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Front Bioeng Biotechnol 2022; 10: 921576.","DOI":"10.3389\/fbioe.2022.921576"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Ren Y, Fan L, Alkildani S, Liu L, Emmert S, Najman S, <i>et al.<\/i> Barrier membranes for guided bone regeneration (GBR): A Focus on recent advances in collagen membranes. Int J Mol Sci 2022; 23: 14987.","DOI":"10.3390\/ijms232314987"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Tang H, Zhang Y. Effects of different oral barrier membranes on the efficacy and safety of guided bone regeneration in patients with dental implants: A systematic review and meta-analysis. Acta Odontol Scand 2025; 84: 318-331.","DOI":"10.2340\/aos.v84.43758"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Yang D, Xu Z, Huang D, Luo Q, Zhang C, Guo J, <i>et al.<\/i> Immunomodulatory multifunctional janus collagen-based membrane for advanced bone regeneration. Nat Commun 2025; 16: 4264.","DOI":"10.1038\/s41467-025-59651-z"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) H\u00fcrzeler MB, Kohal RJ, Naghshbandl J, Mota LF, Conradt J, Hutmacher D, <i>et al.<\/i> Evaluation of a new bioresorbable barrier to facilitate guided bone regeneration around exposed implant threads. An experimental study in the monkey. Int J Oral Maxillofac Surg 1998; 27: 315-320.","DOI":"10.1016\/S0901-5027(05)80623-X"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Owens KW, Yukna RA. Collagen membrane resorption in dogs: A comparative study. Implant Dent 2001; 10: 49-58.","DOI":"10.1097\/00008505-200101000-00016"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Kapogianni E, Alkildani S, Radenkovic M, Xiong X, Krastev R, St\u00f6we I, <i>et al.<\/i> The early fragmentation of a bovine dermis-derived collagen barrier membrane contributes to transmembraneous vascularization\u2014A possible paradigm shift for guided bone regeneration. Membranes (Basel) 2021; 11: 185.","DOI":"10.3390\/membranes11030185"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Al-Maawi S, Vorakulpipat C, Orlowska A, Zrnc TA, Sader RA, Kirkpatrick CJ, <i>et al.<\/i> In vivo implantation of a bovine-derived collagen membrane leads to changes in the physiological cellular pattern of wound healing by the induction of multinucleated giant cells: An adverse reaction? Front Bioeng Biotechnol 2018; 6: 104.","DOI":"10.3389\/fbioe.2018.00104"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Barbeck M, Lorenz J, Holthaus MG, Raetscho N, Kubesch A, <i>et al.<\/i> Porcine dermis and pericardium-based, non cross-linked materials induce multinucleated giant cells after their in vivo implantation: A physiological reaction? J Oral Implantol 2015; 41: e267-e280.","DOI":"10.1563\/aaid-joi-D-14-00155"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Rothamel D, Schwarz F, Sager M, Herten M, Becker J. Biodegradation of differently cross-linked collagen membranes: An experimental study in the rat. Clin Oral Implants Res 2005; 16: 369-378.","DOI":"10.1111\/j.1600-0501.2005.01108.x"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Barbeck M, Lorenz J, Kubesch A, Booms P, Boehm N, Choukroun J, <i>et al.<\/i> Porcine dermis-derived collagen membranes induce implantation bed vascularization via multinucleated giant cells: A physiological reaction? J Oral Implantol 2015; 41: 238-251.","DOI":"10.1563\/aaid-joi-D-14-00274"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Hoornaert A, D\u2019Arros C, Heymann MF, Layrolle P. Biocompatibility, resorption and biofunctionality of a new synthetic biodegradable membrane for guided bone regeneration. Biomed Mater 2016; 11: 045012.","DOI":"10.1088\/1748-6041\/11\/4\/045012"},{"key":"13","unstructured":"13) Rothamel D, Schwarz F, Fienitz T, Smeets R, Dreiseidler T, Ritter L, <i>et al.<\/i> Biocompatibility and biodegradation of a native porcine pericardium membrane: Results of in vitro and in vivo examinations. Int J Oral Maxillofac Implants 2012; 27: 146-154."},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Gupta S, Gupta R. Guided bone regeneration with pericardium membranes. IOSR J Dent Med Sci 2014; 13: 61-65.","DOI":"10.9790\/0853-131156165"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Schwarz F, Rothamel D, Herten M, Sager M, Becker J. Angiogenesis pattern of native and cross-linked collagen membranes: An immunohistochemical study in the rat. Clin Oral Implants Res 2006; 17: 403-409.","DOI":"10.1111\/j.1600-0501.2005.01225.x"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Hirata HH, Munhoz MAS, Plepis AMG, Martins VCA, Santos GR, Galdeano EA, <i>et al.<\/i> Feasibility study of collagen membranes derived from bovine pericardium and intestinal serosa for the repair of cranial defects in ovariectomised rats. Injury 2015; 46: 1215-1222.","DOI":"10.1016\/j.injury.2015.03.039"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Yamanaka JS, Oliveira AC, Bastos AR, Fernandes EM, Reis RL, Correlo VM, <i>et al.<\/i> Collagen membrane from bovine pericardium for treatment of long bone defect. J Biomed Mater Res B Appl Biomater 2023; 111: 261-270.","DOI":"10.1002\/jbm.b.35148"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Lynn AK, Yannas IV, Bonfield W. Antigenicity and immunogenicity of collagen. J Biomed Mater Res B Appl Biomater 2004; 71: 343-354.","DOI":"10.1002\/jbm.b.30096"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Moura CCG, Soares PBF, Carneiro KF, de Souza MA, Magalh\u00e3es D. Cytotoxicity of bovine and porcine collagen membranes in mononuclear cells. Braz Dent J 2012; 23: 39-44.","DOI":"10.1590\/S0103-64402012000100007"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Parenteau-Bareil R, Gauvin R, Cliche S, Gari\u00e9py C, Berthod F. Comparative study of bovine, porcine and avian collagens for the production of a tissue engineered dermis. Acta Biomater 2011; 7: 3757-3765.","DOI":"10.1016\/j.actbio.2011.06.020"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Gu JT, Jiao K, Li J, Yan JF, Wang KY, Wang F, <i>et al.<\/i> Polyphosphate-crosslinked collagen scaffolds for hemostasis and alveolar bone regeneration after tooth extraction. Bioact Mater 2021; 15: 68-81.","DOI":"10.1016\/j.bioactmat.2021.12.019"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Lindner C, Pr\u00f6hl A, Abels M, L\u00f6ffler T, Batinic M, Jung O, <i>et al.<\/i> Specialized histological and histomorphometrical analytical methods for biocompatibility testing of biomaterials for maxillofacial surgery in (pre-) clinical studies. In vivo (Athens, Greece) 2020; 34: 3137-3152.","DOI":"10.21873\/invivo.12148"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Alkildani S, Ren Y, Liu L, Rimashevskiy D, Schnettler R, Radenkovi\u0107 M, <i>et al.<\/i> Analyses of the cellular interactions between the ossification of collagen-based barrier membranes and the underlying bone defects. Int J Mol Sci 2023; 24: 6833.","DOI":"10.3390\/ijms24076833"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Radenkovi\u0107 M, Alkildani S, Stoewe I, Bielenstein J, Sundag B, Bellmann O, <i>et al.<\/i> Comparative in vivo analysis of the integration behavior and immune response of collagen-based dental barrier membranes for guided bone regeneration (GBR). Membranes (Basel) 2021; 11: 712.","DOI":"10.3390\/membranes11090712"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Riaz T, Zeeshan R, Zarif F, Ilyas K, Muhammad N, Safi SZ, <i>et al.<\/i> FTIR analysis of natural and synthetic collagen. Appl Spectrosc Rev 2018; 53: 703-746.","DOI":"10.1080\/05704928.2018.1426595"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Elgali I, Omar O, Dahlin C, Thomsen P. Guided bone regeneration: Materials and biological mechanisms revisited. Eur J Oral Sci 2017; 125: 315-337.","DOI":"10.1111\/eos.12364"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Aprile P, Letourneur D, Simon-Yarza T. Membranes for guided bone regeneration: A road from bench to bedside. Adv Healthc Mater 2020; 9: e2000707.","DOI":"10.1002\/adhm.202000707"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Anderson JM, Rodriguez A, Chang DT. Foreign body reaction to biomaterials. Semin Immunol 2008; 20: 86-100.","DOI":"10.1016\/j.smim.2007.11.004"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Thomsen P, Gretzer C. Macrophage interactions with modified material surfaces. Curr Opin Solid State Mater Sci 2001; 5: 163-176.","DOI":"10.1016\/S1359-0286(01)00004-3"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Cai F, Jiang B, He F. Formation and biological activities of foreign body giant cells in response to biomaterials. Acta Biomater 2024; 188: 1-26.","DOI":"10.1016\/j.actbio.2024.08.034"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Tanneberger AM, Al-Maawi S, Herrera-Vizca\u00edno C, Orlowska A, Kubesch A, Sader R, <i>et al.<\/i> Multinucleated giant cells within the in vivo implantation bed of a collagen-based biomaterial determine its degradation pattern. Clin Oral Investig 2021; 25: 859-873.","DOI":"10.1007\/s00784-020-03373-7"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Delgado LM, Bayon Y, Pandit A, Zeugolis DI. To cross-link or not to cross-link? Cross-linking associated foreign body response of collagen-based devices. Tissue Eng Part B Rev 2015; 21: 298-313.","DOI":"10.1089\/ten.teb.2014.0290"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Ghanaati S, Schlee M, Webber MJ, Willershausen I, Kirkpatrick CJ. Evaluation of the tissue reaction to a new bilayered collagen matrix in vivo and its translation to the clinic. Biomed Mater 2011; 6: 015010.","DOI":"10.1088\/1748-6041\/6\/1\/015010"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Ghanaati S. Non-cross-linked porcine-based collagen I\u2013III membranes do not require high vascularization rates for their integration within the implantation bed: A paradigm shift. Acta Biomater 2012; 8: 3061-3072.","DOI":"10.1016\/j.actbio.2012.04.041"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Barbeck M, Booms P, Unger R, Hoffmann V, Sader R, Kirkpatrick CJ, <i>et al.<\/i> Multinucleated giant cells in the implant bed of bone substitutes are foreign body giant cells\u2014New insights into the material-mediated healing process. J Biomed Mater Res A 2017; 105: 1105-1111.","DOI":"10.1002\/jbm.a.36006"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36) Barbeck M, Udeabor SE, Lorenz J, Kubesch A, Choukroun J, Sader RA, <i>et al.<\/i> Induction of multinucleated giant cells in response to small sized bovine bone substitute (Bio-Oss) results in an enhanced early implantation bed vascularization. Ann Maxillofac Surg 2014; 4: 150-157.","DOI":"10.4103\/2231-0746.147106"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37) Dew L, MacNeil S, Chong CK. Vascularization strategies for tissue engineers. Regen Med 2015; 10: 211-224.","DOI":"10.2217\/rme.14.83"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38) Kusumbe AP, Adams RH. Osteoclast progenitors promote bone vascularization and osteogenesis. Nat Med 2015; 20: 1238-1240.","DOI":"10.1038\/nm.3747"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39) Zhao S, Pinholt EM, Madsen JE, Donath K. Histological evaluation of different biodegradable and non-biodegradable membranes implanted subcutaneously in rats. J Craniomaxillofac Surg 2000; 28: 116-122.","DOI":"10.1054\/jcms.2000.0127"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40) Sbricoli L, Guazzo R, Annunziata M, Gobbato L, Bressan E, Nastri L. Selection of collagen membranes for bone regeneration: A literature review. Materials (Basel) 2020; 13: 786.","DOI":"10.3390\/ma13030786"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41) Turri A, Elgali I, Vazirisani F, Johansson A, Emanuelsson L, Dahlin C, <i>et al.<\/i> Guided bone regeneration is promoted by the molecular events in the membrane compartment. Biomaterials 2016; 84: 167-183.","DOI":"10.1016\/j.biomaterials.2016.01.034"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42) Omar O, Elgali I, Dahlin C, Thomsen P. Barrier membranes: More than the barrier effect? J Clin Periodontol 2019; 46 (S21): 103-123.","DOI":"10.1111\/jcpe.13068"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43) Wang HL, Boyapati L. \u201cPASS\u201d principles for predictable bone regeneration. Implant Dent 2006; 15: 8-17.","DOI":"10.1097\/01.id.0000204762.39826.0f"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44) Spicer PP, Kretlow JD, Young S, Jansen JA, Kasper FK, Mikos AG. Evaluation of bone regeneration using the rat critical size calvarial defect. Nat Protoc 2012; 7: 1918-1929.","DOI":"10.1038\/nprot.2012.113"},{"key":"45","unstructured":"45) Theodoro LH, Campista CCC, Bury LL, de Souza RGB, Muniz YS, Longo M, <i>et al.<\/i> Comparison of different bone substitutes in the repair of rat calvaria critical size defects: Questioning the need for alveolar ridge presentation. Quintessence Int 2024; 55: 328-334."},{"key":"46","doi-asserted-by":"crossref","unstructured":"46) Song Y, Wu H, Gao Y, Li J, Lin K, Liu B, <i>et al.<\/i> Zinc silicate\/nano-hydroxyapatite\/collagen scaffolds promote angiogenesis and bone regeneration via the p38 MAPK pathway in activated monocytes. ACS Appl Mater Interfaces 2020; 12: 16058-16075.","DOI":"10.1021\/acsami.0c00470"},{"key":"47","doi-asserted-by":"crossref","unstructured":"47) Farnezi Bassi AP, Ferreira Bizelli V, Mello Francatti T, Rezende de Moares Ferreira AC, Carvalho Pereira J, Al-Sharani HM, <i>et al.<\/i> Bone regeneration assessment of polycaprolactone membrane on critical-size defects in rat calvaria. Membranes (Basel) 2021; 11: 124.","DOI":"10.3390\/membranes11020124"},{"key":"48","doi-asserted-by":"crossref","unstructured":"48) Bateman JP, Safadi FF, Susin C, Wikesjo UM. Exploratory study on the effect of osteoactivin on bone formation in the rat critical-size calvarial defect model. J Periodontal Res 2012; 47: 243-247.","DOI":"10.1111\/j.1600-0765.2011.01428.x"},{"key":"49","doi-asserted-by":"crossref","unstructured":"49) Hatakeyama W, Taira M, Sawada T, Hoshi M, Hachinohe Y, Sato H, <i>et al.<\/i> Bone regeneration of critical-size calvarial defects in rats using highly pressed nano-apatite\/collagen composites. Materials (Basel) 2022; 15: 3376.","DOI":"10.3390\/ma15093376"},{"key":"50","doi-asserted-by":"crossref","unstructured":"50) Eldesoqi K, Seebach C, Nguyen Ngoc C, Meier S, Nau C, Schaible A, <i>et al.<\/i> High calcium bioglass enhances differentiation and survival of endothelial progenitor cells, inducing early vascularization in critical size bone defects. PLoS One 2013; 8: e79058.","DOI":"10.1371\/journal.pone.0079058"},{"key":"51","doi-asserted-by":"crossref","unstructured":"51) Toledano-Osorio M, Manzano-Moreno FJ, Ruiz C, Toledano M, Osorio R. Testing active membranes for bone regeneration: A review. 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