{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T04:30:44Z","timestamp":1749011444411},"reference-count":23,"publisher":"Japanese Society for Lymphoreticular Tissue Research","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCEH","J Clin Exp Hematopathol"],"published-print":{"date-parts":[[2023]]},"DOI":"10.3960\/jslrt.23021","type":"journal-article","created":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T22:58:05Z","timestamp":1695855485000},"page":"173-176","source":"Crossref","is-referenced-by-count":1,"title":["Impact of single versus multiple spliceosome mutations on                    myelodysplastic syndrome"],"prefix":"10.3960","volume":"63","author":[{"given":"Pakasticali","family":"Nagehan","sequence":"first","affiliation":[{"name":"Department of Pathology and Cell Biology, University of South                            Florida, Tampa, FL, USA,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirza","family":"Sabbir","sequence":"additional","affiliation":[{"name":"William Carey University College of Osteopathic Medicine,                            Hattiesburg, MS, USA,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinming","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Moffitt Cancer                            Center, Tampa, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hussaini","family":"Mohammad","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Moffitt Cancer                            Center, Tampa, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2349","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1 Kitamura                            T,                                Inoue                            D,                                Okochi-Watanabe                            N                    <i>et al.<\/i> The molecular basis of myeloid malignancies. Proc Jpn                    Acad, Ser B, Phys Biol Sci. 2014; 90: 389-404.","DOI":"10.2183\/pjab.90.389"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2 Cazzola                            M.                    Myelodysplastic Syndromes. N Engl J Med. 2020; 383: 1358-1374.","DOI":"10.1056\/NEJMra1904794"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3 Porwit                            A,                                Saft                            L. The AML\u2013MDS                    interface\u2014leukemic transformation in myelodysplastic syndromes. J Hematop. 2011;                    4: 69-79.","DOI":"10.1007\/s12308-011-0088-6"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4 Hellstr\u00f6m-Lindberg                            E,                                Tobiasson                            M,                                Greenberg                            P.                    Myelodysplastic syndromes: moving towards personalized management.                    Haematologica. 2020; 105: 1765-1779.","DOI":"10.3324\/haematol.2020.248955"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5 Bejar                            R,                                Stevenson                            K,                                Abdel-Wahab                            O                    <i>et al.<\/i> Clinical effect of point mutations in myelodysplastic                    syndromes. N Engl J Med. 2011; 364: 2496-2506.","DOI":"10.1056\/NEJMoa1013343"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6 Ganguly                            BB,                                Kadam                            NN. Mutations of                    myelodysplastic syndromes (MDS): An update. Mutat Res Rev Mutat Res. 2016; 769:                    47-62.","DOI":"10.1016\/j.mrrev.2016.04.009"},{"key":"7","unstructured":"7 Dotson JL, Lebowicz Y. Myelodysplastic                    Syndrome, in StatPearls. 2022: Treasure Island (FL)."},{"key":"8","doi-asserted-by":"crossref","unstructured":"8 Greenberg                            P,                                Cox                            C,                                LeBeau                            MM                    <i>et al.<\/i> International scoring system for evaluating prognosis in                    myelodysplastic syndromes. Blood. 1997; 89: 2079-2088.","DOI":"10.1182\/blood.V89.6.2079"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9 Hussaini                            M. Biomarkers in                    Hematological Malignancies: A Review of Molecular Testing in Hematopathology.                    Cancer Control. 2015; 22: 158-166.","DOI":"10.1177\/107327481502200206"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10 Pellagatti                            A,                                Boultwood                            J. The molecular                    pathogenesis of the myelodysplastic syndromes. Eur J Haematol. 2015; 95:                    3-15.","DOI":"10.1111\/ejh.12515"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11 Kennedy                            JA,                                Ebert                            BL. Clinical                    Implications of Genetic Mutations in Myelodysplastic Syndrome. J Clin Oncol.                    2017; 35: 968-974.","DOI":"10.1200\/JCO.2016.71.0806"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12 Gangat                            N,                                Patnaik                            MM,                                Begna                            K                    <i>et al.<\/i> Evaluation of revised IPSS cytogenetic risk                    stratification and prognostic impact of monosomal karyotype in 783 patients with                    primary myelodysplastic syndromes. Am J Hematol. 2013; 88:                    690-693.","DOI":"10.1002\/ajh.23477"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13 Boultwood                            J,                                Dolatshad                            H,                                Varanasi                            SS,                                Yip                            BH,                                Pellagatti                            A. The role of                    splicing factor mutations in the pathogenesis of the myelodysplastic syndromes.                    Adv Biol Regul. 2014; 54: 153-161.","DOI":"10.1016\/j.jbior.2013.09.005"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14 Papaemmanuil                            E,                                Gerstung                            M,                                Malcovati                            L                    <i>et al.<\/i> Clinical and biological implications of driver mutations                    in myelodysplastic syndromes. Blood. 2013; 122: 3616-3627.","DOI":"10.1182\/blood-2013-08-518886"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15 Hussaini                            MO,                                Mirza                            AS,                                Komrokji                            R                    <i>et al.<\/i> Genetic landscape of acute myeloid leukemia interrogated                    by next-generation sequencing: a large cancer center experience. Cancer Genomics                    Proteomics. 2018; 15: 121-126.","DOI":"10.21873\/cgp.20070"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16 Au                            CH,                                Wa                            A,                                Ho                            DN,                                Chan                            TL,                                Ma                            ESK. Clinical                    evaluation of panel testing by next-generation sequencing (NGS) for gene                    mutations in myeloid neoplasms. Diagn Pathol. 2016; 11: 11.","DOI":"10.1186\/s13000-016-0456-8"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17 Roloff                            GW,                                Baron                            JI,                                Neppalli                            VT,                                Sait                            S,                                Griffiths                            EA.                    Next-Generation Sequencing Delineates Clonal Origins and Informs Therapeutic                    Strategies in Acute Lymphoblastic Leukemia and Histiocytic Sarcoma. JCO Precis                    Oncol. 2019; 3: 1-8.","DOI":"10.1200\/PO.19.00126"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18 Frampton                            GM,                                Fichtenholtz                            A,                                Otto                            GA                    <i>et al.<\/i> Development and validation of a clinical cancer genomic                    profiling test based on massively parallel DNA sequencing. Nat Biotechnol. 2013;                    31: 1023-1031.","DOI":"10.1038\/nbt.2696"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19 Greenberg                            PL,                                Tuechler                            H,                                Schanz                            J                    <i>et al.<\/i> Revised international prognostic scoring system for                    myelodysplastic syndromes. Blood. 2012; 120: 2454-2465.","DOI":"10.1182\/blood-2012-03-420489"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20 D\u00f6hner                            H,                                Weisdorf                            DJ,                                Bloomfield                            CD. Acute                    Myeloid Leukemia. N Engl J Med. 2015; 373: 1136-1152.","DOI":"10.1056\/NEJMra1406184"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21 Haider                            M,                                Duncavage                            EJ,                                Afaneh                            KF,                                Bejar                            R,                                List                            AF. New Insight                    Into the Biology, Risk Stratification, and Targeted Treatment of Myelodysplastic                    Syndromes. Am Soc Clin Oncol Educ Book. 2017; 37: 480-494.","DOI":"10.1200\/EDBK_175397"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22 Nagata                            Y,                                Maciejewski                            JP. The                    functional mechanisms of mutations in myelodysplastic syndrome. Leukemia. 2019;                    33: 2779-2794.","DOI":"10.1038\/s41375-019-0617-3"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23 Badaat                            I,                                Mirza                            S,                                Padron                            E                    <i>et al.<\/i> Concurrent mutations in other epigenetic modulators                    portend better prognosis in BCOR-mutated myelodysplastic syndrome. J Clin                    Pathol. 2020; 73: 209-212.","DOI":"10.1136\/jclinpath-2019-206132"}],"container-title":["Journal of Clinical and Experimental Hematopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jslrt\/63\/3\/63_23021\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T05:06:47Z","timestamp":1696050407000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jslrt\/63\/3\/63_23021\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.3960\/jslrt.23021","relation":{},"ISSN":["1346-4280","1880-9952"],"issn-type":[{"value":"1346-4280","type":"print"},{"value":"1880-9952","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]},"article-number":"23021"}}