{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T15:10:50Z","timestamp":1783091450636,"version":"3.54.6"},"reference-count":14,"publisher":"AACN Publishing","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,4,1]]},"abstract":"<jats:p>Central neurogenic diabetes insipidus, syndrome of inappropriate secretion of antidiuretic hormone, and cerebral salt-wasting syndrome are secondary events that affect patients with traumatic brain injury. All 3 syndromes affect both sodium and water balance; however, they have differences in pathophysiology, diagnosis, and treatment. Differentiating between hypernatremia (central neurogenic diabetes insipidus) and the 2 hyponatremia syndromes (syndrome of inappropriate secretion of antidiuretic hormone, and cerebral salt-wasting syndrome) is critical for preventing worsening neurological outcomes in patients with head injuries.<\/jats:p>","DOI":"10.4037\/ccn2012904","type":"journal-article","created":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T07:03:01Z","timestamp":1333263781000},"page":"e1-e7","source":"Crossref","is-referenced-by-count":20,"title":["Central Neurogenic Diabetes Insipidus, Syndrome of Inappropriate Secretion of Antidiuretic Hormone, and Cerebral Salt-Wasting Syndrome in Traumatic Brain Injury"],"prefix":"10.4037","volume":"32","author":[{"given":"Cynthia (Cindi) A.","family":"John","sequence":"first","affiliation":[{"name":"Cynthia (Cindi) A. John is a neuroscience nurse educator and Michael W. Day is trauma care coordinator at Providence Sacred Heart Medical Center and Children\u2019s Hospital, Spokane, Washington."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael W.","family":"Day","sequence":"additional","affiliation":[{"name":"Cynthia (Cindi) A. John is a neuroscience nurse educator and Michael W. Day is trauma care coordinator at Providence Sacred Heart Medical Center and Children\u2019s Hospital, Spokane, Washington."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2471","reference":[{"key":"2019112612074566500_b1-03200e1","unstructured":"Faul M , XuL, WaldMM, CoronadoVG. Traumatic Brain Injury in the United States: Emergency Department Visits, Hospitalizations and Deaths 2002\u20132006. Atlanta, GA: Centers for Disease Control and Prevention, National Center for Injury Prevention and Control. http:\/\/www.cdc.gov\/traumaticbraininjury\/pdf\/blue_book.pdf. Published March 2010. Accessed January 9, 2012."},{"key":"2019112612074566500_b2-03200e1","unstructured":"Pangilinan PH Jr , KellyBM, HornyakJEIV, . Classification and complications of traumatic brain injury. http:\/\/emedicine.medscape.com\/article\/326643. Updated November 10, 2011. Accessed January 9, 2012."},{"key":"2019112612074566500_b3-03200e1","first-page":"195","article-title":"Fluid and metabolic disorders in neuroscience patients","volume-title":"The Clinical Practice of Neurological and Neurosurgical Nursing","author":"Hickey","year":"2009","edition":"6th ed"},{"key":"2019112612074566500_b4-03200e1","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1177\/000313480407000607","article-title":"Diabetes insipidus in the head-injured patient","volume":"70","author":"Boughey","year":"2004","journal-title":"Am Surg."},{"key":"2019112612074566500_b5-03200e1","first-page":"939","article-title":"Pituitary, thyroid, and adrenal disorders","volume-title":"AACN Advanced Critical Care Nursing","author":"Byrum","year":"2009"},{"key":"2019112612074566500_b6-03200e1","unstructured":"Klein MJ . Post head injury endocrine complications. http:\/\/emedicine.medscape.com\/article\/326123. Updated January 5, 2009. Accessed January 9, 2012."},{"issue":"4","key":"2019112612074566500_b7-03200e1","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.jamcollsurg.2008.04.017","article-title":"Acute diabetes insipidus in severe head injury: a prospective study","volume":"207","author":"Hadjizacharia","year":"2008","journal-title":"J Am Coll Surg."},{"key":"2019112612074566500_b8-03200e1","unstructured":"Cooperman M . Diabetes insipidus. http:\/\/emedicine.medscape.com\/article\/117648. Updated June 17, 2011. 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