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Whereas biotech R&amp;D cooperation was characteristically organized in a highly specialized cluster based largely on local face-to-face communications and strategic temporary linkages to other agglomerations, this archetypal configuration may undergo changes due to the emerging applicability of open innovation models such as \u2018open source biotechnology\u2019 or the advanced integration of physicians and patients into therapy development processes. An in-depth case study of an \u2018Open Source Pharma\u2019 network portrays how innovation and knowledge integration mechanisms are put into practice through \u00b4permanence` in virtual space. In this newly created environment a number of geographical patterns are inverted: \u00b4local buzz` turns into \u00b4virtual global buzz`; global pipelines transform to local pipelines. 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