{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:29:40Z","timestamp":1791840580899,"version":"4.3.4"},"reference-count":59,"publisher":"AACN Publishing","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,1]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Physiological functions with circadian rhythmicity are often disrupted during illness.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To assess the utility of circadian rhythmicity of vital signs in predicting outcome of traumatic brain injury (TBI).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A retrospective single-center cohort study of adult intensive care unit (ICU) patients with largely isolated TBI to explore the relationship between the circadian rhythmicity of vital signs during the last 24 hours before ICU discharge and clinical markers of TBI severity and score on the Glasgow Outcome Scale 6 months after injury (GOS-6).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The 130 study participants had a median age of 39.0 years (IQR, 23.0-59.0 years), a median Glasgow Coma Scale score at the scene of 8.0 (IQR, 3.0-13.0), and a median Rotterdam score on computed tomography of the head of 3 (IQR, 3-3), with 105 patients (80.8%) surviving to hospital discharge. Rhythmicity was present for heart rate (30.8% of patients), systolic blood pressure (26.2%), diastolic blood pressure (20.0%), and body temperature (26.9%). Independent predictors of a dichotomized GOS-6 \u22654 were the Rotterdam score (odds ratio [OR], 0.38 [95% CI, 0.18-0.81]; P = .01), Glasgow Coma Scale score at the scene (OR, 1.22 [95% CI, 1.05-1.41]; P = .008), age (OR, 0.95 [95% CI, 0.92-0.98]; P = .003), oxygen saturation &amp;lt;90% in the first 24 hours (OR, 0.19 [95% CI, 0.05-0.73]; P = .02), serum sodium level &amp;lt;130 mmol\/L (OR, 0.20 [95% CI, 0.05-0.70]; P = .01), and active intracranial pressure management (OR, 0.16 [95% CI, 0.04-0.62]; P = .008), but not rhythmicity of any vital sign.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Circadian rhythmicity of vital signs at ICU discharge is not predictive of GOS-6 in patients with TBI.<\/jats:p>\n               <\/jats:sec>","DOI":"10.4037\/ajcc2022821","type":"journal-article","created":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T02:07:58Z","timestamp":1667268478000},"page":"472-482","source":"Crossref","is-referenced-by-count":2,"title":["Circadian Rhythmicity of Vital Signs at Intensive Care Unit Discharge and Outcome of Traumatic Brain Injury"],"prefix":"10.4037","volume":"31","author":[{"given":"Rob","family":"Boots","sequence":"first","affiliation":[{"name":"Rob Boots is an associate professor, Thoracic Medicine, Royal Brisbane and Women\u2019s Hospital, a senior specialist, Intensive Care, Bundaberg Hospital, Faculty of Medicine, The University of Queensland, Herston, and a professsor, Faculty of Medicine and Dentistry, Griffith University, Queensland, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Xue","sequence":"additional","affiliation":[{"name":"George Xue is the medical registrar, Royal Brisbane and Women\u2019s Hospital."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Tromp","sequence":"additional","affiliation":[{"name":"Dirk Tromp is the senior radiology registrar, Royal Brisbane and Women\u2019s Hospital."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Rawashdeh","sequence":"additional","affiliation":[{"name":"Oliver Rawashdeh is director, Chronobiology and Sleep Research, School of Biomedical Sciences, Faculty of Medicine, The University of Queensland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Bellapart","sequence":"additional","affiliation":[{"name":"Judith Bellapart is a senior specialist, Department of Intensive Care Medicine, Royal Brisbane and Women\u2019s Hospital, and Burns, Trauma, and Critical Care, The University of Queensland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shane","family":"Townsend","sequence":"additional","affiliation":[{"name":"Shane Townsend is director, Intensive Care Services, Royal Brisbane and Women\u2019s Hospital."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Rudd","sequence":"additional","affiliation":[{"name":"Michael Rudd is acting director, Trauma, Royal Brisbane and Women\u2019s Hospital."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig","family":"Winter","sequence":"additional","affiliation":[{"name":"Craig Winter is a staff specialist neurosurgeon, Royal Brisbane and Women\u2019s Hospital."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Gary Mitchell is a staff specialist, Emergency Medicine, Royal Brisbane and Women\u2019s Hospital."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Garner","sequence":"additional","affiliation":[{"name":"Nicholas Garner is a PhD student, Chronobiology and Sleep Research Lab, School of 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