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Tehrani, and N. de Kimpe, Tetrahedron, 2001, 57, 2051.","DOI":"10.1016\/S0040-4020(01)00024-2"},{"key":"#cr-split#-10.3987\/COM-08-11434-5.9","doi-asserted-by":"crossref","unstructured":"(i) B. Jiang, W. Xiong, X. Zhang, and F. Zhang, Org. Proc. Res. Dev., 2001, 5, 531.","DOI":"10.1021\/op000109r"},{"key":"#cr-split#-10.3987\/COM-08-11434-6.1","unstructured":"(a) X.-L. Qiu and F.-L.Qing, Synthesis, 2004, 334."},{"key":"#cr-split#-10.3987\/COM-08-11434-6.2","doi-asserted-by":"crossref","unstructured":"(b) T. Mori and J. Ichikawa, Chem. Lett., 2004, 1206.","DOI":"10.1246\/cl.2004.1206"},{"key":"#cr-split#-10.3987\/COM-08-11434-6.3","unstructured":"(c) H.-L. Elbe, H. Rieck, R. Dunkel, U. Wachendorff-Neumann, K.-H. Kuck, A. Mauler-Machnik, M. Kugler, T. Jaetsch, and P. Wachtler, US Pat., 2005, 0124815."},{"key":"10.3987\/COM-08-11434-7","unstructured":"7. An appropriate method was reported for the synthesis of 2-difluoromethyl-6- trifluoromethylpyridines. See L. F. Lee, G. L. Stikes, J. M. Molyneaux,; Y. L. Sing, J. P. Chupp, and S. S. Woodard, J. Org. Chem., 1990, 55, 2872. However, this method is not suitable for the preparation of 2-alkyl-6-difluoromethylpyridines such as 4; it led to a considerable decrease in the yield since the reaction was sluggish and required higher reaction temperature (110-150 \u00b0C)."},{"key":"10.3987\/COM-08-11434-8","doi-asserted-by":"crossref","unstructured":"8. W. J. Middleton, J. Org. Chem., 1975, 40, 574.","DOI":"10.1021\/jo00893a007"},{"key":"10.3987\/COM-08-11434-9","doi-asserted-by":"crossref","unstructured":"9. G. S. Lal, G. P. Pez, F. M. Pesaresi, and H. Cheng, J. Org. Chem., 1999, 64, 7048.","DOI":"10.1021\/jo990566+"},{"key":"10.3987\/COM-08-11434-10","doi-asserted-by":"crossref","unstructured":"10. H. Hayashi, H. Sonoda, K. Fukumura, and T. Nagata, J. Chem. Soc., Chem. Commun., 2002, 1618.","DOI":"10.1039\/b204471d"},{"key":"10.3987\/COM-08-11434-11","doi-asserted-by":"crossref","unstructured":"11. S. Kobayashi, A. Yoneda, T. Fukuhara, and S. Hara, Tetrahedron, 2004, 60, 6923.","DOI":"10.1016\/j.tet.2004.05.089"},{"key":"10.3987\/COM-08-11434-12","doi-asserted-by":"crossref","unstructured":"12. T. Furuya, T. Fukuhara, and S. Hara, J. Fluorine Chem., 2005, 126, 721.","DOI":"10.1016\/j.jfluchem.2005.02.004"},{"key":"10.3987\/COM-08-11434-13","unstructured":"13. It has been reported that CF3 groups attached to aromatic rings can be reduced under specific conditions. See K. Fuchibe, and T. Akiyama, J. Am. Chem. Soc., 2006, 128, 1434 and references therein. Although the reported methods are effective for their objectives, they do not seem to be applicable to selective synthesis of CHF2-aromatic compounds bearing sensitive functional groups."},{"key":"#cr-split#-10.3987\/COM-08-11434-14.1","doi-asserted-by":"crossref","unstructured":"(a) I. Katsuyama, K. Funabiki, M. Matsui, H. Muramatsu, and K. 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