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Blood. 2016; 127:                    2375-2390.","DOI":"10.1182\/blood-2016-01-643569"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2 Shimoyama                            M. Diagnostic                    criteria and classification of clinical subtypes of adult T-cell                    leukaemia-lymphoma. A report from the Lymphoma Study Group (1984\u201387). Br J                    Haematol. 1991; 79: 428-437.","DOI":"10.1111\/j.1365-2141.1991.tb08051.x"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3 Takasaki                            Y,                                Iwanaga                            M,                                Imaizumi                            Y                    <i>et al.<\/i> Long-term study of indolent adult T-cell                    leukemia-lymphoma. Blood. 2010; 115: 4337-4343.","DOI":"10.1182\/blood-2009-09-242347"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4 Yamada                            Y. Phenotypic                    and functional analysis of leukemic cells from 16 patients with adult T-cell                    leukemia\/lymphoma. Blood. 1983; 61: 192-199.","DOI":"10.1182\/blood.V61.1.192.192"},{"key":"5","unstructured":"5 Takatsuki                            K,                                Yamaguchi                            K,                                Watanabe                            T. Adult T-cell                    leukemia and HTLV-I related diseases. Gann Mono Can Res. 1992; 39:                    1-15."},{"key":"6","doi-asserted-by":"crossref","unstructured":"6 Karube                            K,                                Ohshima                            K,                                Tsuchiya                            T                    <i>et al.<\/i> Expression of FoxP3, a key molecule in CD4 + CD25 +                    regulatory T cells, in adult T-cell leukaemia\/lymphoma cells. Br J Haematol.                    2004; 126: 81-84.","DOI":"10.1111\/j.1365-2141.2004.04999.x"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7 Hicklin                            DJ,                                Wang                            Z,                                Arienti                            F                    <i>et al.<\/i> beta2-Microglobulin mutations, HLA class I antigen loss,                    and tumor progression in melanoma. J Clin Invest. 1998; 101:                    2720-2729.","DOI":"10.1172\/JCI498"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8 Momburg                            F,                                M\u00f6ller                            P,                                Moldenhauer                            G,                                H\u00e4mmerling                            GJ. Loss of                    HLA-A,B,C in colorectal carcinoma is related to the degree of                    de-differentiation. J Immunogenet. 1986; 13: 195-199.","DOI":"10.1111\/j.1744-313X.1986.tb01101.x"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9 Kataoka                            K,                                Nagata                            Y,                                Kitanaka                            A                    <i>et al.<\/i> Integrated molecular analysis of adult T cell                    leukemia\/lymphoma. Nat Genet. 2015; 47: 1304-1315.","DOI":"10.1038\/ng.3415"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10 Asano                            N,                                Miyoshi                            H,                                Kato                            T                    <i>et al.<\/i> Expression pattern of immunosurveillance-related antigen                    in adult T cell leukaemia\/lymphoma. Histopathology. 2018; 72:                    945-954.","DOI":"10.1111\/his.13461"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11 Sconocchia                            G,                                Eppenberger-Castori                            S,                                Zlobec                            I                    <i>et al.<\/i> HLA class II antigen expression in colorectal carcinoma                    tumors as a favorable prognostic marker. Neoplasia. 2014; 16:                    31-42.","DOI":"10.1593\/neo.131568"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12 Esteban                            F,                                Ruiz-Cabello                            F,                                Concha                            A                    <i>et al.<\/i> HLA-DR expression is associated with excellent prognosis                    in squamous cell carcinoma of the larynx. Clin Exp Metastasis. 1990; 8:                    319-328.","DOI":"10.1007\/BF01810678"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13 Rimsza                            LM,                                Roberts                            RA,                                Miller                            TP                    <i>et al.<\/i> Loss of MHC class II gene and protein expression in                    diffuse large B-cell lymphoma is related to decreased tumor immunosurveillance                    and poor patient survival regardless of other prognostic factors: a follow-up                    study from the Leukemia and Lymphoma Molecular Profiling Project. Blood. 2004;                    103: 4251-4258.","DOI":"10.1182\/blood-2003-07-2365"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14 He                            Y,                                Rozeboom                            L,                                Rivard                            CJ                    <i>et al.<\/i> MHC class II expression in lung cancer. Lung Cancer.                    2017; 112: 75-80.","DOI":"10.1016\/j.lungcan.2017.07.030"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15 Hemon                            P,                                Jean-Louis                            F,                                Ramgolam                            K                    <i>et al.<\/i> MHC class II engagement by its ligand LAG-3 (CD223)                    contributes to melanoma resistance to apoptosis. 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Profiles of                    expression of activated cell antigens on peripheral blood and lymph node cells                    from different clinical stages of adult T-cell leukemia. Blood. 1989; 73:                    1664-1671.","DOI":"10.1182\/blood.V73.6.1664.1664"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18 Takeuchi                            M,                                Miyoshi                            H,                                Asano                            N                    <i>et al.<\/i> Human leukocyte antigen class II expression is a good                    prognostic factor in adult T-cell leukemia\/lymphoma. Haematologica. 2019; 104:                    1626-1632.","DOI":"10.3324\/haematol.2018.205567"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19 Challa-Malladi                            M,                                Lieu                            YK,                                Califano                            O                    <i>et al.<\/i> Combined genetic inactivation of \u03b22-Microglobulin and                    CD58 reveals frequent escape from immune recognition in diffuse large B cell                    lymphoma. 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Oncol Lett.                    2016; 12: 1519-1524.","DOI":"10.3892\/ol.2016.4774"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26 Takeuchi                            M,                                Miyoshi                            H,                                Nakashima                            K                    <i>et al.<\/i> Comprehensive immunohistochemical analysis of immune                    checkpoint molecules in adult T cell leukemia\/lymphoma. Ann Hematol. 2020; 99:                    1093-1098.","DOI":"10.1007\/s00277-020-03967-x"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27 Fu                            Y,                                Lin                            Q,                                Zhang                            Z,                                Zhang                            L. Therapeutic                    strategies for the costimulatory molecule OX40 in T-cell-mediated immunity. Acta                    Pharm Sin B. 2020; 10: 414-433.","DOI":"10.1016\/j.apsb.2019.08.010"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28 Saito                            M,                                Tanaka                            R,                                Arishima                            S                    <i>et al.<\/i> Increased expression of OX40 is associated with                    progressive disease in patients with HTLV-1-associated myelopathy\/tropical                    spastic paraparesis. Retrovirology. 2013; 10: 51.","DOI":"10.1186\/1742-4690-10-51"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29 Pentcheva-Hoang                            T,                                Egen                            JG,                                Wojnoonski                            K,                                Allison                            JP. B7-1 and                    B7-2 selectively recruit CTLA-4 and CD28 to the immunological synapse. Immunity.                    2004; 21: 401-413.","DOI":"10.1016\/j.immuni.2004.06.017"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30 Chen                            L,                                Flies                            DB. Molecular                    mechanisms of T cell co-stimulation and co-inhibition. Nat Rev Immunol. 2013;                    13: 227-242.","DOI":"10.1038\/nri3405"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31 Vallois                            D,                                Dupuy                            A,                                Lemonnier                            F                    <i>et al.<\/i> RNA fusions involving CD28 are rare in peripheral T-cell                    lymphomas and concentrate mainly in those derived from follicular helper T                    cells. Haematologica. 2018; 103: e360-e363.","DOI":"10.3324\/haematol.2017.186767"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32 Yoshida                            N,                                Shigemori                            K,                                Donaldson                            N                    <i>et al.<\/i> Genomic landscape of young ATLL patients identifies                    frequent targetable CD28 fusions. Blood. 2020; 135: 1467-1471.","DOI":"10.1182\/blood.2019001815"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33 Sakamoto                            Y,                                Ishida                            T,                                Masaki                            A                    <i>et al.<\/i> Clinical significance of CD28 gene-related activating                    alterations in adult T-cell leukaemia\/lymphoma. Br J Haematol. 2021; 192:                    281-291.","DOI":"10.1111\/bjh.17211"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34 Hao                            NB,                                L\u00fc                            MH,                                Fan                            YH                    <i>et al.<\/i> Macrophages in tumor microenvironments and the                    progression of tumors. Clin Dev Immunol. 2012; 2012:                        948098.","DOI":"10.1155\/2012\/948098"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35 Komohara                            Y,                                Niino                            D,                                Saito                            Y                    <i>et al.<\/i> Clinical significance of CD 163 + tumor-associated                    macrophages in patients with adult T-cell leukemia\/lymphoma. Cancer Sci. 2013;                    104: 945-951.","DOI":"10.1111\/cas.12167"},{"key":"36","unstructured":"36 Li                            Y,                                Lu                            S,                                Xu                            Y                    <i>et al.<\/i> Overexpression of CD47 predicts poor prognosis and                    promotes cancer cell invasion in high-grade serous ovarian carcinoma. Am J                    Transl Res. 2017; 9: 2901-2910."},{"key":"37","doi-asserted-by":"crossref","unstructured":"37 Barrera                            L,                                Montes-Serv\u00edn                            E,                                Hernandez-Martinez                            JM                    <i>et al.<\/i> CD47 overexpression is associated with decreased                    neutrophil apoptosis\/phagocytosis and poor prognosis in non-small-cell lung                    cancer patients. Br J Cancer. 2017; 117: 385-397.","DOI":"10.1038\/bjc.2017.173"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38 Yanagida                            E,                                Miyoshi                            H,                                Takeuchi                            M                    <i>et al.<\/i> Clinicopathological analysis of immunohistochemical                    expression of CD47 and SIRP\u03b1 in adult T-cell leukemia\/lymphoma. Hematol Oncol.                    2020; 38: 680-688.","DOI":"10.1002\/hon.2768"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39 Hasegawa                            H,                                Nomura                            T,                                Kohno                            M                    <i>et al.<\/i> Increased chemokine receptor CCR7\/EBI1 expression                    enhances the infiltration of lymphoid organs by adult T-cell leukemia cells.                    Blood. 2000; 95: 30-38.","DOI":"10.1182\/blood.V95.1.30.001k09_30_38"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40 Shimizu                            K,                                Karube                            K,                                Arakawa                            F                    <i>et al.<\/i> Upregulation of CC chemokine ligand 18 and                    downregulation of CX3C chemokine receptor 1 expression in human T-cell leukemia                    virus type 1-associated lymph node lesions: Results of chemokine and chemokine                    receptor DNA chip analysis. Cancer Sci. 2007; 98: 1875-1880.","DOI":"10.1111\/j.1349-7006.2007.00627.x"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41 Korbecki                            J,                                Olbromski                            M,                                Dzi\u0119giel                            P. CCL18 in the                    progression of cancer. Int J Mol Sci. 2020; 21: 7955.","DOI":"10.3390\/ijms21217955"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42 Nishimura                            M,                                Umehara                            H,                                Nakayama                            T                    <i>et al.<\/i> Dual functions of fractalkine\/CX3C ligand 1 in                    trafficking of perforin+\/granzyme B+ cytotoxic effector lymphocytes that are                    defined by CX3CR1 expression. J Immunol. 2002; 168: 6173-6180.","DOI":"10.4049\/jimmunol.168.12.6173"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43 Ratner                            L,                                Waldmann                            TA,                                Janakiram                            M,                                Brammer                            JE. Rapid                    progression of adult T-cell leukemia\u2013lymphoma after PD-1 inhibitor therapy. N                    Engl J Med. 2018; 378: 1947-1948.","DOI":"10.1056\/NEJMc1803181"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44 Ishitsuka                            K,                                Utsunomiya                            A,                                Ishida                            T. PD-1                    inhibitor therapy in adult T-cell leukemia\u2013lymphoma. N Engl J Med. 2018; 379:                    695-697.","DOI":"10.1056\/NEJMc1807852"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45 Roemer                            MGM,                                Redd                            RA,                                Cader                            FZ                    <i>et al.<\/i> Major histocompatibility complex class II and programmed                    death ligand 1 expression predict outcome after programmed death 1 blockade in                    classic Hodgkin lymphoma. 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