{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T11:48:43Z","timestamp":1746532123223},"reference-count":9,"publisher":"AACN Publishing","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,6,15]]},"abstract":"<jats:sec>\n                  <jats:title>Background:<\/jats:title>\n                  <jats:p>Ventricular assist devices require anticoagulation to reduce thrombosis risk. Nurse-driven unfractionated heparin monitoring protocols have been validated for various indications, although data in patients with ventricular assist devices are lacking.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective:<\/jats:title>\n                  <jats:p>To evaluate a nurse-driven protocol for managing unfractionated heparin therapy in stable patients with ventricular assist devices.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods:<\/jats:title>\n                  <jats:p>This was a retrospective analysis of adult patients with ventricular assist devices requiring unfractionated heparin therapy, divided into 2 groups: before and after protocol implementation. The primary outcome was time to first therapeutic activated partial thromboplastin time.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>Each group included 29 patients. There was no difference between the preintervention and postintervention groups in time to therapeutic activated partial thromboplastin time (25 vs 23 hours, P = .95) or proportion of patients with therapeutic activated partial thromboplastin time within the first 24 hours (45% vs 34%, P = .42). Suspected pump thrombosis and bleeding events were similar in the 2 groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion:<\/jats:title>\n                  <jats:p>A nurse-driven heparin monitoring protocol was similar in time to therapeutic activated partial thromboplastin time compared with provider-driven monitoring and adjustments in patients with ventricular assist devices.<\/jats:p>\n               <\/jats:sec>","DOI":"10.4037\/aacnacc2021803","type":"journal-article","created":{"date-parts":[[2021,6,5]],"date-time":"2021-06-05T02:08:50Z","timestamp":1622858930000},"page":"146-151","source":"Crossref","is-referenced-by-count":1,"title":["Impact of a Nurse-Driven Heparin Monitoring Protocol for Ventricular Assist Devices"],"prefix":"10.4037","volume":"32","author":[{"given":"Michelle","family":"Gannon","sequence":"first","affiliation":[{"name":"Michelle Gannon is Clinical Pharmacist, Department of Pharmacy, UChicago Medicine, Chicago, Illinois."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela B.","family":"Simone","sequence":"additional","affiliation":[{"name":"Pamela B. Simone is Cardiology Clinical Pharmacist Specialist, Department of Pharmacy, UChicago Medicine, 5841 S Maryland Ave, Chicago, IL 60637 (pamela.simone@uchospitals.edu)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2471","reference":[{"issue":"2","key":"2021060423071502500_b1-0320146","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.healun.2012.09.013","article-title":"The 2013 International Society for Heart and Lung Transplantation guidelines for mechanical circulatory support: executive summary","volume":"32","author":"Feldman","year":"2013","journal-title":"J Heart Lung Transplant"},{"issue":"1","key":"2021060423071502500_b2-0320146","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.healun.2016.10.001","article-title":"PREVENtion of Heart-Mate II Pump Thrombosis Through Clinical Management: the PREVENT multi-center study","volume":"36","author":"Maltais","year":"2017","journal-title":"J Heart Lung Transplant"},{"issue":"2","key":"2021060423071502500_b3-0320146","first-page":"152","article-title":"Nurse-driven intravenous heparin protocol: quality improvement initiative","volume":"21","author":"Williams","year":"2010","journal-title":"ACCN Adv Crit Care"},{"issue":"2","key":"2021060423071502500_b4-0320146","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1177\/1076029617721009","article-title":"Description and evaluation of the implementation of a weight-based, nurse-driven heparin nomogram in a tertiary academic medical center","volume":"24","author":"Schurr","year":"2018","journal-title":"Clin Appl Thromb Hemost"},{"issue":"10","key":"2021060423071502500_b5-0320146","first-page":"1","article-title":"Anticoagulation monitoring in left ventricular assist device (LVAD) patients","volume":"3","author":"Sieg","year":"2017","journal-title":"VAD J"},{"issue":"1","key":"2021060423071502500_b6-0320146","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.ahj.2009.10.034","article-title":"Hematomas of at least 5 cm and outcomes in patients undergoing elective percutaneous coronary intervention: insights from the SafeTy and Efficacy of Enoxaparin in PCI patients, an internationaL randomized Evaluation (STEEPLE) trial","volume":"159","author":"White","year":"2010","journal-title":"Am Heart J"},{"issue":"6","key":"2021060423071502500_b7-0320146","first-page":"385","article-title":"Comparison of outcomes: nurse-driven vs. physician-driven weight-based intravenous heparin protocol","volume":"25","author":"Davis","year":"2016","journal-title":"Medsurg Nurs"},{"issue":"5","key":"2021060423071502500_b8-0320146","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.jchf.2018.03.005","article-title":"Trends and cost of heart transplantation and left ventricular assist devices: impact of proposed federal cuts","volume":"6","author":"Patel","year":"2018","journal-title":"JACC Heart Fail"},{"issue":"3","key":"2021060423071502500_b9-0320146","doi-asserted-by":"crossref","first-page":"204","DOI":"10.2165\/00003088-198005030-00002","article-title":"Clinical pharmacokinetics of heparin","volume":"5","author":"Estes","year":"1980","journal-title":"Clin Pharmacokinet"}],"container-title":["AACN Advanced Critical Care"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/aacnjournals.org\/aacnacconline\/article-pdf\/32\/2\/146\/136466\/146.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/aacnjournals.org\/aacnacconline\/article-pdf\/32\/2\/146\/136466\/146.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,5]],"date-time":"2021-06-05T02:09:00Z","timestamp":1622858940000},"score":1,"resource":{"primary":{"URL":"https:\/\/aacnjournals.org\/aacnacconline\/article\/32\/2\/146\/31476\/Impact-of-a-Nurse-Driven-Heparin-Monitoring"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,15]]},"references-count":9,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,6,15]]}},"URL":"https:\/\/doi.org\/10.4037\/aacnacc2021803","relation":{},"ISSN":["1559-7768","1559-7776"],"issn-type":[{"value":"1559-7768","type":"print"},{"value":"1559-7776","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,15]]}}}