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Minimally invasive therapies for the management of dental caries\u2014A literature review. Dent J (Basel) 2021; 9: 147.","DOI":"10.3390\/dj9120147"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Schwendicke F, Frencken JE, Bjorndal L, Maltz M, Manton DJ, Ricketts D, <i>et al.<\/i> Managing carious lesions: Consensus recommendations on carious tissue removal. Adv Dent Res 2016; 28: 58-67.","DOI":"10.1177\/0022034516639271"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Murdoch-Kinch CA, McLean ME. Minimally invasive dentistry. J Am Dent Assoc 2003; 134: 87-95.","DOI":"10.14219\/jada.archive.2003.0021"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Ogawa K, Yamashita Y, Ichijo T, Fusayama T. The ultrastructure and hardness of the transparent layer of human carious dentin. 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Physiological recalcification of carious dentin. Bull Tokyo Med Dent Univ 1978; 25: 169-179."},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Veis A, Dorvee JR. Biomineralization mechanisms: A new paradigm for crystal nucleation in organic matrices. Calcif Tissue Int 2013; 93: 307-315.","DOI":"10.1007\/s00223-012-9678-2"},{"key":"13","unstructured":"13) Marchi JJ, Froner AM, Alves HL, Bergmann CP, Araujo FB. Analysis of primary tooth dentin after indirect pulp capping. J Dent Child (Chic) 2008; 75: 295-300."},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Bertassoni LE, Habelitz S, Kinney JH, Marshall SJ, Marshall GW Jr. Biomechanical perspective on the remineralization of dentin. Caries Res 2009; 43: 70-77.","DOI":"10.1159\/000201593"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Kinney JH, Habelitz S, Marshall SJ, Marshall GW. The importance of intrafibrillar mineralization of collagen on the mechanical properties of dentin. J Dent Res 2003; 82: 957-961.","DOI":"10.1177\/154405910308201204"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Vilela HS, Vela BF, Campos AL, Trinca RB, Braga RR. Ion-releasing restorative materials and dentin remineralization: Current strategies and future perspectives. Dent Mater 2025; 41: 1251-1265.","DOI":"10.1016\/j.dental.2025.07.009"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Alania Y, Natale LC, Nesadal D, Vilela H, Magalhaes AC, Braga RR. In vitro remineralization of artificial enamel caries with resin composites containing calcium phosphate particles. J Biomed Mater Res B Appl Biomater 2019; 107: 1542-1550.","DOI":"10.1002\/jbm.b.34246"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Braga RR. Calcium phosphates as ion-releasing fillers in restorative resin-based materials. Dent Mater 2019; 35: 3-14.","DOI":"10.1016\/j.dental.2018.08.288"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Campos AL, Chiari M, Vela BF, Trinca RB, de Souza Balbinot G, Collares FM, <i>et al.<\/i> Dentin remineralization induced by experimental composites containing calcium orthophosphate particles. Dent Mater 2024; 41: 265-271.","DOI":"10.1016\/j.dental.2024.12.004"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Chen WC, Chang KC, Wu HY, Ko CL, Huang CL. Thermal cycling effect of dicalcium phosphate-reinforced composites on auto-mineralized dental resin. Mater Sci Eng C Mater Biol Appl 2014; 45: 359-368.","DOI":"10.1016\/j.msec.2014.09.032"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Peters MC, Bresciani E, Barata TJ, Fagundes TC, Navarro RL, Navarro MF, <i>et al.<\/i> In vivo dentin remineralization by calcium-phosphate cement. 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Refractive index mismatch and monomer reactivity influence composite curing depth. J Dent Res 2008; 87: 84-88.","DOI":"10.1177\/154405910808700115"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38) Resende MCA, Vilela HS, Chiari MDS, Trinca RB, Silva FRO, Braga RR. Physicochemical characterization of experimental resin-based materials containing calcium orthophosphates or calcium silicate. Dent Mater 2024; 40: 1507-1514.","DOI":"10.1016\/j.dental.2024.07.002"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39) Rodrigues MC, Natale LC, Arana-Chaves VE, Braga RR. Calcium and phosphate release from resin-based materials containing different calcium orthophosphate nanoparticles. J Biomed Mater Res B Appl Biomater 2015; 103: 1670-1678.","DOI":"10.1002\/jbm.b.33327"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40) Xu HH, Weir MD, Sun L. Nanocomposites with Ca and PO<sub>4<\/sub> release: Effects of reinforcement, dicalcium phosphate particle size and silanization. Dent Mater 2007; 23: 1482-1491.","DOI":"10.1016\/j.dental.2007.01.002"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41) Alania Y, Chiari MD, Rodrigues MC, Arana-Chavez VE, Bressiani AH, Vichi FM, <i>et al.<\/i> Bioactive composites containing TEGDMA-functionalized calcium phosphate particles: Degree of conversion, fracture strength and ion release evaluation. Dent Mater 2016; 32: e374-e381.","DOI":"10.1016\/j.dental.2016.09.021"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42) Skrtic D, Hailer AW, Takagi S, Antonucci JM, Eanes ED. Quantitative assessment of the efficacy of amorphous calcium phosphate\/methacrylate composites in remineralizing caries-like lesions artificially produced in bovine enamel. 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Dent Mater 2009; 25: 535-542.","DOI":"10.1016\/j.dental.2008.10.009"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46) Bacino M, Girn V, Nurrohman H, Saeki K, Marshall SJ, Gower L, <i>et al.<\/i> Integrating the PILP-mineralization process into a restorative dental treatment. Dent Mater 2019; 35: 53-63.","DOI":"10.1016\/j.dental.2018.11.030"},{"key":"47","doi-asserted-by":"crossref","unstructured":"47) Burwell AK, Thula-Mata T, Gower LB, Habelitz S, Kurylo M, Ho SP, <i>et al.<\/i> Functional remineralization of dentin lesions using polymer-induced liquid-precursor process. PLoS One 2012; 7: e38852.","DOI":"10.1371\/journal.pone.0038852"},{"key":"48","doi-asserted-by":"crossref","unstructured":"48) Xu HH, Moreau JL. Dental glass-reinforced composite for caries inhibition: Calcium phosphate ion release and mechanical properties. 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