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Novel CAR T                    cell therapies for patients with large B cell lymphoma. Int J Hematol. 2024;                    120: 6-14.","DOI":"10.1007\/s12185-024-03792-2"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2 Xiao                            X,                                Huang                            S,                                Chen                            S                    <i>et al.<\/i> Mechanisms of cytokine release syndrome and                    neurotoxicity of CAR T-cell therapy and associated prevention and management                    strategies. J Exp Clin Cancer Res. 2021; 40: 367.","DOI":"10.1186\/s13046-021-02148-6"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3 Morris                            EC,                                Neelapu                            SS,                                Giavridis                            T,                                Sadelain                            M. Cytokine                    release syndrome and associated neurotoxicity in cancer immunotherapy. Nat Rev                    Immunol. 2022; 22: 85-96.","DOI":"10.1038\/s41577-021-00547-6"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4 Lee                            DW,                                Santomasso                            BD,                                Locke                            FL                    <i>et al.<\/i> ASTCT Consensus Grading for Cytokine Release Syndrome                    and Neurologic Toxicity Associated with Immune Effector Cells. Biol Blood Marrow                    Transplant. 2019; 25: 625-638.","DOI":"10.1016\/j.bbmt.2018.12.758"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5 Juluri                            KR,                                Wu                            QV,                                Voutsinas                            J                    <i>et al.<\/i> Severe cytokine release syndrome is associated with                    hematologic toxicity following CD19 CAR T-cell therapy. Blood Adv. 2022; 6:                    2055-2068.","DOI":"10.1182\/bloodadvances.2020004142"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6 Schuster                            SJ,                                Tam                            CS,                                Borchmann                            P                    <i>et al.<\/i> Long-term clinical outcomes of tisagenlecleucel in                    patients with relapsed or refractory aggressive B-cell lymphomas (JULIET): a                    multicentre, open-label, single-arm, phase 2 study. Lancet Oncol. 2021; 22:                    1403-1415.","DOI":"10.1016\/S1470-2045(21)00375-2"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7 Locke                            FL,                                Ghobadi                            A,                                Jacobson                            CA                    <i>et al.<\/i> Long-term safety and activity of axicabtagene ciloleucel                    in refractory large B-cell lymphoma (ZUMA-1): a single-arm, multicentre, phase                    1-2 trial. Lancet Oncol. 2019; 20: 31-42.","DOI":"10.1016\/S1470-2045(18)30864-7"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8 Abramson                            JS,                                Palomba                            ML,                                Gordon                            LI                    <i>et al.<\/i> Lisocabtagene maraleucel for patients with relapsed or                    refractory large B-cell lymphomas (TRANSCEND NHL 001): a multicentre seamless                    design study. Lancet. 2020; 396: 839-852.","DOI":"10.1016\/S0140-6736(20)31366-0"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9 Locke                            FL,                                Miklos                            DB,                                Jacobson                            CA                    <i>et al.<\/i> Axicabtagene Ciloleucel as Second-Line Therapy for Large                    B-Cell Lymphoma. N Engl J Med. 2022; 386: 640-654.","DOI":"10.1056\/NEJMoa2116133"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10 Kamdar                            M,                                Solomon                            SR,                                Arnason                            J                    <i>et al.<\/i> Lisocabtagene maraleucel versus standard of care with                    salvage chemotherapy followed by autologous stem cell transplantation as                    second-line treatment in patients with relapsed or refractory large B-cell                    lymphoma (TRANSFORM): results from an interim analysis of an open-label,                    randomised, phase 3 trial. Lancet. 2022; 399: 2294-2308.","DOI":"10.1016\/S0140-6736(22)00662-6"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11 Sehgal                            A,                                Hoda                            D,                                Riedell                            PA                    <i>et al.<\/i> Lisocabtagene maraleucel as second-line therapy in                    adults with relapsed or refractory large B-cell lymphoma who were not intended                    for haematopoietic stem cell transplantation (PILOT): an open-label, phase 2                    study. Lancet Oncol. 2022; 23: 1066-1077.","DOI":"10.1016\/S1470-2045(22)00339-4"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12 Lee                            DW,                                Gardner                            R,                                Porter                            DL                    <i>et al.<\/i> Current concepts in the diagnosis and management of                    cytokine release syndrome. Blood. 2014; 124: 188-195.","DOI":"10.1182\/blood-2014-05-552729"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13 Landsburg                            DJ,                                Frigault                            MJ,                                Heim                            M                    <i>et al.<\/i> Real-world outcomes with tisagenlecleucel in aggressive                    B-cell lymphoma: subgroup analyses from the CIBMTR registry. J Immunother                    Cancer. 2025; 13: e009890.","DOI":"10.1136\/jitc-2024-009890"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14 Pasquini                            MC,                                Hu                            ZH,                                Curran                            K                    <i>et al.<\/i> Real-world evidence of tisagenlecleucel for pediatric                    acute lymphoblastic leukemia and non-Hodgkin lymphoma. Blood Adv. 2020; 4:                    5414-5424.","DOI":"10.1182\/bloodadvances.2020003092"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15 Goto                            H,                                Kitawaki                            T,                                Fujii                            N                    <i>et al.<\/i> Safety and efficacy of tisagenlecleucel in patients with                    relapsed or refractory B-cell lymphoma: the first real-world evidence in Japan.                    Int J Clin Oncol. 2023; 28: 816-826.","DOI":"10.1007\/s10147-023-02334-w"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16 Nastoupil                            LJ,                                Jain                            MD,                                Feng                            L                    <i>et al.<\/i> Standard-of-Care Axicabtagene Ciloleucel for Relapsed or                    Refractory Large B-Cell Lymphoma: Results From the US Lymphoma CAR T Consortium.                    J Clin Oncol. 2020; 38: 3119-3128.","DOI":"10.1200\/JCO.19.02104"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17 Jacobson                            CA,                                Locke                            FL,                                Ma                            L                    <i>et al.<\/i> Real-World Evidence of Axicabtagene Ciloleucel for the                    Treatment of Large B Cell Lymphoma in the United States. Transplant Cell Ther.                    2022; 28: 581.e1-581.e8.","DOI":"10.1016\/j.jtct.2022.05.026"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18 Bethge                            WA,                                Martus                            P,                                Schmitt                            M                    <i>et al.<\/i> GLA\/DRST real-world outcome analysis of CAR T-cell                    therapies for large B-cell lymphoma in Germany. Blood. 2022; 140:                    349-358.","DOI":"10.1182\/blood.2021015209"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19 Looka                            A,                                Qualls                            DA,                                Matthews                            D                    <i>et al.<\/i> A real-world comparison of commercial-use axicabtagene                    ciloleucel and lisocabtagene maraleucel in large B-cell lymphoma. Blood Adv.                    2025; 9: 455-462.","DOI":"10.1182\/bloodadvances.2024012992"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20 Portuguese                            AJ,                                Huang                            JJ,                                Jeon                            Y                    <i>et al.<\/i> Real-world comparison of lisocabtagene maraleucel and                    axicabtagene ciloleucel in large B-cell lymphoma: an inverse probability of                    treatment weighting analysis with 3-year follow-up. Haematologica. 2025; 110:                    2040-2054.","DOI":"10.3324\/haematol.2024.287010"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21 Sesques                            P,                                Kirkwood                            AA,                                Kwon                            M                    <i>et al.<\/i> Novel prognostic scoring systems for severe CRS and                    ICANS after anti-CD19 CAR T cells in large B-cell lymphoma. J Hematol Oncol.                    2024; 17: 61.","DOI":"10.1186\/s13045-024-01579-w"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22 Wakabayashi                            H,                                Terakura                            S,                                Ishigiwa                            K                    <i>et al.<\/i> Simple and early prediction of severe CAR-T-related                    adverse events after Axi-cel infusion by initial high fever. Int J Hematol.                    2025; 122: 106-116.","DOI":"10.1007\/s12185-025-03957-7"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23 Faramand                            R,                                Jain                            M,                                Staedtke                            V                    <i>et al.<\/i> Tumor Microenvironment Composition and Severe Cytokine                    Release Syndrome (CRS) Influence Toxicity in Patients with Large B-Cell Lymphoma                    Treated with Axicabtagene Ciloleucel. Clin Cancer Res. 2020; 26:                    4823-4831.","DOI":"10.1158\/1078-0432.CCR-20-1434"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24 Filosto                            S,                                Vardhanabhuti                            S,                                Canales                            MA                    <i>et al.<\/i> Product Attributes of CAR T-cell Therapy Differentially                    Associate with Efficacy and Toxicity in Second-line Large B-cell Lymphoma                    (ZUMA-7). Blood Cancer Discov. 2024; 5: 21-33.","DOI":"10.1158\/2643-3230.BCD-23-0112"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25 Hayden                            PJ,                                Roddie                            C,                                Bader                            P                    <i>et al.<\/i> Management of adults and children receiving CAR T-cell                    therapy: 2021 best practice recommendations of the European Society for Blood                    and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT                    and EBMT (JACIE) and the European Haematology Association (EHA). Ann Oncol.                    2022; 33: 259-275.","DOI":"10.1016\/j.annonc.2021.12.003"},{"key":"26","unstructured":"26 National Comprehensive Cancer Network                    Guidelines (NCCN). Management of CAR T-Cell and Lymphocyte Engager-Related                    Toxicities Version 1.2026. Available at:                    https:\/\/www.nccn.org\/guidelines\/guidelines-detail?category=3&amp;id=1547.                    Accessed September 30, 2025."},{"key":"27","doi-asserted-by":"crossref","unstructured":"27 Jain                            MD,                                Smith                            M,                                Shah                            NN. How I treat                    refractory CRS and ICANS after CAR T-cell therapy. Blood. 2023; 141:                    2430-2442.","DOI":"10.1182\/blood.2022017414"}],"container-title":["Journal of Clinical and Experimental Hematopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jslrt\/65\/4\/65_25072\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T04:41:54Z","timestamp":1766810514000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jslrt\/65\/4\/65_25072\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.3960\/jslrt.25072","relation":{},"ISSN":["1346-4280","1880-9952"],"issn-type":[{"value":"1346-4280","type":"print"},{"value":"1880-9952","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]},"article-number":"25072"}}