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The proposed solution can increase the lead time for transitions, which is useful to determine suitable timings (e.g., between tasks\/subtasks) for interruptions in vehicles. Further, it allows responding to Take-Over-Requests directly on handheld devices in emergencies. Different aspects of the Attentive User Interface (AUI) concept were evaluated in two driving simulator studies. Results, mainly based on Take-Over performance and physiological measurements, confirm the positive effect of AUIs on safety and comfort. 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