{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:45:48Z","timestamp":1790768748209,"version":"4.1.0"},"reference-count":45,"publisher":"AACN Publishing","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,12,15]]},"abstract":"<jats:p>More than 356\u2009000 out-of-hospital cardiac arrests occur in the United States annually. Complications involving post\u2013cardiac arrest syndrome occur because of ischemic-reperfusion injury to the brain, lungs, heart, and kidneys. Post\u2013cardiac arrest syndrome is a clinical state that involves global brain injury, myocardial dysfunction, macrocirculatory dysfunction, increased vulnerability to infection, and persistent precipitating pathology (ie, the cause of the arrest). The severity of outcomes varies and depends on precipitating factors, patient health before cardiac arrest, duration of time to return of spontaneous circulation, and underlying comorbidities. In this article, the pathophysiology and treatment of post\u2013cardiac arrest syndrome are reviewed and potential novel therapies are described.<\/jats:p>","DOI":"10.4037\/aacnacc2020535","type":"journal-article","created":{"date-parts":[[2020,12,13]],"date-time":"2020-12-13T21:48:38Z","timestamp":1607896118000},"page":"383-393","source":"Crossref","is-referenced-by-count":14,"title":["Post\u2013Cardiac Arrest Syndrome"],"prefix":"10.4037","volume":"31","author":[{"given":"Linda","family":"Dalessio","sequence":"first","affiliation":[{"name":"Linda Dalessio is Associate Professor of Nursing, Western Connecticut State University, 181 White Street, Danbury, CT 06810 (Dalessiol@wcsu.edu)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2471","reference":[{"issue":"12","key":"2020121321483132700_b1-0310383","doi-asserted-by":"publisher","first-page":"e493","DOI":"10.1161\/cir.0000000000000573","article-title":"Correction to: Benjamin et al, Heart disease and stroke 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