{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:59:08Z","timestamp":1790881148434,"version":"4.1.0"},"reference-count":50,"publisher":"XMLink","issue":"6","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"name":"Institute of Information & Communications Technology Planning & Evaluation (IITP)","award":["RS-2022-II220621"],"award-info":[{"award-number":["RS-2022-II220621"]}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["RS-2023-00262087"],"award-info":[{"award-number":["RS-2023-00262087"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["RS-2023-00265497"],"award-info":[{"award-number":["RS-2023-00265497"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"name":"BK21 FOUR Program (Fostering Outstanding Universities for Research)","award":["NRF-5199990614253"],"award-info":[{"award-number":["NRF-5199990614253"]}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2025-16067160"],"award-info":[{"award-number":["RS-2025-16067160"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["thejcn.com"],"crossmark-restriction":false},"short-container-title":["J Clin Neurol"],"published-print":{"date-parts":[[2025]]},"DOI":"10.3988\/jcn.2025.0317","type":"journal-article","created":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T07:50:27Z","timestamp":1761551427000},"page":"514","update-policy":"https:\/\/doi.org\/10.3988\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Association of Clopidogrel Genetic Polymorphism With Efficacy and Safety for Ischemic Stroke or Transient Ischemic Attack: A Systematic Review and Updated Meta-Analysis"],"prefix":"10.3988","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6112-2939","authenticated-orcid":false,"given":"Hyungjong","family":"Park","sequence":"first","affiliation":[{"name":"Department of Neurology, Keimyung University School of Medicine, Daegu, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3048-4718","authenticated-orcid":false,"given":"Yo Han","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Neurology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea."},{"name":"Severance Institute for Vascular and Metabolic Research, Yonsei University College of Medicine, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4753-4491","authenticated-orcid":false,"given":"Sooyeoun","family":"You","sequence":"additional","affiliation":[{"name":"Department of Neurology, Seoul Medical Center, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8884-4114","authenticated-orcid":false,"given":"Jaeseob","family":"Yun","sequence":"additional","affiliation":[{"name":"Department of Neurology, Keimyung University School of Medicine, Daegu, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9796-8266","authenticated-orcid":false,"given":"Yun Hak","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Anatomy, School of Medicine, Pusan National University, Yangsan, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0345-2278","authenticated-orcid":false,"given":"Yoonkyung","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ewha Womans University Mokdong Hospital, Ewha Womans University College of Medicine, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2779-095X","authenticated-orcid":false,"given":"Moo-Seok","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ewha Womans University Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9937-762X","authenticated-orcid":false,"given":"Tae-Jin","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ewha Womans University Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Korea."},{"name":"Graduate Program in System Health Science and Engineering, Ewha Womans University, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5585-7739","authenticated-orcid":false,"given":"Kyung-Yul","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea."},{"name":"Severance Institute for Vascular and Metabolic Research, Yonsei University College of Medicine, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"18617","reference":[{"key":"10.3988\/jcn.2025.0317_ref1","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.jcin.2023.01.363","volume":"16","author":"Lee","year":"2023","journal-title":"JACC cardiovasc interv"},{"key":"10.3988\/jcn.2025.0317_ref2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1056\/NEJMoa1215340","volume":"369","author":"Wang","year":"2013","journal-title":"N Engl J Med"},{"key":"10.3988\/jcn.2025.0317_ref3","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/ane.12111","volume":"128","author":"Mijajlovic","year":"2013","journal-title":"Acta Neurol Scand"},{"key":"10.3988\/jcn.2025.0317_ref4","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.jacc.2009.12.071","volume":"56","author":"Hulot","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"10.3988\/jcn.2025.0317_ref5","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1056\/NEJMoa0808227","volume":"360","author":"Simon","year":"2009","journal-title":"N Engl J Med"},{"key":"10.3988\/jcn.2025.0317_ref6","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1002\/cpt.2526","volume":"112","author":"Lee","year":"2022","journal-title":"Clin Pharmacol Ther"},{"key":"10.3988\/jcn.2025.0317_ref7","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1586\/ern.10.203","volume":"11","author":"Top\u00e7uoglu","year":"2011","journal-title":"Expert Rev Neurother"},{"key":"10.3988\/jcn.2025.0317_ref8","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1001\/jama.2016.8662","volume":"316","author":"Wang","year":"2016","journal-title":"JAMA"},{"key":"10.3988\/jcn.2025.0317_ref9","doi-asserted-by":"crossref","first-page":"e001652","DOI":"10.1161\/JAHA.114.001652","volume":"4","author":"McDonough","year":"2015","journal-title":"J Am Heart Assoc"},{"key":"10.3988\/jcn.2025.0317_ref10","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1161\/CIRCULATIONAHA.116.024913","volume":"135","author":"Pan","year":"2017","journal-title":"Circulation"},{"key":"10.3988\/jcn.2025.0317_ref11","doi-asserted-by":"crossref","first-page":"e250398","DOI":"10.1001\/jamanetworkopen.2025.0398","volume":"8","author":"Jung","year":"2025","journal-title":"JAMA Netw Open"},{"key":"10.3988\/jcn.2025.0317_ref12","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"10.3988\/jcn.2025.0317_ref13","doi-asserted-by":"crossref","DOI":"10.1002\/9781119536604","volume-title":"Cochrane handbook for systematic reviews of interventions","author":"Higgins","year":"2019","edition":"2"},{"key":"10.3988\/jcn.2025.0317_ref14","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1161\/CIRCULATIONAHA.110.009449","volume":"123","author":"Mehran","year":"2011","journal-title":"Circulation"},{"key":"10.3988\/jcn.2025.0317_ref15","doi-asserted-by":"crossref","first-page":"l4898","DOI":"10.1136\/bmj.l4898","volume":"366","author":"Sterne","year":"2019","journal-title":"BMJ"},{"key":"10.3988\/jcn.2025.0317_ref16","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jclinepi.2018.01.012","volume":"111","author":"Sch\u00fcnemann","year":"2019","journal-title":"J Clin Epidemiol"},{"key":"10.3988\/jcn.2025.0317_ref17","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1136\/bmj.39489.470347.AD","volume":"336","author":"Guyatt","year":"2008","journal-title":"BMJ"},{"key":"10.3988\/jcn.2025.0317_ref18","doi-asserted-by":"crossref","first-page":"l5342","DOI":"10.1136\/bmj.l5342","volume":"367","author":"Seidler","year":"2019","journal-title":"BMJ"},{"key":"10.3988\/jcn.2025.0317_ref19","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1471-2288-14-25","volume":"14","author":"IntHout","year":"2014","journal-title":"BMC Med Res Methodol"},{"key":"10.3988\/jcn.2025.0317_ref20","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1161\/STROKEAHA.113.000823","volume":"44","author":"Jia","year":"2013","journal-title":"Stroke"},{"key":"10.3988\/jcn.2025.0317_ref21","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/cns.12173","volume":"20","author":"Lin","year":"2014","journal-title":"CNS Neurosci Ther"},{"key":"10.3988\/jcn.2025.0317_ref22","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.jstrokecerebrovasdis.2013.06.008","volume":"23","author":"Spokoyny","year":"2014","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"10.3988\/jcn.2025.0317_ref23","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1016\/j.thromres.2014.10.001","volume":"134","author":"Zhang","year":"2014","journal-title":"Thromb Res"},{"key":"10.3988\/jcn.2025.0317_ref24","first-page":"871","volume":"32","author":"Fang","year":"2015","journal-title":"Zhonghua Yi Xue Yi Chuan Xue Za Zhi"},{"key":"10.3988\/jcn.2025.0317_ref25","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1111\/cns.12426","volume":"21","author":"Han","year":"2015","journal-title":"CNS Neurosci Ther"},{"key":"10.3988\/jcn.2025.0317_ref26","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.jstrokecerebrovasdis.2014.09.014","volume":"24","author":"Jeong","year":"2015","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"10.3988\/jcn.2025.0317_ref27","doi-asserted-by":"crossref","first-page":"558","DOI":"10.3109\/09537104.2014.953044","volume":"26","author":"Sun","year":"2015","journal-title":"Platelets"},{"key":"10.3988\/jcn.2025.0317_ref28","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ejphar.2014.11.037","volume":"747","author":"Qiu","year":"2015","journal-title":"Eur J Pharmacol"},{"key":"10.3988\/jcn.2025.0317_ref29","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.3171\/2015.6.JNS15795","volume":"124","author":"Hoh","year":"2016","journal-title":"J Neurosurg"},{"key":"10.3988\/jcn.2025.0317_ref30","doi-asserted-by":"crossref","first-page":"e0148891","DOI":"10.1371\/journal.pone.0148891","volume":"11","author":"Li","year":"2016","journal-title":"PLoS One"},{"key":"10.3988\/jcn.2025.0317_ref31","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.5551\/jat.33290","volume":"23","author":"Yi","year":"2016","journal-title":"J Atheroscler Thromb"},{"key":"10.3988\/jcn.2025.0317_ref32","doi-asserted-by":"crossref","first-page":"25478","DOI":"10.1038\/srep25478","volume":"6","author":"Zhu","year":"2016","journal-title":"Sci Rep"},{"key":"10.3988\/jcn.2025.0317_ref33","doi-asserted-by":"crossref","first-page":"356","DOI":"10.5853\/jos.2017.01249","volume":"19","author":"Han","year":"2017","journal-title":"J Stroke"},{"key":"10.3988\/jcn.2025.0317_ref34","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1007\/s00228-018-2468-7","volume":"74","author":"Lin","year":"2018","journal-title":"Eur J Clin Pharmacol"},{"key":"10.3988\/jcn.2025.0317_ref35","doi-asserted-by":"crossref","first-page":"e202","DOI":"10.1097\/MJT.0000000000000416","volume":"25","author":"Tomek","year":"2018","journal-title":"Am J Ther"},{"key":"10.3988\/jcn.2025.0317_ref36","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1253\/circj.CJ-18-1386","volume":"83","author":"Tanaka","year":"2019","journal-title":"Circ J"},{"key":"10.3988\/jcn.2025.0317_ref37","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/cpt.780","volume":"103","author":"Tornio","year":"2018","journal-title":"Clin Pharmacol Ther"},{"key":"10.3988\/jcn.2025.0317_ref38","doi-asserted-by":"crossref","first-page":"l2211","DOI":"10.1136\/bmj.l2211","volume":"365","author":"Wang","year":"2019","journal-title":"BMJ"},{"key":"10.3988\/jcn.2025.0317_ref39","doi-asserted-by":"crossref","first-page":"e19143","DOI":"10.1097\/MD.0000000000019143","volume":"99","author":"Liu","year":"2020","journal-title":"Medicine (Baltimore)"},{"key":"10.3988\/jcn.2025.0317_ref40","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1161\/STROKEAHA.119.028713","volume":"51","author":"Meschia","year":"2020","journal-title":"Stroke"},{"key":"10.3988\/jcn.2025.0317_ref41","doi-asserted-by":"crossref","first-page":"12171","DOI":"10.21037\/apm-21-2905","volume":"10","author":"Lin","year":"2021","journal-title":"Ann Palliat Med"},{"key":"10.3988\/jcn.2025.0317_ref42","doi-asserted-by":"crossref","first-page":"3994","DOI":"10.18632\/aging.202366","volume":"13","author":"Zhou","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"10.3988\/jcn.2025.0317_ref43","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1515\/dmpt-2021-0104","volume":"37","author":"Al-Rubaish","year":"2022","journal-title":"Drug Metab Pers Ther"},{"key":"10.3988\/jcn.2025.0317_ref44","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s12975-021-00949-7","volume":"13","author":"Lv","year":"2022","journal-title":"Transl Stroke Res"},{"key":"10.3988\/jcn.2025.0317_ref45","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1001\/jamaneurol.2018.4775","volume":"76","author":"Pan","year":"2019","journal-title":"JAMA Neurol"},{"key":"10.3988\/jcn.2025.0317_ref46","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1186\/s12883-024-03723-y","volume":"24","author":"Hidayat","year":"2024","journal-title":"BMC Neurol"},{"key":"10.3988\/jcn.2025.0317_ref47","first-page":"3190","volume":"10","author":"Ni","year":"2017","journal-title":"Int J Clin Exp Med"},{"key":"10.3988\/jcn.2025.0317_ref48","doi-asserted-by":"crossref","first-page":"2704","DOI":"10.1001\/jama.2011.1880","volume":"306","author":"Holmes","year":"2011","journal-title":"JAMA"},{"key":"10.3988\/jcn.2025.0317_ref49","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/gim.2014.76","volume":"17","author":"Osnabrugge","year":"2015","journal-title":"Genet Med"},{"key":"10.3988\/jcn.2025.0317_ref50","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1056\/NEJMoa2111749","volume":"385","author":"Wang","year":"2021","journal-title":"N Engl J Med"}],"container-title":["Journal of Clinical Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/thejcn.com\/pdf\/10.3988\/jcn.2025.0317","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejcn.com\/DOIx.php?id=10.3988\/jcn.2025.0317","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejcn.com\/DOIx.php?id=10.3988\/jcn.2025.0317","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T07:56:47Z","timestamp":1761551807000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejcn.com\/DOIx.php?id=10.3988\/jcn.2025.0317"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":50,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.3988\/jcn.2025.0317","relation":{},"ISSN":["1738-6586","2005-5013"],"issn-type":[{"value":"1738-6586","type":"print"},{"value":"2005-5013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]},"assertion":[{"value":"2025-06-13","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-18","name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-08","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-20","name":"published_online","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"Copyright \u00a9 2025 Korean Neurological Association","name":"copyright","label":"Copyright","group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https:\/\/creativecommons.org\/licenses\/by-nc\/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.","name":"license","label":"License","explanation":{"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},"group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}}]}}