{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T05:57:04Z","timestamp":1773295024941,"version":"3.50.1"},"reference-count":20,"publisher":"AACN Publishing","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,2,1]]},"DOI":"10.4037\/ccn2009451","type":"journal-article","created":{"date-parts":[[2009,2,24]],"date-time":"2009-02-24T20:19:27Z","timestamp":1235506767000},"page":"49-57","source":"Crossref","is-referenced-by-count":22,"title":["The\u201cBroken Heart Syndrome\u201d: Understanding Takotsubo Cardiomyopathy"],"prefix":"10.4037","volume":"29","author":[{"given":"Dawn","family":"Derrick","sequence":"first","affiliation":[{"name":"Dawn Derrick is an advanced practice nurse certified nurse practitioner at NorthShore University Health System in Evanston, Illinois."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2471","reference":[{"key":"2020040718073388500_R1","doi-asserted-by":"crossref","unstructured":"Gianni\n            M\n          , Dentali F, Grandi AM, et al. Apical ballooning syndrome of takotsubo cardiomyopathy: a systematic review. Eur Heart J. 2006;27(13):1523\u20131529.","DOI":"10.1093\/eurheartj\/ehl032"},{"key":"2020040718073388500_R2","unstructured":"Dote\n            K\n          , Sato H, Tateishi H, et al. Myocardial stunning due to simultaneous multivessel coronary spasm: a review of 5 cases. J Cardiol. 1991;21(2):203\u2013214."},{"key":"2020040718073388500_R3","doi-asserted-by":"crossref","unstructured":"Ako\n            J\n          , Sudhir K, Farouque HM, Honda Y, Fitzgerald PJ. Transient left ventricular dysfunction under severe stress: brain-heart relationship revisited. Am J Med. 2006; 119(1):10\u201317.","DOI":"10.1016\/j.amjmed.2005.08.022"},{"key":"2020040718073388500_R4","unstructured":"American College of Cardiology. Heart disease and stroke statistics: 2007 update at a glance. http:\/\/www.americanheart.org\/downloadable\/heart\/1166711577754HS_StatsInsideText.pdf. Accessed November 5, 2008."},{"key":"2020040718073388500_R5","doi-asserted-by":"crossref","unstructured":"Akashi\n            YJ\n          , Nakazawa K, Sakakibara M, et al. The clinical features of takotsubo cardiomyopathy. Q J Med. 2003;96(8):563\u2013573.","DOI":"10.1093\/qjmed\/hcg096"},{"key":"2020040718073388500_R6","doi-asserted-by":"crossref","unstructured":"Bybee\n            KA\n          , Kara T, Prasad A, et al. Systematic review: transient left ventricular apical ballooning: a syndrome that mimics ST-segment elevation myocardial infarction. Ann Intern Med. 2004;141(11):858\u2013865.","DOI":"10.7326\/0003-4819-141-11-200412070-00010"},{"key":"2020040718073388500_R7","doi-asserted-by":"crossref","unstructured":"Wittstein\n            IS\n          , Thiemann DR, Lima JAC, et al. Neurohumoral features of myocardial stunning due to sudden emotional stress. N Engl J Med. 2005;352(6):539\u2013548.","DOI":"10.1056\/NEJMoa043046"},{"key":"2020040718073388500_R8","doi-asserted-by":"crossref","unstructured":"Khot\n            UN\n          , Khot MB, Bajzer CT, et al. Prevalence of conventional risk factors in patients with coronary heart disease. JAMA. 2003; 290(7):898\u2013904.","DOI":"10.1001\/jama.290.7.898"},{"key":"2020040718073388500_R9","doi-asserted-by":"crossref","unstructured":"Ruiz Balie\u0301n\n            M\n          . Reversible myocardial dysfunction in critically ill, noncardiac patients: a review. Crit Care Med. 2002;30(6):1280\u20131290.","DOI":"10.1097\/00003246-200206000-00020"},{"key":"2020040718073388500_R10","doi-asserted-by":"crossref","unstructured":"Lenders\n            JW\n          , Eisenhofer G, Mannelli M, Pacak K. Phaeochromocytoma. Lancet. 2005;366(9486):665\u2013675.","DOI":"10.1016\/S0140-6736(05)67139-5"},{"key":"2020040718073388500_R11","unstructured":"Furster\n            V\n          , Alexander WR, O\u2019Rouke RA. Hurst\u2019s the Heart. 11th ed. New York, NY: McGraw-Hill; 2004."},{"key":"2020040718073388500_R12","doi-asserted-by":"crossref","unstructured":"Moreo\n            A\n          , De Chiara B, Possa M, et al. Functional derangement and cardiac innervation in the apical ballooning syndrome: a 123I-meta-iodobenzylguanidine scintigraphic and dobutamine stress echocardiographic study. J Cardiovasc Med. 2007;8(3):205\u2013209.","DOI":"10.2459\/01.JCM.0000260843.76156.84"},{"key":"2020040718073388500_R13","doi-asserted-by":"crossref","unstructured":"Kazuki\n            I\n          , Hiroki S, Shuji K, et al. Assessment of Takotsubo (ampulla) cardiomyopathy using 99mTc-tetrofosmin myocardial SPECT: comparison with acute coronary syndrome. Ann Nucl Med. 2003;17(2):115\u2013122.","DOI":"10.1007\/BF02988449"},{"key":"2020040718073388500_R14","doi-asserted-by":"crossref","unstructured":"Ibanez\n            B\n          , Navarro F, Cordoba M, et al. Takotsubo transient left ventricular apical ballooning: is intravascular ultrasound the key to resolve the enigma? Heart. 2005; 91(1):102\u2013104.","DOI":"10.1136\/hrt.2004.035709"},{"key":"2020040718073388500_R15","doi-asserted-by":"crossref","unstructured":"Prasad\n            A\n          . Apical ballooning syndrome: an important differential diagnosis of acute myocardial infarction. Circulation. 2007;115(5):56\u201359.","DOI":"10.1161\/CIRCULATIONAHA.106.669341"},{"key":"2020040718073388500_R16","doi-asserted-by":"crossref","unstructured":"Donohue\n            D\n          , Movahed M. Clinical characteristics, demographics, and prognosis of transient left ventricular apical ballooning syndrome. Heart Fail Rev. 2005;10(4):311\u2013316.","DOI":"10.1007\/s10741-005-8555-8"},{"key":"2020040718073388500_R17","doi-asserted-by":"crossref","unstructured":"Bahit\n            MC\n          , Criger DA, Ohman EM, Granger CB, Wagner GS. Thresholds for the electrocardiographic change range of biochemical markers of acute myocardial infarction (GUSTO-IIa data). Am J Cardiol. 2002; 90(3):233\u2013237.","DOI":"10.1016\/S0002-9149(02)02460-8"},{"key":"2020040718073388500_R18","doi-asserted-by":"crossref","unstructured":"Lee\n            WL\n          , Miao LF, Chan HW, Chen MZ. Takotsubo syndrome with transient complete atrioventricular block. Chin Med J (Engl). 2006; 119:73\u201376.","DOI":"10.1097\/00029330-200601010-00013"},{"key":"2020040718073388500_R19","doi-asserted-by":"crossref","unstructured":"Akashi\n            YJ\n          , Tejima T, Sakurada H, et al. Left ventricular rupture associated with takotsubo cardiomyopathy. Mayo Clin Proc. 2004;79(6):821\u2013824.","DOI":"10.1016\/S0025-6196(11)62638-4"},{"key":"2020040718073388500_R20","doi-asserted-by":"crossref","unstructured":"Haley\n            J\n          , Sinak LJ, Tajik J, et al. Dynamic left ventricular outflow tract obstruction in acute coronary syndromes: an important cause of new systolic murmur and cardiogenic shock. Mayo Clin Proc. 1999; 74(9):901\u2013906.","DOI":"10.4065\/74.9.901"}],"container-title":["Critical Care Nurse"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/aacnjournals.org\/ccnonline\/article-pdf\/29\/1\/49\/120836\/49.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/aacnjournals.org\/ccnonline\/article-pdf\/29\/1\/49\/120836\/49.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,8]],"date-time":"2020-04-08T00:00:19Z","timestamp":1586304019000},"score":1,"resource":{"primary":{"URL":"https:\/\/aacnjournals.org\/ccnonline\/article\/29\/1\/49\/4187\/TheBroken-Heart-Syndrome-Understanding-Takotsubo"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2,1]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,2,1]]}},"URL":"https:\/\/doi.org\/10.4037\/ccn2009451","relation":{},"ISSN":["0279-5442","1940-8250"],"issn-type":[{"value":"0279-5442","type":"print"},{"value":"1940-8250","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,2,1]]}}}