{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T03:34:55Z","timestamp":1791516895923,"version":"4.3.4"},"reference-count":15,"publisher":"Japanese Society for Lymphoreticular Tissue Research","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCEH","J Clin Exp Hematopathol"],"published-print":{"date-parts":[[2025,3,28]]},"DOI":"10.3960\/jslrt.24077","type":"journal-article","created":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T22:21:08Z","timestamp":1743114068000},"page":"72-76","source":"Crossref","is-referenced-by-count":1,"title":["Impact of &lt;i&gt;NRAS&lt;\/i&gt; mutation on efficacy of triplet induction therapy in newly diagnosed multiple myeloma"],"prefix":"10.3960","volume":"65","author":[{"given":"Yuko","family":"Mishima","sequence":"first","affiliation":[{"name":"Department of Hematology Oncology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan,"},{"name":"Division of Clinical Research, The Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, Japan,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Shirouchi","sequence":"additional","affiliation":[{"name":"Department of Hematology Oncology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Takayama","sequence":"additional","affiliation":[{"name":"Division of Clinical Research, The Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, Japan,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayuri","family":"Minowa","sequence":"additional","affiliation":[{"name":"Division of Clinical Research, The Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, Japan,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Ishihara","sequence":"additional","affiliation":[{"name":"Department of Hematology Oncology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei","family":"Hirano","sequence":"additional","affiliation":[{"name":"Department of Hematology Oncology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuhito","family":"Hirano","sequence":"additional","affiliation":[{"name":"Department of Hematology Oncology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kikuaki","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Hematology Oncology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukako","family":"Teramoto","sequence":"additional","affiliation":[{"name":"Department of Hematology Oncology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhiko","family":"Yamauchi","sequence":"additional","affiliation":[{"name":"Department of Hematology Oncology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siew-Kee","family":"Low","sequence":"additional","affiliation":[{"name":"Liquid Biopsy Diagnosis Development Project, Cancer Precision Medicine Center, Japanese Foundation for Cancer Research, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dai","family":"Maruyama","sequence":"additional","affiliation":[{"name":"Department of Hematology Oncology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan,"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2349","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1 Fonseca R, Bergsagel PL, Drach J <i>et al.<\/i> International Myeloma Working Group molecular classification of multiple myeloma: spotlight review. Leukemia. 2009; 23: 2210-2221.","DOI":"10.1038\/leu.2009.174"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2 Soekojo CY, Chung TH, Furqan MS, Chng WJ. Genomic characterization of functional high-risk multiple myeloma patients. Blood Cancer J. 2022; 12: 24.","DOI":"10.1038\/s41408-021-00576-3"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3 Rajkumar SV. Multiple myeloma: 2022 update on diagnosis, risk stratification, and management. Am J Hematol. 2022; 97: 1086-1107.","DOI":"10.1002\/ajh.26590"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4 Bolli N, Avet-Loiseau H, Wedge DC <i>et al.<\/i> Heterogeneity of genomic evolution and mutational profiles in multiple myeloma. Nat Commun. 2014; 5: 2997.","DOI":"10.1038\/ncomms3997"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5 Chapman MA, Lawrence MS, Keats JJ <i>et al.<\/i> Initial genome sequencing and analysis of multiple myeloma. Nature. 2011; 471: 467-472.","DOI":"10.1038\/nature09837"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6 Corre J, Cleynen A, Robiou du Pont S <i>et al.<\/i> Multiple myeloma clonal evolution in homogeneously treated patients. Leukemia. 2018; 32: 2636-2647.","DOI":"10.1038\/s41375-018-0153-6"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7 Lohr JG, Stojanov P, Carter SL <i>et al.<\/i> Widespread genetic heterogeneity in multiple myeloma: implications for targeted therapy. Cancer Cell. 2014; 25: 91-101.","DOI":"10.1016\/j.ccr.2013.12.015"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8 Walker BA, Morgan GJ. The genomic features associated with high-risk multiple myeloma. Oncotarget. 2018; 9: 35478-35479.","DOI":"10.18632\/oncotarget.26269"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9 Durie BG, Salmon SE. A clinical staging system for multiple myeloma. Correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival. Cancer. 1975; 36: 842-854.","DOI":"10.1002\/1097-0142(197509)36:3<842::AID-CNCR2820360303>3.0.CO;2-U"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10 Greipp PR, San Miguel J, Durie BG <i>et al.<\/i> International staging system for multiple myeloma. J Clin Oncol. 2005; 23: 3412-3420.","DOI":"10.1200\/JCO.2005.04.242"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11 Palumbo A, Avet-Loiseau H, Oliva S <i>et al.<\/i> Revised international staging system for multiple myeloma: A report from International Myeloma Working Group. J Clin Oncol. 2015; 33: 2863-2869.","DOI":"10.1200\/JCO.2015.61.2267"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12 Giesen N, Paramasivam N, Toprak UH <i>et al.<\/i> Comprehensive genomic analysis of refractory multiple myeloma reveals a complex mutational landscape associated with drug resistance and novel therapeutic vulnerabilities. Haematologica. 2022; 107: 1891-1901.","DOI":"10.3324\/haematol.2021.279360"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13 Morgan GJ, Walker BA, Davies FE. The genetic architecture of multiple myeloma. Nat Rev Cancer. 2012; 12: 335-348.","DOI":"10.1038\/nrc3257"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14 Kanda Y. Investigation of the freely available easy-to-use software \u2018EZR\u2019 for medical statistics. Bone Marrow Transplant. 2013; 48: 452-458.","DOI":"10.1038\/bmt.2012.244"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15 Mulligan G, Lichter DI, Di Bacco A <i>et al.<\/i> Mutation of NRAS but not KRAS significantly reduces myeloma sensitivity to single-agent bortezomib therapy. Blood. 2014; 123: 632-639.","DOI":"10.1182\/blood-2013-05-504340"}],"container-title":["Journal of Clinical and Experimental Hematopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jslrt\/65\/1\/65_24077\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T04:48:26Z","timestamp":1743223706000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jslrt\/65\/1\/65_24077\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,28]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.3960\/jslrt.24077","relation":{},"ISSN":["1346-4280","1880-9952"],"issn-type":[{"value":"1346-4280","type":"print"},{"value":"1880-9952","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,28]]},"article-number":"24077"}}