{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T09:11:31Z","timestamp":1775121091724,"version":"3.50.1"},"reference-count":6,"publisher":"CLOCKSS Archive","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HETEROCYCLES"],"published-print":{"date-parts":[[2001]]},"DOI":"10.3987\/com-00-9115","type":"journal-article","created":{"date-parts":[[2009,3,9]],"date-time":"2009-03-09T04:44:44Z","timestamp":1236573884000},"page":"435","source":"Crossref","is-referenced-by-count":10,"title":["Novel Synthesis of Pyrrolo[2,1-a]isoquinoline Using the Reaction of Isoquinolinium Salts with Active Methylene Compounds"],"prefix":"10.13030","volume":"55","author":[{"given":"Reiko","family":"Fujita","sequence":"first","affiliation":[]},{"given":"Noriyuki","family":"Watanabe","sequence":"additional","affiliation":[]},{"given":"Hiroshi","family":"Tomisawa","sequence":"additional","affiliation":[]}],"member":"5187","reference":[{"key":"10.3987\/COM-00-9115-1","doi-asserted-by":"crossref","unstructured":"1. M. Iwao, and T. Kuraishi, Bull. Chem. Soc. Jpn., 1980, 53, 297 ; Review for synthesis of pyrrolo[2,1-a]isoquinolines : T. Uchida, and K. Matsumoto, Synthesis, 1976, 209.","DOI":"10.1246\/bcsj.53.297"},{"key":"10.3987\/COM-00-9115-2","doi-asserted-by":"crossref","unstructured":"2. F. Ishibashi, Y. Miyazaki, and M. Iwao, Tetrahedron, 1997, 53, 5951; N. Lindquist, W. Fenical, G. D. Van Duyne, and J. Clardy, J. Org. Chem., 1988, 53, 4570; A. R. Carroll, B. F. Bowden, and J. C. Coll, Aust. J. Chem., 1993, 46, 489.","DOI":"10.1016\/S0040-4020(97)00287-1"},{"key":"10.3987\/COM-00-9115-3","unstructured":"3. V. Boekelheide, and J. C. Godfrey, J. Am. Chem. Soc., 1953, 75, 3679."},{"key":"10.3987\/COM-00-9115-4","doi-asserted-by":"crossref","unstructured":"4. R. Husgen, R. Grashey, and E. Steingruber, Tetrahedron Lett., 1963, 1441; Y. Kobayashi, I. Kumadaki, Y. Sekine, and T. Kutsuma, Chem. Pharm. Bull., 1973, 21, 1118; N. S. Basketter, and A. O. Plunkett, J. Chem. Soc., Chem. Comm., 1973, 188.","DOI":"10.1016\/S0040-4039(01)90848-2"},{"key":"10.3987\/COM-00-9115-5","unstructured":"5. F. Krohnke, and W. Zecher, Chem. Ber., 1962, 95, 1128."},{"key":"10.3987\/COM-00-9115-6","unstructured":"6. Representative data for 8a : yellow crystalline powder, mp 237-239 \u00b0C; IR (Nujol): 1720, 1600 cm-1; 1H-NMR (CDCl3)\u03b4 3.56 (s, 6H), 4.15 ( s, 3H), 7.50-8.00 ( m, 5H), 8.35-8.60 (m, 1H); m\/z: 273 (M+); Anal. Calcd for C15H12NO4 : C; 65.92; N, 5.13; H, 5.53. Found: C, 65.66; N, 5.40; H, 5.27. 9a: red plates, mp 239 \u00b0C; IR (Nujol): 1701, 1595, 758; 1H-NMR (CDCl3)\u03b4 3.63 (s, 6H), 5.72 ( s, 2H ), 7.25 (dd, J =2.0, 6.6 Hz, 2H), 7.23 (s, 5H), 7.32-7.39 (m, 3H), 7.58 (d, J =7.0 Hz, 1H), 7.72-7.88 (m, 4H), 8.60 (d, J= 8.2 Hz, 1H); MS m\/z: 349 (M+); Anal. Calcd for C21H19NO4 : C; 72.19; N, 4.01; H, 5.48. Found: C,72.49; N, 3.80; H, 5.61. 10a: yellow needles, mp 165-166 \u00b0C; 1H-NMR (CDCl3)\u03b4 2.25 (s, 3H), 3.95 ( s, 3H), 6.93 (d, J =7.4 Hz, 1H), 7.45-7.60 (m, 8H); MS m\/z: 359 (M+); Anal. Calcd for C22H17NO4 : 359.1158. Found: 359.1187. 12b: yellow crystalline powder, mp 219-222 \u00b0C; IR (Nujol): 3187, 3136, 2217, 1665, 1609 cm-1; 1H-NMR (CDCl3)\u03b4 6.98 (d, J =7.3 Hz, 1H), 7.55-7.71 (m, 8H), 7.93 ( d, J =7.3 Hz, 1H), 8.92-8.94 (m, 1H); MS m\/z: 312 (M+); Anal. Calcd for C15H12NO4 : 312.0899. Found: 312.0862."}],"container-title":["HETEROCYCLES"],"original-title":[],"language":"en","deposited":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T20:31:29Z","timestamp":1719261089000},"score":1,"resource":{"primary":{"URL":"https:\/\/triggered.stanford.clockss.org\/ServeContent?doi=10.3987%2Fcom-00-9115"},"secondary":[{"URL":"https:\/\/triggered.edinburgh.clockss.org\/ServeContent?doi=10.3987%2Fcom-00-9115","label":"edinburgh"}]},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001]]},"references-count":6,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2001]]}},"alternative-id":["COM-00-9115"],"URL":"https:\/\/doi.org\/10.3987\/com-00-9115","relation":{},"ISSN":["0385-5414"],"issn-type":[{"value":"0385-5414","type":"print"}],"subject":[],"published":{"date-parts":[[2001]]}}}