{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T12:56:47Z","timestamp":1780491407136,"version":"3.54.1"},"reference-count":51,"publisher":"AACN Publishing","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,1]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Patients with acute respiratory failure have multiple risk factors for disability following their intensive care unit stay. Interventions to facilitate independence at hospital discharge may be more effective if personalized for patient subtypes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To identify subtypes of patients with acute respiratory failure requiring mechanical ventilation and compare post\u2013intensive care functional disability and intensive care unit mobility level among subtypes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Latent class analysis was conducted in a cohort of adult medical intensive care unit patients with acute respiratory failure receiving mechanical ventilation who survived to hospital discharge. Demographic and clinical medical record data were collected early in the stay. Clinical characteristics and outcomes were compared among subtypes by using Kruskal-Wallis tests and \u03c72 tests of independence.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In a cohort of 934 patients, the 6-class model provided the optimal fit. Patients in class 4 (obesity and kidney impairment) had worse functional impairment at hospital discharge than patients in classes 1 through 3. Patients in class 3 (alert patients) had the lowest magnitude of functional impairment (P &amp;lt; .001) and achieved the earliest out-of-bed mobility and highest mobility level of all subtypes (P &amp;lt; .001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Acute respiratory failure survivor subtypes identified from clinical data available early in the intensive care unit stay differ in post\u2013intensive care functional disability. Future research should target high-risk patients in early rehabilitation trials in the intensive care unit. Additional investigation of contextual factors and mechanisms of disability is critical to improving quality of life in acute respiratory failure survivors.<\/jats:p>\n               <\/jats:sec>","DOI":"10.4037\/ajcc2023980","type":"journal-article","created":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T02:09:19Z","timestamp":1688177359000},"page":"294-301","source":"Crossref","is-referenced-by-count":2,"title":["Identifying Comorbid Subtypes of Patients With Acute Respiratory Failure"],"prefix":"10.4037","volume":"32","author":[{"given":"Kelly M.","family":"Potter","sequence":"first","affiliation":[{"name":"Kelly M. Potter was a PhD candidate at the Medical University of South Carolina College of Nursing during the study and is now a research assistant professor at the Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) Center, Department of Critical Care Medicine, University of Pittsburgh, Pennsylvania."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Dunn","sequence":"additional","affiliation":[{"name":"Heather Dunn is a clinical assistant professor at University of Iowa College of Nursing, Iowa City, Iowa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Krupp","sequence":"additional","affiliation":[{"name":"Anna Krupp is an assistant professor at University of Iowa College of Nursing."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Mueller","sequence":"additional","affiliation":[{"name":"Martina Mueller is a professor of biostatistics at the Medical University of South Carolina College of Nursing, Charleston, South Carolina."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Newman","sequence":"additional","affiliation":[{"name":"Susan Newman is an associate professor and assistant dean at the Medical University of South Carolina College of Nursing."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy D.","family":"Girard","sequence":"additional","affiliation":[{"name":"Timothy D. 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