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WHO                    classification of tumours of haematopoietic and lymphoid tissues. Lyon, IARC.                    2017."},{"key":"2","doi-asserted-by":"crossref","unstructured":"2 Fischer                            T,                                Zing                            NPC,                                Chiattone                            CS,                                Federico                            M,                                Luminari                            S. Transformed                    follicular lymphoma. Ann Hematol. 2018; 97: 17-29.","DOI":"10.1007\/s00277-017-3151-2"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3 Davies                            AJ,                                Rosenwald                            A,                                Wright                            G                    <i>et al.<\/i> Transformation of follicular lymphoma to diffuse large                    B-cell lymphoma proceeds by distinct oncogenic mechanisms. Br J Haematol. 2007;                    136: 286-293.","DOI":"10.1111\/j.1365-2141.2006.06439.x"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4 Al-Tourah                            AJ,                                Gill                            KK,                                Chhanabhai                            M                    <i>et al.<\/i> Population-based analysis of incidence and outcome of                    transformed non-Hodgkin\u2019s lymphoma. J Clin Oncol. 2008; 26:                    5165-5169.","DOI":"10.1200\/JCO.2008.16.0283"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5 Maeshima                            AM,                                Omatsu                            M,                                Nomoto                            J                    <i>et al.<\/i> Diffuse large B-cell lymphoma after transformation from                    low-grade follicular lymphoma: morphological, immunohistochemical, and FISH                    analyses. Cancer Sci. 2008; 99: 1760-1768.","DOI":"10.1111\/j.1349-7006.2008.00873.x"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6 Sham                            RL,                                Phatak                            P,                                Carignan                            J,                                Janas                            J,                                Olson                            JP. Progression                    of follicular large cell lymphoma to Burkitt\u2019s lymphoma. Cancer. 1989; 63:                    700-702.","DOI":"10.1002\/1097-0142(19890215)63:4<700::AID-CNCR2820630417>3.0.CO;2-S"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7 Yano                            T,                                Jaffe                            ES,                                Longo                            DL,                                Raffeld                            M. MYC                    rearrangements in histologically progressed follicular lymphomas. Blood. 1992;                    80: 758-767.","DOI":"10.1182\/blood.V80.3.758.758"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8 Mukhopadhyay                            S,                                Readling                            J,                                Cotter                            PD,                                Shrimpton                            AE,                                Sidhu                            JS.                    Transformation of follicular lymphoma to Burkitt-like lymphoma within a single                    lymph node. Hum Pathol. 2005; 36: 571-575.","DOI":"10.1016\/j.humpath.2005.01.004"},{"key":"9","unstructured":"9 Xu                            X,                                Zhang                            L,                                Wang                            Y                    <i>et al.<\/i> Double-hit and triple-hit lymphomas arising from                    follicular lymphoma following acquisition of MYC: report of two cases and                    literature review. Int J Clin Exp Pathol. 2013; 6: 788-794."},{"key":"10","doi-asserted-by":"crossref","unstructured":"10 Martinez-Mera                            C,                                Herrero-Moyano                            M,                                L\u00f3pez-Elzaurdia                            C,                                Loscertales                            J,                                Arag\u00fces                            M. Cutaneous                    involvement in a high-grade B-cell lymphoma with rearrangement of MYC, BCL2, and                    BCL6 transformed from follicular lymphoma. Am J Dermatopathol. 2019; 41:                    80-82.","DOI":"10.1097\/DAD.0000000000001076"},{"key":"11","unstructured":"11 Jaffe                            ES,                                Zarate-Osorno                            A,                                Medeiros                            LJ. The                    interrelationship of Hodgkin\u2019s disease and non-Hodgkin\u2019s lymphomas--lessons                    learned from composite and sequential malignancies. Semin Diagn Pathol. 1992; 9:                    297-303."},{"key":"12","doi-asserted-by":"crossref","unstructured":"12 LeBrun                            DP,                                Ngan                            BY,                                Weiss                            LM                    <i>et al.<\/i> The bcl-2 oncogene in Hodgkin\u2019s disease arising in the                    setting of follicular non-Hodgkin\u2019s lymphoma. Blood. 1994; 83:                    223-230.","DOI":"10.1182\/blood.V83.1.223.bloodjournal831223"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13 Br\u00e4uninger                            A,                                Hansmann                            ML,                                Strickler                            JG                    <i>et al.<\/i> Identification of common germinal-center B-cell                    precursors in two patients with both Hodgkin\u2019s disease and non-Hodgkin\u2019s                    lymphoma. N Engl J Med. 1999; 340: 1239-1247.","DOI":"10.1056\/NEJM199904223401604"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14 Marafioti                            T,                                Hummel                            M,                                Anagnostopoulos                            I                    <i>et al.<\/i> Classical Hodgkin\u2019s disease and follicular lymphoma                    originating from the same germinal center B cell. J Clin Oncol. 1999; 17:                    3804-3809.","DOI":"10.1200\/JCO.1999.17.12.3804"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15 Maeshima                            AM,                                Taniguchi                            H,                                Nomoto                            J                    <i>et al.<\/i> Clinicopathological features of classical Hodgkin                    lymphoma in patients \u226540 years old, with special reference to composite cases.                    Jpn J Clin Oncol. 2015; 45: 921-928.","DOI":"10.1093\/jjco\/hyv101"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16 de                                Jong                            D,                                Voetdijk                            BMH,                                Beverstock                            GC                    <i>et al.<\/i> Activation of the c-myc oncogene in a precursor-B-cell                    blast crisis of follicular lymphoma, presenting as composite lymphoma. N Engl J                    Med. 1988; 318: 1373-1378.","DOI":"10.1056\/NEJM198805263182106"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17 Gauwerky                            CE,                                Haluska                            FG,                                Tsujimoto                            Y,                                Nowell                            PC,                                Croce                            CM. Evolution of                    B-cell malignancy: pre-B-cell leukemia resulting from MYC activation in a B-cell                    neoplasm with a rearranged BCL2 gene. Proc Natl Acad Sci USA. 1988; 85:                    8548-8552.","DOI":"10.1073\/pnas.85.22.8548"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18 Young                            KH,                                Xie                            Q,                                Zhou                            G                    <i>et al.<\/i> Transformation of follicular lymphoma to precursor                    B-cell lymphoblastic lymphoma with c-myc gene rearrangement as a critical event.                    Am J Clin Pathol. 2008; 129: 157-166.","DOI":"10.1309\/NKK3FEX2BE5L7EKB"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19 Geyer                            JT,                                Subramaniyam                            S,                                Jiang                            Y                    <i>et al.<\/i> Lymphoblastic transformation of follicular lymphoma: a                    clinicopathologic and molecular analysis of 7 patients. Hum Pathol. 2015; 46:                    260-271.","DOI":"10.1016\/j.humpath.2014.10.021"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20 Lau                            SK,                                Weiss                            LM,                                Zhang                            Y,                                Huang                            Q.                    Prolymphocytoid transformation of follicular lymphoma with coexpression of CD5                    and CD10. Leuk Lymphoma. 2006; 47: 541-547.","DOI":"10.1080\/10520290500305310"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21 Ouansafi                            I,                                He                            B,                                Fraser                            C                    <i>et al.<\/i> Transformation of follicular lymphoma to plasmablastic                    lymphoma with c-myc gene rearrangement. Am J Clin Pathol. 2010; 134:                    972-981.","DOI":"10.1309\/AJCPWY1SGJ9IEAOR"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22 Martinez                            D,                                Valera                            A,                                Perez                            NS                    <i>et al.<\/i> Plasmablastic transformation of low-grade B-cell                    lymphomas: report on 6 cases. Am J Surg Pathol. 2013; 37:                    272-281.","DOI":"10.1097\/PAS.0b013e31826cb1d1"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23 Yamada                            T,                                Hara                            T,                                Goto                            N,                                Iwata                            H,                                Tsurumi                            H. Follicular                    lymphoma suggested to transform into EBV-negative plasmablastic lymphoma. Int J                    Hematol. 2019; 109: 723-730.","DOI":"10.1007\/s12185-019-02591-4"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24 Maeshima                            AM,                                Taniguchi                            H,                                Ida                            H                    <i>et al.<\/i> Non-diffuse large B-cell lymphoma transformation from                    follicular lymphoma: a single-institution study of 19 cases. Hum Pathol. 2020;                    102: 33-43.","DOI":"10.1016\/j.humpath.2020.06.001"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25 Alsabeh                            R,                                Medeiros                            LJ,                                Glackin                            C,                                Weiss                            LM.                    Transformation of follicular lymphoma into CD30-large cell lymphoma with                    anaplastic cytologic features. Am J Surg Pathol. 1997; 21:                    528-536.","DOI":"10.1097\/00000478-199705000-00004"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26 Maeshima                            AM,                                Taniguchi                            H,                                Nomoto                            J                    <i>et al.<\/i> Histological and immunophenotypic changes in 59 cases of                    B-cell non-Hodgkin\u2019s lymphoma after rituximab therapy. Cancer Sci. 2009; 100:                    54-61.","DOI":"10.1111\/j.1349-7006.2008.01005.x"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27 Raess                            PW,                                Wang                            HW,                                Pack                            SD,                                Jaffe                            ES. CD30+ large                    B cell lymphoma with anaplastic features and complete loss of B cell marker                    expression arising from follicular lymphoma. Histopathology. 2019; 75:                    602-605.","DOI":"10.1111\/his.13919"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28 Feldman                            AL,                                Arber                            DA,                                Pittaluga                            S                    <i>et al.<\/i> Clonally related follicular lymphomas and                    histiocytic\/dendritic cell sarcomas: evidence for transdifferentiation of the                    follicular lymphoma clone. Blood. 2008; 111: 5433-5439.","DOI":"10.1182\/blood-2007-11-124792"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29 Brunner                            P,                                Rufle                            A,                                Dirnhofer                            S                    <i>et al.<\/i> Follicular lymphoma transformation into histiocytic                    sarcoma: indications for a common neoplastic progenitor. Leukemia. 2014; 28:                    1937-1940.","DOI":"10.1038\/leu.2014.167"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30 Alaggio R, Amador C, Anagnostopoulos I, et                    al. The 5th edition of the World Health Organization Classification of                    Haematolymphoid Tumours: Lymphoid Neoplasms. Leukemia. 2022; 36:                    1720-1748.","DOI":"10.1038\/s41375-022-01620-2"},{"key":"31","unstructured":"31 Siebert R, Alaggio R, Dave SS.                    Transformations of indolent B-cell lymphomas. In: WHO Classification of Tumours                    Editorial Board. Haematolymphoid tumours. Lyon (France): International Agency                    for Research on Cancer. (WHO classification of tumours series, 5th ed.; vol.                    11). https:\/\/publications.iarc.fr."},{"key":"32","doi-asserted-by":"crossref","unstructured":"32 Leoncini                            L,                                Delsol                            G,                                Gascoyne                            RD                    <i>et al.<\/i> Aggressive B-cell lymphomas: a review based on the                    workshop of the XI Meeting of the European Association for Haematopathology.                    Histopathology. 2005; 46: 241-255.","DOI":"10.1111\/j.1365-2559.2005.02068.x"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33 Maeshima                            AM,                                Taniguchi                            H,                                Toyoda                            K                    <i>et al.<\/i> Clinicopathological features of histological                    transformation from extranodal marginal zone B-cell lymphoma of                    mucosa-associated lymphoid tissue to diffuse large B-cell lymphoma: an analysis                    of 467 patients. Br J Haematol. 2016; 174: 923-931.","DOI":"10.1111\/bjh.14153"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34 Maeshima                            AM,                                Taniguchi                            H,                                Hori                            Y                    <i>et al.<\/i> Diagnostic utility and prognostic significance of the                    Ki\u201067 labeling index in diffuse large B\u2010cell lymphoma transformed from                    follicular lymphoma: a study of 76 patients. Pathol Int. 2021; 71:                    674-681.","DOI":"10.1111\/pin.13148"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35 Broyde                            A,                                Boycov                            O,                                Strenov                            Y                    <i>et al.<\/i> Role and prognostic significance of the Ki-67 index in                    non-Hodgkin\u2019s lymphoma. Am J Hematol. 2009; 84: 338-343.","DOI":"10.1002\/ajh.21406"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36 Samols                            MA,                                Smith                            NE,                                Gerber                            JM                    <i>et al.<\/i> Software-automated counting of Ki-67 proliferation index                    correlates with pathologic grade and disease progression of follicular                    lymphomas. Am J Clin Pathol. 2013; 140: 579-587.","DOI":"10.1309\/AJCPTMA1F6LWYTQV"},{"key":"37","unstructured":"37 Kawaguchi                            Y,                                Shiozawa                            E,                                Shimada                            S                    <i>et al.<\/i> Ki-67 expression of immunohistochemistry using                    computerized image analysis is a useful prognostic marker in follicular                    lymphomas. Int J Clin Exp Pathol. 2018; 11: 3366-3374."},{"key":"38","doi-asserted-by":"crossref","unstructured":"38 Hans                            CP,                                Weisenburger                            DD,                                Greiner                            TC                    <i>et al.<\/i> Confirmation of the molecular classification of diffuse                    large B-cell lymphoma by immunohistochemistry using a tissue microarray. Blood.                    2004; 103: 275-282.","DOI":"10.1182\/blood-2003-05-1545"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39 Davies                            AJ,                                Rosenwald                            A,                                Wright                            G                    <i>et al.<\/i> Transformation of follicular lymphoma to diffuse large                    B-cell lymphoma proceeds by distinct oncogenic mechanisms. Br J Haematol. 2007;                    136: 286-293.","DOI":"10.1111\/j.1365-2141.2006.06439.x"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40 Kridel                            R,                                Chan                            FC,                                Mottok                            A                    <i>et al.<\/i> Histological transformation and progression in                    follicular lymphoma: A clonal evolution study. PLoS Med. 2016; 13:                        e1002197.","DOI":"10.1371\/journal.pmed.1002197"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41 Alvaro-Naranjo                            T,                                Ja\u00e9n-Mart\u00ednez                            J,                                Gum\u00e1-Padr\u00f3                            J,                                Bosch-Pr\u00edncep                            R,                                Salvad\u00f3-Usach                            MT.                    CD20-negative DLBCL transformation after rituximab treatment in follicular                    lymphoma: a new case report and review of the literature. Ann Hematol. 2003; 82:                    585-588.","DOI":"10.1007\/s00277-003-0694-1"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42 Huang                            Y,                                Hu                            S,                                Larson                            DP                    <i>et al.<\/i> Composite classic Hodgkin lymphoma and follicular                    lymphoma: a clinicopathologic study of 22 cases with review of 27 additional                    cases in the literature. Am J Surg Pathol. 2022; 46: 793-800.","DOI":"10.1097\/PAS.0000000000001828"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43 Nomoto                            J,                                Hiramoto                            N,                                Kato                            M                    <i>et al.<\/i> Deletion of the TNFAIP3\/A20 gene detected by FICTION                    analysis in classical Hodgkin lymphoma. BMC Cancer. 2012; 12:                    457.","DOI":"10.1186\/1471-2407-12-457"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44 Yoshida                            M,                                Ichikawa                            A,                                Miyoshi                            H                    <i>et al.<\/i> High frequency of t(14;18) in Hodgkin\u2019s lymphoma                    associated with follicular lymphoma. Pathol Int. 2012; 62:                    518-524.","DOI":"10.1111\/j.1440-1827.2012.02835.x"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45 Bischin AM, Dorer R, Aboulafia DM.                    Transformation of follicular lymphoma to a high-grade B-cell lymphoma with MYC                    and BCL2 translocations and overlapping features of Burkitt lymphoma and acute                    lymphoblastic leukemia: a case report and literature review. Clin Med Insights                    Blood Disord. 2017; 10: 1179545X1769254.","DOI":"10.1177\/1179545X17692544"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46 Ok                            CY,                                Medeiros                            LJ,                                Thakral                            B                    <i>et al.<\/i> High-grade B-cell lymphomas with TdT expression: a                    diagnostic and classification dilemma. Mod Pathol. 2019; 32:                    48-58.","DOI":"10.1038\/s41379-018-0112-9"},{"key":"47","doi-asserted-by":"crossref","unstructured":"47 Chen                            W,                                Lau                            SK,                                Fong                            D                    <i>et al.<\/i> High frequency of clonal immunoglobulin receptor gene                    rearrangements in sporadic histiocytic\/dendritic cell sarcomas. Am J Surg                    Pathol. 2009; 33: 863-873.","DOI":"10.1097\/PAS.0b013e31819287b8"},{"key":"48","doi-asserted-by":"crossref","unstructured":"48 Laurent                            C,                                Syrykh                            C,                                Hamon                            M                    <i>et al.<\/i> Resistance of B-cell lymphomas to CAR T-cell therapy is                    associated with genomic tumor changes which can result in transdifferentiation.                    Am J Surg Pathol. 2022; 46: 742-753.","DOI":"10.1097\/PAS.0000000000001834"}],"container-title":["Journal of Clinical and Experimental Hematopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jslrt\/63\/1\/63_22046\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T05:28:21Z","timestamp":1680326901000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jslrt\/63\/1\/63_22046\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.3960\/jslrt.22046","relation":{},"ISSN":["1346-4280","1880-9952"],"issn-type":[{"value":"1346-4280","type":"print"},{"value":"1880-9952","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]},"article-number":"22046"}}