{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:14:35Z","timestamp":1790694875461,"version":"4.1.0"},"reference-count":50,"publisher":"Japanese Society for Lymphoreticular Tissue Research","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Exp Hematopathol","JCEH"],"published-print":{"date-parts":[[2014]]},"DOI":"10.3960\/jslrt.54.3","type":"journal-article","created":{"date-parts":[[2014,6,17]],"date-time":"2014-06-17T23:13:54Z","timestamp":1403046834000},"page":"3-9","source":"Crossref","is-referenced-by-count":50,"title":["Pathology of Follicular Lymphoma"],"prefix":"10.3960","volume":"54","author":[{"given":"Katsuyoshi","family":"Takata","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Miyata-Takata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuharu","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Yoshino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2349","reference":[{"key":"1","unstructured":"1 Harris NL, Swerdlow SH, Jaffe ES, Ott G, Nathwani BN, <I>et al<\/I>.: Follicular lymphoma. In: Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, <I>et al<\/I>. (eds): World Health Organization Classification of Tumours, WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. 4th ed, Lyon, International Agency for Research on Cancer (IARC), pp.220-226, 2008"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2 Hicks EB, Rappaport H, Winter WJ: Follicular lymphoma; A re-evaluation of its position in the scheme of malignant lymphoma, based on a survey of 253 cases. Cancer 9:792-821, 1956","DOI":"10.1002\/1097-0142(195607\/08)9:4<792::AID-CNCR2820090429>3.0.CO;2-B"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3 National Cancer Institute sponsored study of classifications of non-Hodgkin's lymphomas: summary and description of a working formulation for clinical usage. The Non-Hodgkin's Lymphoma Pathologic Classification Project. Cancer 49:2112-2135, 1982","DOI":"10.1002\/1097-0142(19820515)49:10<2112::AID-CNCR2820491024>3.0.CO;2-2"},{"key":"4","unstructured":"4 Harris NL, Jaffe ES, Stein H, Banks PM, Chan JK, <I>et al<\/I>.: A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group. Blood 84:1361-1392, 1994"},{"key":"5","unstructured":"5 Jaffe ES, Harris NL, Stein H, Vardiman JW: World Health Organization Classification of Tumors. Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues, 3rd ed., Lyon, pp.162-167, 2001"},{"key":"6","unstructured":"6 6 Bosga-Bouwer AG, van Imhoff GW, Boonstra R, van der Veen A, Haralambieva E, <I>et al<\/I>.: Follicular lymphoma grade 3B includes 3 cytogenetically defined subgroups with primary t(14;18), 3q27, or other translocations: t(14;18) and 3q27 are mutually excusive. Blood 101:1149-1154, 2003"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7 Katzenberger T, Ott G, Klein T, Kalla J, M&uuml;ller-Hermelink HK, <I>et al<\/I>.: Cytogenetic alterations affecting BCL6 are predominantly found in follicular lymphomas grade 3B with a diffuse large B-cell component. Am J Pathol 165:481-490, 2004","DOI":"10.1016\/S0002-9440(10)63313-5"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8 Karube K, Guo Y, Suzumiya J, Sugita Y, Nomura Y, <I>et al<\/I>.: CD10<SUP>-<\/SUP>MUM1<SUP>+<\/SUP> follicular lymphoma lacks <I>BCL<\/I><I>2<\/I> gene translocation and shows characteristic biologic and clinical features. Blood 109:3076-3079, 2007","DOI":"10.1182\/blood-2006-09-045989"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9 Hans CP, Weisenburger DD, Vose JM, Hock LM, Lynch JC, <I>et al<\/I>.: A significant diffuse component predicts for inferior survival in grade 3 follicular lymphoma, but cytologic subtypes do not predict survival. Blood 101:2363-2367, 2003","DOI":"10.1182\/blood-2002-07-2298"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10 Chau I, Jones R, Cunningham D, Wotherspoon A, Maisey N, <I>et al<\/I>.: Outcome of follicular lymphoma grade 3: Is anthracycline necessary as front-line therapy? Br J Cancer 89:36-42, 2003","DOI":"10.1038\/sj.bjc.6601006"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11 Armitage JO, Weisenburger DD: New approach to classifying non-Hodgkin's lymphomas: Clinical features of the major histologic subtypes. Non-Hodgkin's Lymphoma Classification Project. J Clin Oncol 16:2780-2795, 1998","DOI":"10.1200\/JCO.1998.16.8.2780"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12 Montoto S, Davies AJ, Matthews J, Calaminici M, Norton AJ, <I>et al<\/I>.: Risk and clinical implications of transformation of follicular lymphoma to diffuse large B-cell lymphoma. J Clin Oncol 25:2426-2433, 2007","DOI":"10.1200\/JCO.2006.09.3260"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13 Horning SJ, Rosenberg SA: The natural history of initially untreated low-grade non-Hodgkin's lymphomas. N Engl J Med 311:1471-1475, 1984","DOI":"10.1056\/NEJM198412063112303"},{"key":"14","unstructured":"14 Albinger-Hegyi A, Hochreutener B, Abdou MT, Hegyi I, Dours-Zimmermann MT, <I>et al<\/I>.: High frequency of t(14;18)-translocation breakpoints outside of major breakpoint and minor cluster regions in follicular lymphomas: improved polymerase chain reaction protocols for their detection. Am J Pathol 3:823-832, 2002"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15 Leich E, Salaverria I, Bea S, Zettl A, Wright G, <I>et al<\/I>.: Follicular lymphomas with and without translocation t(14;18) differ in gene expression profiles and genetic alterations. Blood 114:826-834, 2009","DOI":"10.1182\/blood-2009-01-198580"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16 K&uuml;ppers R: Mechanisms of B-cell lymphoma pathogenesis. Nat Rev Cancer 5:251-262, 2005","DOI":"10.1038\/nrc1589"},{"key":"17","unstructured":"17 Horsman DE, Okamoto I, Ludkovski O, Le N, Harder L, <I>et al<\/I>.: Follicular lymphoma lacking the t(14;18)(q32;q21): Identification of two disease subtypes. Br J Haematol 120:424-433, 2003"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18 Katzenberger T, Kalla J, Leich E, St&ouml;cklein H, Hartmann E, <I>et al<\/I>.: A distinctive subtype of t(14;18)-negative nodal follicular non-Hodgkin lymphoma characterized by a predominantly diffuse growth pattern and deletions in the chromosomal region 1p36. Blood 113:1053-1061, 2009","DOI":"10.1182\/blood-2008-07-168682"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19 Horsman DE, Connors JM, Pantzar T, Gascoyne RD: Analysis of secondary chromosomal alterations in 165 cases of follicular lymphoma with t(14;18). Genes Chromosomes Cancer 30:375-382, 2001","DOI":"10.1002\/gcc.1103"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20 Yunis JJ, Frizzera G, Oken MM, McKenna J, Theologides A, <I>et al<\/I>.: Multiple recurrent genomic defects in follicular lymphoma. A possible model for cancer. N Engl J Med 316:79-84, 1987","DOI":"10.1056\/NEJM198701083160204"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21 Johansson B, Mertens F, Mitelman F: Cytogenetic evolution patterns in non-Hodgkin's lymphoma. Blood 86:3905-3914, 1995","DOI":"10.1182\/blood.V86.10.3905.bloodjournal86103905"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22 Cheung KJ, Shah SP, Steidl C, Johnson N, Relander T, <I>et al<\/I>.: Genome-wide profiling of follicular lymphoma by array comparative genomic hybridization reveals prognostically significant DNA copy number imbalances. Blood 113:137-148, 2009","DOI":"10.1182\/blood-2008-02-140616"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23 Viardot A, M&ouml;ller P, H&ouml;gel J, Werner K, Mechtersheimer G, <I>et al<\/I>.: Clinicopathologic correlations of genomic gains and losses in follicular lymphoma. J Clin Oncol 20:4523-4530, 2002","DOI":"10.1200\/JCO.2002.12.006"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24 Schwaenen C, Viardot A, Berger H, Barth TF, Bentink S, <I>et al<\/I>.: Microarray-based genomic profiling reveals novel genomic aberrations in follicular lymphoma which associate with patient survival and gene expression status. Genes Chromosomes Cancer 48:39-54, 2009","DOI":"10.1002\/gcc.20617"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25 O'Shea D, O'Riain C, Gupta M, Waters R, Yang Y, <I>et al<\/I>.: Regions of acquired uniparental disomy at diagnosis of follicular lymphoma are associated with both overall survival and risk of transformation. Blood 113:2298-2301, 2009","DOI":"10.1182\/blood-2008-08-174953"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26 Morin RD, Johnson NA, Severson TM, Mungall AJ, An J, <I>et al<\/I>.: Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin. Nat Genet 42:181-185, 2010","DOI":"10.1038\/ng.518"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27 Morin RD, Mendez-Lago M, Mungall AJ, Goya R, Mungall KL, <I>et al<\/I>.: Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma. Nature 476:298-303, 2011","DOI":"10.1038\/nature10351"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28 Pasqualucci L, Dominguez-Sola D, Chiarenza A, Fabbri G, Grunn A, <I>et al<\/I>.: Inactivating mutations of acetyltransferase genes in B-cell lymphoma. Nature 471:189-195, 2011","DOI":"10.1038\/nature09730"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29 Green MR, Gentles AJ, Nair RV, Irish JM, Kihira S, <I>et al<\/I>.: Hierarchy in somatic mutations arising during genomic evolution and progression of follicular lymphoma. Blood 121:1604-1611, 2013","DOI":"10.1182\/blood-2012-09-457283"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30 Acker B, Hoppe RT, Colby TV, Cox RS, Kaplan HS, <I>et al<\/I>.: Histologic conversion in the non-Hodgkin's lymphomas. J Clin Oncol 1:11-16, 1983","DOI":"10.1200\/JCO.1983.1.1.11"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31 Cullen MH, Lister TA, Brearley RI, Shand WS, Stansfeld AG: Histological transformation of non-Hodgkin's lymphoma: A prospective study. Cancer 44:645-651, 1979","DOI":"10.1002\/1097-0142(197908)44:2<645::AID-CNCR2820440234>3.0.CO;2-Y"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32 Hubbard SM, Chabner BA, DeVita VT Jr, Simon R, Berard CW, <I>et al<\/I>.: Histologic progression in non-Hodgkin's lymphoma. Blood 59:258-264, 1982","DOI":"10.1182\/blood.V59.2.258.bloodjournal592258"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33 Oviatt DL, Cousar JB, Collins RD, Flexner JM, Stein RS: Malignant lymphomas of follicular center cell origin in humans. V. Incidence, clinical features, and prognostic implications of transformation of small cleaved cell nodular lymphoma. Cancer 53:1109-1114, 1984","DOI":"10.1002\/1097-0142(19840301)53:5<1109::AID-CNCR2820530516>3.0.CO;2-O"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34 Elenitoba-Johnson KS, Gascoyne RD, Lim MS, Chhanabai M, Jaffe ES, <I>et al<\/I>.: Homozygous deletions at chromosome 9p21 involving p16 and p15 are associated with histologic progression in follicle center lymphoma. Blood 91:4677-4685, 1998","DOI":"10.1182\/blood.V91.12.4677.412k40_4677_4685"},{"key":"35","unstructured":"35 Lossos IS, Alizadeh AA, Diehn M, Warnke R, Thorstenson Y, <I>et al<\/I>.: Transformation of follicular lymphoma to diffuse large-cell lymphoma: Alternative patterns with increased or decreased expression of c-myc and its regulated genes. Proc Natl Acad Sci USA 99:8886-8891, 2002"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36 Yano T, Jaffe ES, Longo DL, Raffeld M: MYC rearrangements in histologically progressed follicular lymphomas. Blood 80:758-767, 1992","DOI":"10.1182\/blood.V80.3.758.bloodjournal803758"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37 Lossos IS: Molecular pathogenesis of diffuse large B-cell lymphoma. J Clin Oncol 23:6351-6357, 2005","DOI":"10.1200\/JCO.2005.05.012"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38 Streubel B, Chott A, Huber D, Exner M, J&auml;ger U, <I>et al<\/I>.: Lymphoma-specific genetic aberrations in microvascular endothelial cells in B-cell lymphomas. N Engl J Med 351:250-259, 2004","DOI":"10.1056\/NEJMoa033153"},{"key":"39","unstructured":"39 Shiozawa E, Yamochi-Onizuka T, Yamochi T, Yamamoto Y, Naitoh H, <I>et al<\/I>.: Disappearance of CD21-positive follicular dendritic cells preceding the transformation of follicular lymphoma: Immunohistological study of the transformation using CD21, p53, Ki-67, and P-glycoprotein. Pathol Res Pract 199:293-302, 2003"},{"key":"40","unstructured":"40 Kiaii S, Clear AJ, Ramsay AG, Davies D, Sangaralingam A, <I>et al<\/I>.: Follicular lymphoma cells induce changes in T-cell gene expression and function: potential impact on survival and risk of transformation. J Clin Oncol 31:2654-2661, 2013"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41 Lorsbach RB, Shay-Seymore D, Moore J, Banks PM, Hasserjian RP, <I>et al<\/I>.: Clinicopathologic analysis of follicular lymphoma occurring in children. Blood 99:1959-1964, 2002","DOI":"10.1182\/blood.V99.6.1959"},{"key":"42","unstructured":"42 Cong P, Raffeld M, Teruya-Feldstein J, Sorbara L, Pittaluga S, <I>et al<\/I>.: <I>In situ<\/I> localization of follicular lymphoma: description and analysis by laser capture microdissection. Blood 99:3376-3382, 2002"},{"key":"43","unstructured":"43 Jegalian AG, Eberle FC, Pack SD, Mirvis M, Raffeld M, <I>et al<\/I>.: Follicular lymphoma <I>in situ<\/I>: clinical implications and comparisons with partial involvement by follicular lymphoma. Blood 118:2976-2984, 2011"},{"key":"44","unstructured":"44 Roulland S, Navarro JM, Grenot P, Milili M, Agopian J, <I>et al<\/I>.: Follicular lymphoma-like B cells in healthy individuals: a novel intermediate step in early lymphomagenesis. J Exp Med 203:2425-2431, 2006"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45 Roulland S, Lebailly P, Lecluse Y, Heutte N, Nadel B, <I>et al<\/I>.: Long-term clonal persistence and evolution of t(14;18)-bearing B cells in healthy individuals. Leukemia 20:158-162, 2006","DOI":"10.1038\/sj.leu.2404035"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46 Yoshino T, Miyake K, Ichimura K, Mannami T, Ohara N, <I>et al<\/I>.: Increased incidence of follicular lymphoma in the duodenum. Am J Surg Pathol 24:688-693, 2000","DOI":"10.1097\/00000478-200005000-00007"},{"key":"47","unstructured":"47 Kodama M, Kitadai Y, Shishido T, Shimamoto M, Fukumoto A, <I>et al<\/I>.: Primary follicular lymphoma of the gastrointestinal tract: a retrospective case series. Endoscopy 40:343-346, 2008"},{"key":"48","unstructured":"48 Takata K, Okada H, Ohmiya N, Nakamura S, Kitadai Y, <I>et al<\/I>.: Primary gastrointestinal follicular lymphoma involving the duodenal second portion is a distinct entity: A multicenter, retrospective analysis in Japan. Cancer Sci 102:1532-1536, 2011"},{"key":"49","unstructured":"49 Takata K, Sato Y, Nakamura N, Kikuti YY, Ichimura K, <I>et al<\/I>.: Duodenal and nodal follicular lymphomas are distinct: the former lacks activation-induced cytidine deaminase and follicular dendritic cells despite ongoing somatic hypermutations. Mod Pathol 22:940-949, 2009"},{"key":"50","doi-asserted-by":"crossref","unstructured":"50 Takata K, Sato Y, Nakamura N, Tokunaka M, Miki Y, <I>et al<\/I>.: Duodenal follicular lymphoma lacks AID but express BACH2 and has memory B cell characteristics. Mod Pathol 26:22-31, 2013","DOI":"10.1038\/modpathol.2012.127"}],"container-title":["Journal of Clinical and Experimental Hematopathology"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T10:02:24Z","timestamp":1689328944000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jslrt\/54\/1\/54_3\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.3960\/jslrt.54.3","relation":{},"ISSN":["1346-4280","1880-9952"],"issn-type":[{"value":"1346-4280","type":"print"},{"value":"1880-9952","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}