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After carrying out a virtual screening upon such models, new imidazole and guanidine derivatives with potential anticancer activity are proposed.<\/p>","DOI":"10.4018\/ijcce.2013070104","type":"journal-article","created":{"date-parts":[[2013,7,10]],"date-time":"2013-07-10T15:32:50Z","timestamp":1373470370000},"page":"64-74","source":"Crossref","is-referenced-by-count":0,"title":["Application of Molecular Topology to the Prediction of the Reaction Yield and Anticancer Activity of Imidazole and Guanidine Derivatives"],"prefix":"10.4018","volume":"3","author":[{"given":"Miguel Espinosa","family":"L\u00f3pez","sequence":"first","affiliation":[{"name":"Molecular Connectivity and Drug Design Research Unit, Department of Physical Chemistry, University of Valencia, Valencia, Spain"}]},{"given":"Vincenzo La Franca","family":"Pitarresi","sequence":"additional","affiliation":[{"name":"Molecular Connectivity and Drug Design Research Unit, Department of Physical Chemistry, University of Valencia, Valencia, Spain"}]},{"given":"Salvador Sayas","family":"Valero","sequence":"additional","affiliation":[{"name":"Institute of Chemical Technology, University Polytechnic of Valencia, Valencia, Spain"}]},{"given":"Jorge","family":"G\u00e1lvez","sequence":"additional","affiliation":[{"name":"Molecular Connectivity and Drug Design Research Unit, Department of Physical Chemistry, University of Valencia, Valencia, Spain"}]},{"given":"Ram\u00f3n","family":"Garc\u00eda-Domenech","sequence":"additional","affiliation":[{"name":"Molecular Connectivity and Drug Design Research Unit, Department of Physical Chemistry, University of Valencia, Valencia, Spain"}]}],"member":"2432","reference":[{"key":"ijcce.2013070104-0","first-page":"308343","article-title":"Imidazole derivatives as antiinflammatory agents and their preparation, pharmaceutical compositions and use in the treat- ment of inflammation associated with immune system impair- ment. 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