.117.252767","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2017 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}