{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T05:55:04Z","timestamp":1791006904225,"version":"4.1.0"},"reference-count":38,"publisher":"Japanese Society for Lymphoreticular Tissue Research","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCEH","J Clin Exp Hematopathol"],"published-print":{"date-parts":[[2026]]},"DOI":"10.3960\/jslrt.25015","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T22:10:56Z","timestamp":1785363056000},"page":"189-198","source":"Crossref","is-referenced-by-count":0,"title":["Clinicopathological analysis of oral-cavity B-cell neoplasms: Comparison between non-immunosuppressive and immunosuppressive patients"],"prefix":"10.3960","volume":"66","author":[{"given":"Yuuki","family":"Ishii","sequence":"first","affiliation":[{"name":"Department of Pathology, Tokai University School of Medicine, Isehara, Kanagawa, Japan,"},{"name":"Department of Oral Surgery, Tokai University School of Medicine, Isehara, Kanagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mebae","family":"Ichikawa","sequence":"additional","affiliation":[{"name":"Department of Pathology, Tokai University School of Medicine, Isehara, Kanagawa, Japan,"},{"name":"Department of Oral Surgery, Tokai University School of Medicine, Isehara, Kanagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Kondo","sequence":"additional","affiliation":[{"name":"Department of Pathology, Tokai University School of Medicine, Isehara, Kanagawa, Japan,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaquim","family":"Carreras","sequence":"additional","affiliation":[{"name":"Department of Pathology, Tokai University School of Medicine, Isehara, Kanagawa, Japan,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Miyaoka","sequence":"additional","affiliation":[{"name":"Department of Pathology, Tokai University School of Medicine, Isehara, Kanagawa, Japan,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukie Yara","family":"Kikuchi","sequence":"additional","affiliation":[{"name":"Department of Pathology, Tokai University School of Medicine, Isehara, Kanagawa, Japan,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Aoki","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery, Tokai University School of Medicine, Isehara, Kanagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihide","family":"Ota","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery, Tokai University School of Medicine, Isehara, Kanagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoya","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Pathology, Tokai University School of Medicine, Isehara, Kanagawa, Japan,"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2349","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1 Zucca E, Roggero E, Bertoni F, Cavalli F. Primary extranodal non-Hodgkin\u2019s lymphomas. Part 1: Gastrointestinal, cutaneous and genitourinary lymphomas. Ann Oncol. 1997; 8: 727-737.","DOI":"10.1023\/A:1008282818705"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2 Zucca E, Roggero E, Bertoni F, Conconi A, Cavalli F. Primary extranodal non-Hodgkin\u2019s lymphomas. Part 2: Head and neck, central nervous system and other less common sites. Ann Oncol. 1999; 10: 1023-1033.","DOI":"10.1023\/A:1008313229892"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3 Krol AD, le Cessie S, Snijder S <i>et al.<\/i> Primary extranodal non-Hodgkin\u2019s lymphoma (NHL): the impact of alternative definitions tested in the Comprehensive Cancer Centre West population-based NHL registry. Ann Oncol. 2003; 14: 131-139.","DOI":"10.1093\/annonc\/mdg004"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4 Candelaria M, O\u00f1ate-Oca\u00f1a LF, Corona-Herrera J <i>et al.<\/i> Clinical characteristics of primary extranodal versus nodal diffuse large B-cell lymphoma: A retrospective cohort study in a cancer center. Rev Invest Clin. 2019; 71: 349-358.","DOI":"10.24875\/RIC.19003027"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5 Kobler P, Borcic J, Zore IF, Nola M, Sertic D. Primary non-Hodgkin\u2019s lymphoma of the oral cavity. Oral Oncol Extra. 2005; 41: 12-14.","DOI":"10.1016\/j.ooe.2004.10.002"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6 Jayakrishnan R, Thomas G, Kumar A, Nair R. Non-Hodgkin\u2019s lymphoma of the hard palate. J Oral Maxillofac Pathol. 2008; 12: 85-87.","DOI":"10.4103\/0973-029X.44586"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7 Triantafillidou K, Dimitrakopoulos J, Iordanidis F, Gkagkalis A. Extranodal non-Hodgkin lymphomas of the oral cavity and maxillofacial region: A clinical study of 58 cases and review of the literature. J Oral Maxillofac Surg. 2012; 70: 2776-2785.","DOI":"10.1016\/j.joms.2012.01.018"},{"key":"8","unstructured":"8 Gaulard P, Swerdlow SH, Harris NL, Jaffe ES, Sundstr\u00f6m C: WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. World Health Organization Classification of Tumours. 4th ed, Lyon, IARC Press. 2008; pp. 350-351."},{"key":"9","doi-asserted-by":"crossref","unstructured":"9 Alaggio R, Amador C, Anagnostopoulos I, <i>et al.<\/i> The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms. Leukemia. 2022; 36: 1720-1748.","DOI":"10.1038\/s41375-022-01620-2"},{"key":"10","unstructured":"10 Ellman MH, Hurwitz H, Thomas C, Kozloff M. Lymphoma developing in a patient with rheumatoid arthritis taking low dose weekly methotrexate. J Rheumatol. 1991; 18: 1741-1743."},{"key":"11","doi-asserted-by":"crossref","unstructured":"11 Kojima M, Itoh H, Hirabayashi K <i>et al.<\/i> Methotrexate-associated lymphoproliferative disorders. A clinicopathological study of 13 Japanese cases. Pathol Res Pract. 2006; 202: 679-685.","DOI":"10.1016\/j.prp.2006.05.007"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12 Kameda T, Dobashi H, Miyatake N <i>et al.<\/i> Association of higher methotrexate dose with lymphoproliferative disease onset in rheumatoid arthritis patients. Arthritis Care Res. 2014; 66: 1302-1309.","DOI":"10.1002\/acr.22306"},{"key":"13","unstructured":"13 Hoshida Y, Xu JX, Fujita S <i>et al.<\/i> Lymphoproliferative disorders in rheumatoid arthritis: clinicopathological analysis of 76 cases in relation to methotrexate medication. J Rheumatol. 2007; 34: 322-331."},{"key":"14","doi-asserted-by":"crossref","unstructured":"14 Tokuhira M, Watanabe R, Nemoto T <i>et al.<\/i> Clinicopathological analyses in patients with other iatrogenic immunodeficiency-associated lymphoproliferative diseases and rheumatoid arthritis. Leuk Lymphoma. 2012; 53: 616-623.","DOI":"10.3109\/10428194.2011.625101"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15 Salloum E, Cooper DL, Howe G <i>et al.<\/i> Spontaneous regression of lymphoproliferative disorders in patients treated with methotrexate for rheumatoid arthritis and other rheumatic diseases. J Clin Oncol. 1996; 14: 1943-1949.","DOI":"10.1200\/JCO.1996.14.6.1943"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16 Obata K, Okui T, Ono S <i>et al.<\/i> Comparative study on Epstein-Barr virus-positive mucocutaneous ulcer and methotrexate-associated lymphoproliferative disorders developed in the oral mucosa: A case series of 10 patients and literature review. Diagnostics (Basel). 2021; 11: 1375.","DOI":"10.3390\/diagnostics11081375"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17 Mariette X, Cazals-Hatem D, Warszawki J <i>et al.<\/i> Lymphomas in rheumatoid arthritis patients treated with methotrexate: A 3-year prospective study in France. Blood. 2002; 99: 3909-3915.","DOI":"10.1182\/blood.V99.11.3909"},{"key":"18","unstructured":"18 Takahashi E: Other iatrogenic immunodeficiency-related lymphoproliferative disorders. Supervised by Shigeo Nakamura. WHO Hematological Tumor Classification-To Make Good Use of WHO Classification 2008-. 1st Edition, Tokyo, Pharm J. 2010; pp. 549-552."},{"key":"19","doi-asserted-by":"crossref","unstructured":"19 Dojcinov SD, Venkataraman G, Raffeld M, Pittaluga S, Jaffe ES. EBV positive mucocutaneous ulcer\u2014A study of 26 cases associated with various sources of immunosuppression. Am J Surg Pathol. 2010; 34: 405-417.","DOI":"10.1097\/PAS.0b013e3181cf8622"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20 Ikeda T, Gion Y, Yoshino T, Sato Y. A review of EBV-positive mucocutaneous ulcers focusing on clinical and pathological aspects. J Clin Exp Hematop. 2019; 59: 64-71.","DOI":"10.3960\/jslrt.18039"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21 Ikeda T, Gion Y, Nishimura Y <i>et al.<\/i> Epstein-Barr virus-positive mucocutaneous ulcer: A unique and curious disease entity. Int J Mol Sci. 2021; 22: 1053.","DOI":"10.3390\/ijms22031053"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22 Hart M, Thakral B, Yohe S <i>et al.<\/i> EBV-positive mucocutaneous ulcer in organ transplant recipients: A localized indolent posttransplant lymphoproliferative disorder. Am J Surg Pathol. 2014; 38: 1522-1529.","DOI":"10.1097\/PAS.0000000000000282"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23 Satou A, Kohno A, Fukuyama R, Elsayed AA, Nakamura S. Epstein-Barr virus-positive mucocutaneous ulcer arising in a post-hematopoietic cell transplant patient followed by polymorphic posttransplant lymphoproliferative disorder and cytomegalovirus colitis. Hum Pathol. 2017; 59: 147-151.","DOI":"10.1016\/j.humpath.2016.08.001"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24 Bunn B, van Heerden W. EBV-positive mucocutaneous ulcer of the oral cavity associated with HIV\/AIDS. Oral Surg Oral Med Oral Pathol Oral Radiol. 2015; 120: 725-732.","DOI":"10.1016\/j.oooo.2015.06.028"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25 Yamakawa N, Fujimoto M, Kawabata D <i>et al.<\/i> A clinical, pathological, and genetic characterization of methotrexate-associated lymphoproliferative disorders. J Rheumatol. 2014; 41: 293-299.","DOI":"10.3899\/jrheum.130270"},{"key":"26","unstructured":"26 Srivastava AK, Shukla S, Srivastava P <i>et al.<\/i> Real time detection and quantification of Epstein Barr virus in different grades of oral gingivitis and periodontitis patients. J Exp Ther Oncol. 2019; 13: 9-14."},{"key":"27","doi-asserted-by":"crossref","unstructured":"27 Hern\u00e1di K, Szalm\u00e1s A, Mogyor\u00f3si R <i>et al.<\/i> Prevalence and activity of Epstein-Barr virus and human cytomegalovirus in symptomatic and asymptomatic apical periodontitis lesions. J Endod. 2010; 36: 1485-1489.","DOI":"10.1016\/j.joen.2010.06.008"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28 Sigmundsdottir H, Johnston A, Gudjonsson JE, Bjarnason B, Valdimarsson H. Methotrexate markedly reduces the expression of vascular E-selectin, cutaneous lymphocyte-associated antigen and the numbers of mononuclear leucocytes in psoriatic skin. Exp Dermatol. 2004; 13: 426-434.","DOI":"10.1111\/j.0906-6705.2004.00177.x"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29 Ichikawa A, Arakawa F, Kiyasu J <i>et al.<\/i> Methotrexate\/iatrogenic lymphoproliferative disorders in rheumatoid arthritis: histology, Epstein-Barr virus, and clonality are important predictors of disease progression and regression. Eur J Haematol. 2013; 91: 20-28.","DOI":"10.1111\/ejh.12116"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30 Feng WH, Cohen JI, Fischer S <i>et al.<\/i> Reactivation of latent Epstein-Barr virus by methotrexate: A potential contributor to methotrexate-associated lymphomas. J Natl Cancer Inst. 2004; 96: 1691-1702.","DOI":"10.1093\/jnci\/djh313"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31 Oyama T, Ichimura K, Suzuki R <i>et al.<\/i> Senile EBV+ B-cell lymphoproliferative disorders: A clinicopathologic study of 22 patients. Am J Surg Pathol. 2003; 27: 16-26.","DOI":"10.1097\/00000478-200301000-00003"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32 Park S, Lee J, Ko YH <i>et al.<\/i> The impact of Epstein-Barr virus status on clinical outcome in diffuse large B-cell lymphoma. Blood. 2007; 110: 972-978.","DOI":"10.1182\/blood-2007-01-067769"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33 Oyama T, Yamamoto K, Asano N <i>et al.<\/i> Age-related EBV-associated B-cell lymphoproliferative disorders constitute a distinct clinicopathologic group: A study of 96 patients. Clin Cancer Res. 2007; 13: 5124-5132.","DOI":"10.1158\/1078-0432.CCR-06-2823"},{"key":"34","unstructured":"34 Wiernik PH. Spontaneous regression of hematologic cancers. Natl Cancer Inst Monogr. 1976; 44: 35-38."},{"key":"35","doi-asserted-by":"crossref","unstructured":"35 Uohashi A, Imoto S, Matsui T <i>et al.<\/i> Spontaneous regression of diffuse large-cell lymphoma associated with Hashimoto\u2019s thyroiditis. Am J Hematol. 1996; 53: 201-202.","DOI":"10.1002\/(SICI)1096-8652(199611)53:3<201::AID-AJH10>3.0.CO;2-G"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36 Tam\u00e1s L, S\u00e1ri E, R\u00e9p\u00e1ssy G <i>et al.<\/i> Spontaneous remission in localized diffuse large B-cell lymphoma. Pathol Oncol Res. 2011; 17: 779-784.","DOI":"10.1007\/s12253-011-9379-6"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37 Yamamura Y, Mano T, Kamada K <i>et al.<\/i> A clinical study on malignant lymphomas arising in the oral region. J Jpn Soc Oral Tumor. 2021; 33: 35-40.","DOI":"10.5843\/jsot.33.35"},{"key":"38","unstructured":"38 Yamashita M, Jinbu Y. Methotrexate-associated lymphoproliferative disorders in the oral cavity: Two cases and a clinicopathological review of the Japanese literature. J Oral Ther Pharmacol. 2020; 39: 17-22"}],"container-title":["Journal of Clinical and Experimental Hematopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jslrt\/66\/3\/66_25015\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T05:34:57Z","timestamp":1791005697000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jslrt\/66\/3\/66_25015\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.3960\/jslrt.25015","relation":{},"ISSN":["1346-4280","1880-9952"],"issn-type":[{"value":"1346-4280","type":"print"},{"value":"1880-9952","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"article-number":"25015"}}