{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T15:36:24Z","timestamp":1762875384085},"reference-count":37,"publisher":"AACN Publishing","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,6,1]]},"abstract":"<jats:p>Birth asphyxia can induce a cascade of reactions that result in altered brain function known as hypoxic-ischemic encephalopathy. Possible outcomes for survivors of birth asphyxia vary widely, from a normal outcome to death, with a wide range of disabilities in between, including long-term neurodevelopmental disability, cerebral palsy, neuromotor delay, and developmental delay. Treatment of hypoxic-ischemic encephalopathy has centered on dampening or blocking the biochemical pathways that lead to death of neuronal cells. The reduction of body temperature by 3\u00baC to 5\u00baC less than normal body temperature can reduce cerebral injury. At Mount Sinai Hospital in Toronto, Ontario, the goal of therapeutic hypothermia is to achieve a rectal temperature of 33\u00baC to 34\u00baC, and the protocol is started within 6 hours after birth. The hypothermia is maintained for 72 hours, and then the infant is gradually warmed to normal body temperature (36.8\u00baC\u201337\u00baC). The protocol and nursing implications are presented.<\/jats:p>","DOI":"10.4037\/ccn2011873","type":"journal-article","created":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T07:37:23Z","timestamp":1306913843000},"page":"e1-e12","source":"Crossref","is-referenced-by-count":7,"title":["Therapeutic Hypothermia for Management of Neonatal Asphyxia: What Nurses Need to Know"],"prefix":"10.4037","volume":"31","author":[{"given":"Nevart","family":"Chirinian","sequence":"first","affiliation":[{"name":"Nevart Chirinian is a neonatal nurse practitioner and Nancy Mann is a staff nurse in the neonatal intensive care unit at Mount Sinai Hospital, Toronto, Ontario."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy","family":"Mann","sequence":"additional","affiliation":[{"name":"Nevart Chirinian is a neonatal nurse practitioner and Nancy Mann is a staff nurse in the neonatal intensive care unit at Mount Sinai Hospital, Toronto, Ontario."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2471","reference":[{"key":"2019112612055373400_b1-03100e1","first-page":"11","volume-title":"Perinatal Asphyxia","author":"Lacoius-Petruccelli","year":"2007"},{"key":"2019112612055373400_b2-03100e1","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1017\/CBO9780511581281.003","article-title":"Neonatal encephalopathy: epidemiology and overview","volume-title":"Fetal and Neonatal Brain Injury","author":"Sunshine","year":"2009"},{"key":"2019112612055373400_b3-03100e1","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/B978-1-4160-3995-2.10009-3","volume-title":"Neurology of the Newborn","author":"Volpe","year":"2008","edition":"5th ed"},{"issue":"11","key":"2019112612055373400_b4-03100e1","doi-asserted-by":"publisher","first-page":"e513","DOI":"10.1542\/neo.9-11-e513","article-title":"The brain and resuscitation","volume":"9","author":"Savman","year":"2008","journal-title":"Neoreviews."},{"key":"2019112612055373400_b5-03100e1","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.clp.2009.07.011","article-title":"Hypoxic-ischemic encephalopathy in the term infant","volume":"36","author":"Fatemi","year":"2009","journal-title":"Clin Perinatol."},{"issue":"1","key":"2019112612055373400_b6-03100e1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1097\/01.JPN.0000346221.48202.7e","article-title":"The chilling details: hypoxic-ischemic encephalopathy","volume":"23","author":"Verklan","year":"2009","journal-title":"J Perinat Neonatal Nurs."},{"key":"2019112612055373400_b7-03100e1","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1089\/neu.2008.0678","article-title":"Neonatal encephalopathy: treatment with hypothermia","volume":"26","author":"Shankaran","year":"2009","journal-title":"J Neurotrauma."},{"key":"2019112612055373400_b8-03100e1","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1111\/j.1552-6909.2007.00150.x","article-title":"Induced hypothermia for neonates with hypoxic-ischemic encephalopathy","volume":"36","author":"Long","year":"2007","journal-title":"J Obstet Gynecol Neonatal Nurs."},{"key":"2019112612055373400_b9-03100e1","first-page":"224","article-title":"A review of developmental outcomes of term infants with post-asphyxia neonatal encephalopathy","volume":"200","author":"Pin","journal-title":"Eur J Paediatr Neurol."},{"key":"2019112612055373400_b10-03100e1","volume-title":"Neonatal Encephalopathy and Cerebral Palsy. 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