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The science and practice of caries prevention. J Am Dent Assoc 2000; 131: 887-899.","DOI":"10.14219\/jada.archive.2000.0307"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Xu J, Shi H, Luo J, Yao H, Wang P, Li Z, <i>et al<\/i>. Advanced materials for enamel remineralization. Front Bioeng Biotechnol 2022; 10: 985881.","DOI":"10.3389\/fbioe.2022.985881"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) O\u2019Hagan-Wong K, Enax J, Meyer F, Ganss B. The use of hydroxyapatite toothpaste to prevent dental caries. Odontology 2022; 110: 223-230.","DOI":"10.1007\/s10266-021-00675-4"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Ten Cate JM, Featherstone JD. Mechanistic aspects of the interactions between fluoride and dental enamel. Crit Rev Oral Biol Med 1991; 2: 283-296.","DOI":"10.1177\/10454411910020030101"},{"key":"5","unstructured":"5) Grigalauskien\u0117 R, Slab\u0161inskien\u0117 E, Vasiliauskien\u0117 I. Biological approach of dental caries management. Stomatologija 2015; 17: 107-112."},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Morris AJ, O Connor R, Holmes R, Landes D, Shah K, Tanday A, <i>et al<\/i>. Dental fluorosis. Br Dent J 2022; 232: 492.","DOI":"10.1038\/s41415-022-4210-1"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Lin Y, Chen J, Zhou X, Li Y. Inhibition of Streptococcus mutans biofilm formation by strategies targeting the metabolism of exopolysaccharides. Crit Rev Microbiol 2021; 47: 667-677.","DOI":"10.1080\/1040841X.2021.1915959"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) O-Chongpian P, Chaiwarit T, Jantanasakulwong K, Rachtanapun P, Worajittiphon P, Kantrong N, <i>et al<\/i>. Surface-modified carboxylated cellulose nanofiber hydrogels for prolonged release of polyhexamethylene biguanide hydrochloride (PHMB) for antimicrobial applications. Polymers (Basel) 2023; 15: 3572.","DOI":"10.3390\/polym15173572"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Ramasamy S, Muthusamy S, Nagarajan S, Nath AV, Savarimuthu JS, Jayaprakash J, <i>et al<\/i>. Fabrication of collagen with polyhexamethylene biguanide: A potential scaffold for infected wounds. J Biomed Mater Res B 2022; 110: 535-546.","DOI":"10.1002\/jbm.b.34933"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Medvedec Miki\u0107 I, Cigi\u0107 L, Kero D, Kalibovi\u0107 Govorko D, Prpi\u0107 Mehi\u010di\u0107 G, Tambi\u0107 Andra\u0161evi\u0107 A, <i>et al<\/i>. Antimicrobial effectiveness of polyhexamethylene biguanide on Enterococcus faecalis, Staphylococcus epidermidis and Candida albicans. Med Glas (Zenica) 2018; 15: 132-138.","DOI":"10.17392\/959-18"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Rosin M, Welk A, Bernhardt O, Ruhnau M, Pitten FA, Kocher T, <i>et al<\/i>. Effect of a polyhexamethylene biguanide mouthrinse on bacterial counts and plaque. J Clin Periodontol 2001; 28: 1121-1126.","DOI":"10.1034\/j.1600-051X.2001.281206.x"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Rosin M, Welk A, Kocher T, Majic-Todt A, Kramer A, Pitten FA. The effect of a polyhexamethylene biguanide mouthrinse compared to an essential oil rinse and a chlorhexidine rinse on bacterial counts and 4-day plaque regrowth. J Clin Periodontol 2002; 29: 392-399.","DOI":"10.1034\/j.1600-051X.2002.290503.x"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Rohrer N, Widmer AF, Waltimo T, Kulik EM, Weiger R, Filipuzzi-Jenny E, <i>et al<\/i>. Antimicrobial efficacy of 3 oral antiseptics containing octenidine, polyhexamethylene biguanide, or Citroxx: Can chlorhexidine be replaced? Infect Control Hosp Epidemiol 2010; 31: 733-739.","DOI":"10.1086\/653822"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Uzer Celik E, Tunac AT, Ates M, Sen BH. Antimicrobial activity of different disinfectants against cariogenic microorganisms. Braz Oral Res 2016; 30: e125.","DOI":"10.1590\/1807-3107bor-2016.vol30.0125"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Chen YD, Shu C, Duan ZH, Xu JJ, Li XJ, Chen F, <i>et al<\/i>. Synthesis and characterization of an anti-caries and remineralizing fluorine-containing cationic polymer PHMB-F. Biomater Sci 2021; 9: 2009-2019.","DOI":"10.1039\/D0BM01627F"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Zhu K, Zheng L, Xing J, Chen S, Chen R, Ren L. Mechanical, antibacterial, biocompatible and microleakage evaluation of glass ionomer cement modified by nanohydroxyapatite\/polyhexamethylene biguanide. Dent Mater J 2022; 41: 197-208.","DOI":"10.4012\/dmj.2021-096"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Jones N, Ray B, Ranjit KT, Manna AC. Antibacterial activity of ZnO nanoparticle suspensions on a broad spectrum of microorganisms. FEMS Microbiol Lett 2008; 279: 71-76.","DOI":"10.1111\/j.1574-6968.2007.01012.x"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Mitwalli H, Balhaddad AA, AlSahafi R, Oates TW, Melo MA, Xu HH, <i>et al<\/i>. Novel CaF<sub>2<\/sub> nanocomposites with antibacterial function and fluoride and calcium ion release to inhibit oral biofilm and protect teeth. J Funct Biomater 2020; 11: 56.","DOI":"10.3390\/jfb11030056"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Wang D, Deng J, Deng X, Fang C, Zhang X, Yang P. Controlling enamel remineralization by amyloid-like amelogenin mimics. Adv Mater 2020; 32: e2002080.","DOI":"10.1002\/adma.202002080"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Yang X, Wang L, Qin Y, Sun Z, Henneman ZJ, Moradian-Oldak J, <i>et al<\/i>. How amelogenin orchestrates the organization of hierarchical elongated microstructures of apatite. J Phys Chem B 2010; 114: 2293-2300.","DOI":"10.1021\/jp910219s"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Dey A, Bomans PH, M\u00fcller FA, Will J, Frederik PM, de With G, <i>et al<\/i>. The role of prenucleation clusters in surface-induced calcium phosphate crystallization. Nat Mater 2010; 9: 1010-1014.","DOI":"10.1038\/nmat2900"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Bartlett DW, Lussi A, West NX, Bouchard P, Sanz M, Bourgeois D. Prevalence of tooth wear on buccal and lingual surfaces and possible risk factors in young European adults. J Dent 2013; 41: 1007-1013.","DOI":"10.1016\/j.jdent.2013.08.018"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Pratap B, Gupta RK, Bhardwaj B, Nag M. Resin based restorative dental materials: Characteristics and future perspectives. 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PLoS One 2015; 10: e0116553.","DOI":"10.1371\/journal.pone.0116553"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Xiao Z, Que K, Wang H, An R, Chen Z, Qiu Z, <i>et al<\/i>. Rapid biomimetic remineralization of the demineralized enamel surface using nano-particles of amorphous calcium phosphate guided by chimaeric peptides. Dent Mater 2017; 33: 1217-1228.","DOI":"10.1016\/j.dental.2017.07.015"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Wang R, Guo J, Lin X, Chen S, Mai S. Influence of molecular weight and concentration of carboxymethyl chitosan on biomimetic mineralization of collagen. RSC Adv 2020; 10: 12970-12981.","DOI":"10.1039\/D0RA00999G"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Song J, Wang H, Yang Y, Xiao Z, Lin H, Jin L, <i>et al<\/i>. Nanogels of carboxymethyl chitosan and lysozyme encapsulated amorphous calcium phosphate to occlude dentinal tubules. J Mater Sci Mater Med 2018; 29: 84.","DOI":"10.1007\/s10856-018-6094-9"},{"key":"30","unstructured":"30) Chu JP, Li JY, Hao YQ, Zhou XD. Effect of chemical compounds of Galla chinensis on enamel surface rehardening in vitro. Zhonghua Kou Qiang Yi Xue Za Zhi 2006; 41: 616-617."},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Pitts NB, Zero DT, Marsh PD, Ekstrand K, Weintraub JA, Ramos-Gomez F, <i>et al<\/i>. Dental caries. Nat Rev Dis Primers 2017; 3: 17030.","DOI":"10.1038\/nrdp.2017.30"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Wang YL, Zhou YN, Li XY, Huang J, Wahid F, Zhong C, <i>et al<\/i>. Continuous production of antibacterial carboxymethyl chitosan-zinc supramolecular hydrogel fiber using a double-syringe injection device. Int J Biol Macromol 2020; 156: 252-261.","DOI":"10.1016\/j.ijbiomac.2020.04.073"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Borges J, Mano JF. Molecular interactions driving the layer-by-layer assembly of multilayers. Chem Rev 2014; 114: 8883-8942.","DOI":"10.1021\/cr400531v"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Hosseinpour-Moghadam R, Mehryab F, Torshabi M, Haeri A. Applications of novel and nanostructured drug delivery systems for the treatment of oral cavity diseases. Clin Ther 2021; 43: e377-e402.","DOI":"10.1016\/j.clinthera.2021.10.016"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Khan M, Sohail, Raja NI, Asad MJ, Mashwani ZU. Antioxidant and hypoglycemic potential of phytogenic cerium oxide nanoparticles. Sci Rep 2023; 13: 4514.","DOI":"10.1038\/s41598-023-31498-8"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36) Lacruz A, Salvador M, Blanco M, Vidal K, Goitandia AM, Martinkov\u00e1 L, <i>et al<\/i>. Biobased waterborne polyurethane-urea\/SWCNT nanocomposites for hydrophobic and electrically conductive textile coatings. Polymers (Basel) 2021; 13: 1624.","DOI":"10.3390\/polym13101624"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37) Welk A, Splieth CH, Schmidt-Martens G, Schwahn Ch, Kocher T, Kramer A, <i>et al<\/i>. The effect of a polyhexamethylene biguanide mouthrinse compared with a triclosan rinse and a chlorhexidine rinse on bacterial counts and 4-day plaque re-growth. J Clin Periodontol 2005; 32: 499-505.","DOI":"10.1111\/j.1600-051X.2005.00702.x"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38) He J, Bao Y, Li J, Qiu Z, Liu Y, Zhang X. Nanocomplexes of carboxymethyl chitosan\/amorphous calcium phosphate reduce oral bacteria adherence and biofilm formation on human enamel surface. J Dent 2019; 80: 15-22.","DOI":"10.1016\/j.jdent.2018.11.003"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39) Chen LY, Du YM, Huang RH. Novel pH, ion sensitive polyampholyte gels based on carboxymethyl chitosan and gelatin. Polym Int 2003; 52: 56-61.","DOI":"10.1002\/pi.997"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40) Nimbeni BS, Nimbeni SB, Divakar DD, Samiullah M. Carboxymethyl chitosan-fluoride-doped amorphous calcium phosphate: A novel remineralizing gel. Int J Clin Pediatr Dent 2023; 16: 734-739.","DOI":"10.5005\/jp-journals-10005-2669"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41) C\u00f6lfen H, Mann S. Higher-order organization by mesoscale self-assembly and transformation of hybrid nanostructures. Angew Chem Int Ed 2003; 42: 2350-2365.","DOI":"10.1002\/anie.200200562"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42) Pan H, Tao J, Xu X, Tang R. Adsorption processes of Gly and Glu amino acids on hydroxyapatite surfaces at the atomic level. Langmuir 2007; 23: 8972-8981.","DOI":"10.1021\/la700567r"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43) Spoutil F, Vlcek V, Hor\u00e1cek I. Enamel microarchitecture of a tribosphenic molar. 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