{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T14:50:17Z","timestamp":1769007017696,"version":"3.49.0"},"reference-count":50,"publisher":"Korean Society for Microbiology and Biotechnology","funder":[{"name":"Jiangsu Province Traditional Chinese Medicine Science and Technology Development Project","award":["MS2022051"],"award-info":[{"award-number":["MS2022051"]}]},{"name":"Nanjing Medical Science and Technology Development Fund Project","award":["YKK16157"],"award-info":[{"award-number":["YKK16157"]}]},{"name":"Jiangsu Province Cadre Health Research Project","award":["BJ23035"],"award-info":[{"award-number":["BJ23035"]}]}],"content-domain":{"domain":["www.jmb.or.kr"],"crossmark-restriction":true},"short-container-title":["J. Microbiol. Biotechnol."],"DOI":"10.4014\/jmb.2502.02053","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T02:03:45Z","timestamp":1753841025000},"update-policy":"https:\/\/doi.org\/10.4014\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Longitudinal Analysis of the Immunostimulatory Properties and Safety Profile of <i>Lacticaseibacillus rhamnosus<\/i> LRa05 as a Dietary Supplement"],"prefix":"10.4014","volume":"35","author":[{"given":"Jiayi","family":"Wu","sequence":"first","affiliation":[{"name":"School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing 210023, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing 210023, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sitong","family":"He","sequence":"additional","affiliation":[{"name":"School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing 210023, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuna","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of specialist clinic, Nanjing Stomatological Hospital, Medical School, Nanjing University 210008, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jue","family":"Wang","sequence":"additional","affiliation":[{"name":"National Institutes for Food and Drug Control, National Key Laboratory for Quality Control of Pharmaceutical Excipients, Beijing, China; Shanghai Medical Device and Cosmetics Evaluation and Verification Center, Shanghai, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanan","family":"Li","sequence":"additional","affiliation":[{"name":"School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing 210023, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"28042","published-online":{"date-parts":[[2025,7,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2014.66"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.1925"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038\/nmicrobiol.2017.57"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/j.1536-4801.1995.tb11561.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2018.1425977"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3945\/an.116.014407"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2021.108863"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-019-05628-0"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1080\/87559129.2021.1967380"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s12602-022-10005-x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1186\/s12986-016-0067-0"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2018.10.002"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3390\/nu12071973"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms8111715"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.109914"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2891-13-60"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1128\/jb.176.8.2398-2405.1994"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics11101367"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2024.114600"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1039\/D0FO01720E"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.1c02925"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2023.1105694"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2023.104533"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2023.152415"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-006-0818-3"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms11092312"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1111\/1750-3841.17538"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1097\/00024382-200014030-00021"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.46929-0"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-4453(95)91736-5"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2023.2284869"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1080\/13880200500530542"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-960888"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1007\/s11250-023-03500-y"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1016\/j.psj.2023.102629"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(83)90046-4"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1084\/jem.185.12.2089"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1038\/nm1248"},{"key":"ref39","unstructured":"Wu X, Cai Y, Zhao Y, Li S. 2005. Effects of extract from taraxacum monogon (ETM) on immune modulation in mice. Acta Univ. Med. Nanjing 25: 163-165."},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1038\/icb.1996.64"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.2019.1627955"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.3390\/nu13041143"},{"key":"ref43","unstructured":"Perdigon G, Fuller R, Raya R. 2001. Lactic acid bacteria and their effect on the immune system. Curr. Issues Intest. Microbiol. 2: 27-42."},{"key":"ref44","unstructured":"Viti\u00f1i E, Alvarez S, Medina M, Medici M, de Budeguer MV, Perdig\u00f3n G. 2000. Gut mucosal immunostimulation by lactic acid bacteria. Biocell 24: 223-232."},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1039\/C9FO02761K"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.3390\/foods10123099"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1016\/S0271-5317(00)00294-3"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2017.12.003"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2024.106337"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2018.5403"}],"container-title":["Journal of Microbiology and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pdf.medrang.co.kr\/JMB2\/2025\/035\/jmb-35-e2502053.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T01:10:47Z","timestamp":1754442647000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jmb.or.kr\/journal\/view.html?doi=10.4014\/jmb.2502.02053"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,14]]},"references-count":50,"alternative-id":["10.4014\/jmb.2502.02053"],"URL":"https:\/\/doi.org\/10.4014\/jmb.2502.02053","relation":{},"ISSN":["1017-7825","1738-8872"],"issn-type":[{"value":"1017-7825","type":"print"},{"value":"1738-8872","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,14]]},"assertion":[{"value":"http:\/\/www.jmb.or.kr\/journal\/view.html?doi=10.4014\/jmb.2502.02053","URL":"http:\/\/www.jmb.or.kr\/journal\/view.html?doi=10.4014\/jmb.2502.02053","name":"the_journal","label":"J. Microbiol. Biotechnol.","group":{"name":"multiple_resolution","label":"Full text available at:"}},{"value":"2025-03-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-11","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}},{"value":"\u00a9 2025 The Korean Society for Microbiology and Biotechnology","name":"copyright","label":"Copyright","group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}},{"name":"license","label":"License","group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}}],"article-number":"e2502053"}}