{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T16:29:30Z","timestamp":1781108970498,"version":"3.54.1"},"reference-count":0,"publisher":"IGI Global Scientific Publishing","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,1,1]]},"abstract":"<p>Oxidative damage (OD) is considered to be a central component in the progression of Alzheimer's disease (AD). 8-hydroxyguanosine (8-OHG), a readily oxidized ribonucleic acid found in AD, was used as a biomarker to investigate the role of OD in the progression of the disease. A disruption in two critical Thioredoxin-Dependent Peroxiredoxin System components, peroxiredoxin-3 (Prx-3) and thioredoxin (Trx), may serve as a source of the increased accumulation of OD observed in AD. We demonstrate that OD, in the form of 8-OHG, was quantitatively most significant during the earliest stage of AD [F (3, 25) = 5.08, p &lt; .01]. A drastic decline in mitochondrial protein levels of Prx-3 [F (3, 25) = 8.74, p. &lt; 01] and Trx [F (3, 25) = 4.33, p. &lt; 05] were also observed across the progression of the disease. We then tested the efficacy of pioglitazone, a thiazolidinedione class drug aimed to delay onset of AD by acting on mitoNEET. Our results showed a significant reduction in the oxidized variant of mitoNEET within the incipient population when a 0.8mg dose was simulated in silico (p = 0.0242; a. &lt; 05).<\/p>","DOI":"10.4018\/ijkdb.2015010103","type":"journal-article","created":{"date-parts":[[2016,9,12]],"date-time":"2016-09-12T08:24:45Z","timestamp":1473668685000},"page":"24-45","source":"Crossref","is-referenced-by-count":6,"title":["Low Dose Pioglitazone Attenuates Oxidative Damage in Early Alzheimer's Disease by Binding mitoNEET"],"prefix":"10.4018","volume":"5","author":[{"given":"Charles D.","family":"Hammack","sequence":"first","affiliation":[{"name":"University of Texas at San Antonio, San Antonio, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Perry","sequence":"additional","affiliation":[{"name":"University of Texas at San Antonio, San Antonio, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard G.","family":"LeBaron","sequence":"additional","affiliation":[{"name":"University of Texas at San Antonio, San Antonio, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg","family":"Villareal","sequence":"additional","affiliation":[{"name":"AL Phahelix Biometrics, Inc., San Antonio, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clyde F.","family":"Phelix","sequence":"additional","affiliation":[{"name":"University of Texas at San Antonio, San Antonio, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2432","container-title":["International Journal of Knowledge Discovery in Bioinformatics"],"original-title":[],"language":"ng","link":[{"URL":"https:\/\/www.igi-global.com\/viewtitle.aspx?TitleId=165548","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T19:10:54Z","timestamp":1654110654000},"score":1,"resource":{"primary":{"URL":"https:\/\/services.igi-global.com\/resolvedoi\/resolve.aspx?doi=10.4018\/IJKDB.2015010103"}},"subtitle":["Transcriptome-To-Reactome\u2122 Biosimulation of Neurons"],"short-title":[],"issued":{"date-parts":[[2015,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"URL":"https:\/\/doi.org\/10.4018\/ijkdb.2015010103","relation":{},"ISSN":["1947-9115","1947-9123"],"issn-type":[{"value":"1947-9115","type":"print"},{"value":"1947-9123","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,1]]}}}