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Available from: http:\/\/www.homd.org\/."},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Thomas S, Izard J, Walsh E, Batich K, Chongsathidkiet P, Clarke G, <i>et al.<\/i> The host microbiome regulates and maintains human health: A primer and perspective for non-microbiologists. Cancer Res 2017; 77: 1783-1812.","DOI":"10.1158\/0008-5472.CAN-16-2929"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Lamont RJ, Koo H, Hajishengallis G. The oral microbiota: Dynamic communities and host interactions. Nat Rev Microbiol 2018; 16: 745-759.","DOI":"10.1038\/s41579-018-0089-x"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Rajasekaran JJ, Krishnamurthy HK, Bosco J, Jayaraman V, Krishna K, Wang T, <i>et al.<\/i> Oral microbiome: A review of its impact on oral and systemic health. Microorganisms 2024; 12: 1797.","DOI":"10.3390\/microorganisms12091797"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Park SE, Periathamby AR, Loza JC. Effect of surface-charged poly (methyl methacrylate) on the adhesion of <i>Candida albicans<\/i>. J Prosthodont 2003; 12: 249-254.","DOI":"10.1016\/S1059-941X(03)00107-4"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Shi B, Wu T, McLean J, Edlund A, Young Y, He X, <i>et al.<\/i> The denture-associated oral microbiome in health and stomatitis. mSphere 2016; 1: doi: 10.1128\/mSphere.00215-16.","DOI":"10.1128\/mSphere.00215-16"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Nwaokorie FO, Akinboboye B, Akeredolua PA, Dania M. Effect of denture on oral microbiome diversity of denture-wearing older adult: Denture effect on oral microbiome diversity. Niger J Dent Res 2024; 9: 53-62.","DOI":"10.4314\/njdr.v9i2.2"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Tournu H, Van Dijck P. <i>Candida<\/i> biofilms and the host: Models and new concepts for eradication. 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J Investig Clin Dent 2016; 7: 141-148.","DOI":"10.1111\/jicd.12125"},{"key":"12","unstructured":"12) Hegde V, Rodrigues SJ, Saldanha S. Redefining the treatment modalities for denture stomatitis\u2014A review. Int J Res Dent 2014; 4: 8-27."},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Davies JM, Stacey AJ, Gilligan CA. <i>Candida albicans<\/i> hyphal invasion: Thigmotropism or chemotropism? FEMS Microbiol Lett 1999; 171: 245-249.","DOI":"10.1111\/j.1574-6968.1999.tb13439.x"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Jia B, Zhang B, Li J, Qin J, Huang Y, Huang M, <i>et al.<\/i> Emerging polymeric materials for treatment of oral diseases: Design strategy towards a unique oral environment. Chem Soc Rev 2024; 53: 3273-3301.","DOI":"10.1039\/D3CS01039B"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Le PH, Linklater DP, Medina AA, MacLaughlin S, Crawford RJ, Ivanova EP. Impact of multiscale surface topography characteristics on <i>Candida albicans<\/i> biofilm formation: From cell repellence to fungicidal activity. Acta Biomater 2024; 177: 20-36.","DOI":"10.1016\/j.actbio.2024.02.006"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Marsh PD, Head DA, Devine DA. Ecological approaches to oral biofilms: Control without killing. Caries Res 2015; 49: 46-54.","DOI":"10.1159\/000377732"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Brookes ZL, Belfield LA, Ashworth A, Casas-Agustench P, Raja M, Pollard AJ, <i>et al.<\/i> Effects of chlorhexidine mouthwash on the oral microbiome. J Dent 2021; 113: 103768.","DOI":"10.1016\/j.jdent.2021.103768"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Vieira APC, Senna PM, Silva WJd, Del Bel Cury AA. Long-term efficacy of denture cleansers in preventing <i>Candida spp<\/i>. biofilm recolonization on liner surface. Braz Oral Res 2010; 24: 342-348.","DOI":"10.1590\/S1806-83242010000300014"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Le Bars P, Kouadio AA, N\u2019goran JK, Badran Z, Soueidan A. Relationship between removable prosthesis and some systemics disorders. J Indian Prosthodont Soc 2015; 15: 292-299.","DOI":"10.4103\/0972-4052.171828"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Preshaw P, Walls A, Jakubovics N, Moynihan P, Jepson N, Loewy Z. Association of removable partial denture use with oral and systemic health. J Dent 2011; 39: 711-719.","DOI":"10.1016\/j.jdent.2011.08.018"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Coulthwaite L, Verran J. Potential pathogenic aspects of denture plaque. Br J Biomed Sci 2007; 64: 180-189.","DOI":"10.1080\/09674845.2007.11732784"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Kalelkar PP, Riddick M, Garc\u00eda AJ. Biomaterial-based antimicrobial therapies for the treatment of bacterial infections. Nat Rev Mater 2022; 7: 39-54.","DOI":"10.1038\/s41578-021-00362-4"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Braem A, Kamarudin NHN, Bhaskar N, Hadzhieva Z, Mele A, Souli\u00e9 J, <i>et al.<\/i> Biomaterial strategies to combat implant infections: New perspectives to old challenges. Int Mater Rev 2023; 68: 1011-1049.","DOI":"10.1080\/09506608.2023.2193784"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Gomez Casas C, Shukla A. Engineering immunomodulatory biomaterials to combat bacterial infections. Front Biomater Sci 2024; 2: 1336842.","DOI":"10.3389\/fbiom.2023.1336842"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Yang K, Han Q, Chen B, Zheng Y, Zhang K, Li Q, <i>et al.<\/i> Antimicrobial hydrogels: Promising materials for medical application. Int J Nanomedicine 2018; 13: 2217-2263.","DOI":"10.2147\/IJN.S154748"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Parhi S, Pal S, Das SK, Ghosh P. Strategies toward development of antimicrobial biomaterials for dental healthcare applications. Biotechnol Bioeng 2021; 118: 4590-4622.","DOI":"10.1002\/bit.27948"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Hoare A, Marsh PD, Diaz PI. Ecological therapeutic opportunities for oral diseases. Microbiol Spectr 2017; 5: 23.","DOI":"10.1128\/microbiolspec.BAD-0006-2016"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Coad BR, Kidd SE, Ellis DH, Griesser HJ. Biomaterials surfaces capable of resisting fungal attachment and biofilm formation. Biotechnol Adv 2014; 32: 296-307.","DOI":"10.1016\/j.biotechadv.2013.10.015"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Francolini I, Vuotto C, Piozzi A, Donelli G. Antifouling and antimicrobial biomaterials: An overview. Apmis 2017; 125: 392-417.","DOI":"10.1111\/apm.12675"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Takahashi N. Microbial ecosystem in the oral cavity: Metabolic diversity in an ecological niche and its relationship with oral diseases. International Congress Series. Int Congr Ser 2005; 1284: 103-112.","DOI":"10.1016\/j.ics.2005.06.071"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Budtz-J\u00f6rgensen E. The significance of <i>Candida albicans<\/i> in denture stomatitis. Eur J Oral Sci 1974; 82: 151-190.","DOI":"10.1111\/j.1600-0722.1974.tb00378.x"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Verran J. Malodour in denture wearers: An ill-defined problem. Oral Dis 2005; 11: 24-28.","DOI":"10.1111\/j.1601-0825.2005.01083.x"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Wu T, Shi W, Loewy ZG, He X. Managing denture biofilm related diseases. Dent Open J 2015; 2: 80-86.","DOI":"10.17140\/DOJ-2-116"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Porter S, Scully C. Oral malodour (halitosis). BMJ 2006; 333: 632-635.","DOI":"10.1136\/bmj.38954.631968.AE"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Murillo LA, Newport G, Lan C-Y, Habelitz S, Dungan J, Agabian NM. Genome-wide transcription profiling of the early phase of biofilm formation by <i>Candida albicans<\/i>. Eukaryot Cell 2005; 4: 1562-1573.","DOI":"10.1128\/EC.4.9.1562-1573.2005"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36) Li L, Finnegan M, \u00d6zkan S, Kim Y, Lillehoj P, Ho CM, <i>et al.<\/i> In vitro study of biofilm formation and effectiveness of antimicrobial treatment on various dental material surfaces. Mol Oral Microbiol 2010; 25: 384-390.","DOI":"10.1111\/j.2041-1014.2010.00586.x"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37) Gupta B, Hilborn JG, Bisson I, Frey P. Plasma-induced graft polymerization of acrylic acid onto poly(ethylene terephthalate) films. J Appl Polym Sci 2001; 81: 2993-3001.","DOI":"10.1002\/app.1749"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38) Bhatt S, Pulpytel J, Arefi-Khonsari F. Low and atmospheric plasma polymerisation of nanocoatings for bio-applications. Surf Innov 2015; 3: 63-83.","DOI":"10.1680\/sufi.14.00008"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39) Cools P, Astoreca L, Esbah Tabaei PS, Thukkaram M, De Smet H, Morent R, <i>et al.<\/i> Surface treatment of polymers by plasma. In: Pinson J, Thiry D, editors. Surface modification of polymers: Methods and applications. Weinheim (Germany) Wiley-VCH; 2019. p. 31-65.","DOI":"10.1002\/9783527819249.ch2"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40) Jiang L, Zhu W, Qian H, Wang C, Chen Y, Liu P. Fabrication of PMPC\/PTM\/PEGDA micropatterns onto polypropylene films behaving with dual functions of antifouling and antimicrobial activities. J Mater Chem B 2019; 7: 5078-5088.","DOI":"10.1039\/C9TB00927B"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41) Beyler-\u00c7i\u011fil A, Birtane H, \u015een F, Kahraman MV. Transparent and flexible antibacterial photocrosslinked thin films against the <i>S. aureus<\/i> and <i>E. coli<\/i> pathogen bacteria. Mater Today Commun 2021; 27: 102463.","DOI":"10.1016\/j.mtcomm.2021.102463"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42) Gao F, Shao T, Yu Y, Xiong Y, Yang L. Surface-bound reactive oxygen species generating nanozymes for selective antibacterial action. Nat Commun 2021; 12: 745.","DOI":"10.1038\/s41467-021-20965-3"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43) Yang Y, Huang J, Dornbusch D, Grundmeier G, Fahmy K, Keller A, <i>et al.<\/i> Effect of surface hydrophobicity on the adsorption of a pilus-derived adhesin-like peptide. Langmuir 2022; 38: 9257-9265.","DOI":"10.1021\/acs.langmuir.2c01016"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44) Steinmassl O, Dumfahrt H, Grunert I, Steinmassl PA. Influence of CAD\/CAM fabrication on denture surface properties. J Oral Rehabil 2018; 45: 406-413.","DOI":"10.1111\/joor.12621"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45) Hazen KC, Wu JG, Masuoka J. Comparison of the hydrophobic properties of <i>Candida albicans<\/i> and <i>Candida dubliniensis<\/i>. Infect Immun 2001; 69: 779-786.","DOI":"10.1128\/IAI.69.2.779-786.2001"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46) Finnegan S, Percival SL. EDTA: An antimicrobial and antibiofilm agent for use in wound care. Adv Wound Care 2015; 4: 415-421.","DOI":"10.1089\/wound.2014.0577"},{"key":"47","doi-asserted-by":"crossref","unstructured":"47) Ziental D, Czarczynska-Goslinska B, Mlynarczyk DT, Glowacka-Sobotta A, Stanisz B, Goslinski T, <i>et al.<\/i> Titanium dioxide nanoparticles: Prospects and applications in medicine. Nanomaterials 2020; 10: 387.","DOI":"10.3390\/nano10020387"},{"key":"48","doi-asserted-by":"crossref","unstructured":"48) Je J-Y, Kim S-K. Reactive oxygen species scavenging activity of aminoderivatized chitosan with different degree of deacetylation. Bioorg Med Chem 2006; 14: 5989-5994.","DOI":"10.1016\/j.bmc.2006.05.016"},{"key":"49","unstructured":"49) Karuppaiah J. In Vitro evaluation of free radical scavenging activity of chitosan. Int J Pharm Life Sci 2013; 4: 2685-2690."},{"key":"50","doi-asserted-by":"crossref","unstructured":"50) Lee CY, Hu SM, Christy J, Chou FY, Ramli TC, Chen HY. 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