{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T12:19:01Z","timestamp":1784204341602,"version":"3.55.0"},"reference-count":27,"publisher":"Japanese Society for Dental Materials and Devices","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dent. Mater. J.","Dental Materials Journal"],"published-print":{"date-parts":[[2026,5,25]]},"DOI":"10.4012\/dmj.2025-317","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T22:08:45Z","timestamp":1775599725000},"page":"300-312","source":"Crossref","is-referenced-by-count":2,"title":["Borneol-grafted poly(amidoamine) dendrimer with dual antimicrobial and enamel-remineralizing activities against early-stage dental caries"],"prefix":"10.4012","volume":"45","author":[{"given":"Ziyi","family":"QIN","sequence":"first","affiliation":[{"name":"Department of General Dentistry, The Affiliated Stomatological Hospital of Nanjing Medical University"},{"name":"State Key Laboratory Cultivation Base of Research, Prevention and Treatment for Oral Diseases"},{"name":"Jiangsu Province Engineering Research Center of Stomatological Translational Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"SHA","sequence":"additional","affiliation":[{"name":"Department of General Dentistry, The Affiliated Stomatological Hospital of Nanjing Medical University"},{"name":"State Key Laboratory Cultivation Base of Research, Prevention and Treatment for Oral Diseases"},{"name":"Jiangsu Province Engineering Research Center of Stomatological Translational Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyi","family":"SUN","sequence":"additional","affiliation":[{"name":"Department of General Dentistry, The Affiliated Stomatological Hospital of Nanjing Medical University"},{"name":"State Key Laboratory Cultivation Base of Research, Prevention and Treatment for Oral Diseases"},{"name":"Jiangsu Province Engineering Research Center of Stomatological Translational Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyuan","family":"LI","sequence":"additional","affiliation":[{"name":"Department of General Dentistry, The Affiliated Stomatological Hospital of Nanjing Medical University"},{"name":"State Key Laboratory Cultivation Base of Research, Prevention and Treatment for Oral Diseases"},{"name":"Jiangsu Province Engineering Research Center of Stomatological Translational Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"JIANG","sequence":"additional","affiliation":[{"name":"Department of General Dentistry, The Affiliated Stomatological Hospital of Nanjing Medical University"},{"name":"State Key Laboratory Cultivation Base of Research, Prevention and Treatment for Oral Diseases"},{"name":"Jiangsu Province Engineering Research Center of Stomatological Translational Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yichen","family":"ZONG","sequence":"additional","affiliation":[{"name":"Department of General Dentistry, The Affiliated Stomatological Hospital of Nanjing Medical University"},{"name":"State Key Laboratory Cultivation Base of Research, Prevention and Treatment for Oral Diseases"},{"name":"Jiangsu Province Engineering Research Center of Stomatological Translational Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"LI","sequence":"additional","affiliation":[{"name":"Department of General Dentistry, The Affiliated Stomatological Hospital of Nanjing Medical University"},{"name":"State Key Laboratory Cultivation Base of Research, Prevention and Treatment for Oral Diseases"},{"name":"Jiangsu Province Engineering Research Center of Stomatological Translational Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangdong","family":"ZHANG","sequence":"additional","affiliation":[{"name":"Department of General Dentistry, The Affiliated Stomatological Hospital of Nanjing Medical University"},{"name":"State Key Laboratory Cultivation Base of Research, Prevention and Treatment for Oral Diseases"},{"name":"Jiangsu Province Engineering Research Center of Stomatological Translational Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2427","reference":[{"key":"1","unstructured":"1) World Health Organization. Global oral health status report: Towards universal health coverage for oral health. Geneva: World Health Organization; 2022. Available from: https:\/\/www.who.int\/publications\/i\/item\/9789240061484"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Abou Neel EA, Aljabo A, Strange A, Ibrahim S, Coathup M, Young AM, <i>et al.<\/i> Demineralization-remineralization dynamics in teeth and bone. Int J Nanomedicine 2016; 11: 4743-4763.","DOI":"10.2147\/IJN.S107624"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Lamont RJ, Koo H, Hajishengallis G. The oral microbiota: Dynamic communities and host interactions. Nat Rev Microbiol 2018; 16: 745-759.","DOI":"10.1038\/s41579-018-0089-x"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Koo H, Falsetta ML, Klein MI. The exopolysaccharide matrix: A virulence determinant of cariogenic biofilm. J Dent Res 2013; 92: 1065-1073.","DOI":"10.1177\/0022034513504218"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Xiao J, Klein MI, Falsetta ML, Lu B, Delahunty CM, Yates JR, <i>et al.<\/i> The exopolysaccharide matrix modulates the interaction between 3D architecture and virulence of a mixed-species oral biofilm. PLoS Pathog 2012; 8: e1002623.","DOI":"10.1371\/journal.ppat.1002623"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Jakubovics NS, Goodman SD, Mashburn-Warren L, Stafford GP, Cieplik F. The dental plaque biofilm matrix. Periodontol 2000 2021; 86: 32-56.","DOI":"10.1111\/prd.12361"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Madhubala MM, Jayasree R, Kumar TSS, Locs J, Mahalaxmi S. Evaluation of enamel remineralization potential and anticariogenic efficacy of polydopamine coated biogenic amorphous calcium phosphate. Clin Oral Investig 2025; 29: 302.","DOI":"10.1007\/s00784-025-06384-4"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Xu X, Wang N, Wu M, Wang J, Wang D, Chen Z, <i>et al.<\/i> Programmed antibacterial and mineralization therapy for dental caries based on zinc-substituted hydroxyapatite\/alendronate-grafted polyacrylic acid hybrid material. Colloids Surf B Biointerfaces 2020; 194: 111206.","DOI":"10.1016\/j.colsurfb.2020.111206"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Munir A, Marovic D, Nogueira LP, Simm R, Naemi AO, Landr\u00f8 SM, <i>et al.<\/i> Using copper-doped mesoporous bioactive glass nanospheres to impart anti-bacterial properties to dental composites. Pharmaceutics 2022; 14: 2241.","DOI":"10.3390\/pharmaceutics14102241"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Lu D, Li F, Zhao C, Ye Y, Zhang X, Yang P, <i>et al.<\/i> A remineralizing and antibacterial coating for arresting caries. J Dent Res 2023; 102: 1315-1325.","DOI":"10.1177\/00220345231189992"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Zhi C, Chen X, Yu K, Li M, Li F, Ye Y, <i>et al.<\/i> A bifunctional nanocomplex with remineralizing and antibacterial activities to interrupt dental caries. J Control Release 2024; 376: 717-731.","DOI":"10.1016\/j.jconrel.2024.10.041"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Gao H, Wu N, Wang N, Li J, Sun J, Peng Q. Chitosan-based therapeutic systems and their potentials in treatment of oral diseases. Int J Biol Macromol 2022; 222: 3178-3194.","DOI":"10.1016\/j.ijbiomac.2022.10.090"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Zhou W, Chen H, Weir MD, Oates TW, Zhou X, Wang S, <i>et al.<\/i> Novel bioactive dental restorations to inhibit secondary caries in enamel and dentin under oral biofilms. J Dent 2023; 133: 104497.","DOI":"10.1016\/j.jdent.2023.104497"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Chen CZ, Cooper SL. Interactions between dendrimer biocides and bacterial membranes. Biomaterials 2002; 23: 3359-3368.","DOI":"10.1016\/S0142-9612(02)00036-4"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Kaurav M, Ruhi S, Al-Goshae HA, Jeppu AK, Ramachandran D, Sahu RK, <i>et al.<\/i> Dendrimer: An update on recent developments and future opportunities for the brain tumors diagnosis and treatment. Front Pharmacol 2023; 14: 1159131.","DOI":"10.3389\/fphar.2023.1159131"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Yang S, He H, Wang L, Jia X, Feng H. Oriented crystallization of hydroxyapatite by the biomimetic amelogenin nanospheres from self-assemblies of amphiphilic dendrons. Chem Commun 2011; 47: 10100-10102.","DOI":"10.1039\/c1cc13661e"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Hu X, Yan Y, Liu W, Liu J, Fan T, Deng H, <i>et al.<\/i> Advances and perspectives on pharmacological activities and mechanisms of the monoterpene borneol. Phytomedicine 2024; 132: 155848.","DOI":"10.1016\/j.phymed.2024.155848"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Luo L, Li G, Luan D, Yuan Q, Wei Y, Wang X. Antibacterial adhesion of borneol-based polymer via surface chiral stereochemistry. ACS Appl Mater Interfaces 2014; 6: 19371-19377.","DOI":"10.1021\/am505481q"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Tang M, Zhong W, Guo L, Zeng H, Pang Y. Role of borneol as enhancer in drug formulation: A review. Chin Herb Med 2025; 17: 473-483.","DOI":"10.1016\/j.chmed.2024.04.003"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Filipowicz A, Wo\u0142owiec S. Bioconjugates of PAMAM dendrimers with trans-retinal, pyridoxal, and pyridoxal phosphate. Int J Nanomedicine 2012; 7: 4819-4828.","DOI":"10.2147\/IJN.S34175"},{"key":"21","unstructured":"21) Zheng Z. Modified chitosan antimicrobial materials based on Schiff base regulation [master\u2019s thesis]. Beijing, China: Beijing University of Chemical Technology; 2018."},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Xu J, Shi H, Luo J, Yao H, Wang P, Li Z, <i>et al.<\/i> Advanced materials for enamel remineralization. Front Bioeng Biotechnol 2022; 10: 985881.","DOI":"10.3389\/fbioe.2022.985881"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Bijle MN, Abdalla MM, Ashraf U, Ekambaram M, Yiu CKY. Enamel remineralization potential of arginine-fluoride varnish in a multi-species bacterial pH-cycling model. J Dent 2021; 104: 103528.","DOI":"10.1016\/j.jdent.2020.103528"},{"key":"24","unstructured":"24) International Organization for Standardization. ISO 10993-5: 2009 Biological evaluation of medical devices\u2014Part 5: Tests for in vitro cytotoxicity. ISO; 2009. Available from: https:\/\/www.iso.org\/standard\/36406.html"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Aibani N, Rai R, Patel P, Cuddihy G, Wasan EK. Chitosan nanoparticles at the biological interface: Implications for drug delivery. Pharmaceutics 2021; 13: 1686.","DOI":"10.3390\/pharmaceutics13101686"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Rafiee A, Memarpour M, Amiri M, Azadi A, Fekri N, Mozafari N, <i>et al.<\/i> Comparison of various chitosan-based in situ forming gels with sodium fluoride varnish for enamel biomineralization: an in-vitro pH cycling model. Sci Rep 2024; 14: 21100.","DOI":"10.1038\/s41598-024-71993-0"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Marsh PD, Head DA, Devine DA. Ecological approaches to oral biofilms: control without killing. Caries Res 2015; 49 Suppl 1: 46-54.","DOI":"10.1159\/000377732"}],"container-title":["Dental Materials Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/dmj\/45\/3\/45_2025-317\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T03:27:22Z","timestamp":1780111642000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/dmj\/45\/3\/45_2025-317\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,25]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4012\/dmj.2025-317","relation":{},"ISSN":["0287-4547","1881-1361"],"issn-type":[{"value":"0287-4547","type":"print"},{"value":"1881-1361","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,25]]},"article-number":"2025-317"}}