{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T13:52:29Z","timestamp":1788875549363,"version":"build-2803163510"},"reference-count":33,"publisher":"AACN Publishing","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,3,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Patients sometimes require insertion of a nasogastric tube for the administration of a large volume of a polyethylene glycol electrolyte solution. If the tube is malpositioned, the risk for direct instillation of the solution into the lung increases. The risk for aspiration also increases if the infusion rate exceeds gastrointestinal tolerance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To review published cases of patients\u2019 experiencing adverse pulmonary events after administration of polyethylene glycol electrolyte solution via a nasogastric tube and to offer suggestions to prevent these outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A search of the literature from 1993 through 2014 was performed by using the PubMed, MEDLINE, Cumulative Index to Nursing and Allied Health Literature, and Scopus databases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the 12 case reports located, none of the patients had radiographs to verify tube location before infusion of polyethylene glycol electrolyte solution. After symptoms developed in 3 children (ages 8\u201311 years), radiographs showed their tubes incorrectly positioned in the bronchus, lung, or esophagus; ports of a fourth child\u2019s tube were in the oropharynx. The remaining 8 patients (ages 5\u201386 years) never had radiographs to determine tube placement. Pulmonary complications from the infusions of polyethylene glycol electrolyte solution contributed to the death of 5 of the patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Relatively simple maneuvers to reduce the likelihood of adverse pulmonary events following the administration of large volumes of polyethylene glycol electrolyte solution via a nasogastric tube are well worth the cost and effort to protect patients from potential serious injury.<\/jats:p><\/jats:sec>","DOI":"10.4037\/ajcc2017522","type":"journal-article","created":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T08:10:18Z","timestamp":1488355818000},"page":"e11-e17","source":"Crossref","is-referenced-by-count":8,"title":["Administering Polyethylene Glycol Electrolyte Solution Via a Nasogastric Tube: Pulmonary Complications"],"prefix":"10.4037","volume":"26","author":[{"given":"Norma A.","family":"Metheny","sequence":"first","affiliation":[{"name":"Norma A. Metheny is a professor of nursing and holds the Dorothy A. Votsmier Endowed Chair in Nursing at Saint Louis University School of Nursing, St Louis, Missouri. Kathleen L. Meert is a professor of medicine in the Department of Pediatrics, Wayne State University, and chief, Division of Critical Care Medicine, Children\u2019s Hospital of Michigan, Detroit, Michigan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen L.","family":"Meert","sequence":"first","affiliation":[{"name":"Norma A. Metheny is a professor of nursing and holds the Dorothy A. Votsmier Endowed Chair in Nursing at Saint Louis University School of Nursing, St Louis, Missouri. Kathleen L. 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Surg"},{"issue":"4","key":"2020032708464576500_b3-02600e1","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/j.1365-2036.2006.03212.x","article-title":"Systematic review: oral bowel preparation for colonoscopy","volume":"25","author":"Belsey","year":"2007","journal-title":"Aliment Pharmacol Ther"},{"issue":"1","key":"2020032708464576500_b4-02600e1","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1081\/CLT-100102888","article-title":"Life-threatening respiratory failure following accidental infusion of polyethylene glycol electrolyte solution into the lung","volume":"39","author":"Narsinghani","year":"2001","journal-title":"J Toxicol Clin Toxicol"},{"issue":"2","key":"2020032708464576500_b5-02600e1","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1097\/00005176-200308000-00020","article-title":"Therapy for pulmonary aspiration of a polyethylene glycol solution","volume":"37","author":"Liangthanasarn","year":"2003","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"2020032708464576500_b6-02600e1","first-page":"872634","article-title":"Aspiration pneumonitis caused by polyethylene glycol-electrolyte solution treated with conservative management","volume":"2014","author":"Mosquera","year":"2014","journal-title":"Case Rep Pediatr"},{"issue":"4","key":"2020032708464576500_b7-02600e1","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1097\/PEC.0b013e31803f5a83","article-title":"Cardiotoxicity associated with accidental bupropion ingestion in a child","volume":"23","author":"Givens","year":"2007","journal-title":"Pediatr Emerg Care"},{"issue":"3","key":"2020032708464576500_b8-02600e1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1136\/adc.86.3.209","article-title":"Fulminant pulmonary oedema after administration of a balanced electrolyte polyethylene glycol solution","volume":"86","author":"Argent","year":"2002","journal-title":"Arch Dis Child"},{"issue":"6","key":"2020032708464576500_b9-02600e1","first-page":"196","article-title":"Fatal aspiration of polyethylene glycol solution","volume":"64","author":"De Graaf","year":"2006","journal-title":"Neth J Med"},{"issue":"3","key":"2020032708464576500_b10-02600e1","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1159\/000007672","article-title":"Aspiration: a possible severe complication in colonoscopy preparation of elderly people by orthograde intestine lavage","volume":"60","author":"Gabel","year":"1999","journal-title":"Digestion"},{"issue":"3","key":"2020032708464576500_b11-02600e1","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.gie.2010.11.050","article-title":"Colonic cleansing for colonoscopy: a risk to be taken seriously","volume":"73","author":"Hasan","year":"2011","journal-title":"Gastrointest Endosc"},{"key":"2020032708464576500_b12-02600e1","first-page":"26","article-title":"Aspiration complications following nasogastric administration of polyethylene glycol solution","author":"Lutz","year":"2002","journal-title":"Pract Gastroenterol"},{"issue":"5","key":"2020032708464576500_b13-02600e1","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/S0016-5107(98)70229-9","article-title":"Life-threatening complications of nasogastric administration of polyethylene glycol-electrolyte solutions (GoLytely) for bowel cleansing","volume":"47","author":"Marschall","year":"1998","journal-title":"Gastrointest Endosc"},{"issue":"9","key":"2020032708464576500_b14-02600e1","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1177\/106002809302700905","article-title":"Acute pulmonary edema after polyethylene glycol intestinal lavage in a child","volume":"27","author":"Paap","year":"1993","journal-title":"Ann Pharmacother"},{"issue":"6","key":"2020032708464576500_b15-02600e1","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1136\/adc.87.6.537","article-title":"Acute pulmonary oedema complicating polyethylene glycol intestinal lavage","volume":"87","author":"Wong","year":"2002","journal-title":"Arch Dis Child"},{"issue":"1","key":"2020032708464576500_b16-02600e1","doi-asserted-by":"crossref","first-page":"e7","DOI":"10.1016\/j.pedn.2013.08.009","article-title":"A review of published case reports of inadvertent pulmonary placement of nasogastric tubes in children","volume":"29","author":"Metheny","year":"2014","journal-title":"J Pediatr Nurs"},{"issue":"2","key":"2020032708464576500_b17-02600e1","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1097\/01.PCC.0000257035.54831.26","article-title":"Oral and nasal enteral tube placement errors and complications in a pediatric intensive care unit","volume":"8","author":"Creel","year":"2007","journal-title":"Pediatr Crit Care Med"},{"issue":"5","key":"2020032708464576500_b18-02600e1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1177\/0115426594009005185","article-title":"pH testing of feeding-tube aspirates to determine placement","volume":"9","author":"Metheny","year":"1994","journal-title":"Nutr Clin Pract"},{"issue":"5","key":"2020032708464576500_b19-02600e1","doi-asserted-by":"crossref","first-page":"e-72","DOI":"10.4037\/ajcc2015971","article-title":"The pH of feeding tube aspirates from critically ill infants","volume":"24","author":"Meert","year":"2015","journal-title":"Am J Crit Care"},{"issue":"1","key":"2020032708464576500_b20-02600e1","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1177\/011542650602100140","article-title":"Acute complications associated with bedside placement of feeding tubes","volume":"21","author":"Baskin","year":"2006","journal-title":"Nutr Clin Pract"},{"key":"2020032708464576500_b21-02600e1","unstructured":"American Association of Clinical-Care Nurses. AACN Practice Alert. Initial and ongoing verification of feeding tube placement in adults. February2016. AACN website. http:\/\/www.aacn.org\/wd\/practice\/content\/feeding-tube-practice-alert.pcms?menu=practice. Accessed November 17, 2016."},{"issue":"2","key":"2020032708464576500_b22-02600e1","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1053\/j.gastro.2011.06.001","article-title":"Multidisciplinary practical guidelines for gastrointestinal access for enteral nutrition and decompression from the Society of Interventional Radiology and American Gastroenterological Association (AGA) Institute, with endorsement by Canadian Interventional Radiological Association (CIRA) and Cardiovascular and Interventional Radiological Society of Europe (CIRSE)","volume":"141","author":"Itkin","year":"2011","journal-title":"Gastroenterology"},{"issue":"6","key":"2020032708464576500_b23-02600e1","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1081\/CLT-200035932","article-title":"Position paper: whole bowel irrigation","volume":"42","author":"American Academy of Clinical Toxicology, European Association of Poison Centres and Clinical Toxicologists","year":"2004","journal-title":"J Toxicol Clin Toxicol"},{"issue":"1","key":"2020032708464576500_b24-02600e1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3109\/15563650.2014.989326","article-title":"Position paper update: whole bowel irrigation for gastrointestinal decontamination of overdose patients","volume":"53","author":"Thanacoody","year":"2015","journal-title":"Clin Toxicol (Phila)"},{"key":"2020032708464576500_b25-02600e1","unstructured":"Brown CA . The decision to intubate. UpToDate web site. http:\/\/www.uptodate.com\/contents\/the-decision-to-intubate?source=machineLearning&search=airway+protection&selectedTitle=1~150&sectionRank=2&anchor=H2#H2. Accessed November 17, 2016."},{"issue":"5","key":"2020032708464576500_b26-02600e1","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/0736-4679(93)90312-U","article-title":"The use of Glasgow coma scale in poisoning","volume":"11","author":"Chan","year":"1993","journal-title":"J Emerg Med"},{"issue":"11","key":"2020032708464576500_b27-02600e1","first-page":"2741","article-title":"Bowel preparation for pediatric colonoscopy: report of the NASPGHAN endoscopy and procedures committee","volume":"20","author":"Pall","year":"2014","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"11","key":"2020032708464576500_b28-02600e1","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.3748\/wjg.v20.i11.2741","article-title":"What is the best strategy for successful bowel preparation under special conditions?","volume":"20","author":"Lim","year":"2014","journal-title":"World J Gastroenterol"},{"issue":"3","key":"2020032708464576500_b29-02600e1","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1097\/MPG.0b013e3181eb6a1c","article-title":"Bowel preparation for pediatric colonoscopy procedures","volume":"51","author":"Hunter","year":"2010","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"4","key":"2020032708464576500_b30-02600e1","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.gie.2014.09.048","article-title":"Bowel preparation before colonoscopy","volume":"81","author":"Saltzman","year":"2015","journal-title":"Gastrointest Endosc"},{"issue":"4","key":"2020032708464576500_b31-02600e1","doi-asserted-by":"crossref","first-page":"360","DOI":"10.4037\/ajcc2006.15.4.360","article-title":"Preventing respiratory complications of tube feedings: evidence-based practice","volume":"15","author":"Metheny","year":"2006","journal-title":"Am J Crit Care"},{"issue":"3","key":"2020032708464576500_b32-02600e1","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1001\/jama.2012.196377","article-title":"Effect of not monitoring residual gastric volume on risk of ventilator-associated pneumonia in adults receiving mechanical ventilation and early enteral feeding: a randomized controlled trial","volume":"309","author":"Reignier","year":"2013","journal-title":"JAMA"},{"issue":"3","key":"2020032708464576500_b33-02600e1","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1002\/nur.4770090309","article-title":"Frequency of nasoenteral tube displacement and associated risk factors","volume":"9","author":"Metheny","year":"1986","journal-title":"Res Nurs Health"}],"container-title":["American Journal of Critical Care"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/aacnjournals.org\/ajcconline\/article-pdf\/26\/2\/e11\/98116\/e1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/aacnjournals.org\/ajcconline\/article-pdf\/26\/2\/e11\/98116\/e1.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T00:02:36Z","timestamp":1658707356000},"score":1,"resource":{"primary":{"URL":"https:\/\/aacnjournals.org\/ajcconline\/article\/26\/2\/e11\/3228\/Administering-Polyethylene-Glycol-Electrolyte"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,1]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,3,1]]}},"URL":"https:\/\/doi.org\/10.4037\/ajcc2017522","relation":{},"ISSN":["1062-3264","1937-710X"],"issn-type":[{"value":"1062-3264","type":"print"},{"value":"1937-710X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,1]]}}}