{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T20:00:38Z","timestamp":1794340838921,"version":"4.9.0"},"reference-count":19,"publisher":"AACN Publishing","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Delirium affects many critically ill patients receiving mechanical ventilation and is an independent predictor of death, length of stay, cost of care, and acquired dementia. More evidence is needed for nonpharmacological interventions that reduce delirium in patients receiving mechanical ventilation in intensive care units (ICUs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>A structured intervention, Family Automated Voice Recording (FAVoR), used recorded voices of family members to provide patients receiving mechanical ventilation with hourly reorientation to the ICU environment during daytime hours. The primary aim was to compare the effect of the FAVoR intervention vs usual care on delirium in adults receiving mechanical ventilation in the ICU.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective, 2-arm, blinded randomized controlled trial included 178 adults receiving mechanical ventilation in 9 ICUs at 2 large hospitals in south Florida. Delirium was measured with the Confusion Assessment Method for the ICU, administered by study personnel twice daily for 7 days or until ICU discharge. Data analyses included descriptive statistics, \u03c72 tests, and multivariable modeling analysis following the intent-to-treat principle.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Clinical characteristics and demographics were similar between groups. Patients in the FAVoR group (n = 89) had more delirium-free days than did those in the usual-care group (n = 89) (P &amp;lt; .001). Response to the intervention was dose dependent; more doses of intervention were associated with less delirium (P &amp;lt; .001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The FAVoR intervention is a nonpharmacological, low-resource-using intervention to reorient ICU patients receiving mechanical ventilation. In this trial, FAVoR was effective in preventing delirium among these patients. ClinicalTrials.gov identifier: NCT03128671<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4037\/ajcc2025486","type":"journal-article","created":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T02:03:11Z","timestamp":1761962591000},"page":"429-437","source":"Crossref","is-referenced-by-count":7,"title":["Delirium Reduction via Scripted Family Voice Recordings in Critically Ill Patients Receiving Mechanical Ventilation"],"prefix":"10.4037","volume":"34","author":[{"given":"Cindy L.","family":"Munro","sequence":"first","affiliation":[{"name":"Cindy L. Munro is emeritus dean, University of Miami School of Nursing and Health Studies, Coral Gables, Florida."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhan","family":"Liang","sequence":"additional","affiliation":[{"name":"Zhan Liang is an assistant professor, University of Miami School of Nursing and Health Studies."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya N.","family":"Elias","sequence":"additional","affiliation":[{"name":"Maya N. Elias is an assistant professor, Department of Biobehavioral Nursing and Health Informatics, University of Washington School of Nursing, Seattle."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Ji","sequence":"additional","affiliation":[{"name":"Ming Ji is a professor, University of South Florida College of Nursing, Tampa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xusheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Xusheng Chen is a senior research associate, University of Miami School of Nursing and Health Studies."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula L.","family":"Kip","sequence":"additional","affiliation":[{"name":"Paula L. Kip is a senior manager and research writer, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judy","family":"Greengold","sequence":"additional","affiliation":[{"name":"Judy Greengold is a PhD candidate, University of Miami School of Nursing and Health Studies."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Wesley","family":"Ely","sequence":"additional","affiliation":[{"name":"E. Wesley Ely is a professor of medicine and critical care and founder and co-director of the Critical Illness, Brain Dysfunction, and Survivorship Center at Vanderbilt University Medical Center, and associate director for aging research, Tennessee Valley Veterans Affairs Geriatric Research Education Clinical Center, Nashville, Tennessee."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karel","family":"Calero","sequence":"additional","affiliation":[{"name":"Karel Calero is an associate professor of medicine, pulmonary critical care, and sleep medicine, University of South Florida, and James A. 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