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The archetype is responsible for the definition of clinical concepts which has limitations in terms of supporting complex reasoning and knowledge discovery requirements. The objective of this article is to propose a semantic-mediation architecture to support semantic interoperability among healthcare organizations. It provides an intermediate semantic layer to exploit clinical information based on richer ontological representations to create a \u201cmodel of meaning\u201d for enabling semantic mediation. The proposed model also provides secure mechanisms to allow interoperable sharing of patient data between healthcare organizations.<\/jats:p>","DOI":"10.4018\/jitr.2018100106","type":"journal-article","created":{"date-parts":[[2018,8,24]],"date-time":"2018-08-24T08:08:11Z","timestamp":1535098091000},"page":"87-98","source":"Crossref","is-referenced-by-count":0,"title":["Semantic Health Mediation and Access Control Manager for Interoperability Among Healthcare Systems"],"prefix":"10.4018","volume":"11","author":[{"given":"Abdullah","family":"Alamri","sequence":"first","affiliation":[{"name":"Faculty of Computing and Information Technology, University of Jeddah, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2432","reference":[{"key":"JITR.2018100106-0","author":"D.Allemang","year":"2011","journal-title":"Semantic Web for the Working Ontologist: Effective Modeling in RDFS and OWL"},{"key":"JITR.2018100106-1","doi-asserted-by":"publisher","DOI":"10.1200\/jop.2005.1.2.57"},{"key":"JITR.2018100106-2","unstructured":"Beckett, D. & McBride, B. 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