{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T03:41:40Z","timestamp":1785296500148,"version":"3.55.0"},"reference-count":22,"publisher":"AACN Publishing","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,1]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Between 30% and 80% of survivors of critical illness experience cognitive impairment, but the underlying mechanisms remain unknown.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To determine whether intensive care unit (ICU) delirium biomarkers align with the National Institute on Aging\u2013Alzheimer\u2019s Association (NIA-AA) research framework for diagnostic biomarkers for Alzheimer disease and other related dementias (ADRD).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Ovid MEDLINE, PsycInfo, Embase, and the Cochrane Library were systematically searched for articles published between January 1, 2000, and February 20, 2020, on the relationship between delirium and biomarkers listed in the NIA-AA framework. Only studies that addressed delirium in the ICU setting and fluid biomarkers were included in these analyses.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of 61 256 records screened, 38 studies met inclusion criteria, 8 of which were suitable for meta-analysis. In pooled analysis, significant associations were found between ICU delirium and amyloid \u03b2-peptide 1-40 (standard mean difference [SMD], 0.42; 95% CI, 0.09-0.75), interleukin (IL)-1 receptor antagonist (SMD, 0.58; 95% CI, 0.21-0.94), and IL-6 (SMD, 0.31; 95% CI, 0.06-0.56). No significant association was observed in pooled analyses between ICU delirium and the other biomarkers. Few studies have examined ICU delirium and pathologic tau or neurodegeneration biomarkers.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Inflammatory biomarkers and amyloid \u03b2 are associated with ICU delirium and point to potential overlapping mechanisms between delirium and ADRD. Critical care providers should consider integrating diagnostic approaches used in ADRD in their assessment of post\u2013ICU cognitive dysfunction.<\/jats:p>\n               <\/jats:sec>","DOI":"10.4037\/ajcc2021771","type":"journal-article","created":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T02:24:23Z","timestamp":1625106263000},"page":"312-319","source":"Crossref","is-referenced-by-count":11,"title":["Meta-analysis of ICU Delirium Biomarkers and Their Alignment With the NIA-AA Research Framework"],"prefix":"10.4037","volume":"30","author":[{"given":"Carol K.","family":"Chan","sequence":"first","affiliation":[{"name":"Carol K. Chan is a clinical fellow in geriatric psychiatry, Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqing","family":"Song","sequence":"additional","affiliation":[{"name":"Yiqing Song is a professor, Fairbanks School of Public Health, Indiana University, Indianapolis."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Greene","sequence":"additional","affiliation":[{"name":"Ryan Greene is an assistant professor, Department of Psychiatry, Indiana University School of Medicine, Indianapolis."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi","family":"Lindroth","sequence":"additional","affiliation":[{"name":"Heidi Lindroth is a postdoctoral fellow, Division of Pulmonary, Critical Care, Sleep and Occupational Medicine, Department of Medicine, Indiana University School of Medicine; Indiana Center for Aging Research, Regenstrief Institute, Indianapolis; and Center for Health Innovation and Implementation Science, Indianapolis."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sikandar","family":"Khan","sequence":"additional","affiliation":[{"name":"Sikandar Khan is an assistant professor, Division of Pulmonary, Critical Care, Sleep and Occupational Medicine, Department of Medicine, Indiana University School of Medicine; Indiana Center for Aging Research, Regenstrief Institute, Indianapolis; and Center for Health Innovation and Implementation Science, Indianapolis."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Rios","sequence":"additional","affiliation":[{"name":"Gabriel Rios is director, Ruth Lilly Medical Library, Indiana University School of Medicine."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babar","family":"Khan","sequence":"additional","affiliation":[{"name":"Babar Khan is an associate professor, Division of Pulmonary, Critical Care, Sleep and Occupational Medicine, Department of Medicine, Indiana University School of Medicine; 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