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To address this limitation, we designed Dis2PPI, a workflow that integrates information retrieved from genetic disease databases and interactomes. Dis2PPI extracts protein names from a disease report and uses this information to mine protein-protein interaction (PPI) networks. The data gathered from this mining can be used in systems biology analyses. To demonstrate the functionality of Dis2PPI for systems biology analyses, the authors mined information about xeroderma pigmentosum and Cockayne syndrome, two monogenic diseases that lead to skin cancer when the patients are exposed to sunlight and neurodegeneration.<\/p>","DOI":"10.4018\/jkdb.2012070104","type":"journal-article","created":{"date-parts":[[2013,6,20]],"date-time":"2013-06-20T16:03:53Z","timestamp":1371744233000},"page":"67-85","source":"Crossref","is-referenced-by-count":1,"title":["Dis2PPI"],"prefix":"10.4018","volume":"3","author":[{"given":"Daniel Luis","family":"Notari","sequence":"first","affiliation":[{"name":"Centro de Computa\u00e7\u00e3o e Tecnologia da Informa\u00e7\u00e3o, Universidade de Caxias do Sul, Caxias do Sul, Rio Grande do Sul, Brazil"}]},{"given":"Samuel Brando","family":"Oldra","sequence":"additional","affiliation":[{"name":"Centro de Computa\u00e7\u00e3o e Tecnologia da Informa\u00e7\u00e3o, Universidade de Caxias do Sul, Caxias do Sul, Rio Grande do Sul, Brazil"}]},{"given":"Mauricio Adami","family":"Mariani","sequence":"additional","affiliation":[{"name":"Centro de Computa\u00e7\u00e3o e Tecnologia da Informa\u00e7\u00e3o, Universidade de Caxias do Sul, Caxias do Sul, Rio Grande do Sul, Brazil"}]},{"given":"Cristian","family":"Reolon","sequence":"additional","affiliation":[{"name":"Centro de Computa\u00e7\u00e3o e Tecnologia da Informa\u00e7\u00e3o, Universidade de Caxias do Sul, Caxias do Sul, Rio Grande do Sul, Brazil"}]},{"given":"Diego","family":"Bonatto","sequence":"additional","affiliation":[{"name":"Centro de Biotecnologia da UFRGS, Departamento de Biologia Molecular e Biotecnologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil"}]}],"member":"2432","reference":[{"key":"jkdb.2012070104-0","unstructured":"Agilent Literature Search Software. 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