{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:28:59Z","timestamp":1791332939349,"version":"4.3.1"},"reference-count":68,"publisher":"Japanese Society for Lymphoreticular Tissue Research","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Exp Hematopathol","JCEH"],"published-print":{"date-parts":[[2010]]},"DOI":"10.3960\/jslrt.50.1","type":"journal-article","created":{"date-parts":[[2010,5,26]],"date-time":"2010-05-26T06:04:53Z","timestamp":1274853893000},"page":"1-8","source":"Crossref","is-referenced-by-count":41,"title":["HTLV-1 and the Host Immune System : How the Virus Disrupts Immune Regulation, Leading to HTLV-1 Associated Diseases"],"prefix":"10.3960","volume":"50","author":[{"given":"Yorifumi","family":"Satou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Matsuoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2349","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1 Van Dooren S, Salemi M, Vandamme AM : Dating the origin of the African human T-cell lymphotropic virus type-I (HTLV-I) subtypes. Mol Biol Evol 18 : 661-671, 2001","DOI":"10.1093\/oxfordjournals.molbev.a003846"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-2-16"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3 Matsuoka M, Jeang KT : Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation. Nat Rev Cancer 7 : 270-280, 2007","DOI":"10.1038\/nrc2111"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)91298-5"},{"key":"5","unstructured":"5 Mochizuki M, Yamaguchi K, Takatsuki K, Watanabe T, Mori S, <I>et al<\/I>. : HTLV-I and uveitis. Lancet 339 : 1110, 1992"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)95357-2"},{"key":"7","unstructured":"7 Sugimoto M, Nakashima H, Watanabe S, Uyama E, Tanaka F, <I>et al<\/I>. : T-lymphocyte alveolitis in HTLV-I-associated myelopathy. Lancet 2 : 1220, 1987"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1126\/science.1080115"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1993.1451"},{"issue":"21","key":"10","first-page":"4862","volume":"57","year":"1997","ISSN":"https:\/\/id.crossref.org\/issn\/0008-5472","issn-type":"print"},{"issue":"11","key":"11","doi-asserted-by":"crossref","first-page":"5682","DOI":"10.1128\/JVI.64.11.5682-5687.1990","volume":"64","year":"1990","ISSN":"https:\/\/id.crossref.org\/issn\/0022-538X","issn-type":"print"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.19.1.475"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R400009200"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1038\/348245a0"},{"key":"15","unstructured":"15 Kannagi M, Harada S, Maruyama I, Inoko H, Igarashi H, <I>et al<\/I>. : Predominant recognition of human T cell leukemia virus type I (HTLV-I) pX gene products by human CD8<SUP>+<\/SUP> cytotoxic T cells directed against HTLV-I-infected cells. Int Immunol 3 : 761-767, 1991"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16 Furukawa Y, Osame M, Kubota R, Tara M, Yoshida M : Human T-cell leukemia virus type-1 (HTLV-1) Tax is expressed at the same level in infected cells of HTLV-1-associated myelopathy or tropical spastic paraparesis patients as in asymptomatic carriers but at a lower level in adult T-cell leukemia cells. Blood 85 : 1865-1870, 1995","DOI":"10.1182\/blood.V85.7.1865.bloodjournal8571865"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.24.12813-12822.2002"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-3-15"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.80.5.2495-2505.2006"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0507631103"},{"key":"21","unstructured":"21 Usui T, Yanagihara K, Tsukasaki K, Murata K, Hasegawa H, <I>et al<\/I>. : Characteristic expression of HTLV-1 basic zipper factor (HBZ) transcripts in HTLV-1 provirus-positive cells. Retrovirology 5 : 34, 2008"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00242-08"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23 Arnold J, Zimmerman B, Li M, Lairmore MD, Green PL : Human T-cell leukemia virus type-1 antisense-encoded gene, Hbz, promotes T-lymphocyte proliferation. Blood 112 : 3788-3797, 2008","DOI":"10.1182\/blood-2008-04-154286"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M307275200"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25 Matsumoto J, Ohshima T, Isono O, Shimotohno K : HTLV-1 HBZ suppresses AP-1 activity by impairing both the DNA-binding ability and the stability of c-Jun protein. Oncogene 24 : 1001-1010, 2005","DOI":"10.1038\/sj.onc.1208297"},{"key":"26","unstructured":"26 Zhao T, Yasunaga J, Satou Y, Nakao M, Takahashi M, <I>et al<\/I>. : Human T-cell leukemia virus type 1 bZIP factor selectively suppresses the classical pathway of NF-&kappa;B. Blood 113 : 2755-2764, 2009"},{"key":"27","unstructured":"27 Arnold J, Yamamoto B, Li M, Phipps AJ, Younis I, <I>et al<\/I>. : Enhancement of infectivity and persistence <I>in vivo<\/I> by HBZ, a natural antisense coded protein of HTLV-1. Blood 107 : 3976-3982, 2006"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28 Uchiyama T, Yodoi J, Sagawa K, Takatsuki K, Uchino H : Adult T-cell leukemia : clinical and hematologic features of 16 cases. Blood 50 : 481-492, 1977","DOI":"10.1182\/blood.V50.3.481.bloodjournal503481"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29 Hattori T, Uchiyama T, Toibana T, Takatsuki K, Uchino H : Surface phenotype of Japanese adult T-cell leukemia cells characterized by monoclonal antibodies. Blood 58 : 645-647, 1981","DOI":"10.1182\/blood.V58.3.645.bloodjournal583645"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30 Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M : Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 155 : 1151-1164, 1995","DOI":"10.4049\/jimmunol.155.3.1151"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1038\/ni909"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1126\/science.1079490"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1038\/ni904"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2005.00080.x"},{"key":"35","unstructured":"35 Karube K, Ohshima K, Tsuchiya T, Yamaguchi T, Kawano R, <I>et al<\/I>. : Expression of FoxP3, a key molecule in CD4<SUP>+<\/SUP>CD25<SUP>+<\/SUP> regulatory T cells, in adult T-cell leukaemia\/lymphoma cells. Br J Haematol 126 : 81-84, 2004"},{"key":"36","unstructured":"36 Karube K, Aoki R, Sugita Y, Yoshida S, Nomura Y, <I>et al<\/I>. : The relationship of FOXP3 expression and clinicopathological characteristics in adult T-cell leukemia\/lymphoma. Mod Pathol 21 : 617-625, 2008"},{"key":"37","unstructured":"37 Yano H, Ishida T, Inagaki A, Ishii T, Kusumoto S, <I>et al<\/I>. : Regulatory T-cell function of adult T-cell leukemia\/lymphoma cells. Int J Cancer 120 : 2052-2057, 2007"},{"key":"38","unstructured":"38 Chen S, Ishii N, Ine S, Ikeda S, Fujimura T, <I>et al<\/I>. : Regulatory T cell-like activity of Foxp3<SUP>+<\/SUP> adult T cell leukemia cells. Int Immunol 18 : 269-277, 2006."},{"issue":"1","key":"39","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1111\/j.1349-7006.2007.00646.x","volume":"99","author":"SHIMAUCHI TAKATOSHI","year":"2008","ISSN":"https:\/\/id.crossref.org\/issn\/1347-9032","issn-type":"print"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200636435"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0811556106"},{"key":"42","unstructured":"42 Yamano Y, Takenouchi N, Li HC, Tomaru U, Yao K, <I>et al<\/I>. : Virus-induced dysfunction of CD4<SUP>+<\/SUP>CD25<SUP>+<\/SUP> T cells in patients with HTLV-I-associated neuroimmunological disease. J Clin Invest 115 : 1361-1368, 2005"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.10.3177"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0608832104"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.021908.132653"},{"key":"46","unstructured":"46 Iwasaki Y, Ohara Y, Kobayashi I, Akizuki S : Infiltration of helper\/inducer T lymphocytes heralds central nervous system damage in human T-cell leukemia virus infection. Am J Pathol 140 : 1003-1008, 1992"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5728(93)90014-P"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.240460405"},{"key":"49","unstructured":"49 Yamano Y, Araya N, Sato T, Utsunomiya A, Azakami K, <I>et al<\/I>. : Abnormally high levels of virus-infected IFN-&gamma;<SUP>+<\/SUP>CCR4<SUP>+<\/SUP>CD4<SUP>+<\/SUP>CD25<SUP>+<\/SUP> T cells in a retrovirus-associated neuroinflammatory disorder. PLoS One 4 : e6517, 2009"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.03.019"},{"key":"51","unstructured":"51 Hasegawa H, Sawa H, Lewis MJ, Orba Y, Sheehy N, <I>et al<\/I>. : Thymus-derived leukemia-lymphoma in mice transgenic for the Tax gene of human T-lymphotropic virus type I. Nat Med 12 : 466-472, 2006"},{"key":"52","doi-asserted-by":"crossref","unstructured":"52 Ohsugi T, Kumasaka T, Okada S, Urano T : The Tax protein of HTLV-1 promotes oncogenesis in not only immature T cells but also mature T cells. Nat Med 13 : 527-528, 2007","DOI":"10.1038\/nm0507-527"},{"key":"53","unstructured":"53 Iwakura Y, Tosu M, Yoshida E, Takiguchi M, Sato K, <I>et al<\/I>. : Induction of inflammatory arthropathy resembling rheumatoid arthritis in mice transgenic for HTLV-I. Science 253 : 1026-1028, 1991"},{"key":"54","doi-asserted-by":"crossref","unstructured":"54 Lairmore MD, Silverman L, Ratner L : Animal models for human T-lymphotropic virus type 1 (HTLV-1) infection and transformation. Oncogene 24 : 6005-6015, 2005","DOI":"10.1038\/sj.onc.1208974"},{"key":"55","doi-asserted-by":"crossref","unstructured":"55 Macatonia SE, Cruickshank JK, Rudge P, Knight SC : Dendritic cells from patients with tropical spastic paraparesis are infected with HTLV-1 and stimulate autologous lymphocyte proliferation. AIDS Res Hum Retroviruses 8 : 1699-1706, 1992","DOI":"10.1089\/aid.1992.8.1699"},{"issue":"6","key":"56","doi-asserted-by":"crossref","first-page":"4575","DOI":"10.1128\/JVI.73.6.4575-4581.1999","volume":"73","author":"MAKINO M","year":"1999","ISSN":"https:\/\/id.crossref.org\/issn\/0022-538X","issn-type":"print"},{"key":"57","doi-asserted-by":"crossref","unstructured":"57 Jones KS, Petrow-Sadowski C, Huang YK, Bertolette DC, Ruscetti FW : Cell-free HTLV-1 infects dendritic cells leading to transmission and transformation of CD4<SUP>+<\/SUP> T cells. Nat Med 14 : 429-436, 2008","DOI":"10.1038\/nm1745"},{"key":"58","unstructured":"58 Hanon E, Stinchcombe JC, Saito M, Asquith BE, Taylor GP, <I>et al<\/I>. : Fratricide among CD8<SUP>+<\/SUP> T lymphocytes naturally infected with human T cell lymphotropic virus type I. Immunity 13 : 657-664, 2000"},{"key":"59","unstructured":"59 Goon PK, Biancardi A, Fast N, Igakura T, Hanon E, <I>et al<\/I>. : Human T cell lymphotropic virus (HTLV) type-1-specific CD8<SUP>+<\/SUP> T cells : frequency and immunodominance hierarchy. J Infect Dis 189 : 2294-2298, 2004"},{"key":"60","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.80766-0"},{"key":"61","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.7.3848"},{"key":"62","unstructured":"62 Jeffery KJ, Siddiqui AA, Bunce M, Lloyd AL, Vine AM, <I>et al<\/I>. : The influence of HLA class I alleles and heterozygosity on the outcome of human T cell lymphotropic virus type I infection. J Immunol 165 : 7278-7284, 2000"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.05.009"},{"key":"64","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-10-118539"},{"key":"65","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1702731"},{"key":"66","unstructured":"66 Okamura J, Utsunomiya A, Tanosaki R, Uike N, Sonoda S, <I>et al<\/I>. : Allogeneic stem-cell transplantation with reduced conditioning intensity as a novel immunotherapy and antiviral therapy for adult T-cell leukemia\/lymphoma. Blood 105 : 4143-4145, 2005"},{"key":"67","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-1452"},{"key":"68","unstructured":"68 Hino S, Katamine S, Kawase K, Miyamoto T, Doi H, <I>et al<\/I>. : Intervention of maternal transmission of HTLV-1 in Nagasaki, Japan. Leukemia 8 Suppl 1 : S68-70, 1994"}],"container-title":["Journal of Clinical and Experimental Hematopathology"],"original-title":[],"language":"en","deposited":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T00:13:20Z","timestamp":1711498400000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jstage.jst.go.jp\/article\/jslrt\/50\/1\/50_1_1\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":68,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010]]}},"URL":"https:\/\/doi.org\/10.3960\/jslrt.50.1","relation":{},"ISSN":["1880-9952","1346-4280"],"issn-type":[{"value":"1880-9952","type":"electronic"},{"value":"1346-4280","type":"print"}],"subject":[],"published":{"date-parts":[[2010]]}}}