{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T23:18:03Z","timestamp":1787613483992,"version":"build-2736575974"},"reference-count":104,"publisher":"Korean Society for Microbiology and Biotechnology","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260901"],"award-info":[{"award-number":["82260901"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Guangxi Science and Technology Major Project under the 14th Five-Year Plan","award":["Guike AA2209602"],"award-info":[{"award-number":["Guike AA2209602"]}]},{"name":"Guangxi Science and Technology Base and Talent Special Program","award":["Guike AD22035165"],"award-info":[{"award-number":["Guike AD22035165"]}]}],"content-domain":{"domain":["www.jmb.or.kr"],"crossmark-restriction":true},"short-container-title":["J. Microbiol. Biotechnol."],"DOI":"10.4014\/jmb.2411.11040","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T06:17:19Z","timestamp":1748585839000},"update-policy":"https:\/\/doi.org\/10.4014\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Human Brain Organoids: Development and Applications"],"prefix":"10.4014","volume":"35","author":[{"given":"Wu","family":"Hongxi","sequence":"first","affiliation":[{"name":"Graduate School, Guangxi University of Chinese Medicine, Nanning, Guangxi, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Ruting","sequence":"additional","affiliation":[{"name":"Graduate School, Guangxi University of Chinese Medicine, Nanning, Guangxi, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Yiyang","sequence":"additional","affiliation":[{"name":"Graduate School, Guangxi University of Chinese Medicine, Nanning, Guangxi, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huang","family":"Qinglian","sequence":"additional","affiliation":[{"name":"Affiliated Hospital, Guangdong Medical University, Zhanjiang, Guangdong, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Jibing","sequence":"additional","affiliation":[{"name":"Ruikang Hospital, Guangxi University of Chinese Medicine, Nanning, Guangxi, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Feng","sequence":"additional","affiliation":[{"name":"Ruikang Hospital, Guangxi University of Chinese Medicine, Nanning, Guangxi, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"28042","published-online":{"date-parts":[[2025,5,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.10.003"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.01.015"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-023-03382-9"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.1025825"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3791\/63431"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3001868"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3390\/cells11071120"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.63.12.9"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-20096-9"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038\/nature12517"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05219-6"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-023-04547-1"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.51820"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2021.06.012"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/cpz1.568"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2023.03.007"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-24776-4"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-91846-4"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.3791\/61143"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-023-00839-2"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.3390\/cells12060930"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-28043-y"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2018.0112"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2023.1114420"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-021-00632-z"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2022.07.112"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1039\/D1LC00535A"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202210083"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1177\/20417314221147113"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05277-w"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2023.01.004"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.04.022"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1242\/dev.200439"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.3791\/64770"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1016\/j.xpro.2023.102470"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.4127"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3002141"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000705"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-019-0586-5"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.15283\/ijsc21157"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-023-01523-w"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2022.10.001"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1002\/med.21922"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.2c17467"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1039\/D2LC01109C"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.24662"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.12.032"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1038\/srep45091"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109042"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-023-03444-y"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-2655-9_7"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.3390\/nano13050893"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1007\/s00108-022-01444-3"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21030694"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.106267"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2022.0044"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-40431-y"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.3390\/cells10102683"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1186\/s13578-024-01252-2"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1097\/PAF.0000000000000619"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1038\/s41536-023-00301-7"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noab200"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noab106"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noab155"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202205525"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-024-03225-4"},{"key":"ref67","doi-asserted-by":"publisher","DOI":"10.1016\/j.bulcan.2023.02.002"},{"key":"ref68","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13989-3"},{"key":"ref69","doi-asserted-by":"publisher","DOI":"10.1109\/RBME.2021.3111744"},{"key":"ref70","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-020-01077-3"},{"key":"ref71","doi-asserted-by":"publisher","DOI":"10.1242\/bio.056416"},{"key":"ref72","doi-asserted-by":"publisher","DOI":"10.3791\/63745-v"},{"key":"ref73","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2021.5298"},{"key":"ref74","doi-asserted-by":"publisher","DOI":"10.1002\/1878-0261.13389"},{"key":"ref75","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00680-21"},{"key":"ref76","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01795-8"},{"key":"ref77","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.3379"},{"key":"ref78","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19115-y"},{"key":"ref79","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2023.114386"},{"key":"ref80","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-72214-0"},{"key":"ref81","doi-asserted-by":"publisher","DOI":"10.1111\/imm.13181"},{"key":"ref82","doi-asserted-by":"publisher","DOI":"10.3390\/v14040829"},{"key":"ref83","doi-asserted-by":"publisher","DOI":"10.1002\/sctm.21-0183"},{"key":"ref84","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2020106230"},{"key":"ref85","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2020.09.016"},{"key":"ref86","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202200475"},{"key":"ref87","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.2c00981"},{"key":"ref88","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-021-01344-8"},{"key":"ref89","doi-asserted-by":"publisher","DOI":"10.1016\/j.spen.2022.100973"},{"key":"ref90","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2020.06.001"},{"key":"ref91","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.01718-22"},{"key":"ref92","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2020.100002"},{"key":"ref93","doi-asserted-by":"publisher","DOI":"10.1186\/s13041-021-00841-3"},{"key":"ref94","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17454-4"},{"key":"ref95","doi-asserted-by":"publisher","DOI":"10.1111\/cns.14079"},{"key":"ref96","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-023-01987-3"},{"key":"ref97","doi-asserted-by":"publisher","DOI":"10.3390\/cells12131697"},{"key":"ref98","doi-asserted-by":"publisher","DOI":"10.1186\/s13010-022-00119-z"},{"key":"ref99","doi-asserted-by":"publisher","DOI":"10.14573\/altex.2303261"},{"key":"ref100","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2022.09.001"},{"key":"ref101","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2022.03.020"},{"key":"ref102","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-023-03291-x"},{"key":"ref103","doi-asserted-by":"publisher","DOI":"10.1017\/S096318012300021X"},{"key":"ref104","doi-asserted-by":"publisher","DOI":"10.1017\/S0963180123000221"}],"container-title":["Journal of Microbiology and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pdf.medrang.co.kr\/JMB2\/2025\/035\/jmb-35-e2411040.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T03:02:27Z","timestamp":1749524547000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jmb.or.kr\/journal\/view.html?doi=10.4014\/jmb.2411.11040"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,28]]},"references-count":104,"alternative-id":["10.4014\/jmb.2411.11040"],"URL":"https:\/\/doi.org\/10.4014\/jmb.2411.11040","relation":{},"ISSN":["1017-7825","1738-8872"],"issn-type":[{"value":"1017-7825","type":"print"},{"value":"1738-8872","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,28]]},"assertion":[{"value":"http:\/\/www.jmb.or.kr\/journal\/view.html?doi=10.4014\/jmb.2411.11040","URL":"http:\/\/www.jmb.or.kr\/journal\/view.html?doi=10.4014\/jmb.2411.11040","name":"the_journal","label":"J. Microbiol. Biotechnol.","group":{"name":"multiple_resolution","label":"Full text available at:"}},{"value":"2024-11-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-01","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}},{"value":"\u00a9 2025 The Korean Society for Microbiology and Biotechnology","name":"copyright","label":"Copyright","group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}},{"name":"license","label":"License","group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}}],"article-number":"e2411040"}}