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Blood 101 : 2335-2339, 2003","DOI":"10.1182\/blood-2002-09-2963"},{"key":"67","doi-asserted-by":"crossref","unstructured":"67 Sanchez-Izquierdo D, Buchonnet G, Siebert R, Gascoyne RD, Climent J, Karran L, Marin M, Blesa D, Horsman D, Rosenwald A, Staudt LM, Albertson DG, Du MQ, Ye H, Marynen P, Garcia-Conde J, Pinkel D, Dyer MJ, Martinez-Climent JA : <I>MALT1<\/I> is deregulated by both chromosomal translocation and amplification in B-cell non-Hodgkin lymphoma. Blood 101 : 4539-4546, 2003","DOI":"10.1182\/blood-2002-10-3236"},{"key":"68","doi-asserted-by":"crossref","unstructured":"68 Remstein ED, Kurtin PJ, Einerson RR, Paternoster SF, Dewald GW : Primary pulmonary MALT lymphomas show frequent and heterogeneous cytogenetic abnormalities, including aneuploidy and translocations involving <I>API2<\/I> and <I>MALT1<\/I> and <I>IGH<\/I> and <I>MALT1<\/I>. Leukemia 18 : 156-160, 2004","DOI":"10.1038\/sj.leu.2403185"},{"key":"69","doi-asserted-by":"crossref","unstructured":"69 Murga Penas EM, Hinz K, Roser K, Copie-Bergman C, Wlodarska I, Marynen P, Hagemeijer A, Gaulard P, Loning T, Hossfeld DK, Dierlamm J : Translocations t(11;18)(q21;q21) and t(14;18)(q32;q21) are the main chromosomal abnormalities involving <I>MLT\/MALT1<\/I> in MALT lymphomas. Leukemia 17 : 2225-2229, 2003","DOI":"10.1038\/sj.leu.2403122"},{"key":"70","doi-asserted-by":"crossref","unstructured":"70 Streubel B, Simonitsch-Klupp I, Mullauer L, Lamprecht A, Huber D, Siebert R, Stolte M, Trautinger F, Lukas J, Puspok A, Formanek M, Assanasen T, Muller-Hermelink HK, Cerroni L, Raderer M, Chott A : Variable frequencies of MALT lymphoma-associated genetic aberrations in MALT lymphomas of different sites. Leukemia 18 : 1722-1726, 2004","DOI":"10.1038\/sj.leu.2403501"},{"key":"71","doi-asserted-by":"crossref","unstructured":"71 Ye H, Gong L, Liu H, Hamoudi RA, Shirali S, Ho L, Chott A, Streubel B, Siebert R, Gesk S, Martin-Subero JI, Radford JA, Banerjee S, Nicholson AG, Ranaldi R, Remstein ED, Gao Z, Zheng J, Isaacson PG, Dogan A, Du MQ : MALT lymphoma with t(14;18)(q32;q21)\/<I>IGH-MALT1<\/I> is characterized by strong cytoplasmic MALT1 and BCL10 expression. J Pathol 205 : 293-301, 2005","DOI":"10.1002\/path.1715"},{"key":"72","doi-asserted-by":"crossref","unstructured":"72 Cook JR, Sherer M, Craig FE, Shekhter-Levin S, Swerdlow SH : T(14;18)(q32;q21) involving <I>MALT1<\/I> and <I>IGH<\/I> genes in an extranodal diffuse large B-cell lymphoma. Hum Pathol 34 : 1212-1215, 2003","DOI":"10.1016\/j.humpath.2003.08.007"},{"key":"73","doi-asserted-by":"crossref","unstructured":"73 Dijkman R, Tensen CP, Jordanova ES, Knijnenburg J, Hoefnagel JJ, Mulder AA, Rosenberg C, Raap AK, Willemze R, Szuhai K, Vermeer MH : Array-based comparative genomic hybridization analysis reveals recurrent chromosomal alterations and prognostic parameters in primary cutaneous large B-cell lymphoma. J Clin Oncol 24 : 296-305, 2006","DOI":"10.1200\/JCO.2005.02.0842"},{"key":"74","doi-asserted-by":"crossref","unstructured":"74 Streubel B, Vinatzer U, Lamprecht A, Raderer M, Chott A : T(3;14)(p14.1;q32) involving <I>IGH<\/I> and <I>FOXP1<\/I> is a novel recurrent chromosomal aberration in MALT lymphoma. Leukemia 19 : 652-658, 2005","DOI":"10.1038\/sj.leu.2403644"},{"key":"75","doi-asserted-by":"crossref","unstructured":"75 Wlodarska I, Veyt E, De Paepe P, Vandenberghe P, Nooijen P, Theate I, Michaux L, Sagaert X, Marynen P, Hagemeijer A, Wolf-Peeters C : <I>FOXP1<\/I>, a gene highly expressed in a subset of diffuse large B-cell lymphoma, is recurrently targeted by genomic aberrations. Leukemia 19 : 1299-1305, 2005","DOI":"10.1038\/sj.leu.2403813"},{"key":"76","doi-asserted-by":"crossref","unstructured":"76 Fenton JA, Schuuring E, Barrans SL, Banham AH, Rollinson SJ, Morgan GJ, Jack AS, van Krieken JH, Kluin PM : t(3;14)(p14;q32) results in aberrant expression of FOXP1 in a case of diffuse large B-cell lymphoma. Genes Chromosomes Cancer 45 : 164-168, 2006","DOI":"10.1002\/gcc.20278"},{"key":"77","doi-asserted-by":"crossref","unstructured":"77 Hu H, Wang B, Borde M, Nardone J, Maika S, Allred L, Tucker PW, Rao A : Foxp1 is an essential transcriptional regulator of B cell development. Nat Immunol 7 : 819-826, 2006","DOI":"10.1038\/ni1358"},{"key":"78","doi-asserted-by":"crossref","unstructured":"78 Haralambieva E, Adam P, Ventura R, Katzenberger T, Kalla J, Holler S, Hartmann M, Rosenwald A, Greiner A, Muller-Hermelink HK, Banham AH, Ott G : Genetic rearrangement of FOXP1 is predominantly detected in a subset of diffuse large B-cell lymphomas with extranodal presentation. Leukemia 20 : 1300-1303, 2006","DOI":"10.1038\/sj.leu.2404244"},{"key":"79","doi-asserted-by":"crossref","unstructured":"79 Ruefli-Brasse AA, French DM, Dixit VM : Regulation of NF-kappaB-dependent lymphocyte activation and development by paracaspase. Science 302 : 1581-1584, 2003","DOI":"10.1126\/science.1090769"},{"key":"80","doi-asserted-by":"crossref","unstructured":"80 Matsumoto R, Wang D, Blonska M, Li H, Kobayashi M, Pappu B, Chen Y, Wang D, Lin X : Phosphorylation of CARMA1 plays a critical role in T Cell receptor-mediated NF-kappaB activation. Immunity 23 : 575-585, 2005","DOI":"10.1016\/j.immuni.2005.10.007"},{"key":"81","doi-asserted-by":"crossref","unstructured":"81 Sommer K, Guo B, Pomerantz JL, Bandaranayake AD, Moreno-Garcia ME, Ovechkina YL, Rawlings DJ : Phosphorylation of the CARMA1 linker controls NF-kappaB activation. Immunity 23 : 561-574, 2005","DOI":"10.1016\/j.immuni.2005.09.014"},{"key":"82","doi-asserted-by":"crossref","unstructured":"82 Gaide O, Martinon F, Micheau O, Bonnet D, Thome M, Tschopp J : Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation. FEBS Lett 496 : 121-127, 2001","DOI":"10.1016\/S0014-5793(01)02414-0"},{"key":"83","doi-asserted-by":"crossref","unstructured":"83 Bertin J, Wang L, Guo Y, Jacobson MD, Poyet JL, Srinivasula SM, Merriam S, DiStefano PS, Alnemri ES : CARD11 and CARD14 are novel caspase recruitment domain (CARD)\/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappaB. J Biol Chem 276 : 11877-11882, 2001","DOI":"10.1074\/jbc.M010512200"},{"key":"84","doi-asserted-by":"crossref","unstructured":"84 McAllister-Lucas LM, Inohara N, Lucas PC, Ruland J, Benito A, Li Q, Chen S, Chen FF, Yamaoka S, Verma IM, Mak TW, Nunez G : Bimp1, a MAGUK family member linking protein kinase C activation to Bcl10-mediated NF-kappaB induction. J Biol Chem 276 : 30589-30597, 2001","DOI":"10.1074\/jbc.M103824200"},{"key":"85","doi-asserted-by":"crossref","unstructured":"85 Zhou H, Wertz I, O'Rourke K, Ultsch M, Seshagiri S, Eby M, Xiao W, Dixit VM : Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO. Nature 427 : 167-171, 2004","DOI":"10.1038\/nature02273"},{"key":"86","doi-asserted-by":"crossref","unstructured":"86 Sun L, Deng L, Ea CK, Xia ZP, Chen ZJ : The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes. Mol Cell 14 : 289-301, 2004","DOI":"10.1016\/S1097-2765(04)00236-9"},{"key":"87","doi-asserted-by":"crossref","unstructured":"87 Lucas PC, Kuffa P, Gu S, Kohrt D, Kim DS, Siu K, Jin X, Swenson J, McAllister-Lucas LM : A dual role for the API2 moiety in API2-MALT1-dependent NF-kappaB activation : heterotypic oligomerization and TRAF2 recruitment. Oncogene 26 : 5643-5654, 2007","DOI":"10.1038\/sj.onc.1210342"},{"key":"88","doi-asserted-by":"crossref","unstructured":"88 Baens M, Fevery S, Sagaert X, Noels H, Hagens S, Broeckx V, Billiau AD, De Wolf-Peeters C, Marynen P : Selective expansion of marginal zone B cells in Emicro-API2-MALT1 mice is linked to enhanced IkappaB kinase gamma polyubiquitination. Cancer Res 66 : 5270-5277, 2006","DOI":"10.1158\/0008-5472.CAN-05-4590"},{"key":"89","doi-asserted-by":"crossref","unstructured":"89 Macintyre E, Willerford D, Morris SW : Non-Hodgkin's Lymphoma : Molecular Features of B Cell Lymphoma. <I>In <\/I>: Hematology (Am Soc Hematol Educ Program), The American Society of Hematology, Washington DC, pp. 180-204, 2000","DOI":"10.1182\/asheducation-2000.1.180"},{"key":"90","doi-asserted-by":"crossref","unstructured":"90 Ho L, Davis RE, Conne B, Chappuis R, Berczy M, Mhawech P, Staudt LM, Schwaller J : MALT1 and the API2-MALT1 fusion act between CD40 and IKK and confer NF-kappaB-dependent proliferative advantage and resistance against FAS-induced cell death in B cells. Blood 105 : 2891-2899, 2005","DOI":"10.1182\/blood-2004-06-2297"},{"key":"91","unstructured":"91 Sagaert X, Theys T, Wolf-Peeters C, Marynen P, Baens M : Splenic marginal zone lymphoma-like features in API2-MALT1 transgenic mice that are exposed to antigenic stimulation. Haematologica 91 : 1693-1696, 2006"},{"key":"92","doi-asserted-by":"crossref","unstructured":"92 Zhou Y, Ye H, Martin-Subero JI, Hamoudi R, Lu YJ, Wang R, Siebert R, Shipley J, Isaacson PG, Dogan A, Du MQ : Distinct comparative genomic hybridisation profiles in gastric mucosa-associated lymphoid tissue lymphomas with and without t(11;18)(q21;q21). Br J Haematol 133 : 35-42, 2006","DOI":"10.1111\/j.1365-2141.2006.05969.x"},{"key":"93","doi-asserted-by":"crossref","unstructured":"93 Zhou Y, Ye H, Martin-Subero JI, Gesk S, Hamoudi RA, Lu YJ, Wang R, Shipley J, Siebert R, Isaacson PG, Dogan A, Du MQ : Salivary gland MALT lymphomas show a conserved pattern of genomic gains. Haematologica 92 : 921-927, 2007","DOI":"10.3324\/haematol.10191"},{"key":"94","doi-asserted-by":"crossref","unstructured":"94 Urisman A, Molinaro RJ, Fischer N, Plummer SJ, Casey G, Klein EA, Malathi K, Magi-Galluzzi C, Tubbs RR, Ganem D, Silverman RH, Derisi JL : Identification of a novel Gammaretrovirus in prostate tumors of patients homozygous for R462Q RNASEL Variant. PLoS Pathog 2 : e25, 2006","DOI":"10.1371\/journal.ppat.0020025"},{"key":"95","unstructured":"95 Streubel B, Bilban M, Raderer M, Chott A : MALT lymphoma : novel translocations and three distinct gene expression profiles. Lab Invest 87 [Suppl 1], 261A, 2007"},{"key":"96","unstructured":"96 Remstein ED, Law ME, Dewald GW, Kurtin PJ, Dogan A : CpG oligonucleotides induce growth of MALT lymphoma cells <I>in vitro<\/I> and reveal novel cytogenetic abnormalities. Lab Invest 87 [Suppl 1], 257A, 2007"},{"key":"97","doi-asserted-by":"crossref","unstructured":"97 Ye H, Dogan A, Karran L, Willis TG, Chen L, Wlodarska I, Dyer MJ, Isaacson PG, Du MQ : BCL10 expression in normal and neoplastic lymphoid tissue : Nuclear localization in MALT lymphoma. Am J Pathol 157 : 1147-1154, 2000","DOI":"10.1016\/S0002-9440(10)64630-5"},{"key":"98","doi-asserted-by":"crossref","unstructured":"98 Maes B, Demunter A, Peeters B, Wolf-Peeters C : <I>BCL10<\/I> mutation does not represent an important pathogenic mechanism in gastric MALT-type lymphoma, and the presence of the API2-MLT fusion is associated with aberrant nuclear BCL10 expression. Blood 99 : 1398-1404, 2002","DOI":"10.1182\/blood.V99.4.1398"},{"key":"99","doi-asserted-by":"crossref","unstructured":"99 Nakagawa M, Hosokawa Y, Yonezumi M, Izumiyama K, Suzuki R, Tsuzuki S, Asaka M, Seto M : MALT1 contains nuclear export signals and regulates cytoplasmic localization of BCL10. 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