{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T18:48:37Z","timestamp":1773341317291,"version":"3.50.1"},"reference-count":10,"publisher":"AACN Publishing","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,7,1]]},"abstract":"Background<\/jats:title>Albumin is broadly prescribed for critically ill patients although it does not have a mortality benefit over crystalloids. One common use of albumin is to promote diuresis.<\/jats:p><\/jats:sec>Objectives<\/jats:title>To compare urine output in patients treated with furosemide with and without albumin and to assess other variables possibly associated with enhanced diuresis.<\/jats:p><\/jats:sec>Methods<\/jats:title>A retrospective study was conducted on patients in a medical intensive care unit who received furosemide therapy as a continuous infusion with and without 25% albumin for more than 6 hours. Primary end points were urine output and net fluid loss.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 31 patients were included in the final analysis. Mean urine output in patients treated with furosemide alone did not differ significantly from output in patients treated with furo-semide plus albumin at 6, 24, and 48 hours: mean output, 1119 (SD, 597) mL vs 1201 (SD, 612) mL, P = .56; 4323 (SD, 1717) mL vs 4615 (SD, 1741) mL, P = .42; and 7563 mL (SD, 2766) vs 7432 (SD, 2324) mL, P = .94, respectively. Additionally, net fluid loss did not differ significantly between the 2 groups at 6, 24, and 48 hours. Higher concentrations of serum albumin did not improve urine output. The only independent variable significantly associated with enhanced urine output at 24 and 48 hours was increased fluid intake.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Addition of albumin to a furosemide infusion did not enhance diuresis obtained with furosemide alone in critically ill patients.<\/jats:p><\/jats:sec>","DOI":"10.4037\/ajcc2012999","type":"journal-article","created":{"date-parts":[[2012,7,2]],"date-time":"2012-07-02T23:21:32Z","timestamp":1341271292000},"page":"280-286","source":"Crossref","is-referenced-by-count":19,"title":["Effect of Albumin on Diuretic Response to Furosemide in Patients With Hypoalbuminemia"],"prefix":"10.4037","volume":"21","author":[{"given":"Thitima","family":"Doungngern","sequence":"first","affiliation":[{"name":"Thitima Doungngern is a member of the faculty of pharmaceutical sciences at Prince of Songkla University, Hat Yai, Songkhla, Thailand. At the time of the study, Doungngern was a specialized resident in internal medicine. Yvonne Huckleberry is a critical care pharmacist, University of Arizona Medical Center, John W. Bloom is an associate professor, Departments of Pharmacology and Medicine, College of Medicine, and Brian Erstad is a professor, College of Pharmacy, at the University of Arizona, Tucson, Arizona"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yvonne","family":"Huckleberry","sequence":"first","affiliation":[{"name":"Thitima Doungngern is a member of the faculty of pharmaceutical sciences at Prince of Songkla University, Hat Yai, Songkhla, Thailand. At the time of the study, Doungngern was a specialized resident in internal medicine. Yvonne Huckleberry is a critical care pharmacist, University of Arizona Medical Center, John W. Bloom is an associate professor, Departments of Pharmacology and Medicine, College of Medicine, and Brian Erstad is a professor, College of Pharmacy, at the University of Arizona, Tucson, Arizona"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John W.","family":"Bloom","sequence":"first","affiliation":[{"name":"Thitima Doungngern is a member of the faculty of pharmaceutical sciences at Prince of Songkla University, Hat Yai, Songkhla, Thailand. At the time of the study, Doungngern was a specialized resident in internal medicine. Yvonne Huckleberry is a critical care pharmacist, University of Arizona Medical Center, John W. Bloom is an associate professor, Departments of Pharmacology and Medicine, College of Medicine, and Brian Erstad is a professor, College of Pharmacy, at the University of Arizona, Tucson, Arizona"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Erstad","sequence":"first","affiliation":[{"name":"Thitima Doungngern is a member of the faculty of pharmaceutical sciences at Prince of Songkla University, Hat Yai, Songkhla, Thailand. At the time of the study, Doungngern was a specialized resident in internal medicine. Yvonne Huckleberry is a critical care pharmacist, University of Arizona Medical Center, John W. Bloom is an associate professor, Departments of Pharmacology and Medicine, College of Medicine, and Brian Erstad is a professor, College of Pharmacy, at the University of Arizona, Tucson, Arizona"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2471","reference":[{"issue":"3","key":"2020032705434407800_b1-0210280","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1440-1797.2007.00889.x","article-title":"The comparison of the diuretic and natriuretic effect of continuous and bolus intravenous furosemide in patients with chronic kidney disease","volume":"13","author":"Sanjay","year":"2008","journal-title":"Nephrology (Carlton)"},{"key":"2020032705434407800_b2-0210280","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.2146\/ajhp090068","article-title":"Management of loop diuretic resistance in the intensive care unit","volume":"66","author":"Asare","year":"2009","journal-title":"Am J Health Syst Pharm"},{"issue":"2","key":"2020032705434407800_b3-0210280","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/ki.1987.192","article-title":"Mechanism of furosemide resistance in analbuminemic rats and hypoalbuminemic patients","volume":"32","author":"Inoue","year":"1987","journal-title":"Kidney Int"},{"key":"2020032705434407800_b4-0210280","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1038\/ki.1991.228","article-title":"Binding inhibitors restore furosemide potency in tubule fluid containing albumin","volume":"40","author":"Kirchner","year":"1991","journal-title":"Kidney Int"},{"issue":"6973","key":"2020032705434407800_b5-0210280","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1136\/bmj.310.6973.162","article-title":"Diuretic effect of furosemide in patients with nephrotic syndrome: is it potentiated by intravenous albumin?","volume":"310","author":"Akcicek","year":"1995","journal-title":"BMJ"},{"issue":"2","key":"2020032705434407800_b6-0210280","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1046\/j.1523-1755.1999.00298.x","article-title":"Coadministration of albumin and furosemide in patients with the nephrotic syndrome","volume":"55","author":"Fliser","year":"1999","journal-title":"Kidney Int"},{"issue":"4","key":"2020032705434407800_b7-0210280","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/S0168-8278(99)80194-9","article-title":"Albumin improves the response to diuretics in patients with cirrhosis and ascites: results of a randomized, controlled trial","volume":"30","author":"Gentilini","year":"1999","journal-title":"J Hepatol"},{"issue":"5","key":"2020032705434407800_b8-0210280","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1681\/ASN.V1251010","article-title":"Effects of albumin\/furosemide mixtures on responses to furosemide in hypoalbuminemic patients","volume":"12","author":"Chalasani","year":"2001","journal-title":"J Am Soc Nephrol"},{"issue":"8","key":"2020032705434407800_b9-0210280","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1097\/01.CCM.0000171539.47006.02","article-title":"A randomized, controlled trial of furosemide with or without albumin in hypoproteinemic patients with acute lung injury","volume":"33","author":"Martin","year":"2005","journal-title":"Crit Care Med"},{"issue":"7","key":"2020032705434407800_b10-0210280","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1093\/ndt\/11.7.1224","article-title":"Does it make sense to administer albumin to the patient with nephrotic oedema?","volume":"11","author":"Dorhout Mees","year":"1996","journal-title":"Nephrol Dial Transplant"}],"container-title":["American Journal of Critical Care"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/aacnjournals.org\/ajcconline\/article-pdf\/21\/4\/280\/97429\/280.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/aacnjournals.org\/ajcconline\/article-pdf\/21\/4\/280\/97429\/280.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T02:29:47Z","timestamp":1642645787000},"score":1,"resource":{"primary":{"URL":"https:\/\/aacnjournals.org\/ajcconline\/article\/21\/4\/280\/2948\/Effect-of-Albumin-on-Diuretic-Response-to"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7,1]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,7,1]]}},"URL":"https:\/\/doi.org\/10.4037\/ajcc2012999","relation":{},"ISSN":["1062-3264","1937-710X"],"issn-type":[{"value":"1062-3264","type":"print"},{"value":"1937-710X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,1]]}}}