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On the basis of AAQ\/TMQ structure\u2013activity relationship new derivatives are designed. The AAQs\/TMQs are classified using nine characteristic chemical properties in molecules. Many classification algorithms are based on information entropy. When applying the procedures to sets of moderate size, an excessive number of results appear compatible with data and suffer a combinatorial explosion. However, after equipartition conjecture, one has a selection criterion between different variants resulting from classification between hierarchical trees. A classification of anti-cancer agents is obtained. The features denote positions R2\u20138 on the quinoline bicycle.<\/p>","DOI":"10.4018\/ijcce.2013070101","type":"journal-article","created":{"date-parts":[[2013,7,10]],"date-time":"2013-07-10T11:32:50Z","timestamp":1373455970000},"page":"1-26","source":"Crossref","is-referenced-by-count":1,"title":["Molecular Classification of 5-Amino-2-Aroylquinolines and 4-Aroyl-6,7,8-Trimethoxyquinolines as Highly Potent Tubulin Polymerization Inhibitors"],"prefix":"10.4018","volume":"3","author":[{"given":"Francisco","family":"Torrens","sequence":"first","affiliation":[{"name":"Institute for Molecular Science, Universitat de Val\u00e8ncia, Val\u00e8ncia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Castellano","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary and Experimental Sciences, Universidad Cat\u00f3lica de Valencia San Vicente M\u00e1rtir, Val\u00e8ncia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2432","reference":[{"key":"ijcce.2013070101-0","doi-asserted-by":"publisher","DOI":"10.1063\/1.531236"},{"key":"ijcce.2013070101-1","volume":"Vol. 1","author":"J.-P.Benzecri","year":"1984","journal-title":"L\u2019Analyse des Donn\u00e9es"},{"key":"ijcce.2013070101-2","unstructured":"Castellano, G., Gonz\u00e1lez-Santander, J. 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