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Classic                    Hodgkin lymphoma. In : Swerdlow SH, Campo E, Harris NL, <i>et al<\/i>.                    (eds) : WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues.                    Lyon, IARC. 2017; pp. 425-442."},{"key":"2","doi-asserted-by":"crossref","unstructured":"2 Roemer                            MGM,                                Advani                            RH,                                Ligon                            AH                    <i>et al.<\/i> PD-L1 and PD-L2 genetic alterations define classical                    Hodgkin lymphoma and predict outcome. J Clin Oncol. 2016; 34:                    2690-2697.","DOI":"10.1200\/JCO.2016.66.4482"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3 De                                Goycoechea                            D,                                Stalder                            G,                                Martins                            F,                                Duchosal                            MA. Immune                    checkpoint inhibition in classical Hodgkin lymphoma: from early achievements                    towards new perspectives. J Oncol. 2019; 2019:                        9513701.","DOI":"10.1155\/2019\/9513701"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4 Wang                            HW,                                Balakrishna                            JP,                                Pittaluga                            S,                                Jaffe                            ES. Diagnosis of                    Hodgkin lymphoma in the modern era. Br J Haematol. 2019; 184:                    45-59.","DOI":"10.1111\/bjh.15614"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5 Xing                            W,                                Mai                            N,                                Dresser                            K,                                Chen                            BJ. PD-L1                    immunohistochemistry highlights bone marrow involvement by classic Hodgkin                    lymphoma in staging biopsies: implications for diagnosis and tumor                    microenvironment alterations. Appl Immunohistochem Mol Morphol. 2019; 27:                    356-363.","DOI":"10.1097\/PAI.0000000000000628"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6 Oliveira                            CC,                                Paschoalini                            RB,                                Domingues                            MAC. Fas-ligand                    and caspase-3 positivity in three cases of histiocytic sarcoma: a different                    etiopathogenic pathway? Autops Case Rep. 2018; 8:                        e2018001.","DOI":"10.4322\/acr.2018.001"},{"key":"7","unstructured":"7 Nakamura S, Jaffe ES, Swerdlow SH. EBV                    positive diffuse large B-cell lymphoma, not otherwise specified. In : Swerdlow                    SH, Campo E, Harris NL, <i>et al<\/i>. (eds) : WHO Classification of                    Tumours of Haematopoietic and Lymphoid Tissues. Lyon, IARC. 2017; pp.                    304-306."},{"key":"8","doi-asserted-by":"crossref","unstructured":"8 Sakakibara                            A,                                Kohno                            K,                                Ishikawa                            E                    <i>et al.<\/i> Age-related EBV-associated B-cell lymphoproliferative                    disorders and other EBV + lymphoproliferative diseases: new insights into immune                    escape and immunodeficiency through staining with anti-PD-L1 antibody clone                    SP142. Pathol Int. 2020; 70: 481-492.","DOI":"10.1111\/pin.12946"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9 Oyama                            T,                                Ichimura                            K,                                Suzuki                            R                    <i>et al.<\/i> Senile EBV+ B-cell lymphoproliferative disorders: a                    clinicopathologic study of 22 patients. Am J Surg Pathol. 2003; 27:                    16-26.","DOI":"10.1097\/00000478-200301000-00003"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10 Oyama                            T,                                Yamamoto                            K,                                Asano                            N                    <i>et al.<\/i> Age-related EBV-associated B-cell lymphoproliferative                    disorders constitute a distinct clinicopathologic group: a study of 96 patients.                    Clin Cancer Res. 2007; 13: 5124-5132.","DOI":"10.1158\/1078-0432.CCR-06-2823"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11 Shimoyama                            Y,                                Yamamoto                            K,                                Asano                            N                    <i>et al.<\/i> Age-related Epstein-Barr virus-associated B-cell                    lymphoproliferative disorders: special references to lymphomas surrounding this                    newly recognized clinicopathologic disease. Cancer Sci. 2008; 99:                    1085-1091.","DOI":"10.1111\/j.1349-7006.2008.00813.x"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12 Asano                            N,                                Yamamoto                            K,                                Tamaru                            J                    <i>et al.<\/i> Age-related Epstein-Barr virus (EBV)\u2013associated B-cell                    lymphoproliferative disorders: comparison with EBV-positive classic Hodgkin                    lymphoma in elderly patients. Blood. 2009; 113: 2629-2636.","DOI":"10.1182\/blood-2008-06-164806"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13 Shimoyama                            Y,                                Asano                            N,                                Kojima                            M                    <i>et al.<\/i> Age-related EBV-associated B-cell lymphoproliferative                    disorders: diagnostic approach to a newly recognized clinicopathological entity.                    Pathol Int. 2009; 59: 835-843.","DOI":"10.1111\/j.1440-1827.2009.02466.x"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14 Dojcinov                            SD,                                Venkataraman                            G,                                Pittaluga                            S                    <i>et al.<\/i> Age-related EBV-associated lymphoproliferative disorders                    in the Western population: a spectrum of reactive lymphoid hyperplasia and                    lymphoma. Blood. 2011; 117: 4726-4735.","DOI":"10.1182\/blood-2010-12-323238"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15 Sakakibara                            A,                                Kohno                            K,                                Eladl                            AE                    <i>et al.<\/i> Immunohistochemical assessment of the diagnostic utility                    of PD-L1: a preliminary analysis of anti-PD-L1 antibody (SP142) for                    lymphoproliferative diseases with tumour and non-malignant                    Hodgkin-Reed-Sternberg (HRS)-like cells. Histopathology. 2018; 72:                    1156-1163.","DOI":"10.1111\/his.13475"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16 Kiyasu                            J,                                Miyoshi                            H,                                Hirata                            A                    <i>et al.<\/i> Expression of programmed cell death ligand 1 is                    associated with poor overall survival in patients with diffuse large B-cell                    lymphoma. Blood. 2015; 126: 2193-2201.","DOI":"10.1182\/blood-2015-02-629600"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17 Ishikawa                            E,                                Tanaka                            T,                                Shimada                            K                    <i>et al.<\/i> A prognostic model, including the EBV status of tumor                    cells, for primary gastric diffuse large B-cell lymphoma in the rituximab era.                    Cancer Med. 2018; 7: 3510-3520.","DOI":"10.1002\/cam4.1595"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18 Ishikawa                            E,                                Kato                            S,                                Shimada                            K                    <i>et al.<\/i> Clinicopathological analysis of primary intestinal                    diffuse large B-cell lymphoma: prognostic evaluation of CD5, PD-L1, and                    Epstein-Barr virus on tumor cells. Cancer Med. 2018; 7:                    6051-6063.","DOI":"10.1002\/cam4.1875"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19 Chen                            BJ,                                Chapuy                            B,                                Ouyang                            J                    <i>et al.<\/i> PD-L1 expression is characteristic of a subset of                    aggressive B-cell lymphomas and virus-associated malignancies. Clin Cancer Res.                    2013; 19: 3462-3473.","DOI":"10.1158\/1078-0432.CCR-13-0855"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20 Nicolae                            A,                                Pittaluga                            S,                                Abdullah                            S                    <i>et al.<\/i> EBV-positive large B-cell lymphomas in young patients: a                    nodal lymphoma with evidence for a tolerogenic immune environment. Blood. 2015;                    126: 863-872.","DOI":"10.1182\/blood-2015-02-630632"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21 Takahara                            T,                                Satou                            A,                                Ishikawa                            E                    <i>et al.<\/i> Clinicopathological analysis of neoplastic                    PD-L1-positive EBV+ diffuse large B cell lymphoma, not otherwise specified, in a                    Japanese cohort. Virchows Arch. 2021; 478: 541-552.","DOI":"10.1007\/s00428-020-02901-w"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22 Ohshima                            K,                                Suzumiya                            J,                                Kato                            A,                                Tashiro                            K,                                Kikuchi                            M. Clonal                    HTLV-I-infected CD4+ T-lymphocytes and non-clonal non-HTLV-I-infected giant                    cells in incipient ATLL with Hodgkin-like histologic features. Int J Cancer.                    1997; 72: 592-598.","DOI":"10.1002\/(SICI)1097-0215(19970807)72:4<592::AID-IJC7>3.0.CO;2-L"},{"key":"23","unstructured":"23 Ohshima K, Jaffe ES, Yoshino T, Siebert R.                    Adult T-cell leukaemia\/lymphoma. In : Swerdlow SH, Campo E, Harris NL,                        <i>et al<\/i>. (eds) : WHO Classification of Tumours of                    Haematopoietic and Lymphoid Tissues. Lyon, IARC. 2017; pp.                    363-367."},{"key":"24","doi-asserted-by":"crossref","unstructured":"24 Suefuji                            H,                                Ohshima                            K,                                Hayabuchi                            N,                                Nakamura                            K,                                Kikuchi                            M. HTLV-1                    carriers with B-cell lymphoma of localized stage head and neck: prognosis,                    clinical and immunopathological features. Br J Haematol. 2003; 123:                    606-612.","DOI":"10.1046\/j.1365-2141.2003.04653.x"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25 Beltran                            BE,                                Qui\u00f1ones                            P,                                Morales                            D                    <i>et al.<\/i> Diffuse large B-cell lymphoma in human T-lymphotropic                    virus type 1 carriers. Leukemia Res Treat. 2012; 2012:                        262363.","DOI":"10.1155\/2012\/262363"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26 Spina                            M,                                Carbone                            A,                                Gloghini                            A                    <i>et al.<\/i> Hodgkin\u2019s disease in patients with HIV infection. Adv                    Hematol. 2011; 2011: 402682.","DOI":"10.1155\/2011\/402682"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27 Ding                            J,                                Kumar                            AJ,                                Wilding                            E,                                Lee                            ST,                                Law                            JY. Multi-organ                    failure as the initial presentation of lymphocyte-depleted Hodgkin lymphoma in                    two patients with human immunodeficiency virus. Acta Haematol. 2020; 143:                    184-188.","DOI":"10.1159\/000500222"},{"key":"28","unstructured":"28 Said J, Cesarman E, Rosenwald A, Harris NL.                    Lymphomas associated HIV infection. In : Swerdlow SH, Campo E, Harris NL,                        <i>et al<\/i>. (eds) : WHO Classification of Tumours of                    Haematopoietic and Lymphoid Tissues. Lyon, IARC. 2017; pp.                    449-452."}],"container-title":["Journal of Clinical and Experimental Hematopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jslrt\/61\/3\/61_21008\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T05:25:43Z","timestamp":1715145943000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jslrt\/61\/3\/61_21008\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.3960\/jslrt.21008","relation":{},"ISSN":["1346-4280","1880-9952"],"issn-type":[{"value":"1346-4280","type":"print"},{"value":"1880-9952","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]},"article-number":"21008"}}