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My primary program of research is focused on exploration of methods to improve intracranial blood flow in patients with hyperacute ischemic stroke who have viable, yet vulnerable, brain tissue to prevent worsening or enable improvement of stroke symptoms. I am also examining augmentation of recombinant tissue plasminogen activator treatment and stimulation of both arteriogenesis and angiogenesis with external counter-pulsation in patients with intracranial atherosclerosis. My secondary program of research focuses on methods to improve stroke systems of care, including improvement of advance practice providers\u2019 contributions to acute stroke care, use of innovative mobile stroke units, and improvement of quality core measure processes. Lessons learned along the way are highlighted, along with the value of interdisciplinary \u201cteam science\u201d to build knowledge and enhance the care of highly vulnerable patients with acute stroke.<\/jats:p>","DOI":"10.4037\/ajcc2022109","type":"journal-article","created":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T02:05:49Z","timestamp":1656641149000},"page":"266-274","source":"Crossref","is-referenced-by-count":1,"title":["The Sky\u2019s the Limit: Expanding Nursing\u2019s Contribution to Acute Stroke Science"],"prefix":"10.4037","volume":"31","author":[{"given":"Anne W.","family":"Alexandrov","sequence":"first","affiliation":[{"name":"Anne W. 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