{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:00:38Z","timestamp":1790398838122,"version":"4.1.0"},"reference-count":38,"publisher":"Japanese Society for Dental Materials and Devices","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dent. Mater. J.","Dental Materials Journal"],"published-print":{"date-parts":[[2026,9,25]]},"DOI":"10.4012\/dmj.2026-050","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T22:11:47Z","timestamp":1788473507000},"page":"549-558","source":"Crossref","is-referenced-by-count":0,"title":["Influence of magnesium oxide nanoparticles on &lt;i&gt;in vitro&lt;\/i&gt; mechanical and antibacterial performance of self-curing dental polymethyl-methacrylate"],"prefix":"10.4012","volume":"45","author":[{"given":"Alejandro L.","family":"VEGA-JIMENEZ","sequence":"first","affiliation":[{"name":"Tissue Bioengineering Laboratory, Division of Graduate Studies and Research, Faculty of Dentistry, National Autonomous University of Mexico (UNAM)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Am\u00e9rica R.","family":"VAZQUEZ-OLMOS","sequence":"additional","affiliation":[{"name":"Hybrid Systems and Nanospectroscopy, Institute of Applied Sciences and Technology, National Autonomous University of Mexico (UNAM)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa Itzel","family":"CHAVEZ-PAZ","sequence":"additional","affiliation":[{"name":"Tissue Bioengineering Laboratory, Division of Graduate Studies and Research, Faculty of Dentistry, National Autonomous University of Mexico (UNAM)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"GONZALEZ-ALVA","sequence":"additional","affiliation":[{"name":"Tissue Bioengineering Laboratory, Division of Graduate Studies and Research, Faculty of Dentistry, National Autonomous University of Mexico (UNAM)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"GUERRERO-IBARRA","sequence":"additional","affiliation":[{"name":"Dental Materials Laboratory, Division of Graduate Studies and Research, Faculty of Dentistry, National Autonomous University of Mexico (UNAM)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea Damaris","family":"SANCHEZ-JIMENEZ","sequence":"additional","affiliation":[{"name":"Faculty of Higher Education Zaragoza, National Autonomous University of Mexico (UNAM)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana-Patricia RODRIGUEZ","family":"HERNANDEZ","sequence":"additional","affiliation":[{"name":"Molecular Genetics Laboratory, Division of Graduate Studies and Research, Faculty of Dentistry, National Autonomous University of Mexico (UNAM)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2427","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Sharifian S, Loghmani A, Nayyerain S, Javanbakht S, Daneii P. Application of magnesium oxide nanoparticles in dentistry: A literature review. Eur J Gen Dent 2023; 12: 1-6.","DOI":"10.1055\/s-0042-1760673"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Noori AJ, Kareem FA. The effect of magnesium oxide nanoparticles on the antibacterial and antibiofilm properties of glass-ionomer cement. Heliyon 2019; 5: e02568.","DOI":"10.1016\/j.heliyon.2019.e02568"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Vega-Jim\u00e9nez AL, Gonz\u00e1lez-Alva P, Rodr\u00edguez-Hern\u00e1ndez AP, V\u00e1zquez-Olmos AR, Paz-D\u00edaz B. Oxide nanoparticles based in magnesium as a potential dental tool to inhibit bacterial activity and promote osteoblast viability. Dent Mater J 2024; 43: 11-19.","DOI":"10.4012\/dmj.2023-041"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Rodr\u00edguez-Hern\u00e1ndez AP, Vega-Jim\u00e9nez AL, V\u00e1zquez-Olmos AR, Ortega-Maldonado M, Ximenez-Fyvie LA. Antibacterial properties in vitro of magnesium oxide nanoparticles for dental applications. Nanomaterials 2023; 13: 502.","DOI":"10.3390\/nano13030502"},{"key":"5","unstructured":"5) Naguib GH, Hosny KM, Hassan AH, Al Hazmi F, Al Dharrab A, Alkhalidi HM, <i>et al.<\/i> Zein based magnesium oxide nanoparticles: Assessment of antimicrobial activity for dental implications. Pak J Pharm Sci 2018; 31(1 Suppl): 245-250."},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Naguib GH, Nassar HM, Hamed MT. Antimicrobial properties of dental cements modified with zein-coated magnesium oxide nanoparticles. Bioact Mater 2022; 8: 49-56.","DOI":"10.1016\/j.bioactmat.2021.06.011"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Ricker A, Liu-Snyder P, Webster TJ. The influence of nano MgO and BaSO<sub>4<\/sub> particle size additives on properties of PMMA bone cement. Int J Nanomedicine 2008; 3: 125-132.","DOI":"10.2147\/IJN.S2322"},{"key":"8","unstructured":"8) Shakir TA, Abass SM. The effect of magnesium oxide (MgO) nano-fillers on the antibacterial activity and some properties of heat cured acrylic resin. Int J Sci Res 2018; 7: 1-6."},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Sadeq JA, Majeed AMA, Hussain RK, Bamsaoud SF. Synthesis and characterization of PMMA\/HAP\/MgO nanocomposite as an antibacterial activity for dental applications. Al-Mustansiriyah J Sci 2023; 34: 129-134.","DOI":"10.23851\/mjs.v34i2.1330"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Mansour AAA, Al-Ramadhan ZA, Abdulrazaq RA. Mechanical and physical properties of PMMA reinforced HA-MgO nanocomposite. J Phys Conf Ser 2021; 1795: 012039.","DOI":"10.1088\/1742-6596\/1795\/1\/012039"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Ma X, Yang Y, Ma J, Wang X, Zeng Y. Comparison of mechanical properties of polymethyl methacrylate of different mixing ratios. J Med Eng Technol 2011; 35: 54-58.","DOI":"10.3109\/03091902.2010.525686"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Al Hatem O, Ontiveros JC, Belles DM, Gonzalez MD, van der Hoeven R. Surface roughness and microbial adhesion on four provisional prosthodontic restorative materials. Dent J (Basel) 2025; 13: 498.","DOI":"10.3390\/dj13110498"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Kreve S, Dos Reis AC. Antibiofilm capacity of PMMA surfaces: A review of current knowledge. Microb Pathog 2025; 202: 107426.","DOI":"10.1016\/j.micpath.2025.107426"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Abdelaziz AA, Doghish AS, Salah AN, Mansour RM, Moustafa YM, Mageed SSA, <i>et al.<\/i> When oral health affects overall health: Biofilms, dental infections, and emerging antimicrobial strategies. Infection 2025; 53: 1603-1624.","DOI":"10.1007\/s15010-025-02533-9"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Kumari S, Mishra RK, Parveen S, Avinashi SK, Hussain A, Kumar S, <i>et al.<\/i> Fabrication, structural, and enhanced mechanical behavior of MgO substituted PMMA composites for dental applications. Sci Rep 2024; 14: 2128.","DOI":"10.1038\/s41598-024-52202-4"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Khandaker M, Li Y, Morris T. Micro- and nano MgO particles for the improvement of fracture toughness of bone-cement interfaces. J Biomech 2013; 46: 1035-1039.","DOI":"10.1016\/j.jbiomech.2012.12.006"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Yaseen ST, Khaleel AS. Study of the mechanical and thermal properties of PMMA\/TiO<sub>2<\/sub> nanocomposite. IOP Conf Ser Mater Sci Eng 2020; 757: 012004.","DOI":"10.1088\/1757-899X\/757\/1\/012004"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Safarabadi M, Mehri Khansari N, Rezaei A. An experimental investigation of HA\/Al<sub>2<\/sub>O<sub>3<\/sub> nanoparticles on mechanical properties of restoration materials. Eng Solid Mech 2014; 2: 173-182.","DOI":"10.5267\/j.esm.2014.4.006"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Rashahmadi S, Hasanzadeh R, Mosalman S. Improving the mechanical properties of poly methyl methacrylate nanocomposites for dentistry applications reinforced with different nanoparticles. Polym Plast Technol Eng 2017; 56: 1730-1740.","DOI":"10.1080\/03602559.2017.1289402"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Salman AD, Jani GH, Fatalla AA. Comparative study of the effect of incorporating SiO<sub>2<\/sub> nanoparticles on properties of poly methyl methacrylate denture bases. Biomed Pharm J 2017; 10: 1525-1535.","DOI":"10.13005\/bpj\/1262"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Zidan S, Silikas N, Haider J, Yates J. Long-term sorption and solubility of zirconia-impregnated PMMA nanocomposite in water and artificial saliva. Materials 2020; 13: 3732.","DOI":"10.3390\/ma13173732"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Ergun G, Sahin Z, Ataol AS. The effects of adding various ratios of zirconium oxide nanoparticles to poly(methyl methacrylate) on physical and mechanical properties. J Oral Sci 2018; 60: 304-315.","DOI":"10.2334\/josnusd.17-0206"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Jasim BS, Ismail IJ. The effect of silanized alumina nano-fillers addition on some physical and mechanical properties of heat cured polymethyl methacrylate denture base material. J Bagh Coll Dent 2014; 26: 18-23.","DOI":"10.12816\/0015190"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Alhotan A, Yates J, Zidan S, Haider J, Jurado CA, Silikas N. Behaviour of PMMA resin composites incorporated with nanoparticles or fibre following prolonged water storage. Nanomaterials 2021; 11: 3453.","DOI":"10.3390\/nano11123453"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Seil JT, Webster TJ. Antimicrobial applications of nanotechnology: Methods and literature. Int J Nanomedicine 2012; 7: 2767-2781.","DOI":"10.2147\/IJN.S24805"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Mohammed A, McKenzie C, Ford R, Azzawi M, Radecka I, Kowalczuk M. A comparison of conventional methods for the quantification of bacterial cells after exposure to metal oxide nanoparticles. BMC Microbiol 2014; 14: 222.","DOI":"10.1186\/s12866-014-0222-6"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Wang J, Wang X. Antibacterial properties of magnesium oxide nanoparticles and their composites. AIP Adv 2024; 14: 025238.","DOI":"10.1063\/5.0171608"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Vega Jim\u00e9nez AL, Rodr\u00edguez-Hern\u00e1ndez AP, V\u00e1zquez-Olmos AR, Luna-Ram\u00edrez RE, Sato-Berr\u00fa RY, Calder\u00f3n-Olvera RM. Exploring antibacterial properties of mechanochemically synthesized MgAl<sub>2<\/sub>O<sub>4<\/sub> spinel nanoparticles for dental and medical applications. Int J Mol Sci 2025; 27: 438.","DOI":"10.3390\/ijms27010438"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Tripathi N, Goshisht MK. Recent advances and mechanistic insights into antibacterial activity, antibiofilm activity, and cytotoxicity of silver nanoparticles. ACS Appl Bio Mater 2022; 5: 1391-1463.","DOI":"10.1021\/acsabm.2c00014"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Nguyen NYT, Grelling N, Wetteland CL, Rosario R, Liu H. Antimicrobial activities and mechanisms of magnesium oxide nanoparticles (nMgO) against pathogenic bacteria, yeasts, and biofilms. Sci Rep 2018; 8: 16260.","DOI":"10.1038\/s41598-018-34567-5"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Krishnamoorthy K, Manivannan G, Kim SJ, Jeyasubramanian K, Premanathan M. Antibacterial activity of MgO nanoparticles based on lipid peroxidation by oxygen vacancy. J Nanopart Res 2012; 14: 1063.","DOI":"10.1007\/s11051-012-1063-6"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Wang Y, Wu Z, Wang T, Tang W, Li T, Xu H, <i>et al.<\/i> Bioactive dental resin composites with MgO nanoparticles. ACS Biomater Sci Eng 2023; 9: 4632-4645.","DOI":"10.1021\/acsbiomaterials.3c00490"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Naguib GH, Abuelenain D, Mazhar J, Alnowaiser A, Aljawi R, Hamed MT. Maximizing dental composite performance: Strength and hardness enhanced by innovative polymer-coated MgO nanoparticles. J Dent 2024; 149: 105271.","DOI":"10.1016\/j.jdent.2024.105271"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Naguib GH, Nassar H, Mira A, Alnowaiser A, Hamed MT. Imparting antimicrobial efficacy: Novel polymer-coated MgO nanoparticles transform dental composites. Int Dent J 2025; 75: 100919.","DOI":"10.1016\/j.identj.2025.100919"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Emon NU, Zhang L, Osborne SD, Lanoue MA, Huang Y, Tian ZR. Novel nanomaterials for developing bone scaffolds and tissue regeneration. Nanomaterials 2025; 15: 1198.","DOI":"10.3390\/nano15151198"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36) Mahmoud A, Ezgi \u00d6, Merve A, \u00d6zhan G. In vitro toxicological assessment of magnesium oxide nanoparticle exposure in several mammalian cell types. Int J Toxicol 2016; 35: 429-437.","DOI":"10.1177\/1091581816648624"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37) Meran ZD, Hassan PA, Salaie RN. Comparing the antibacterial effect of coated and impregnated flexible dentures with magnesium oxide nanoparticles against <i>Streptococcus mutans<\/i>. Coatings 2023; 13: 1429.","DOI":"10.3390\/coatings13081429"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38) Wang Y, Wu Z, Wang T, Tian J, Zhou Z, Guo D, <i>et al.<\/i> Antibacterial and physical properties of resin cements containing MgO nanoparticles. J Mech Behav Biomed Mater 2023; 142: 105815.","DOI":"10.1016\/j.jmbbm.2023.105815"}],"container-title":["Dental Materials Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/dmj\/45\/5\/45_2026-050\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T04:39:25Z","timestamp":1790397565000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/dmj\/45\/5\/45_2026-050\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,25]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4012\/dmj.2026-050","relation":{},"ISSN":["0287-4547","1881-1361"],"issn-type":[{"value":"0287-4547","type":"print"},{"value":"1881-1361","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,25]]},"article-number":"2026-050"}}