{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T13:06:48Z","timestamp":1785589608209,"version":"3.56.0"},"reference-count":35,"publisher":"Japanese Society for Lymphoreticular Tissue Research","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCEH","J Clin Exp Hematopathol"],"published-print":{"date-parts":[[2023]]},"DOI":"10.3960\/jslrt.23010","type":"journal-article","created":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T22:12:49Z","timestamp":1687903969000},"page":"65-72","source":"Crossref","is-referenced-by-count":4,"title":["Precursory or early lesions of follicular lymphoma: clinical                    features, pathology, and genetics"],"prefix":"10.3960","volume":"63","author":[{"given":"Naoki","family":"Oishi","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Yamanashi, Chuo,                            Yamanashi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2349","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1 Chihara                            D,                                Ito                            H,                                Matsuda                            T                    <i>et al.<\/i> Differences in incidence and trends of haematological                    malignancies in J apan and the United States. Br J Haematol. 2014; 164:                    536-545.","DOI":"10.1111\/bjh.12659"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2 Takata                            K,                                Miyata-Takata                            T,                                Sato                            Y,                                Yoshino                            T. Pathology of                    follicular lymphoma. J Clin Exp Hematop. 2014; 54: 3-9.","DOI":"10.3960\/jslrt.54.3"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3 Kridel                            R,                                Sehn                            LH,                                Gascoyne                            RD. Pathogenesis                    of follicular lymphoma. J Clin Invest. 2012; 122: 3424-3431.","DOI":"10.1172\/JCI63186"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4 Huet                            S,                                Sujobert                            P,                                Salles                            G. From genetics                    to the clinic: a translational perspective on follicular lymphoma. Nat Rev                    Cancer. 2018; 18: 224-239.","DOI":"10.1038\/nrc.2017.127"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5 Roulland                            S,                                Kelly                            RS,                                Morgado                            E                    <i>et al.<\/i> t(14;18) Translocation: A predictive blood biomarker for                    follicular lymphoma. J Clin Oncol. 2014; 32: 1347-1355.","DOI":"10.1200\/JCO.2013.52.8190"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6 Ganapathi                            KA,                                Pittaluga                            S,                                Odejide                            OO,                                Freedman                            AS,                                Jaffe                            ES. Early                    lymphoid lesions: conceptual, diagnostic and clinical challenges. Haematologica.                    2014; 99: 1421-1432.","DOI":"10.3324\/haematol.2014.107938"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7 Tsujimoto                            Y,                                Gorham                            J,                                Cossman                            J,                                Jaffe                            E,                                Croce                            CM. The t(14;18)                    chromosome translocations involved in B-cell neoplasms result from mistakes in                    VDJ joining. Science. 1985; 229: 1390-1393.","DOI":"10.1126\/science.3929382"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8 Summers                            KE,                                Goff                            LK,                                Wilson                            AG                    <i>et al.<\/i> Frequency of the Bcl-2\/IgH rearrangement in normal                    individuals: implications for the monitoring of disease in patients with                    follicular lymphoma. J Clin Oncol. 2001; 19: 420-424.","DOI":"10.1200\/JCO.2001.19.2.420"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9 D\u00f6lken                            G,                                D\u00f6lken                            L,                                Hirt                            C                    <i>et al.<\/i> Age-dependent prevalence and frequency of circulating                    t(14;18)-positive cells in the peripheral blood of healthy individuals. J Natl                    Cancer Inst Monogr. 2008; 2008: 44-47.","DOI":"10.1093\/jncimonographs\/lgn005"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10 Nambiar                            M,                                Raghavan                            SC. Prevalence                    and analysis of t(14;18) and t(11;14) chromosomal translocations in healthy                    Indian population. Ann Hematol. 2010; 89: 35-43.","DOI":"10.1007\/s00277-009-0755-1"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11 Yasukawa                            M,                                Bando                            S,                                D\u00f6lken                            G                    <i>et al.<\/i> Low frequency of BCL-2\/J(H) translocation in peripheral                    blood lymphocytes of healthy Japanese individuals. Blood. 2001; 98:                    486-488.","DOI":"10.1182\/blood.V98.2.486"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12 Hirt                            C,                                Weitmann                            K,                                Sch\u00fcler                            F                    <i>et al.<\/i> Circulating t(14;18)-positive cells in healthy                    individuals: association with age and sex but not with smoking. Leuk Lymphoma.                    2013; 54: 2678-2684.","DOI":"10.3109\/10428194.2013.788177"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13 Schmitt                            C,                                Balogh                            B,                                Grundt                            A                    <i>et al.<\/i> The bcl-2\/IgH rearrangement in a population of 204                    healthy individuals: Occurrence, age and gender distribution, breakpoints, and                    detection method validity. Leuk Res. 2006; 30: 745-750.","DOI":"10.1016\/j.leukres.2005.10.001"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14 Colon-Otero                            G, Van                                Wier                            SA,                                Ahmann                            GJ                    <i>et al.<\/i> Prevalence of BCL-2\/J(H) translocation in healthy                    African Americans. Ann Hematol. 2017; 96: 51-55.","DOI":"10.1007\/s00277-016-2842-4"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15 Levy                            D,                                Bertoldi                            ERM,                                Ruiz                            JLM,                                Pereira                            J,                                Bydlowski                            SP. Presence of                    t(14;18) translocation in healthy individuals varies according to ethnic                    background in the Brazilian population. Braz J Med Biol Res. 2017; 50:                        e6172.","DOI":"10.1590\/1414-431x20176172"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16 Hirt                            C,                                D\u00f6lken                            G,                                Janz                            S,                                Rabkin                            CS. Distribution                    of t(14;18)-positive, putative lymphoma precursor cells among B-cell subsets in                    healthy individuals. Br J Haematol. 2007; 138: 349-353.","DOI":"10.1111\/j.1365-2141.2007.06671.x"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17 Sakai                            T,                                Nishikori                            M,                                Tashima                            M                    <i>et al.<\/i> Distinctive cell properties of B cells carrying the BCL2                    translocation and their potential roles in the development of lymphoma of                    germinal center type. Cancer Sci. 2009; 100: 2361-2367.","DOI":"10.1111\/j.1349-7006.2009.01344.x"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18 Oishi                            N,                                Montes-Moreno                            S,                                Feldman                            AL. In situ                    neoplasia in lymph node pathology. Semin Diagn Pathol. 2018; 35:                    76-83.","DOI":"10.1053\/j.semdp.2017.11.001"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19 Cong                            P,                                Raffeld                            M,                                Teruya-Feldstein                            J                    <i>et al.<\/i> In situ localization of follicular lymphoma: description                    and analysis by laser capture microdissection. Blood. 2002; 99:                    3376-3382.","DOI":"10.1182\/blood.V99.9.3376"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20 Jegalian                            AG,                                Eberle                            FC,                                Pack                            SD                    <i>et al.<\/i> Follicular lymphoma in situ: clinical implications and                    comparisons with partial involvement by follicular lymphoma. Blood. 2011; 118:                    2976-2984.","DOI":"10.1182\/blood-2011-05-355255"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21 Swerdlow                            SH,                                Campo                            E,                                Pileri                            SA                    <i>et al.<\/i> The 2016 revision of the World Health Organization                    classification of lymphoid neoplasms. Blood. 2016; 127:                    2375-2390.","DOI":"10.1182\/blood-2016-01-643569"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22 Alaggio R, Amador C, Anagnostopoulos I, et                    al. The 5th edition of the World Health Organization classification of                    haematolymphoid tumours: lymphoid neoplasms. Leukemia. 2022; 36:                    1720-1748.","DOI":"10.1038\/s41375-022-01620-2"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23 Dobson                            R,                                Venkatraman                            L,                                Cucco                            F                    <i>et al.<\/i> In situ follicular neoplasia in a young post\u2010liver                    transplant patient. Pathol Int. 2023; 73: 58-60.","DOI":"10.1111\/pin.13291"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24 Oishi                            N,                                Segawa                            T,                                Miyake                            K,                                Mochizuki                            K,                                Kondo                            T. Incidence,                    clinicopathological features and genetics of in\u2010situ follicular neoplasia: a                    comprehensive screening study in a Japanese cohort. Histopathology. 2022; 80:                    820-826.","DOI":"10.1111\/his.14617"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25 Bermudez                            G,                                Gonz\u00e1lez de Villambros\u00eda                            S,                                Mart\u00ednez-L\u00f3pez                            A                    <i>et al.<\/i> Incidental and isolated follicular lymphoma in situ and                    mantle cell lymphoma in situ lack clinical significance. Am J Surg Pathol. 2016;                    40: 943-949.","DOI":"10.1097\/PAS.0000000000000628"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26 Pillai                            RK,                                Surti                            U,                                Swerdlow                            SH. Follicular                    lymphoma-like B cells of uncertain significance (in situ follicular lymphoma)                    may infrequently progress, but precedes follicular lymphoma, is associated with                    other overt lymphomas and mimics follicular lymphoma in flow cytometric studies.                    Haematologica. 2013; 98: 1571-1580.","DOI":"10.3324\/haematol.2013.085506"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27 Vogelsberg                            A,                                Steinhilber                            J,                                Mankel                            B                    <i>et al.<\/i> Genetic evolution of in situ follicular neoplasia to                    aggressive B-cell lymphoma of germinal center subtype. Haematologica. 2021; 106:                    2673-2681.","DOI":"10.3324\/haematol.2020.254854"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28 Schmidt                            J,                                Ramis-Zaldivar                            JE,                                Bonzheim                            I                    <i>et al.<\/i> CREBBP gene mutations are frequently detected in in situ                    follicular neoplasia. Blood. 2018; 132: 2687-2690.","DOI":"10.1182\/blood-2018-03-837039"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29 Henopp                            T,                                Quintanilla-Mart\u00ednez                            L,                                Fend                            F,                                Adam                            P. Prevalence of                    follicular lymphoma in situ in consecutively analysed reactive lymph nodes.                    Histopathology. 2011; 59: 139-142.","DOI":"10.1111\/j.1365-2559.2011.03897.x"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30 Carvajal-Cuenca                            A,                                Sua                            LF,                                Silva                            NM                    <i>et al.<\/i> In situ mantle cell lymphoma: clinical implications of                    an incidental finding with indolent clinical behavior. Haematologica. 2012; 97:                    270-278.","DOI":"10.3324\/haematol.2011.052621"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31 Mamessier                            E,                                Broussais-Guillaumot                            F,                                Chetaille                            B                    <i>et al.<\/i> Nature and importance of follicular lymphoma precursors.                    Haematologica. 2014; 99: 802-810.","DOI":"10.3324\/haematol.2013.085548"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32 Goyal                            T,                                Ondrejka                            SL,                                Bodo                            J,                                Durkin                            L,                                Hsi                            ED. Lack of                    activation-induced cytidine deaminase expression in in situ follicular                    neoplasia. Haematologica. 2021; 106: 1212-1215.","DOI":"10.3324\/haematol.2020.249342"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33 Takata                            K,                                Sato                            Y,                                Nakamura                            N                    <i>et al.<\/i> Duodenal follicular lymphoma lacks AID but expresses                    BACH2 and has memory B-cell characteristics. Mod Pathol. 2013; 26:                    22-31.","DOI":"10.1038\/modpathol.2012.127"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34 Schmidt                            J,                                Salaverria                            I,                                Haake                            A                    <i>et al.<\/i> Increasing genomic and epigenomic complexity in the                    clonal evolution from in situ to manifest t(14;18)-positive follicular lymphoma.                    Leukemia. 2014; 28: 1103-1112.","DOI":"10.1038\/leu.2013.307"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35 Mamessier                            E,                                Song                            JY,                                Eberle                            FC                    <i>et al.<\/i> Early lesions of follicular lymphoma: a genetic                    perspective. Haematologica. 2014; 99: 481-488.","DOI":"10.3324\/haematol.2013.094474"}],"container-title":["Journal of Clinical and Experimental Hematopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jslrt\/63\/2\/63_23010\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T05:11:18Z","timestamp":1688188278000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jslrt\/63\/2\/63_23010\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.3960\/jslrt.23010","relation":{},"ISSN":["1346-4280","1880-9952"],"issn-type":[{"value":"1346-4280","type":"print"},{"value":"1880-9952","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]},"article-number":"23010"}}