{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:00:51Z","timestamp":1753884051777},"reference-count":23,"publisher":"AACN Publishing","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,1]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Patients\u2019 anxiety on intensive care unit (ICU) admission is associated with subsequent deterioration.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To assess whether patients\u2019 fears\/anxiety are predictive of new organ failure within 7 days of ICU admission.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In a prospective 3-center cohort study of non-comatose patients without delirium or invasive mechanical ventilation, 9 specific fears were evaluated through yes\/no questions. Illness severity was assessed using the Simplified Acute Physiology Score II (SAPS II) and the Sequential Organ Failure Assessment (SOFA). Intensity of acute and chronic anxiety was assessed with the state and trait components of the State-Trait Anxiety Inventory (STAI). Patients were followed up for 7 days.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>From April 2014 to December 2017, 373 patients (median [IQR] age, 63 [48-74] years; 152 [40.8%] women; median (IQR) SAPS II, 27 [19-37]) were included. Feelings of vulnerability and fear of dying were reported by 203 (54.4%) and 172 (46.1%) patients, respectively. The STAI-State score was 40 or greater in 192 patients (51.5%). Ninety-four patients (25.2%) had new organ failure. Feelings of vulnerability (odds ratio, 1.96 [95% CI, 1.12-3.43]; P=.02) and absence of fear of dying (odds ratio, 2.38 [95% CI, 1.37-4.17]; P=.002) were associated with new organ failure after adjustment for STAI-State score (\u226540), SAPS II, and SOFA score.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Absence of fear of dying is associated with new organ failure within the first 7 days after ICU admission. Fear of dying may protect against subsequent deterioration by mobilizing patients\u2019 homeostatic resources. ClinicalTrials.gov Identifier: NCT02355626<\/jats:p>\n               <\/jats:sec>","DOI":"10.4037\/ajcc2024517","type":"journal-article","created":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T03:05:55Z","timestamp":1704078355000},"page":"36-44","source":"Crossref","is-referenced-by-count":1,"title":["Association of Lack of Fear of Dying With New Organ Failure: Results of a Multicenter Prospective Cohort Study"],"prefix":"10.4037","volume":"33","author":[{"given":"Aur\u00e9lien","family":"Mazeraud","sequence":"first","affiliation":[{"name":"Aur\u00e9lien Mazeraud is an intensivist\/anesthesiologist, GHU Paris Psychiatrie et Neurosciences Pole Neuro\u2013Anesthesiology and Intensive Care and Universit\u00e9 de Paris, Paris, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillaume","family":"Turc","sequence":"additional","affiliation":[{"name":"Guillaume Turc is a professor, Department of Neurology, GHU Paris Psychiatrie et Neurosciences, Universit\u00e9 de Paris, Paris, France; research director, INSERM U1266; and member of the FHU NeuroVasc."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sivanthiny","family":"Sivanandamoorthy","sequence":"additional","affiliation":[{"name":"Sivanthiny Sivanandamoorthy is an intensivist, General Intensive Care Unit, Sud-Essonne Hospital, Etampes, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rapha\u00ebl","family":"Porcher","sequence":"additional","affiliation":[{"name":"Rapha\u00ebl Porcher is a professor of biostatistics, Center for Clinical Epidemiology, Assistance Publique H\u00f4pitaux de Paris, H\u00f4tel Dieu Hospital, Universit\u00e9 de Paris, Paris, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annabelle","family":"Stoclin","sequence":"additional","affiliation":[{"name":"Annabelle Stoclin is an intensivist, General Intensive Care Unit, Institut Gustave Roussy Hospital, Villejuif, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marion","family":"Antona","sequence":"additional","affiliation":[{"name":"Marion Antona is an intensivist\/anesthesiologist, General Intensive Care Unit, Assistance Publique H\u00f4pitaux de Paris, Raymond Poincar\u00e9 Hospital, Universit\u00e9 de Paris Saclay, Garches, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Polito","sequence":"additional","affiliation":[{"name":"Andrea Polito is an intensivist\/anesthesiologist, General Intensive Care Unit, Assistance Publique H\u00f4pitaux de Paris, Raymond Poincar\u00e9 Hospital, Universit\u00e9 de Paris Saclay, Garches, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cassia","family":"Righy","sequence":"additional","affiliation":[{"name":"Cassia Righy is an intensivist and internal medicine practitioner, D\u2019Or Institute of Research and Education (IDOR), Rio de Janeiro, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando A. B.","family":"Bozza","sequence":"additional","affiliation":[{"name":"Fernando A. B. 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