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Soc., 2001, 123, 7727.","DOI":"10.1021\/ja016226z"},{"key":"10.3987\/COM-05-10493-20","doi-asserted-by":"crossref","unstructured":"20. M. C. Harris, X. Huang, and S. L. Buchwald, Org. Lett., 2002, 4, 2885.","DOI":"10.1021\/ol0262688"},{"key":"10.3987\/COM-05-10493-21","unstructured":"21. E. J. Jr. Cragoe, US Patent 3360517 (Chem. Abstr., 1968, 69, 2564)."},{"key":"10.3987\/COM-05-10493-22","doi-asserted-by":"crossref","unstructured":"22. Y. Tamura, J. H. Kim, and M. Ikeda, J. Hetereocycl. Chem., 1975, 12, 107.","DOI":"10.1002\/jhet.5570120118"},{"key":"10.3987\/COM-05-10493-23","unstructured":"23. Detailed description for membrane preparation and radioligand binding assay has been reported."},{"key":"10.3987\/COM-05-10493-24","unstructured":"24. All proton and 13C magnetic resonance spectra were determined in the indicated solvent using a 300 MHz Bruker NMR spectrometer with the appropriate internal standard. HRMS spectra were obtained on a MALDI-TOF MS (Voyager-DE STR, Perseptive Biosystems) in the reflector mode with delayed extraction and an accelerating voltage of 20 kV. Preparative HPLC was carried out using a Gilson platform equipped with UV\/VIS detector and an automatic fraction collector. The data for target compound (12) is included as an example: white amorphous powder, 1H NMR (300 MHz, CDCl3) \u03b4 2.66 (t, J = 4.5 Hz, 4H), 3.34 (t, J = 4.5 Hz, 4H), 3.73 (s, 2H), 5.61 (s, 2H), 6.54 (dd, J = 1.8, 3.6 Hz, 1H), 6.67 (d, J = 7.8 Hz, 1H), 6.70 (d, J = 7.8 Hz, 1H), 7.07 (d, J = 3.6 Hz, 1H), 7.26 (s, 1H), 7.57 (d, J = 1.8 Hz, 1H); 13C NMR (100 MHz, CDCl3) \u03b4 46.5, 48.4, 51.5, 95.6, 99.8, 100.1, 100.3, 110.2, 111.7, 134.8, 143.8, 146.0, 146.4, 149.0, 155.1; HRMS calculated for C20H18N7OF3 (M+ + H) 429.1525, found 429.1531; Anal. Calcd for C20H18N7OF3: C, 55.94; H, 4.23; N, 22.83. Found: C, 55.60, H, 4.28, N, 23.00."},{"key":"10.3987\/COM-05-10493-25","unstructured":"25. To address the problem of acidic protons in the Pd-catalyzed coupling reaction of compound (4), we chose Buchwald\u2019s conditions using LHMDS as the base, which was proposed to protect the deprotonated species in situ as lithiate\/aggregate, to prevent deactivation of the Pd catalyst. We were delighted to observe a clean reaction potentially forming the desired product as monitored by LC-MS spectrum. However, the crude product decomposed into baseline material during work-up (Table 1, Entry 9). So far, we haven\u2019t been able to figure out the underlining problem."},{"key":"10.3987\/COM-05-10493-26","unstructured":"26. 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