{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T12:05:57Z","timestamp":1744805157645},"reference-count":20,"publisher":"AACN Publishing","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,10,1]]},"abstract":"<jats:p>The implications of genetics and genomics for critical care nurses are becoming more evident, not only in the care provided but also in the numerous medications administered. Genetic causes are being discovered for an increasing number of chronic illnesses and diseases, such as Huntington disease. Because of the scientific and pharmacological advances, leading nursing organizations, such as the American Nurses Association, have established competencies in genetic knowledge for nurses. Such competencies help ensure quality care. Recent advances in the pharmacogenomics of therapy for human immunodeficiency virus disease, cancer, cardiovascular disease, and malignant hyperthermia have indicated a genetic linkage; therefore treatments are targeted toward the genetic aspect of the abnormality. Critical care nurses need knowledge of these genetic conditions and of medications affected by genetic factors.<\/jats:p>","DOI":"10.4037\/ccn2011867","type":"journal-article","created":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T07:18:17Z","timestamp":1317453497000},"page":"e1-e7","source":"Crossref","is-referenced-by-count":10,"title":["Essential Nursing Competencies for Genetics and Genomics: Implications for Critical Care"],"prefix":"10.4037","volume":"31","author":[{"given":"Lynnette","family":"Howington","sequence":"first","affiliation":[{"name":"Lynnette Howington is a clinical instructor at Harris College of Nursing and Health Sciences, Texas Christian University, Fort Worth, Texas."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina","family":"Riddlesperger","sequence":"additional","affiliation":[{"name":"Kristina Riddlesperger is a clinical assistant professor at Harris College of Nursing and Health Sciences, Texas Christian University."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis J.","family":"Cheek","sequence":"additional","affiliation":[{"name":"Dennis J. Cheek is the Abell-Hanger Professor, School of Nurse Anesthesia and Harris College of Nursing and Health Sciences, Texas Christian University."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2471","reference":[{"key":"2019112521530032200_b1-03100e1","unstructured":"Core competencies in genetics for all health professionals. 3rd ed. National Coalition for Health Professional Education in Genetics Web site. http:\/\/www.nchpeg.org\/index.php?option=com_content&view=article&id=94&Itemid=84. Published September 2007. Accessed July 5, 2011."},{"key":"2019112521530032200_b2-03100e1","volume-title":"Human Heredity: Principles and Issues","author":"Cummings","year":"2010","edition":"9th ed"},{"issue":"4","key":"2019112521530032200_b3-03100e1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00044067-200211000-00003","article-title":"Education for genetics and nursing practice","volume":"13","author":"Williams","year":"2002","journal-title":"AACN Clin Issues."},{"key":"2019112521530032200_b4-03100e1","volume-title":"Genetics\/ Genomics Nursing: Scope and Standards of Practice","author":"American Nurses Association and International Society of Nurses in Genetics","year":"2007"},{"key":"2019112521530032200_b5-03100e1","volume-title":"The Essentials of Baccalaureate Education for Professional Nursing Practice","author":"American Association of Colleges of Nursing","year":"2008"},{"key":"2019112521530032200_b6-03100e1","unstructured":"American Nurses Association. Essential nursing competencies and curricula guidelines for genetics and genomics. National Nursing Staff Development Organization Web site. http:\/\/www.genome.gov\/Pages\/Careers\/HealthProfessionalEducation\/geneticscompetency.pdf. Published 2006. Accessed July 6, 2011."},{"key":"2019112521530032200_b7-03100e1","volume-title":"Essentials of Genetic and Genomic Nursing: Competencies, Curricula Guidelines, and Outcome Indicators","author":"Consensus Panel on Genetic\/Genomic Nursing Competencies","year":"2009","edition":"2nd ed"},{"issue":"2","key":"2019112521530032200_b8-03100e1","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1056\/NEJMcp0706513","article-title":"Long-QT syndrome","volume":"358","author":"Roden","year":"2008","journal-title":"N Engl J Med."},{"issue":"6","key":"2019112521530032200_b9-03100e1","doi-asserted-by":"crossref","first-page":"32","DOI":"10.4037\/ccn2008.28.6.32","article-title":"Genetics and susceptibility to malignant hyperthermia [published correction appears in Crit Care Nurse. 2009;29(2):24]","volume":"28","author":"Anderson-Pompa","year":"2008","journal-title":"Crit Care Nurse."},{"key":"2019112521530032200_b10-03100e1","volume-title":"Medical Genetics","author":"Jorde","year":"2010","edition":"4th ed"},{"issue":"4","key":"2019112521530032200_b11-03100e1","first-page":"242","article-title":"The variation of response to pharmacotherapy: pharmacogenetics\u2014a new perspective to \u201cthe right drug for the right person.\u201d","volume":"12","author":"Nicol","year":"2003","journal-title":"Medsurg Nurs."},{"issue":"2","key":"2019112521530032200_b12-03100e1","doi-asserted-by":"crossref","first-page":"215","DOI":"10.2165\/11203700-000000000-00000","article-title":"Trastuzumab: a review of its use as adjuvant treatment in human epidermal growth factor receptor 2 (HER2)-positive early breast cancer","volume":"70","author":"Garnock-Jones","year":"2010","journal-title":"Drugs."},{"issue":"3","key":"2019112521530032200_b13-03100e1","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1080\/10408360902937817","article-title":"HLA-B*5701 screening prior to abacavir prescription: clinical and laboratory aspects","volume":"46","author":"Nolan","year":"2009","journal-title":"Crit Rev Clin Lab Sci."},{"issue":"3","key":"2019112521530032200_b14-03100e1","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1080\/1024533031000134929","article-title":"Imatinib mesylate (Gleevec) is a useful agent in the salvage treatment of adults with relapsed\/ refractory Philadelphia positive acute leukemias","volume":"8","author":"Gupta","year":"2003","journal-title":"Hematology."},{"issue":"7","key":"2019112521530032200_b15-03100e1","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1080\/02841860903229124","article-title":"Cardiotoxicity induced by tyrosine kinase inhibitors","volume":"48","author":"Orphanoa","year":"2009","journal-title":"Acta Oncol."},{"key":"2019112521530032200_b16-03100e1","unstructured":"Flockhart DA . Drug interactions: cytochrome P450 drug interaction table. Indiana University School of Medicine Web site. http:\/\/medicine.iupui.edu\/clinpharm\/ddis\/table.aspx. Published 2007. 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