{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T06:59:34Z","timestamp":1780901974445,"version":"3.54.1"},"reference-count":26,"publisher":"Korean Society for Preventive Medicine","issue":"3","license":[{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["RS-2024-00461755"],"award-info":[{"award-number":["RS-2024-00461755"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jpmph.org"],"crossmark-restriction":true},"short-container-title":["JPMPH"],"published-print":{"date-parts":[[2026,5,31]]},"abstract":"<jats:p>Objectives: Ischemic stroke is influenced by long-term metabolic and renal deterioration; however, many risk prediction frameworks rely on single time-point measurements. We examined whether multi-period patterns in national health screening indicators are associated with incident ischemic stroke in Korea.Methods: Using customized National Health Insurance Service data with 3 biennial screenings (P1: 2013\u20132014; P2: 2015\u20132016; P3: 2017\u20132018), we identified incident ischemic stroke during 2019\u20132023 (Korean Standard Classification of Diseases-7 I63). After applying eligibility criteria and excluding individuals with missing screening values, we performed 1:1 propensity score matching on sex, 1-year age strata, and insurance type (97 454 matched pairs; n=194 908). Multi-period indicators included waist circumference increase \u226510%, sustained blood pressure \u2265130\/80 mmHg, sustained fasting glucose \u2265126 mg\/dL, proteinuria progression, and creatinine elevation in \u22652 periods (sex-specific thresholds). Associations were evaluated using conditional logistic regression; a comparator model used P3-only indicators.Results: In the multi-period model, stroke was associated with waist circumference increase \u226510% (odds ratio [OR], 1.05; 95% confidence interval [CI], 1.01 to 1.08), sustained blood pressure \u2265130\/80 mmHg (OR, 1.34; 95% CI, 1.31 to 1.37), sustained fasting glucose \u2265126 mg\/dL (OR, 1.66; 95% CI, 1.60 to 1.73), creatinine elevation in \u22652 periods (OR, 1.08; 95% CI, 1.06 to 1.10), and proteinuria progression (OR, 1.36; 95% CI, 1.32 to 1.39). In the P3-only model, all single-time-point indicators were associated with incident stroke (ORs, 1.08 to 1.47).Conclusions: Multi-year patterns in metabolic screening indicators were associated with incident ischemic stroke. Repeated health screening measurements may complement single time-point assessments and support continuous risk-factor monitoring and patient-centered prevention.<\/jats:p>","DOI":"10.3961\/jpmph.25.810","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T08:10:51Z","timestamp":1780042251000},"page":"318-327","update-policy":"https:\/\/doi.org\/10.3961\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Repeated Health Screening Measures and Incident Ischemic Stroke: Evidence From a Korean Population Study"],"prefix":"10.3961","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6252-2013","authenticated-orcid":true,"given":"Inhyeok","family":"Yim","sequence":"first","affiliation":[{"name":"Department of Family Medicine, Kangwon National University Hospital, Kangwon National University School of Medicine, Chuncheon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0245-3583","authenticated-orcid":true,"given":"Heui Sug","family":"Jo","sequence":"additional","affiliation":[{"name":"Department of Health Policy and Management, Kangwon National University School of Medicine, Chuncheon, Korea"},{"name":"Department of Preventive  Medicine, Kangwon National University Hospital, Chuncheon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4253-7522","authenticated-orcid":true,"given":"Seongheon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Kangwon National University Hospital, Kangwon  National University School of Medicine, Chuncheon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0415-1538","authenticated-orcid":true,"given":"Su Kyoung","family":"Kim","sequence":"additional","affiliation":[{"name":"Institute of Medical Science, Kangwon National University, Chuncheon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5052-2232","authenticated-orcid":true,"given":"Gyoung-Min","family":"Lee","sequence":"additional","affiliation":[{"name":"Research Institute for Healthcare Policy, Dankook University, Cheonan, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8934-3533","authenticated-orcid":true,"given":"Yu Seong","family":"Hwang","sequence":"additional","affiliation":[{"name":"Institute of Medical Science, Kangwon National University, Chuncheon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2350","reference":[{"key":"ref1","volume-title":"Ischemic 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